Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXI5_LEIIN

TriTrypDb:

LINF_170018000

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXI5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.635
CLV_C14_Caspase3-7	190	194	PF00656	0.577
CLV_C14_Caspase3-7	390	394	PF00656	0.577
CLV_C14_Caspase3-7	472	476	PF00656	0.647
CLV_C14_Caspase3-7	493	497	PF00656	0.431
CLV_C14_Caspase3-7	639	643	PF00656	0.508
CLV_NRD_NRD_1	72	74	PF00675	0.419
CLV_PCSK_SKI1_1	214	218	PF00082	0.478
CLV_PCSK_SKI1_1	402	406	PF00082	0.710
CLV_PCSK_SKI1_1	460	464	PF00082	0.648
CLV_PCSK_SKI1_1	48	52	PF00082	0.549
CLV_PCSK_SKI1_1	503	507	PF00082	0.405
CLV_PCSK_SKI1_1	523	527	PF00082	0.456
CLV_PCSK_SKI1_1	573	577	PF00082	0.634
CLV_PCSK_SKI1_1	653	657	PF00082	0.423
CLV_PCSK_SKI1_1	7	11	PF00082	0.420
DEG_APCC_DBOX_1	502	510	PF00400	0.471
DEG_Nend_Nbox_1	1	3	PF02207	0.461
DEG_SCF_FBW7_1	447	454	PF00400	0.578
DEG_SCF_FBW7_2	131	138	PF00400	0.615
DEG_SPOP_SBC_1	109	113	PF00917	0.635
DEG_SPOP_SBC_1	250	254	PF00917	0.604
DOC_CKS1_1	132	137	PF01111	0.649
DOC_CKS1_1	448	453	PF01111	0.586
DOC_CYCLIN_RxL_1	276	287	PF00134	0.498
DOC_CYCLIN_RxL_1	500	510	PF00134	0.415
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	618	624	PF00134	0.496
DOC_MAPK_gen_1	500	508	PF00069	0.418
DOC_MAPK_gen_1	98	107	PF00069	0.481
DOC_MAPK_MEF2A_6	347	355	PF00069	0.631
DOC_PP2B_LxvP_1	106	109	PF13499	0.488
DOC_PP2B_LxvP_1	340	343	PF13499	0.521
DOC_USP7_MATH_1	110	114	PF00917	0.589
DOC_USP7_MATH_1	251	255	PF00917	0.686
DOC_USP7_MATH_1	288	292	PF00917	0.539
DOC_USP7_MATH_1	325	329	PF00917	0.599
DOC_USP7_MATH_1	357	361	PF00917	0.755
DOC_USP7_MATH_1	367	371	PF00917	0.657
DOC_USP7_MATH_1	431	435	PF00917	0.594
DOC_USP7_MATH_1	451	455	PF00917	0.462
DOC_USP7_MATH_1	462	466	PF00917	0.589
DOC_USP7_MATH_1	481	485	PF00917	0.423
DOC_USP7_MATH_1	612	616	PF00917	0.422
DOC_USP7_MATH_1	726	730	PF00917	0.614
DOC_WW_Pin1_4	131	136	PF00397	0.619
DOC_WW_Pin1_4	199	204	PF00397	0.647
DOC_WW_Pin1_4	447	452	PF00397	0.567
DOC_WW_Pin1_4	539	544	PF00397	0.518
DOC_WW_Pin1_4	562	567	PF00397	0.608
DOC_WW_Pin1_4	586	591	PF00397	0.658
DOC_WW_Pin1_4	692	697	PF00397	0.697
DOC_WW_Pin1_4	698	703	PF00397	0.688
DOC_WW_Pin1_4	729	734	PF00397	0.620
LIG_14-3-3_CanoR_1	507	516	PF00244	0.428
LIG_14-3-3_CanoR_1	57	65	PF00244	0.418
LIG_14-3-3_CanoR_1	632	641	PF00244	0.546
LIG_14-3-3_CanoR_1	713	721	PF00244	0.442
LIG_14-3-3_CanoR_1	73	79	PF00244	0.443
LIG_14-3-3_CanoR_1	98	107	PF00244	0.574
LIG_Actin_WH2_2	428	445	PF00022	0.510
LIG_BIR_III_4	496	500	PF00653	0.467
LIG_BRCT_BRCA1_1	682	686	PF00533	0.654
LIG_BRCT_BRCA1_1	714	718	PF00533	0.430
LIG_Clathr_ClatBox_1	489	493	PF01394	0.408
LIG_deltaCOP1_diTrp_1	642	648	PF00928	0.434
LIG_FHA_1	139	145	PF00498	0.602
LIG_FHA_1	204	210	PF00498	0.569
LIG_FHA_1	240	246	PF00498	0.700
LIG_FHA_1	251	257	PF00498	0.609
LIG_FHA_1	336	342	PF00498	0.600
LIG_FHA_1	4	10	PF00498	0.531
LIG_FHA_1	451	457	PF00498	0.682
LIG_FHA_1	469	475	PF00498	0.718
LIG_FHA_1	496	502	PF00498	0.550
LIG_FHA_1	543	549	PF00498	0.407
LIG_FHA_1	56	62	PF00498	0.436
LIG_FHA_1	642	648	PF00498	0.333
LIG_FHA_1	707	713	PF00498	0.467
LIG_FHA_1	74	80	PF00498	0.528
LIG_FHA_2	467	473	PF00498	0.614
LIG_FHA_2	510	516	PF00498	0.437
LIG_FHA_2	73	79	PF00498	0.513
LIG_FXI_DFP_1	62	66	PF00024	0.506
LIG_LIR_Gen_1	127	135	PF02991	0.650
LIG_LIR_Gen_1	141	147	PF02991	0.448
LIG_LIR_Gen_1	646	656	PF02991	0.497
LIG_LIR_Gen_1	715	726	PF02991	0.456
LIG_LIR_Nem_3	127	132	PF02991	0.648
LIG_LIR_Nem_3	141	145	PF02991	0.453
LIG_LIR_Nem_3	544	549	PF02991	0.389
LIG_LIR_Nem_3	646	651	PF02991	0.503
LIG_LIR_Nem_3	715	721	PF02991	0.435
LIG_NRBOX	279	285	PF00104	0.402
LIG_PDZ_Class_2	738	743	PF00595	0.579
LIG_SH2_CRK	129	133	PF00017	0.555
LIG_SH2_CRK	222	226	PF00017	0.376
LIG_SH2_NCK_1	142	146	PF00017	0.529
LIG_SH2_NCK_1	37	41	PF00017	0.536
LIG_SH2_STAT5	222	225	PF00017	0.379
LIG_SH3_3	197	203	PF00018	0.741
LIG_SH3_3	563	569	PF00018	0.659
LIG_SH3_3	588	594	PF00018	0.524
LIG_SH3_3	693	699	PF00018	0.702
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.469
LIG_SUMO_SIM_anti_2	483	490	PF11976	0.541
LIG_SUMO_SIM_par_1	143	149	PF11976	0.634
LIG_TRAF2_1	359	362	PF00917	0.644
LIG_UBA3_1	9	15	PF00899	0.389
LIG_WW_3	119	123	PF00397	0.599
MOD_CK1_1	112	118	PF00069	0.696
MOD_CK1_1	149	155	PF00069	0.615
MOD_CK1_1	204	210	PF00069	0.554
MOD_CK1_1	316	322	PF00069	0.619
MOD_CK1_1	370	376	PF00069	0.692
MOD_CK1_1	382	388	PF00069	0.591
MOD_CK1_1	466	472	PF00069	0.665
MOD_CK1_1	542	548	PF00069	0.539
MOD_CK1_1	636	642	PF00069	0.487
MOD_CK1_1	677	683	PF00069	0.644
MOD_CK1_1	689	695	PF00069	0.635
MOD_CK1_1	729	735	PF00069	0.618
MOD_CK1_1	88	94	PF00069	0.527
MOD_CK2_1	158	164	PF00069	0.697
MOD_CK2_1	166	172	PF00069	0.743
MOD_CK2_1	182	188	PF00069	0.545
MOD_CK2_1	466	472	PF00069	0.610
MOD_CMANNOS	645	648	PF00535	0.415
MOD_GlcNHglycan	101	104	PF01048	0.517
MOD_GlcNHglycan	117	120	PF01048	0.746
MOD_GlcNHglycan	151	154	PF01048	0.677
MOD_GlcNHglycan	160	163	PF01048	0.678
MOD_GlcNHglycan	166	171	PF01048	0.574
MOD_GlcNHglycan	228	231	PF01048	0.520
MOD_GlcNHglycan	290	293	PF01048	0.568
MOD_GlcNHglycan	3	6	PF01048	0.529
MOD_GlcNHglycan	315	318	PF01048	0.750
MOD_GlcNHglycan	323	326	PF01048	0.610
MOD_GlcNHglycan	381	384	PF01048	0.654
MOD_GlcNHglycan	520	523	PF01048	0.579
MOD_GlcNHglycan	527	530	PF01048	0.716
MOD_GlcNHglycan	573	576	PF01048	0.627
MOD_GlcNHglycan	627	630	PF01048	0.416
MOD_GlcNHglycan	688	691	PF01048	0.805
MOD_GlcNHglycan	714	717	PF01048	0.446
MOD_GSK3_1	108	115	PF00069	0.580
MOD_GSK3_1	127	134	PF00069	0.646
MOD_GSK3_1	145	152	PF00069	0.434
MOD_GSK3_1	158	165	PF00069	0.553
MOD_GSK3_1	199	206	PF00069	0.635
MOD_GSK3_1	220	227	PF00069	0.403
MOD_GSK3_1	246	253	PF00069	0.683
MOD_GSK3_1	313	320	PF00069	0.668
MOD_GSK3_1	321	328	PF00069	0.638
MOD_GSK3_1	363	370	PF00069	0.710
MOD_GSK3_1	419	426	PF00069	0.725
MOD_GSK3_1	446	453	PF00069	0.552
MOD_GSK3_1	462	469	PF00069	0.504
MOD_GSK3_1	476	483	PF00069	0.490
MOD_GSK3_1	491	498	PF00069	0.504
MOD_GSK3_1	582	589	PF00069	0.713
MOD_GSK3_1	73	80	PF00069	0.547
MOD_N-GLC_1	239	244	PF02516	0.773
MOD_N-GLC_2	244	246	PF02516	0.590
MOD_NEK2_1	1	6	PF00069	0.545
MOD_NEK2_1	224	229	PF00069	0.432
MOD_NEK2_1	296	301	PF00069	0.517
MOD_NEK2_1	463	468	PF00069	0.695
MOD_NEK2_1	501	506	PF00069	0.542
MOD_NEK2_1	525	530	PF00069	0.620
MOD_NEK2_1	548	553	PF00069	0.535
MOD_NEK2_1	641	646	PF00069	0.339
MOD_NEK2_1	665	670	PF00069	0.569
MOD_NEK2_1	712	717	PF00069	0.446
MOD_NEK2_1	72	77	PF00069	0.487
MOD_PIKK_1	112	118	PF00454	0.625
MOD_PIKK_1	357	363	PF00454	0.602
MOD_PIKK_1	491	497	PF00454	0.406
MOD_PIKK_1	56	62	PF00454	0.394
MOD_PIKK_1	573	579	PF00454	0.636
MOD_PIKK_1	636	642	PF00454	0.467
MOD_PK_1	294	300	PF00069	0.419
MOD_PKA_1	73	79	PF00069	0.411
MOD_PKA_2	16	22	PF00069	0.391
MOD_PKA_2	56	62	PF00069	0.414
MOD_PKA_2	677	683	PF00069	0.587
MOD_PKA_2	686	692	PF00069	0.592
MOD_PKA_2	712	718	PF00069	0.440
MOD_PKA_2	72	78	PF00069	0.445
MOD_Plk_1	363	369	PF00069	0.683
MOD_Plk_1	641	647	PF00069	0.338
MOD_Plk_1	680	686	PF00069	0.568
MOD_Plk_2-3	138	144	PF00069	0.567
MOD_Plk_4	127	133	PF00069	0.551
MOD_Plk_4	204	210	PF00069	0.476
MOD_Plk_4	220	226	PF00069	0.391
MOD_Plk_4	367	373	PF00069	0.579
MOD_Plk_4	387	393	PF00069	0.624
MOD_Plk_4	481	487	PF00069	0.546
MOD_ProDKin_1	131	137	PF00069	0.622
MOD_ProDKin_1	199	205	PF00069	0.637
MOD_ProDKin_1	447	453	PF00069	0.576
MOD_ProDKin_1	539	545	PF00069	0.508
MOD_ProDKin_1	562	568	PF00069	0.615
MOD_ProDKin_1	586	592	PF00069	0.651
MOD_ProDKin_1	692	698	PF00069	0.697
MOD_ProDKin_1	729	735	PF00069	0.618
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.489
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.642
TRG_DiLeu_BaLyEn_6	591	596	PF01217	0.482
TRG_ENDOCYTIC_2	129	132	PF00928	0.550
TRG_ENDOCYTIC_2	142	145	PF00928	0.527
TRG_ENDOCYTIC_2	222	225	PF00928	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIE2	Leptomonas seymouri	34%	100%
A0A3S5H715	Leishmania donovani	99%	100%
A4H963	Leishmania braziliensis	66%	100%
E9AR80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4QE83	Leishmania major	87%	100%