TPR_REGION domain-containing protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXK1_LEIIN

TriTrypDb:

LINF_170019700

Length:

954

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote: 114

Expansion

Sequence features

A4HXK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.723
CLV_C14_Caspase3-7	314	318	PF00656	0.437
CLV_C14_Caspase3-7	696	700	PF00656	0.536
CLV_C14_Caspase3-7	701	705	PF00656	0.555
CLV_C14_Caspase3-7	706	710	PF00656	0.477
CLV_C14_Caspase3-7	769	773	PF00656	0.431
CLV_C14_Caspase3-7	864	868	PF00656	0.434
CLV_NRD_NRD_1	250	252	PF00675	0.415
CLV_NRD_NRD_1	400	402	PF00675	0.475
CLV_NRD_NRD_1	422	424	PF00675	0.586
CLV_NRD_NRD_1	490	492	PF00675	0.353
CLV_NRD_NRD_1	531	533	PF00675	0.258
CLV_NRD_NRD_1	616	618	PF00675	0.549
CLV_NRD_NRD_1	634	636	PF00675	0.331
CLV_NRD_NRD_1	780	782	PF00675	0.519
CLV_NRD_NRD_1	943	945	PF00675	0.476
CLV_PCSK_FUR_1	941	945	PF00082	0.458
CLV_PCSK_KEX2_1	250	252	PF00082	0.423
CLV_PCSK_KEX2_1	400	402	PF00082	0.478
CLV_PCSK_KEX2_1	422	424	PF00082	0.586
CLV_PCSK_KEX2_1	450	452	PF00082	0.460
CLV_PCSK_KEX2_1	488	490	PF00082	0.382
CLV_PCSK_KEX2_1	634	636	PF00082	0.391
CLV_PCSK_KEX2_1	779	781	PF00082	0.538
CLV_PCSK_KEX2_1	933	935	PF00082	0.506
CLV_PCSK_KEX2_1	943	945	PF00082	0.556
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.441
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.382
CLV_PCSK_PC1ET2_1	933	935	PF00082	0.482
CLV_PCSK_PC7_1	396	402	PF00082	0.386
CLV_PCSK_SKI1_1	152	156	PF00082	0.496
CLV_PCSK_SKI1_1	198	202	PF00082	0.441
CLV_PCSK_SKI1_1	344	348	PF00082	0.389
CLV_PCSK_SKI1_1	464	468	PF00082	0.318
CLV_PCSK_SKI1_1	497	501	PF00082	0.377
CLV_PCSK_SKI1_1	543	547	PF00082	0.326
CLV_PCSK_SKI1_1	651	655	PF00082	0.312
CLV_PCSK_SKI1_1	787	791	PF00082	0.356
CLV_PCSK_SKI1_1	916	920	PF00082	0.498
CLV_PCSK_SKI1_1	950	954	PF00082	0.405
DEG_APCC_DBOX_1	141	149	PF00400	0.484
DEG_APCC_DBOX_1	249	257	PF00400	0.294
DEG_MDM2_SWIB_1	568	575	PF02201	0.324
DEG_Nend_UBRbox_2	1	3	PF02207	0.533
DEG_SPOP_SBC_1	123	127	PF00917	0.653
DOC_CKS1_1	335	340	PF01111	0.567
DOC_CKS1_1	879	884	PF01111	0.494
DOC_CYCLIN_RxL_1	491	503	PF00134	0.330
DOC_CYCLIN_RxL_1	787	800	PF00134	0.378
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.387
DOC_MAPK_gen_1	142	150	PF00069	0.455
DOC_MAPK_gen_1	250	258	PF00069	0.335
DOC_MAPK_HePTP_8	33	45	PF00069	0.496
DOC_MAPK_MEF2A_6	166	174	PF00069	0.353
DOC_MAPK_MEF2A_6	179	188	PF00069	0.413
DOC_MAPK_MEF2A_6	210	218	PF00069	0.364
DOC_MAPK_MEF2A_6	344	352	PF00069	0.318
DOC_MAPK_MEF2A_6	36	45	PF00069	0.387
DOC_MAPK_MEF2A_6	675	682	PF00069	0.474
DOC_MAPK_NFAT4_5	675	683	PF00069	0.476
DOC_PP1_RVXF_1	253	259	PF00149	0.280
DOC_PP1_RVXF_1	948	954	PF00149	0.429
DOC_PP2B_LxvP_1	226	229	PF13499	0.380
DOC_PP2B_LxvP_1	5	8	PF13499	0.346
DOC_USP7_MATH_1	293	297	PF00917	0.503
DOC_USP7_MATH_1	817	821	PF00917	0.472
DOC_USP7_MATH_1	853	857	PF00917	0.336
DOC_USP7_UBL2_3	484	488	PF12436	0.366
DOC_WW_Pin1_4	124	129	PF00397	0.599
DOC_WW_Pin1_4	190	195	PF00397	0.405
DOC_WW_Pin1_4	325	330	PF00397	0.445
DOC_WW_Pin1_4	334	339	PF00397	0.431
DOC_WW_Pin1_4	379	384	PF00397	0.458
DOC_WW_Pin1_4	6	11	PF00397	0.464
DOC_WW_Pin1_4	744	749	PF00397	0.561
DOC_WW_Pin1_4	878	883	PF00397	0.524
LIG_14-3-3_CanoR_1	152	162	PF00244	0.349
LIG_14-3-3_CanoR_1	210	215	PF00244	0.451
LIG_14-3-3_CanoR_1	22	28	PF00244	0.438
LIG_14-3-3_CanoR_1	387	392	PF00244	0.421
LIG_14-3-3_CanoR_1	432	441	PF00244	0.414
LIG_14-3-3_CanoR_1	46	54	PF00244	0.585
LIG_Actin_WH2_2	605	622	PF00022	0.354
LIG_APCC_ABBA_1	678	683	PF00400	0.394
LIG_BIR_III_4	602	606	PF00653	0.456
LIG_BRCT_BRCA1_1	434	438	PF00533	0.351
LIG_BRCT_BRCA1_1	439	443	PF00533	0.311
LIG_BRCT_BRCA1_1	600	604	PF00533	0.483
LIG_BRCT_BRCA1_1	855	859	PF00533	0.384
LIG_deltaCOP1_diTrp_1	636	644	PF00928	0.301
LIG_deltaCOP1_diTrp_1	835	844	PF00928	0.372
LIG_FHA_1	124	130	PF00498	0.701
LIG_FHA_1	211	217	PF00498	0.436
LIG_FHA_1	411	417	PF00498	0.336
LIG_FHA_1	424	430	PF00498	0.393
LIG_FHA_1	500	506	PF00498	0.515
LIG_FHA_1	655	661	PF00498	0.350
LIG_FHA_1	66	72	PF00498	0.306
LIG_FHA_1	675	681	PF00498	0.225
LIG_FHA_2	154	160	PF00498	0.447
LIG_FHA_2	24	30	PF00498	0.421
LIG_FHA_2	312	318	PF00498	0.416
LIG_FHA_2	368	374	PF00498	0.346
LIG_FHA_2	431	437	PF00498	0.363
LIG_FHA_2	463	469	PF00498	0.359
LIG_FHA_2	515	521	PF00498	0.439
LIG_FHA_2	733	739	PF00498	0.718
LIG_FHA_2	765	771	PF00498	0.498
LIG_FHA_2	82	88	PF00498	0.384
LIG_GBD_Chelix_1	63	71	PF00786	0.384
LIG_LIR_Gen_1	213	222	PF02991	0.315
LIG_LIR_Gen_1	406	416	PF02991	0.387
LIG_LIR_Gen_1	468	474	PF02991	0.354
LIG_LIR_Gen_1	475	480	PF02991	0.305
LIG_LIR_Gen_1	549	558	PF02991	0.320
LIG_LIR_Gen_1	590	600	PF02991	0.338
LIG_LIR_Gen_1	622	630	PF02991	0.357
LIG_LIR_Gen_1	856	865	PF02991	0.373
LIG_LIR_Nem_3	213	218	PF02991	0.321
LIG_LIR_Nem_3	406	412	PF02991	0.411
LIG_LIR_Nem_3	435	441	PF02991	0.305
LIG_LIR_Nem_3	452	456	PF02991	0.297
LIG_LIR_Nem_3	468	473	PF02991	0.325
LIG_LIR_Nem_3	475	479	PF02991	0.305
LIG_LIR_Nem_3	549	554	PF02991	0.329
LIG_LIR_Nem_3	571	575	PF02991	0.303
LIG_LIR_Nem_3	590	595	PF02991	0.329
LIG_LIR_Nem_3	856	862	PF02991	0.364
LIG_LIR_Nem_3	906	911	PF02991	0.471
LIG_MLH1_MIPbox_1	434	438	PF16413	0.371
LIG_NRBOX	149	155	PF00104	0.424
LIG_Pex14_1	640	644	PF04695	0.313
LIG_Pex14_2	443	447	PF04695	0.429
LIG_Pex14_2	568	572	PF04695	0.335
LIG_PTB_Apo_2	562	569	PF02174	0.335
LIG_REV1ctd_RIR_1	198	206	PF16727	0.427
LIG_RPA_C_Fungi	396	408	PF08784	0.380
LIG_SH2_CRK	551	555	PF00017	0.389
LIG_SH2_CRK	577	581	PF00017	0.447
LIG_SH2_CRK	713	717	PF00017	0.592
LIG_SH2_CRK	91	95	PF00017	0.475
LIG_SH2_CRK	932	936	PF00017	0.383
LIG_SH2_NCK_1	439	443	PF00017	0.317
LIG_SH2_NCK_1	804	808	PF00017	0.379
LIG_SH2_STAP1	439	443	PF00017	0.316
LIG_SH2_STAP1	470	474	PF00017	0.376
LIG_SH2_STAP1	551	555	PF00017	0.329
LIG_SH2_STAP1	804	808	PF00017	0.379
LIG_SH2_STAT5	17	20	PF00017	0.397
LIG_SH2_STAT5	371	374	PF00017	0.326
LIG_SH2_STAT5	437	440	PF00017	0.308
LIG_SH2_STAT5	557	560	PF00017	0.423
LIG_SH2_STAT5	643	646	PF00017	0.320
LIG_SH2_STAT5	688	691	PF00017	0.489
LIG_SH3_3	125	131	PF00018	0.589
LIG_SH3_3	181	187	PF00018	0.602
LIG_SH3_3	295	301	PF00018	0.453
LIG_SH3_3	332	338	PF00018	0.492
LIG_SH3_3	438	444	PF00018	0.297
LIG_SH3_3	501	507	PF00018	0.324
LIG_SH3_3	750	756	PF00018	0.563
LIG_SH3_3	795	801	PF00018	0.354
LIG_SH3_3	886	892	PF00018	0.486
LIG_SUMO_SIM_par_1	2	9	PF11976	0.387
LIG_TRAF2_1	229	232	PF00917	0.517
LIG_TRAF2_1	26	29	PF00917	0.432
LIG_TRAF2_1	736	739	PF00917	0.729
LIG_TRAF2_1	767	770	PF00917	0.534
LIG_TRAF2_1	921	924	PF00917	0.445
LIG_TYR_ITIM	575	580	PF00017	0.430
LIG_TYR_ITIM	711	716	PF00017	0.525
LIG_UBA3_1	170	179	PF00899	0.436
LIG_WRC_WIRS_1	818	823	PF05994	0.468
MOD_CDC14_SPxK_1	193	196	PF00782	0.379
MOD_CDK_SPxK_1	190	196	PF00069	0.399
MOD_CK1_1	132	138	PF00069	0.559
MOD_CK1_1	208	214	PF00069	0.409
MOD_CK1_1	47	53	PF00069	0.480
MOD_CK1_1	65	71	PF00069	0.199
MOD_CK2_1	111	117	PF00069	0.701
MOD_CK2_1	153	159	PF00069	0.311
MOD_CK2_1	23	29	PF00069	0.489
MOD_CK2_1	300	306	PF00069	0.570
MOD_CK2_1	367	373	PF00069	0.352
MOD_CK2_1	46	52	PF00069	0.599
MOD_CK2_1	6	12	PF00069	0.429
MOD_CK2_1	732	738	PF00069	0.693
MOD_CK2_1	764	770	PF00069	0.558
MOD_CK2_1	81	87	PF00069	0.403
MOD_CMANNOS	524	527	PF00535	0.361
MOD_CMANNOS	637	640	PF00535	0.331
MOD_Cter_Amidation	530	533	PF01082	0.242
MOD_GlcNHglycan	132	135	PF01048	0.536
MOD_GlcNHglycan	264	267	PF01048	0.346
MOD_GlcNHglycan	419	422	PF01048	0.453
MOD_GlcNHglycan	587	590	PF01048	0.326
MOD_GlcNHglycan	64	67	PF01048	0.478
MOD_GlcNHglycan	79	82	PF01048	0.278
MOD_GSK3_1	227	234	PF00069	0.395
MOD_GSK3_1	458	465	PF00069	0.405
MOD_GSK3_1	77	84	PF00069	0.458
MOD_LATS_1	44	50	PF00433	0.410
MOD_N-GLC_1	291	296	PF02516	0.495
MOD_N-GLC_1	77	82	PF02516	0.324
MOD_NEK2_1	205	210	PF00069	0.413
MOD_NEK2_1	262	267	PF00069	0.505
MOD_NEK2_1	291	296	PF00069	0.577
MOD_NEK2_1	3	8	PF00069	0.421
MOD_NEK2_1	430	435	PF00069	0.408
MOD_NEK2_1	45	50	PF00069	0.582
MOD_NEK2_1	458	463	PF00069	0.343
MOD_NEK2_1	98	103	PF00069	0.419
MOD_NEK2_2	576	581	PF00069	0.442
MOD_NEK2_2	817	822	PF00069	0.463
MOD_PIKK_1	624	630	PF00454	0.358
MOD_PKA_2	111	117	PF00069	0.674
MOD_PKA_2	262	268	PF00069	0.376
MOD_PKA_2	45	51	PF00069	0.602
MOD_PKA_2	619	625	PF00069	0.365
MOD_PKA_2	674	680	PF00069	0.375
MOD_PKB_1	394	402	PF00069	0.376
MOD_PKB_1	489	497	PF00069	0.352
MOD_PKB_1	934	942	PF00069	0.421
MOD_Plk_1	231	237	PF00069	0.379
MOD_Plk_1	269	275	PF00069	0.464
MOD_Plk_1	458	464	PF00069	0.384
MOD_Plk_1	682	688	PF00069	0.387
MOD_Plk_2-3	231	237	PF00069	0.437
MOD_Plk_2-3	674	680	PF00069	0.491
MOD_Plk_4	210	216	PF00069	0.403
MOD_Plk_4	270	276	PF00069	0.467
MOD_Plk_4	300	306	PF00069	0.522
MOD_Plk_4	308	314	PF00069	0.470
MOD_Plk_4	367	373	PF00069	0.352
MOD_Plk_4	387	393	PF00069	0.186
MOD_Plk_4	458	464	PF00069	0.428
MOD_Plk_4	608	614	PF00069	0.317
MOD_ProDKin_1	124	130	PF00069	0.595
MOD_ProDKin_1	190	196	PF00069	0.399
MOD_ProDKin_1	325	331	PF00069	0.444
MOD_ProDKin_1	334	340	PF00069	0.418
MOD_ProDKin_1	379	385	PF00069	0.456
MOD_ProDKin_1	6	12	PF00069	0.475
MOD_ProDKin_1	744	750	PF00069	0.557
MOD_ProDKin_1	878	884	PF00069	0.532
MOD_SUMO_for_1	178	181	PF00179	0.378
MOD_SUMO_for_1	449	452	PF00179	0.336
MOD_SUMO_for_1	689	692	PF00179	0.443
MOD_SUMO_rev_2	611	619	PF00179	0.413
TRG_DiLeu_BaEn_4	28	34	PF01217	0.405
TRG_DiLeu_BaEn_4	741	747	PF01217	0.697
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.316
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.325
TRG_ENDOCYTIC_2	453	456	PF00928	0.375
TRG_ENDOCYTIC_2	470	473	PF00928	0.253
TRG_ENDOCYTIC_2	551	554	PF00928	0.336
TRG_ENDOCYTIC_2	577	580	PF00928	0.304
TRG_ENDOCYTIC_2	643	646	PF00928	0.352
TRG_ENDOCYTIC_2	713	716	PF00928	0.587
TRG_ENDOCYTIC_2	91	94	PF00928	0.440
TRG_ENDOCYTIC_2	932	935	PF00928	0.378
TRG_ER_diArg_1	195	198	PF00400	0.299
TRG_ER_diArg_1	277	280	PF00400	0.368
TRG_ER_diArg_1	393	396	PF00400	0.343
TRG_ER_diArg_1	400	403	PF00400	0.457
TRG_ER_diArg_1	489	491	PF00400	0.414
TRG_ER_diArg_1	778	781	PF00400	0.546
TRG_ER_diArg_1	88	91	PF00400	0.423
TRG_ER_diArg_1	934	937	PF00400	0.442
TRG_ER_diArg_1	941	944	PF00400	0.431
TRG_NES_CRM1_1	503	515	PF08389	0.377
TRG_NES_CRM1_1	61	77	PF08389	0.370
TRG_NES_CRM1_1	745	757	PF08389	0.569
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA34	Leptomonas seymouri	70%	95%
A0A1X0NSN3	Trypanosomatidae	48%	98%
A0A3R7K6J2	Trypanosoma rangeli	53%	100%
A0A3S7WUL1	Leishmania donovani	100%	100%
A4H983	Leishmania braziliensis	82%	99%
C9ZP90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AR96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QE67	Leishmania major	95%	100%
Q5RBW9	Pongo abelii	28%	100%
Q6P3X3	Homo sapiens	28%	100%
V5AZD3	Trypanosoma cruzi	56%	100%