Hydrolase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase-like protein

Species:

Leishmania infantum

UniProt:

A4HXI2_LEIIN

TriTrypDb:

LINF_170017700

Length:

390

Annotations

Annotations by Jardim et al.

Hydrolase, Hydrolase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HXI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXI2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	33
GO:0016787	hydrolase activity	2	33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	272	274	PF00675	0.294
CLV_PCSK_KEX2_1	272	274	PF00082	0.321
CLV_PCSK_SKI1_1	136	140	PF00082	0.236
CLV_PCSK_SKI1_1	238	242	PF00082	0.292
CLV_PCSK_SKI1_1	67	71	PF00082	0.431
DEG_APCC_DBOX_1	271	279	PF00400	0.394
DOC_MAPK_gen_1	252	260	PF00069	0.360
DOC_MAPK_MEF2A_6	319	326	PF00069	0.415
DOC_PP1_RVXF_1	234	240	PF00149	0.399
DOC_PP1_RVXF_1	348	355	PF00149	0.362
DOC_PP4_FxxP_1	48	51	PF00568	0.290
DOC_PP4_FxxP_1	76	79	PF00568	0.353
DOC_USP7_MATH_1	211	215	PF00917	0.355
DOC_WW_Pin1_4	128	133	PF00397	0.352
DOC_WW_Pin1_4	15	20	PF00397	0.640
DOC_WW_Pin1_4	313	318	PF00397	0.258
LIG_14-3-3_CanoR_1	169	176	PF00244	0.156
LIG_14-3-3_CanoR_1	212	216	PF00244	0.192
LIG_14-3-3_CanoR_1	294	300	PF00244	0.342
LIG_14-3-3_CanoR_1	305	311	PF00244	0.456
LIG_14-3-3_CanoR_1	61	69	PF00244	0.420
LIG_BIR_III_4	160	164	PF00653	0.398
LIG_BRCT_BRCA1_1	44	48	PF00533	0.267
LIG_EVH1_1	48	52	PF00568	0.287
LIG_FHA_1	224	230	PF00498	0.224
LIG_FHA_2	122	128	PF00498	0.334
LIG_FHA_2	151	157	PF00498	0.306
LIG_FHA_2	246	252	PF00498	0.182
LIG_FHA_2	27	33	PF00498	0.414
LIG_FHA_2	63	69	PF00498	0.402
LIG_HP1_1	322	326	PF01393	0.399
LIG_HP1_1	332	336	PF01393	0.399
LIG_IRF3_LxIS_1	164	171	PF10401	0.313
LIG_LIR_Apic_2	127	132	PF02991	0.399
LIG_LIR_Apic_2	45	51	PF02991	0.493
LIG_LIR_Apic_2	74	79	PF02991	0.386
LIG_LIR_Gen_1	141	150	PF02991	0.194
LIG_LIR_Gen_1	53	63	PF02991	0.451
LIG_LIR_Gen_1	6	14	PF02991	0.444
LIG_LIR_Gen_1	70	79	PF02991	0.255
LIG_LIR_LC3C_4	331	335	PF02991	0.192
LIG_LIR_Nem_3	141	145	PF02991	0.335
LIG_LIR_Nem_3	364	369	PF02991	0.374
LIG_LIR_Nem_3	53	59	PF02991	0.423
LIG_LIR_Nem_3	6	12	PF02991	0.443
LIG_LIR_Nem_3	70	76	PF02991	0.280
LIG_LIR_Nem_3	98	104	PF02991	0.336
LIG_Pex14_1	97	101	PF04695	0.257
LIG_REV1ctd_RIR_1	237	245	PF16727	0.212
LIG_SH2_CRK	366	370	PF00017	0.229
LIG_SH2_GRB2like	115	118	PF00017	0.307
LIG_SH2_PTP2	9	12	PF00017	0.451
LIG_SH2_STAT5	104	107	PF00017	0.301
LIG_SH2_STAT5	111	114	PF00017	0.271
LIG_SH2_STAT5	152	155	PF00017	0.288
LIG_SH2_STAT5	360	363	PF00017	0.378
LIG_SH2_STAT5	9	12	PF00017	0.451
LIG_SH3_1	46	52	PF00018	0.285
LIG_SH3_3	205	211	PF00018	0.375
LIG_SH3_3	25	31	PF00018	0.619
LIG_SH3_3	349	355	PF00018	0.325
LIG_SH3_3	46	52	PF00018	0.508
LIG_SH3_3	76	82	PF00018	0.426
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.474
LIG_SUMO_SIM_par_1	331	337	PF11976	0.192
MOD_CDK_SPxK_1	313	319	PF00069	0.156
MOD_CK1_1	13	19	PF00069	0.660
MOD_CK1_1	297	303	PF00069	0.277
MOD_CK1_1	313	319	PF00069	0.340
MOD_CK2_1	141	147	PF00069	0.337
MOD_CK2_1	245	251	PF00069	0.402
MOD_CK2_1	26	32	PF00069	0.430
MOD_Cter_Amidation	270	273	PF01082	0.212
MOD_GlcNHglycan	204	207	PF01048	0.372
MOD_GlcNHglycan	283	287	PF01048	0.320
MOD_GlcNHglycan	312	315	PF01048	0.409
MOD_GlcNHglycan	73	76	PF01048	0.422
MOD_GSK3_1	10	17	PF00069	0.729
MOD_GSK3_1	146	153	PF00069	0.304
MOD_GSK3_1	22	29	PF00069	0.702
MOD_GSK3_1	278	285	PF00069	0.416
MOD_GSK3_1	300	307	PF00069	0.380
MOD_GSK3_1	67	74	PF00069	0.459
MOD_N-GLC_1	295	300	PF02516	0.191
MOD_N-GLC_1	90	95	PF02516	0.212
MOD_NEK2_1	168	173	PF00069	0.315
MOD_NEK2_1	195	200	PF00069	0.302
MOD_NEK2_1	201	206	PF00069	0.285
MOD_NEK2_1	295	300	PF00069	0.229
MOD_NEK2_1	71	76	PF00069	0.507
MOD_NEK2_1	90	95	PF00069	0.393
MOD_NEK2_1	96	101	PF00069	0.392
MOD_NEK2_2	245	250	PF00069	0.362
MOD_PIKK_1	168	174	PF00454	0.212
MOD_PKA_2	168	174	PF00069	0.307
MOD_PKA_2	211	217	PF00069	0.386
MOD_PKA_2	300	306	PF00069	0.447
MOD_Plk_1	245	251	PF00069	0.429
MOD_Plk_1	295	301	PF00069	0.156
MOD_Plk_1	379	385	PF00069	0.544
MOD_Plk_1	42	48	PF00069	0.424
MOD_Plk_1	67	73	PF00069	0.352
MOD_Plk_1	90	96	PF00069	0.423
MOD_Plk_2-3	228	234	PF00069	0.399
MOD_Plk_4	211	217	PF00069	0.362
MOD_Plk_4	228	234	PF00069	0.365
MOD_Plk_4	91	97	PF00069	0.408
MOD_ProDKin_1	128	134	PF00069	0.352
MOD_ProDKin_1	15	21	PF00069	0.643
MOD_ProDKin_1	313	319	PF00069	0.258
TRG_ENDOCYTIC_2	366	369	PF00928	0.453
TRG_ENDOCYTIC_2	73	76	PF00928	0.346
TRG_ENDOCYTIC_2	9	12	PF00928	0.451
TRG_ER_diArg_1	235	238	PF00400	0.413
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	36%	90%
A0A0N0P3S4	Leptomonas seymouri	62%	100%
A0A0N1PA10	Leptomonas seymouri	38%	100%
A0A0N1PCQ2	Leptomonas seymouri	44%	100%
A0A0S4JQB3	Bodo saltans	36%	100%
A0A1X0NSR3	Trypanosomatidae	35%	87%
A0A1X0NSS6	Trypanosomatidae	41%	100%
A0A3Q8IAY1	Leishmania donovani	100%	100%
A0A3R7KKJ0	Trypanosoma rangeli	39%	100%
A0A3S5IRR1	Trypanosoma rangeli	33%	96%
A0A3S7WUJ3	Leishmania donovani	40%	100%
A0A3S7WUK0	Leishmania donovani	38%	90%
A0A3S7X1K2	Leishmania donovani	37%	100%
A0A422NS41	Trypanosoma rangeli	35%	91%
A4H956	Leishmania braziliensis	41%	100%
A4H959	Leishmania braziliensis	36%	100%
A4H960	Leishmania braziliensis	76%	100%
A4HGL0	Leishmania braziliensis	38%	100%
A4HXH8	Leishmania infantum	40%	100%
A4HXI1	Leishmania infantum	38%	100%
A4I3N6	Leishmania infantum	36%	100%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	98%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q4Q8A8	Leishmania major	36%	100%
Q4QE86	Leishmania major	94%	100%
Q4QE87	Leishmania major	37%	100%
Q4QE90	Leishmania major	40%	100%
Q54528	Streptomyces purpurascens	27%	100%
Q54809	Streptomyces peucetius	28%	100%
Q55217	Streptomyces sp. (strain C5)	28%	100%
V5AZB9	Trypanosoma cruzi	34%	91%
V5BER0	Trypanosoma cruzi	40%	100%
V5BNU9	Trypanosoma cruzi	31%	96%