Hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

esterase-like protein

Species:

Leishmania infantum

UniProt:

A4HXI3_LEIIN

TriTrypDb:

LINF_170017800

Length:

794

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXI3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	396	400	PF00656	0.673
CLV_C14_Caspase3-7	526	530	PF00656	0.658
CLV_C14_Caspase3-7	535	539	PF00656	0.578
CLV_NRD_NRD_1	242	244	PF00675	0.262
CLV_NRD_NRD_1	278	280	PF00675	0.429
CLV_NRD_NRD_1	285	287	PF00675	0.417
CLV_NRD_NRD_1	301	303	PF00675	0.269
CLV_NRD_NRD_1	540	542	PF00675	0.660
CLV_NRD_NRD_1	56	58	PF00675	0.541
CLV_NRD_NRD_1	585	587	PF00675	0.603
CLV_NRD_NRD_1	59	61	PF00675	0.502
CLV_NRD_NRD_1	770	772	PF00675	0.587
CLV_PCSK_FUR_1	57	61	PF00082	0.488
CLV_PCSK_KEX2_1	242	244	PF00082	0.279
CLV_PCSK_KEX2_1	277	279	PF00082	0.420
CLV_PCSK_KEX2_1	285	287	PF00082	0.307
CLV_PCSK_KEX2_1	301	303	PF00082	0.400
CLV_PCSK_KEX2_1	378	380	PF00082	0.566
CLV_PCSK_KEX2_1	506	508	PF00082	0.658
CLV_PCSK_KEX2_1	540	542	PF00082	0.622
CLV_PCSK_KEX2_1	58	60	PF00082	0.530
CLV_PCSK_KEX2_1	585	587	PF00082	0.618
CLV_PCSK_KEX2_1	770	772	PF00082	0.587
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.315
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.570
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.658
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.530
CLV_PCSK_SKI1_1	159	163	PF00082	0.364
CLV_PCSK_SKI1_1	262	266	PF00082	0.312
CLV_PCSK_SKI1_1	278	282	PF00082	0.312
CLV_PCSK_SKI1_1	306	310	PF00082	0.314
CLV_PCSK_SKI1_1	335	339	PF00082	0.319
CLV_PCSK_SKI1_1	382	386	PF00082	0.646
CLV_PCSK_SKI1_1	520	524	PF00082	0.597
CLV_PCSK_SKI1_1	549	553	PF00082	0.640
CLV_PCSK_SKI1_1	611	615	PF00082	0.678
DEG_APCC_DBOX_1	277	285	PF00400	0.340
DEG_SCF_FBW7_1	632	638	PF00400	0.605
DEG_SPOP_SBC_1	20	24	PF00917	0.545
DEG_SPOP_SBC_1	220	224	PF00917	0.312
DEG_SPOP_SBC_1	509	513	PF00917	0.648
DEG_SPOP_SBC_1	543	547	PF00917	0.553
DEG_SPOP_SBC_1	617	621	PF00917	0.614
DOC_CKS1_1	499	504	PF01111	0.639
DOC_CKS1_1	632	637	PF01111	0.605
DOC_CKS1_1	65	70	PF01111	0.392
DOC_CYCLIN_RxL_1	341	350	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	313	319	PF00134	0.312
DOC_MAPK_gen_1	148	156	PF00069	0.321
DOC_MAPK_gen_1	277	284	PF00069	0.312
DOC_MAPK_gen_1	63	72	PF00069	0.384
DOC_MAPK_gen_1	653	662	PF00069	0.538
DOC_MAPK_MEF2A_6	148	156	PF00069	0.388
DOC_MAPK_MEF2A_6	656	664	PF00069	0.548
DOC_MAPK_MEF2A_6	66	74	PF00069	0.377
DOC_PP2B_LxvP_1	154	157	PF13499	0.312
DOC_PP2B_LxvP_1	186	189	PF13499	0.312
DOC_PP2B_LxvP_1	208	211	PF13499	0.312
DOC_PP2B_LxvP_1	25	28	PF13499	0.544
DOC_PP2B_LxvP_1	313	316	PF13499	0.326
DOC_PP4_FxxP_1	91	94	PF00568	0.369
DOC_USP7_MATH_1	11	15	PF00917	0.552
DOC_USP7_MATH_1	20	24	PF00917	0.529
DOC_USP7_MATH_1	32	36	PF00917	0.486
DOC_USP7_MATH_1	384	388	PF00917	0.640
DOC_USP7_MATH_1	495	499	PF00917	0.628
DOC_USP7_MATH_1	508	512	PF00917	0.635
DOC_USP7_MATH_1	567	571	PF00917	0.723
DOC_USP7_MATH_1	617	621	PF00917	0.650
DOC_USP7_MATH_1	623	627	PF00917	0.721
DOC_USP7_MATH_1	635	639	PF00917	0.523
DOC_USP7_MATH_1	687	691	PF00917	0.648
DOC_USP7_MATH_1	737	741	PF00917	0.619
DOC_USP7_MATH_1	761	765	PF00917	0.651
DOC_WW_Pin1_4	453	458	PF00397	0.528
DOC_WW_Pin1_4	498	503	PF00397	0.635
DOC_WW_Pin1_4	510	515	PF00397	0.552
DOC_WW_Pin1_4	553	558	PF00397	0.662
DOC_WW_Pin1_4	569	574	PF00397	0.505
DOC_WW_Pin1_4	631	636	PF00397	0.653
DOC_WW_Pin1_4	64	69	PF00397	0.399
DOC_WW_Pin1_4	680	685	PF00397	0.565
DOC_WW_Pin1_4	730	735	PF00397	0.631
DOC_WW_Pin1_4	757	762	PF00397	0.647
LIG_14-3-3_CanoR_1	213	218	PF00244	0.352
LIG_14-3-3_CanoR_1	246	251	PF00244	0.401
LIG_14-3-3_CanoR_1	257	262	PF00244	0.256
LIG_14-3-3_CanoR_1	279	285	PF00244	0.444
LIG_14-3-3_CanoR_1	286	290	PF00244	0.312
LIG_14-3-3_CanoR_1	335	340	PF00244	0.297
LIG_14-3-3_CanoR_1	407	416	PF00244	0.551
LIG_14-3-3_CanoR_1	438	444	PF00244	0.579
LIG_14-3-3_CanoR_1	698	706	PF00244	0.622
LIG_Actin_WH2_2	251	268	PF00022	0.318
LIG_BIR_II_1	1	5	PF00653	0.548
LIG_deltaCOP1_diTrp_1	233	239	PF00928	0.340
LIG_DLG_GKlike_1	257	264	PF00625	0.312
LIG_DLG_GKlike_1	285	293	PF00625	0.364
LIG_FHA_1	212	218	PF00498	0.307
LIG_FHA_1	42	48	PF00498	0.501
LIG_FHA_1	494	500	PF00498	0.610
LIG_FHA_1	596	602	PF00498	0.582
LIG_FHA_1	711	717	PF00498	0.644
LIG_FHA_2	110	116	PF00498	0.340
LIG_FHA_2	139	145	PF00498	0.352
LIG_FHA_2	247	253	PF00498	0.384
LIG_FHA_2	394	400	PF00498	0.674
LIG_FHA_2	663	669	PF00498	0.587
LIG_LIR_Apic_2	445	449	PF02991	0.653
LIG_LIR_Gen_1	178	188	PF02991	0.347
LIG_LIR_Gen_1	233	241	PF02991	0.340
LIG_LIR_Gen_1	492	502	PF02991	0.668
LIG_LIR_Gen_1	574	583	PF02991	0.600
LIG_LIR_Gen_1	667	676	PF02991	0.512
LIG_LIR_Gen_1	789	794	PF02991	0.670
LIG_LIR_Gen_1	85	94	PF02991	0.338
LIG_LIR_Nem_3	178	183	PF02991	0.311
LIG_LIR_Nem_3	233	238	PF02991	0.340
LIG_LIR_Nem_3	492	497	PF02991	0.656
LIG_LIR_Nem_3	574	579	PF02991	0.580
LIG_LIR_Nem_3	789	794	PF02991	0.622
LIG_LIR_Nem_3	85	91	PF02991	0.334
LIG_NRBOX	260	266	PF00104	0.312
LIG_PCNA_yPIPBox_3	242	254	PF02747	0.312
LIG_PDZ_Class_1	789	794	PF00595	0.622
LIG_Pex14_1	114	118	PF04695	0.352
LIG_Pex14_2	355	359	PF04695	0.356
LIG_SH2_CRK	267	271	PF00017	0.388
LIG_SH2_CRK	342	346	PF00017	0.388
LIG_SH2_CRK	494	498	PF00017	0.666
LIG_SH2_GRB2like	132	135	PF00017	0.312
LIG_SH2_NCK_1	267	271	PF00017	0.388
LIG_SH2_NCK_1	494	498	PF00017	0.618
LIG_SH2_PTP2	446	449	PF00017	0.603
LIG_SH2_STAP1	139	143	PF00017	0.315
LIG_SH2_STAP1	342	346	PF00017	0.312
LIG_SH2_STAT5	128	131	PF00017	0.338
LIG_SH2_STAT5	275	278	PF00017	0.314
LIG_SH2_STAT5	354	357	PF00017	0.377
LIG_SH2_STAT5	380	383	PF00017	0.559
LIG_SH2_STAT5	446	449	PF00017	0.603
LIG_SH2_STAT5	669	672	PF00017	0.547
LIG_SH3_1	380	386	PF00018	0.536
LIG_SH3_1	59	65	PF00018	0.473
LIG_SH3_3	224	230	PF00018	0.312
LIG_SH3_3	323	329	PF00018	0.312
LIG_SH3_3	380	386	PF00018	0.655
LIG_SH3_3	465	471	PF00018	0.547
LIG_SH3_3	474	480	PF00018	0.563
LIG_SH3_3	494	500	PF00018	0.466
LIG_SH3_3	59	65	PF00018	0.473
LIG_SH3_3	629	635	PF00018	0.615
LIG_SH3_3	731	737	PF00018	0.581
LIG_SUMO_SIM_par_1	212	219	PF11976	0.250
LIG_SUMO_SIM_par_1	344	350	PF11976	0.312
LIG_SUMO_SIM_par_1	495	501	PF11976	0.543
LIG_SUMO_SIM_par_1	711	717	PF11976	0.626
LIG_TRAF2_1	389	392	PF00917	0.561
LIG_TRAF2_1	412	415	PF00917	0.606
LIG_TRAF2_1	665	668	PF00917	0.562
LIG_TRAF2_1	766	769	PF00917	0.639
LIG_TRAF2_2	169	174	PF00917	0.388
LIG_TRFH_1	267	271	PF08558	0.388
LIG_TYR_ITIM	340	345	PF00017	0.388
LIG_UBA3_1	345	349	PF00899	0.312
LIG_WW_3	243	247	PF00397	0.388
LIG_WW_3	60	64	PF00397	0.459
MOD_CDC14_SPxK_1	572	575	PF00782	0.557
MOD_CDK_SPxK_1	569	575	PF00069	0.562
MOD_CDK_SPxxK_3	453	460	PF00069	0.596
MOD_CK1_1	2	8	PF00069	0.541
MOD_CK1_1	216	222	PF00069	0.341
MOD_CK1_1	498	504	PF00069	0.721
MOD_CK1_1	513	519	PF00069	0.550
MOD_CK1_1	545	551	PF00069	0.593
MOD_CK1_1	619	625	PF00069	0.618
MOD_CK1_1	680	686	PF00069	0.602
MOD_CK1_1	730	736	PF00069	0.692
MOD_CK1_1	760	766	PF00069	0.634
MOD_CK2_1	114	120	PF00069	0.340
MOD_CK2_1	138	144	PF00069	0.312
MOD_CK2_1	246	252	PF00069	0.384
MOD_CK2_1	386	392	PF00069	0.560
MOD_CK2_1	409	415	PF00069	0.606
MOD_CK2_1	439	445	PF00069	0.650
MOD_CK2_1	557	563	PF00069	0.639
MOD_CK2_1	662	668	PF00069	0.594
MOD_GlcNHglycan	1	4	PF01048	0.537
MOD_GlcNHglycan	331	334	PF01048	0.255
MOD_GlcNHglycan	34	37	PF01048	0.513
MOD_GlcNHglycan	386	389	PF01048	0.635
MOD_GlcNHglycan	399	402	PF01048	0.627
MOD_GlcNHglycan	409	412	PF01048	0.651
MOD_GlcNHglycan	422	428	PF01048	0.593
MOD_GlcNHglycan	48	51	PF01048	0.469
MOD_GlcNHglycan	6	9	PF01048	0.530
MOD_GlcNHglycan	600	604	PF01048	0.629
MOD_GlcNHglycan	607	610	PF01048	0.584
MOD_GlcNHglycan	621	624	PF01048	0.625
MOD_GlcNHglycan	637	640	PF01048	0.536
MOD_GlcNHglycan	679	682	PF01048	0.624
MOD_GlcNHglycan	729	732	PF01048	0.590
MOD_GlcNHglycan	755	758	PF01048	0.599
MOD_GSK3_1	114	121	PF00069	0.340
MOD_GSK3_1	211	218	PF00069	0.345
MOD_GSK3_1	280	287	PF00069	0.312
MOD_GSK3_1	329	336	PF00069	0.255
MOD_GSK3_1	393	400	PF00069	0.669
MOD_GSK3_1	509	516	PF00069	0.633
MOD_GSK3_1	520	527	PF00069	0.605
MOD_GSK3_1	553	560	PF00069	0.629
MOD_GSK3_1	567	574	PF00069	0.520
MOD_GSK3_1	595	602	PF00069	0.612
MOD_GSK3_1	605	612	PF00069	0.622
MOD_GSK3_1	617	624	PF00069	0.581
MOD_GSK3_1	631	638	PF00069	0.590
MOD_GSK3_1	683	690	PF00069	0.657
MOD_GSK3_1	710	717	PF00069	0.625
MOD_GSK3_1	753	760	PF00069	0.652
MOD_GSK3_1	786	793	PF00069	0.582
MOD_N-GLC_1	246	251	PF02516	0.312
MOD_NEK2_1	1	6	PF00069	0.549
MOD_NEK2_1	109	114	PF00069	0.399
MOD_NEK2_1	118	123	PF00069	0.296
MOD_NEK2_1	194	199	PF00069	0.350
MOD_NEK2_1	221	226	PF00069	0.299
MOD_NEK2_1	280	285	PF00069	0.444
MOD_NEK2_1	359	364	PF00069	0.373
MOD_NEK2_1	439	444	PF00069	0.572
MOD_NEK2_1	532	537	PF00069	0.654
MOD_NEK2_1	714	719	PF00069	0.580
MOD_NEK2_2	745	750	PF00069	0.616
MOD_PK_1	409	415	PF00069	0.610
MOD_PKA_1	285	291	PF00069	0.302
MOD_PKA_2	284	290	PF00069	0.322
MOD_PKA_2	605	611	PF00069	0.675
MOD_PKA_2	697	703	PF00069	0.623
MOD_Plk_1	114	120	PF00069	0.340
MOD_Plk_1	211	217	PF00069	0.312
MOD_Plk_1	246	252	PF00069	0.312
MOD_Plk_1	710	716	PF00069	0.625
MOD_Plk_4	118	124	PF00069	0.332
MOD_Plk_4	216	222	PF00069	0.317
MOD_Plk_4	335	341	PF00069	0.297
MOD_Plk_4	359	365	PF00069	0.354
MOD_ProDKin_1	453	459	PF00069	0.519
MOD_ProDKin_1	498	504	PF00069	0.637
MOD_ProDKin_1	510	516	PF00069	0.549
MOD_ProDKin_1	553	559	PF00069	0.660
MOD_ProDKin_1	569	575	PF00069	0.506
MOD_ProDKin_1	631	637	PF00069	0.653
MOD_ProDKin_1	64	70	PF00069	0.391
MOD_ProDKin_1	680	686	PF00069	0.563
MOD_ProDKin_1	730	736	PF00069	0.631
MOD_ProDKin_1	757	763	PF00069	0.648
MOD_SUMO_rev_2	428	437	PF00179	0.606
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.388
TRG_ENDOCYTIC_2	342	345	PF00928	0.317
TRG_ENDOCYTIC_2	494	497	PF00928	0.664
TRG_ENDOCYTIC_2	669	672	PF00928	0.576
TRG_ENDOCYTIC_2	88	91	PF00928	0.382
TRG_ER_diArg_1	241	243	PF00400	0.279
TRG_ER_diArg_1	278	280	PF00400	0.449
TRG_ER_diArg_1	284	286	PF00400	0.422
TRG_ER_diArg_1	300	302	PF00400	0.269
TRG_ER_diArg_1	56	59	PF00400	0.552
TRG_ER_diArg_1	72	75	PF00400	0.375
TRG_NLS_MonoCore_2	56	61	PF00514	0.514
TRG_NLS_MonoExtC_3	56	61	PF00514	0.526
TRG_NLS_MonoExtN_4	56	62	PF00514	0.520
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI2	Leptomonas seymouri	49%	98%
A0A3Q8IAT8	Leishmania donovani	99%	100%
A4H961	Leishmania braziliensis	69%	97%
E9AR78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QE85	Leishmania major	92%	99%