3-oxo-5-alpha-steroid 4-dehydrogenase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-oxo-5-alpha-steroid 4-dehydrogenase-like protein

Species:

Leishmania infantum

UniProt:

A4HXI7_LEIIN

TriTrypDb:

LINF_170018200

Length:

540

Annotations

LeishMANIAdb annotations

Related to other eukaryotic steroid 5 alpha reductases. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HXI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXI7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	5	6
GO:0016229	steroid dehydrogenase activity	3	6
GO:0016491	oxidoreductase activity	2	7
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	7
GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.299
CLV_C14_Caspase3-7	84	88	PF00656	0.589
CLV_MEL_PAP_1	135	141	PF00089	0.491
CLV_MEL_PAP_1	316	322	PF00089	0.278
CLV_NRD_NRD_1	358	360	PF00675	0.570
CLV_NRD_NRD_1	375	377	PF00675	0.629
CLV_NRD_NRD_1	51	53	PF00675	0.488
CLV_PCSK_FUR_1	356	360	PF00082	0.575
CLV_PCSK_KEX2_1	358	360	PF00082	0.571
CLV_PCSK_KEX2_1	375	377	PF00082	0.624
CLV_PCSK_KEX2_1	51	53	PF00082	0.488
CLV_PCSK_SKI1_1	323	327	PF00082	0.258
CLV_PCSK_SKI1_1	482	486	PF00082	0.614
CLV_PCSK_SKI1_1	532	536	PF00082	0.274
DEG_APCC_DBOX_1	225	233	PF00400	0.327
DEG_APCC_DBOX_1	299	307	PF00400	0.621
DEG_SCF_FBW7_1	281	288	PF00400	0.577
DEG_SPOP_SBC_1	175	179	PF00917	0.468
DEG_SPOP_SBC_1	386	390	PF00917	0.501
DEG_SPOP_SBC_1	461	465	PF00917	0.384
DOC_CDC14_PxL_1	157	165	PF14671	0.338
DOC_CYCLIN_yCln2_LP_2	232	238	PF00134	0.373
DOC_MAPK_DCC_7	226	234	PF00069	0.290
DOC_MAPK_HePTP_8	316	328	PF00069	0.480
DOC_MAPK_MEF2A_6	319	328	PF00069	0.512
DOC_PP1_RVXF_1	136	142	PF00149	0.349
DOC_PP1_RVXF_1	317	323	PF00149	0.523
DOC_PP1_RVXF_1	480	486	PF00149	0.353
DOC_PP1_RVXF_1	92	98	PF00149	0.546
DOC_PP2B_LxvP_1	133	136	PF13499	0.366
DOC_PP2B_LxvP_1	232	235	PF13499	0.307
DOC_PP4_FxxP_1	523	526	PF00568	0.454
DOC_PP4_FxxP_1	64	67	PF00568	0.619
DOC_SPAK_OSR1_1	115	119	PF12202	0.383
DOC_USP7_MATH_1	175	179	PF00917	0.469
DOC_USP7_MATH_1	277	281	PF00917	0.663
DOC_USP7_MATH_1	307	311	PF00917	0.604
DOC_USP7_MATH_1	386	390	PF00917	0.470
DOC_USP7_MATH_1	437	441	PF00917	0.349
DOC_USP7_MATH_1	461	465	PF00917	0.384
DOC_USP7_MATH_1	90	94	PF00917	0.551
DOC_WW_Pin1_4	143	148	PF00397	0.313
DOC_WW_Pin1_4	164	169	PF00397	0.386
DOC_WW_Pin1_4	281	286	PF00397	0.645
DOC_WW_Pin1_4	37	42	PF00397	0.580
DOC_WW_Pin1_4	59	64	PF00397	0.639
LIG_14-3-3_CanoR_1	115	121	PF00244	0.310
LIG_14-3-3_CanoR_1	124	130	PF00244	0.383
LIG_14-3-3_CanoR_1	138	142	PF00244	0.261
LIG_14-3-3_CanoR_1	206	216	PF00244	0.342
LIG_14-3-3_CanoR_1	81	89	PF00244	0.626
LIG_14-3-3_CanoR_1	98	106	PF00244	0.499
LIG_Actin_WH2_2	8	25	PF00022	0.345
LIG_Actin_WH2_2	99	117	PF00022	0.383
LIG_APCC_ABBA_1	32	37	PF00400	0.560
LIG_BIR_II_1	1	5	PF00653	0.349
LIG_BRCT_BRCA1_1	127	131	PF00533	0.352
LIG_BRCT_BRCA1_1	289	293	PF00533	0.535
LIG_BRCT_BRCA1_1	336	340	PF00533	0.383
LIG_BRCT_BRCA1_1	98	102	PF00533	0.474
LIG_deltaCOP1_diTrp_1	57	64	PF00928	0.666
LIG_FHA_1	103	109	PF00498	0.331
LIG_FHA_1	16	22	PF00498	0.405
LIG_FHA_1	428	434	PF00498	0.379
LIG_FHA_1	449	455	PF00498	0.429
LIG_FHA_2	235	241	PF00498	0.349
LIG_FHA_2	450	456	PF00498	0.402
LIG_FHA_2	520	526	PF00498	0.543
LIG_Integrin_isoDGR_2	256	258	PF01839	0.279
LIG_Integrin_RGD_1	359	361	PF01839	0.600
LIG_LIR_Apic_2	227	231	PF02991	0.300
LIG_LIR_Apic_2	404	409	PF02991	0.299
LIG_LIR_Apic_2	522	526	PF02991	0.454
LIG_LIR_Apic_2	62	67	PF02991	0.572
LIG_LIR_Gen_1	110	118	PF02991	0.372
LIG_LIR_Gen_1	148	158	PF02991	0.373
LIG_LIR_Gen_1	18	26	PF02991	0.400
LIG_LIR_Gen_1	250	259	PF02991	0.326
LIG_LIR_Gen_1	430	438	PF02991	0.300
LIG_LIR_Gen_1	465	475	PF02991	0.392
LIG_LIR_Gen_1	525	535	PF02991	0.526
LIG_LIR_LC3C_4	240	245	PF02991	0.345
LIG_LIR_Nem_3	110	114	PF02991	0.372
LIG_LIR_Nem_3	148	153	PF02991	0.382
LIG_LIR_Nem_3	159	163	PF02991	0.288
LIG_LIR_Nem_3	167	173	PF02991	0.364
LIG_LIR_Nem_3	18	22	PF02991	0.400
LIG_LIR_Nem_3	200	205	PF02991	0.323
LIG_LIR_Nem_3	250	255	PF02991	0.310
LIG_LIR_Nem_3	351	355	PF02991	0.308
LIG_LIR_Nem_3	428	432	PF02991	0.264
LIG_LIR_Nem_3	464	470	PF02991	0.404
LIG_LIR_Nem_3	499	503	PF02991	0.349
LIG_LIR_Nem_3	525	530	PF02991	0.484
LIG_LIR_Nem_3	59	64	PF02991	0.633
LIG_LYPXL_yS_3	160	163	PF13949	0.354
LIG_MYND_1	171	175	PF01753	0.479
LIG_MYND_1	63	67	PF01753	0.616
LIG_NRBOX	213	219	PF00104	0.355
LIG_PCNA_PIPBox_1	248	257	PF02747	0.358
LIG_Pex14_1	127	131	PF04695	0.387
LIG_Pex14_2	293	297	PF04695	0.532
LIG_SH2_CRK	111	115	PF00017	0.345
LIG_SH2_CRK	406	410	PF00017	0.274
LIG_SH2_CRK	527	531	PF00017	0.526
LIG_SH2_PTP2	432	435	PF00017	0.274
LIG_SH2_SRC	432	435	PF00017	0.326
LIG_SH2_STAP1	287	291	PF00017	0.578
LIG_SH2_STAP1	519	523	PF00017	0.526
LIG_SH2_STAP1	72	76	PF00017	0.551
LIG_SH2_STAT3	72	75	PF00017	0.627
LIG_SH2_STAT5	223	226	PF00017	0.291
LIG_SH2_STAT5	24	27	PF00017	0.352
LIG_SH2_STAT5	252	255	PF00017	0.310
LIG_SH2_STAT5	287	290	PF00017	0.605
LIG_SH2_STAT5	33	36	PF00017	0.535
LIG_SH2_STAT5	353	356	PF00017	0.319
LIG_SH2_STAT5	432	435	PF00017	0.274
LIG_SH2_STAT5	503	506	PF00017	0.310
LIG_SH2_STAT5	527	530	PF00017	0.526
LIG_SH3_3	115	121	PF00018	0.310
LIG_SH3_3	165	171	PF00018	0.407
LIG_SUMO_SIM_par_1	104	110	PF11976	0.383
LIG_SUMO_SIM_par_1	240	246	PF11976	0.309
LIG_TRAF2_1	453	456	PF00917	0.338
LIG_TRAF2_1	67	70	PF00917	0.649
LIG_TYR_ITIM	158	163	PF00017	0.414
LIG_TYR_ITSM	428	435	PF00017	0.383
MOD_CK1_1	137	143	PF00069	0.365
MOD_CK1_1	169	175	PF00069	0.588
MOD_CK1_1	176	182	PF00069	0.605
MOD_CK1_1	190	196	PF00069	0.480
MOD_CK1_1	305	311	PF00069	0.553
MOD_CK1_1	440	446	PF00069	0.567
MOD_CK1_1	449	455	PF00069	0.439
MOD_CK1_1	463	469	PF00069	0.392
MOD_CK2_1	386	392	PF00069	0.537
MOD_CK2_1	449	455	PF00069	0.440
MOD_CMANNOS	58	61	PF00535	0.574
MOD_Cter_Amidation	373	376	PF01082	0.706
MOD_GlcNHglycan	1	4	PF01048	0.538
MOD_GlcNHglycan	178	181	PF01048	0.651
MOD_GlcNHglycan	193	196	PF01048	0.616
MOD_GlcNHglycan	263	266	PF01048	0.521
MOD_GlcNHglycan	27	30	PF01048	0.439
MOD_GlcNHglycan	309	312	PF01048	0.648
MOD_GlcNHglycan	336	339	PF01048	0.410
MOD_GlcNHglycan	439	442	PF01048	0.412
MOD_GlcNHglycan	83	86	PF01048	0.515
MOD_GlcNHglycan	99	102	PF01048	0.439
MOD_GSK3_1	169	176	PF00069	0.626
MOD_GSK3_1	187	194	PF00069	0.584
MOD_GSK3_1	230	237	PF00069	0.412
MOD_GSK3_1	243	250	PF00069	0.289
MOD_GSK3_1	267	274	PF00069	0.546
MOD_GSK3_1	277	284	PF00069	0.697
MOD_GSK3_1	302	309	PF00069	0.543
MOD_GSK3_1	363	370	PF00069	0.610
MOD_GSK3_1	387	394	PF00069	0.648
MOD_GSK3_1	436	443	PF00069	0.513
MOD_GSK3_1	462	469	PF00069	0.510
MOD_NEK2_1	102	107	PF00069	0.436
MOD_NEK2_1	116	121	PF00069	0.563
MOD_NEK2_1	131	136	PF00069	0.555
MOD_NEK2_1	15	20	PF00069	0.408
MOD_NEK2_1	243	248	PF00069	0.310
MOD_NEK2_1	334	339	PF00069	0.418
MOD_NEK2_1	385	390	PF00069	0.639
MOD_NEK2_1	448	453	PF00069	0.455
MOD_NEK2_1	462	467	PF00069	0.512
MOD_NEK2_2	247	252	PF00069	0.310
MOD_PIKK_1	207	213	PF00454	0.371
MOD_PIKK_1	65	71	PF00454	0.520
MOD_PKA_2	123	129	PF00069	0.498
MOD_PKA_2	137	143	PF00069	0.285
MOD_PKA_2	399	405	PF00069	0.320
MOD_PKA_2	80	86	PF00069	0.500
MOD_PKA_2	97	103	PF00069	0.310
MOD_Plk_4	137	143	PF00069	0.381
MOD_Plk_4	145	151	PF00069	0.392
MOD_Plk_4	15	21	PF00069	0.383
MOD_Plk_4	169	175	PF00069	0.580
MOD_Plk_4	197	203	PF00069	0.430
MOD_Plk_4	243	249	PF00069	0.321
MOD_Plk_4	463	469	PF00069	0.502
MOD_ProDKin_1	143	149	PF00069	0.365
MOD_ProDKin_1	164	170	PF00069	0.482
MOD_ProDKin_1	281	287	PF00069	0.547
MOD_ProDKin_1	37	43	PF00069	0.466
MOD_ProDKin_1	59	65	PF00069	0.540
TRG_DiLeu_BaEn_1	159	164	PF01217	0.434
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.338
TRG_ENDOCYTIC_2	111	114	PF00928	0.383
TRG_ENDOCYTIC_2	154	157	PF00928	0.460
TRG_ENDOCYTIC_2	160	163	PF00928	0.369
TRG_ENDOCYTIC_2	252	255	PF00928	0.310
TRG_ENDOCYTIC_2	352	355	PF00928	0.365
TRG_ENDOCYTIC_2	432	435	PF00928	0.310
TRG_ENDOCYTIC_2	527	530	PF00928	0.310
TRG_ER_diArg_1	355	358	PF00400	0.420
TRG_ER_diArg_1	50	52	PF00400	0.631
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P837	Leptomonas seymouri	47%	100%
A0A3S7WUK3	Leishmania donovani	99%	100%
A4H965	Leishmania braziliensis	72%	100%
E9AR82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QE81	Leishmania major	92%	100%