Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXJ6_LEIIN

TriTrypDb:

LINF_170019200

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.751
CLV_NRD_NRD_1	231	233	PF00675	0.722
CLV_NRD_NRD_1	239	241	PF00675	0.674
CLV_NRD_NRD_1	334	336	PF00675	0.651
CLV_NRD_NRD_1	345	347	PF00675	0.603
CLV_NRD_NRD_1	79	81	PF00675	0.790
CLV_PCSK_KEX2_1	123	125	PF00082	0.756
CLV_PCSK_KEX2_1	231	233	PF00082	0.722
CLV_PCSK_KEX2_1	239	241	PF00082	0.674
CLV_PCSK_KEX2_1	344	346	PF00082	0.705
CLV_PCSK_KEX2_1	350	352	PF00082	0.656
CLV_PCSK_KEX2_1	79	81	PF00082	0.790
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.718
CLV_PCSK_PC7_1	341	347	PF00082	0.673
CLV_PCSK_SKI1_1	300	304	PF00082	0.616
CLV_PCSK_SKI1_1	325	329	PF00082	0.627
CLV_PCSK_SKI1_1	345	349	PF00082	0.604
DEG_SCF_FBW7_1	362	369	PF00400	0.541
DEG_SPOP_SBC_1	273	277	PF00917	0.689
DEG_SPOP_SBC_1	62	66	PF00917	0.681
DOC_CKS1_1	83	88	PF01111	0.702
DOC_MAPK_MEF2A_6	317	326	PF00069	0.594
DOC_PP4_FxxP_1	149	152	PF00568	0.578
DOC_USP7_MATH_1	108	112	PF00917	0.639
DOC_USP7_MATH_1	163	167	PF00917	0.698
DOC_USP7_MATH_1	186	190	PF00917	0.650
DOC_USP7_MATH_1	269	273	PF00917	0.688
DOC_USP7_MATH_1	274	278	PF00917	0.734
DOC_USP7_MATH_1	295	299	PF00917	0.615
DOC_USP7_MATH_1	414	418	PF00917	0.676
DOC_USP7_MATH_1	432	436	PF00917	0.719
DOC_USP7_MATH_1	448	452	PF00917	0.586
DOC_USP7_MATH_1	466	470	PF00917	0.657
DOC_USP7_MATH_1	63	67	PF00917	0.686
DOC_USP7_MATH_1	99	103	PF00917	0.696
DOC_WW_Pin1_4	106	111	PF00397	0.622
DOC_WW_Pin1_4	155	160	PF00397	0.711
DOC_WW_Pin1_4	265	270	PF00397	0.619
DOC_WW_Pin1_4	349	354	PF00397	0.603
DOC_WW_Pin1_4	362	367	PF00397	0.555
DOC_WW_Pin1_4	371	376	PF00397	0.599
DOC_WW_Pin1_4	381	386	PF00397	0.610
DOC_WW_Pin1_4	393	398	PF00397	0.606
DOC_WW_Pin1_4	42	47	PF00397	0.611
DOC_WW_Pin1_4	442	447	PF00397	0.773
DOC_WW_Pin1_4	82	87	PF00397	0.698
LIG_14-3-3_CanoR_1	239	244	PF00244	0.749
LIG_14-3-3_CanoR_1	390	395	PF00244	0.692
LIG_14-3-3_CanoR_1	405	414	PF00244	0.537
LIG_14-3-3_CanoR_1	58	63	PF00244	0.711
LIG_Actin_WH2_2	309	327	PF00022	0.586
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_BRCT_BRCA1_1	275	279	PF00533	0.654
LIG_BRCT_BRCA1_1	395	399	PF00533	0.669
LIG_CSL_BTD_1	83	86	PF09270	0.700
LIG_deltaCOP1_diTrp_1	310	320	PF00928	0.569
LIG_eIF4E_1	321	327	PF01652	0.613
LIG_FHA_1	2	8	PF00498	0.679
LIG_FHA_1	249	255	PF00498	0.697
LIG_FHA_1	368	374	PF00498	0.623
LIG_FHA_1	425	431	PF00498	0.675
LIG_FHA_1	49	55	PF00498	0.695
LIG_FHA_1	62	68	PF00498	0.568
LIG_FHA_1	83	89	PF00498	0.708
LIG_FHA_2	197	203	PF00498	0.713
LIG_FHA_2	363	369	PF00498	0.539
LIG_FHA_2	91	97	PF00498	0.607
LIG_LIR_Apic_2	148	152	PF02991	0.575
LIG_LIR_Gen_1	310	321	PF02991	0.571
LIG_LIR_Nem_3	310	316	PF02991	0.568
LIG_LYPXL_yS_3	321	324	PF13949	0.598
LIG_PDZ_Class_2	474	479	PF00595	0.619
LIG_PTB_Apo_2	257	264	PF02174	0.586
LIG_PTB_Apo_2	315	322	PF02174	0.570
LIG_PTB_Phospho_1	315	321	PF10480	0.566
LIG_SH2_NCK_1	27	31	PF00017	0.721
LIG_SH2_STAT3	311	314	PF00017	0.579
LIG_SH2_STAT5	311	314	PF00017	0.579
LIG_SH3_3	12	18	PF00018	0.699
LIG_SH3_3	391	397	PF00018	0.594
LIG_SH3_3	80	86	PF00018	0.696
LIG_SUMO_SIM_par_1	58	66	PF11976	0.683
LIG_TRAF2_1	199	202	PF00917	0.715
LIG_UBA3_1	179	185	PF00899	0.639
MOD_CK1_1	102	108	PF00069	0.673
MOD_CK1_1	118	124	PF00069	0.481
MOD_CK1_1	222	228	PF00069	0.657
MOD_CK1_1	242	248	PF00069	0.638
MOD_CK1_1	265	271	PF00069	0.672
MOD_CK1_1	272	278	PF00069	0.699
MOD_CK1_1	35	41	PF00069	0.656
MOD_CK1_1	393	399	PF00069	0.752
MOD_CK1_1	42	48	PF00069	0.654
MOD_CK1_1	435	441	PF00069	0.729
MOD_CK1_1	61	67	PF00069	0.683
MOD_CK1_1	9	15	PF00069	0.686
MOD_CK2_1	127	133	PF00069	0.524
MOD_CK2_1	196	202	PF00069	0.783
MOD_CK2_1	448	454	PF00069	0.606
MOD_CK2_1	66	72	PF00069	0.695
MOD_GlcNHglycan	127	132	PF01048	0.542
MOD_GlcNHglycan	165	168	PF01048	0.768
MOD_GlcNHglycan	205	209	PF01048	0.692
MOD_GlcNHglycan	219	222	PF01048	0.628
MOD_GlcNHglycan	255	258	PF01048	0.696
MOD_GlcNHglycan	264	267	PF01048	0.668
MOD_GlcNHglycan	271	274	PF01048	0.606
MOD_GlcNHglycan	332	335	PF01048	0.649
MOD_GlcNHglycan	357	360	PF01048	0.740
MOD_GlcNHglycan	409	412	PF01048	0.621
MOD_GlcNHglycan	42	45	PF01048	0.719
MOD_GlcNHglycan	440	443	PF01048	0.765
MOD_GlcNHglycan	468	471	PF01048	0.650
MOD_GSK3_1	151	158	PF00069	0.709
MOD_GSK3_1	17	24	PF00069	0.587
MOD_GSK3_1	235	242	PF00069	0.644
MOD_GSK3_1	244	251	PF00069	0.560
MOD_GSK3_1	258	265	PF00069	0.601
MOD_GSK3_1	268	275	PF00069	0.685
MOD_GSK3_1	277	284	PF00069	0.550
MOD_GSK3_1	28	35	PF00069	0.601
MOD_GSK3_1	360	367	PF00069	0.762
MOD_GSK3_1	381	388	PF00069	0.573
MOD_GSK3_1	430	437	PF00069	0.761
MOD_GSK3_1	438	445	PF00069	0.682
MOD_GSK3_1	58	65	PF00069	0.727
MOD_GSK3_1	6	13	PF00069	0.562
MOD_GSK3_1	88	95	PF00069	0.680
MOD_GSK3_1	98	105	PF00069	0.579
MOD_N-GLC_1	210	215	PF02516	0.579
MOD_N-GLC_1	259	264	PF02516	0.588
MOD_N-GLC_1	435	440	PF02516	0.713
MOD_NEK2_1	1	6	PF00069	0.695
MOD_NEK2_1	103	108	PF00069	0.535
MOD_NEK2_1	217	222	PF00069	0.658
MOD_NEK2_1	243	248	PF00069	0.637
MOD_NEK2_1	249	254	PF00069	0.623
MOD_NEK2_1	258	263	PF00069	0.547
MOD_NEK2_1	281	286	PF00069	0.715
MOD_NEK2_1	430	435	PF00069	0.696
MOD_NEK2_1	75	80	PF00069	0.700
MOD_NEK2_1	88	93	PF00069	0.550
MOD_NEK2_2	274	279	PF00069	0.681
MOD_NEK2_2	385	390	PF00069	0.561
MOD_NEK2_2	424	429	PF00069	0.632
MOD_PIKK_1	285	291	PF00454	0.640
MOD_PIKK_1	295	301	PF00454	0.511
MOD_PK_1	390	396	PF00069	0.675
MOD_PK_1	58	64	PF00069	0.682
MOD_PKA_1	239	245	PF00069	0.734
MOD_PKA_2	239	245	PF00069	0.738
MOD_PKA_2	404	410	PF00069	0.702
MOD_PKB_1	390	398	PF00069	0.689
MOD_Plk_1	118	124	PF00069	0.646
MOD_Plk_1	259	265	PF00069	0.591
MOD_Plk_1	281	287	PF00069	0.749
MOD_Plk_2-3	90	96	PF00069	0.597
MOD_Plk_4	239	245	PF00069	0.639
MOD_Plk_4	249	255	PF00069	0.577
MOD_Plk_4	274	280	PF00069	0.681
MOD_Plk_4	281	287	PF00069	0.566
MOD_ProDKin_1	106	112	PF00069	0.623
MOD_ProDKin_1	155	161	PF00069	0.708
MOD_ProDKin_1	265	271	PF00069	0.617
MOD_ProDKin_1	349	355	PF00069	0.606
MOD_ProDKin_1	362	368	PF00069	0.554
MOD_ProDKin_1	371	377	PF00069	0.597
MOD_ProDKin_1	381	387	PF00069	0.607
MOD_ProDKin_1	393	399	PF00069	0.607
MOD_ProDKin_1	42	48	PF00069	0.609
MOD_ProDKin_1	442	448	PF00069	0.770
MOD_ProDKin_1	82	88	PF00069	0.698
TRG_ENDOCYTIC_2	321	324	PF00928	0.598
TRG_ENDOCYTIC_2	459	462	PF00928	0.654
TRG_ER_diArg_1	122	124	PF00400	0.763
TRG_ER_diArg_1	239	241	PF00400	0.757
TRG_ER_diArg_1	344	346	PF00400	0.694
TRG_ER_diArg_1	389	392	PF00400	0.760
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUL3	Leishmania donovani	99%	67%
E9AR91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QE72	Leishmania major	91%	100%