Putative ubiquitin hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

cysteine peptidase - Clan CA - family C19 - putative

Species:

Leishmania infantum

UniProt:

A4HXI6_LEIIN

TriTrypDb:

LINF_170018100

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXI6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016579	protein deubiquitination	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070646	protein modification by small protein removal	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004843	cysteine-type deubiquitinase activity	5	2
GO:0008233	peptidase activity	3	2
GO:0008234	cysteine-type peptidase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0019783	ubiquitin-like protein peptidase activity	4	2
GO:0101005	deubiquitinase activity	5	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.199
CLV_NRD_NRD_1	328	330	PF00675	0.199
CLV_NRD_NRD_1	353	355	PF00675	0.199
CLV_NRD_NRD_1	359	361	PF00675	0.199
CLV_NRD_NRD_1	492	494	PF00675	0.199
CLV_NRD_NRD_1	517	519	PF00675	0.199
CLV_NRD_NRD_1	520	522	PF00675	0.199
CLV_NRD_NRD_1	538	540	PF00675	0.199
CLV_NRD_NRD_1	89	91	PF00675	0.199
CLV_PCSK_FUR_1	490	494	PF00082	0.199
CLV_PCSK_FUR_1	518	522	PF00082	0.199
CLV_PCSK_KEX2_1	127	129	PF00082	0.199
CLV_PCSK_KEX2_1	310	312	PF00082	0.199
CLV_PCSK_KEX2_1	328	330	PF00082	0.199
CLV_PCSK_KEX2_1	352	354	PF00082	0.199
CLV_PCSK_KEX2_1	359	361	PF00082	0.199
CLV_PCSK_KEX2_1	492	494	PF00082	0.199
CLV_PCSK_KEX2_1	516	518	PF00082	0.199
CLV_PCSK_KEX2_1	520	522	PF00082	0.199
CLV_PCSK_KEX2_1	538	540	PF00082	0.199
CLV_PCSK_KEX2_1	89	91	PF00082	0.199
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.199
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.199
CLV_PCSK_PC7_1	516	522	PF00082	0.199
CLV_PCSK_SKI1_1	127	131	PF00082	0.199
CLV_PCSK_SKI1_1	311	315	PF00082	0.199
DEG_SPOP_SBC_1	501	505	PF00917	0.199
DOC_CKS1_1	566	571	PF01111	0.358
DOC_MAPK_DCC_7	360	370	PF00069	0.199
DOC_MAPK_gen_1	450	458	PF00069	0.199
DOC_MAPK_JIP1_4	154	160	PF00069	0.199
DOC_MAPK_MEF2A_6	300	309	PF00069	0.199
DOC_PP2B_LxvP_1	217	220	PF13499	0.199
DOC_USP7_MATH_1	150	154	PF00917	0.199
DOC_USP7_MATH_1	239	243	PF00917	0.199
DOC_USP7_MATH_1	340	344	PF00917	0.199
DOC_USP7_MATH_1	540	544	PF00917	0.199
DOC_USP7_MATH_2	95	101	PF00917	0.199
DOC_WW_Pin1_4	148	153	PF00397	0.199
DOC_WW_Pin1_4	209	214	PF00397	0.199
DOC_WW_Pin1_4	230	235	PF00397	0.199
DOC_WW_Pin1_4	358	363	PF00397	0.199
DOC_WW_Pin1_4	565	570	PF00397	0.340
DOC_WW_Pin1_4	91	96	PF00397	0.199
LIG_14-3-3_CanoR_1	157	167	PF00244	0.199
LIG_14-3-3_CanoR_1	260	265	PF00244	0.199
LIG_14-3-3_CanoR_1	450	458	PF00244	0.199
LIG_14-3-3_CanoR_1	539	549	PF00244	0.199
LIG_14-3-3_CanoR_1	89	94	PF00244	0.199
LIG_14-3-3_CanoR_1	98	105	PF00244	0.199
LIG_DLG_GKlike_1	260	267	PF00625	0.199
LIG_EVH1_1	217	221	PF00568	0.199
LIG_FHA_1	173	179	PF00498	0.199
LIG_FHA_1	192	198	PF00498	0.199
LIG_FHA_1	312	318	PF00498	0.199
LIG_FHA_1	35	41	PF00498	0.410
LIG_FHA_1	369	375	PF00498	0.199
LIG_FHA_1	543	549	PF00498	0.199
LIG_FHA_1	72	78	PF00498	0.199
LIG_FHA_2	161	167	PF00498	0.199
LIG_FHA_2	92	98	PF00498	0.199
LIG_GBD_Chelix_1	264	272	PF00786	0.199
LIG_Integrin_isoDGR_2	326	328	PF01839	0.199
LIG_LIR_Gen_1	271	280	PF02991	0.199
LIG_LIR_Gen_1	543	554	PF02991	0.199
LIG_LIR_Gen_1	63	72	PF02991	0.199
LIG_LIR_Nem_3	271	277	PF02991	0.199
LIG_LIR_Nem_3	461	467	PF02991	0.199
LIG_LIR_Nem_3	543	549	PF02991	0.199
LIG_LIR_Nem_3	63	68	PF02991	0.199
LIG_MYND_1	230	234	PF01753	0.199
LIG_NRBOX	263	269	PF00104	0.199
LIG_Pex14_2	312	316	PF04695	0.199
LIG_Pex14_2	49	53	PF04695	0.199
LIG_Rb_pABgroove_1	43	51	PF01858	0.396
LIG_SH2_CRK	298	302	PF00017	0.199
LIG_SH2_NCK_1	298	302	PF00017	0.199
LIG_SH2_NCK_1	550	554	PF00017	0.269
LIG_SH2_STAP1	550	554	PF00017	0.269
LIG_SH2_STAT5	298	301	PF00017	0.199
LIG_SH2_STAT5	36	39	PF00017	0.405
LIG_SH2_STAT5	467	470	PF00017	0.199
LIG_SH2_STAT5	546	549	PF00017	0.199
LIG_SH3_2	152	157	PF14604	0.199
LIG_SH3_3	149	155	PF00018	0.199
LIG_SH3_3	2	8	PF00018	0.418
LIG_SH3_3	200	206	PF00018	0.199
LIG_SH3_3	212	218	PF00018	0.199
LIG_SH3_3	223	229	PF00018	0.199
LIG_SH3_3	233	239	PF00018	0.199
LIG_SH3_3	244	250	PF00018	0.199
LIG_SH3_3	361	367	PF00018	0.199
LIG_SH3_3	555	561	PF00018	0.291
LIG_SUMO_SIM_anti_2	524	533	PF11976	0.199
LIG_SUMO_SIM_par_1	366	372	PF11976	0.199
LIG_TRAF2_1	397	400	PF00917	0.199
LIG_TRAF2_1	495	498	PF00917	0.199
LIG_TYR_ITIM	548	553	PF00017	0.261
LIG_UBA3_1	304	310	PF00899	0.199
MOD_CDC14_SPxK_1	151	154	PF00782	0.199
MOD_CDK_SPxK_1	148	154	PF00069	0.199
MOD_CDK_SPxxK_3	565	572	PF00069	0.365
MOD_CDK_SPxxK_3	91	98	PF00069	0.199
MOD_CK1_1	137	143	PF00069	0.199
MOD_CK1_1	159	165	PF00069	0.199
MOD_CK1_1	287	293	PF00069	0.199
MOD_CK1_1	505	511	PF00069	0.199
MOD_CK1_1	91	97	PF00069	0.199
MOD_CK2_1	120	126	PF00069	0.199
MOD_CK2_1	160	166	PF00069	0.199
MOD_CK2_1	340	346	PF00069	0.199
MOD_CK2_1	91	97	PF00069	0.199
MOD_Cter_Amidation	326	329	PF01082	0.199
MOD_GlcNHglycan	136	139	PF01048	0.199
MOD_GlcNHglycan	342	345	PF01048	0.199
MOD_GlcNHglycan	394	397	PF01048	0.199
MOD_GlcNHglycan	403	407	PF01048	0.199
MOD_GlcNHglycan	512	515	PF01048	0.199
MOD_GlcNHglycan	99	102	PF01048	0.199
MOD_GSK3_1	137	144	PF00069	0.199
MOD_GSK3_1	156	163	PF00069	0.199
MOD_GSK3_1	168	175	PF00069	0.199
MOD_GSK3_1	501	508	PF00069	0.199
MOD_GSK3_1	89	96	PF00069	0.199
MOD_N-GLC_1	199	204	PF02516	0.199
MOD_N-GLC_1	317	322	PF02516	0.199
MOD_N-GLC_2	510	512	PF02516	0.199
MOD_NEK2_1	158	163	PF00069	0.199
MOD_NEK2_1	172	177	PF00069	0.199
MOD_NEK2_1	18	23	PF00069	0.425
MOD_NEK2_1	268	273	PF00069	0.199
MOD_NEK2_1	428	433	PF00069	0.199
MOD_NEK2_1	458	463	PF00069	0.199
MOD_NEK2_1	64	69	PF00069	0.199
MOD_OFUCOSY	447	454	PF10250	0.199
MOD_PIKK_1	287	293	PF00454	0.199
MOD_PIKK_1	311	317	PF00454	0.199
MOD_PIKK_1	502	508	PF00454	0.199
MOD_PK_1	89	95	PF00069	0.199
MOD_PKA_1	89	95	PF00069	0.199
MOD_PKA_2	141	147	PF00069	0.199
MOD_PKA_2	156	162	PF00069	0.199
MOD_PKA_2	287	293	PF00069	0.199
MOD_PKA_2	491	497	PF00069	0.199
MOD_PKA_2	571	577	PF00069	0.484
MOD_PKA_2	88	94	PF00069	0.199
MOD_PKA_2	97	103	PF00069	0.199
MOD_Plk_1	199	205	PF00069	0.199
MOD_Plk_2-3	191	197	PF00069	0.199
MOD_Plk_2-3	528	534	PF00069	0.199
MOD_Plk_4	168	174	PF00069	0.199
MOD_Plk_4	317	323	PF00069	0.199
MOD_Plk_4	437	443	PF00069	0.199
MOD_Plk_4	542	548	PF00069	0.199
MOD_Plk_4	64	70	PF00069	0.199
MOD_ProDKin_1	148	154	PF00069	0.199
MOD_ProDKin_1	209	215	PF00069	0.199
MOD_ProDKin_1	230	236	PF00069	0.199
MOD_ProDKin_1	358	364	PF00069	0.199
MOD_ProDKin_1	565	571	PF00069	0.348
MOD_ProDKin_1	91	97	PF00069	0.199
MOD_SUMO_for_1	416	419	PF00179	0.199
MOD_SUMO_for_1	70	73	PF00179	0.199
MOD_SUMO_rev_2	14	23	PF00179	0.419
MOD_SUMO_rev_2	388	394	PF00179	0.199
TRG_DiLeu_BaEn_1	14	19	PF01217	0.407
TRG_DiLeu_BaLyEn_6	125	130	PF01217	0.199
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.199
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.199
TRG_DiLeu_LyEn_5	14	19	PF01217	0.407
TRG_ENDOCYTIC_2	274	277	PF00928	0.199
TRG_ENDOCYTIC_2	546	549	PF00928	0.199
TRG_ENDOCYTIC_2	550	553	PF00928	0.265
TRG_ER_diArg_1	15	18	PF00400	0.404
TRG_ER_diArg_1	181	184	PF00400	0.199
TRG_ER_diArg_1	328	330	PF00400	0.199
TRG_ER_diArg_1	352	354	PF00400	0.199
TRG_ER_diArg_1	449	452	PF00400	0.199
TRG_ER_diArg_1	490	493	PF00400	0.199
TRG_ER_diArg_1	515	518	PF00400	0.199
TRG_ER_diArg_1	519	521	PF00400	0.199