Hydrolase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase-like protein

Species:

Leishmania infantum

UniProt:

A4HXI1_LEIIN

TriTrypDb:

LINF_170017600

Length:

431

Annotations

Annotations by Jardim et al.

Hydrolase, Hydrolase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 36
NetGPI	no	yes: 0, no: 36

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HXI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXI1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	35
GO:0016787	hydrolase activity	2	35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	403	405	PF00675	0.527
CLV_PCSK_KEX2_1	276	278	PF00082	0.247
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.293
CLV_PCSK_SKI1_1	269	273	PF00082	0.294
CLV_PCSK_SKI1_1	286	290	PF00082	0.295
CLV_PCSK_SKI1_1	324	328	PF00082	0.186
DEG_APCC_DBOX_1	285	293	PF00400	0.391
DEG_COP1_1	331	339	PF00400	0.372
DEG_SPOP_SBC_1	207	211	PF00917	0.399
DOC_CKS1_1	330	335	PF01111	0.327
DOC_CYCLIN_RxL_1	172	183	PF00134	0.260
DOC_MAPK_gen_1	273	281	PF00069	0.387
DOC_MAPK_MEF2A_6	49	57	PF00069	0.365
DOC_MIT_MIM_1	146	155	PF04212	0.186
DOC_PP1_RVXF_1	147	153	PF00149	0.186
DOC_PP2B_LxvP_1	292	295	PF13499	0.345
DOC_PP2B_PxIxI_1	336	342	PF00149	0.203
DOC_PP4_FxxP_1	334	337	PF00568	0.186
DOC_USP7_MATH_1	398	402	PF00917	0.397
DOC_USP7_MATH_1	5	9	PF00917	0.515
DOC_USP7_UBL2_3	248	252	PF12436	0.369
DOC_USP7_UBL2_3	422	426	PF12436	0.668
DOC_WW_Pin1_4	185	190	PF00397	0.319
DOC_WW_Pin1_4	329	334	PF00397	0.239
DOC_WW_Pin1_4	58	63	PF00397	0.330
LIG_14-3-3_CanoR_1	175	180	PF00244	0.286
LIG_14-3-3_CanoR_1	238	246	PF00244	0.277
LIG_14-3-3_CanoR_1	30	38	PF00244	0.423
LIG_14-3-3_CanoR_1	302	311	PF00244	0.322
LIG_14-3-3_CanoR_1	324	334	PF00244	0.470
LIG_14-3-3_CanoR_1	355	361	PF00244	0.316
LIG_14-3-3_CanoR_1	69	74	PF00244	0.406
LIG_Actin_WH2_1	365	383	PF00022	0.382
LIG_BIR_III_4	140	144	PF00653	0.396
LIG_FHA_1	123	129	PF00498	0.408
LIG_FHA_1	245	251	PF00498	0.321
LIG_FHA_1	325	331	PF00498	0.280
LIG_FHA_1	336	342	PF00498	0.235
LIG_FHA_1	35	41	PF00498	0.356
LIG_FHA_2	131	137	PF00498	0.299
LIG_FHA_2	220	226	PF00498	0.186
LIG_FHA_2	92	98	PF00498	0.331
LIG_LIR_Apic_2	331	337	PF02991	0.185
LIG_LIR_Gen_1	245	253	PF02991	0.398
LIG_LIR_Gen_1	383	392	PF02991	0.400
LIG_LIR_Gen_1	77	85	PF02991	0.415
LIG_LIR_Nem_3	112	116	PF02991	0.335
LIG_LIR_Nem_3	140	145	PF02991	0.400
LIG_LIR_Nem_3	23	28	PF02991	0.429
LIG_LIR_Nem_3	245	249	PF02991	0.365
LIG_LIR_Nem_3	383	387	PF02991	0.403
LIG_LIR_Nem_3	77	83	PF02991	0.297
LIG_NRBOX	69	75	PF00104	0.249
LIG_PDZ_Class_1	426	431	PF00595	0.672
LIG_SH2_CRK	118	122	PF00017	0.292
LIG_SH2_CRK	80	84	PF00017	0.474
LIG_SH2_PTP2	384	387	PF00017	0.431
LIG_SH2_SRC	116	119	PF00017	0.203
LIG_SH2_STAP1	116	120	PF00017	0.406
LIG_SH2_STAP1	214	218	PF00017	0.398
LIG_SH2_STAP1	242	246	PF00017	0.399
LIG_SH2_STAT5	113	116	PF00017	0.399
LIG_SH2_STAT5	132	135	PF00017	0.278
LIG_SH2_STAT5	335	338	PF00017	0.377
LIG_SH2_STAT5	367	370	PF00017	0.326
LIG_SH2_STAT5	384	387	PF00017	0.428
LIG_SH3_3	1	7	PF00018	0.708
LIG_SH3_3	104	110	PF00018	0.435
LIG_SH3_3	15	21	PF00018	0.577
LIG_SH3_3	327	333	PF00018	0.310
LIG_SH3_3	344	350	PF00018	0.282
LIG_SUMO_SIM_anti_2	178	184	PF11976	0.222
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.418
LIG_SUMO_SIM_par_1	174	180	PF11976	0.282
LIG_TRAF2_1	223	226	PF00917	0.399
LIG_UBA3_1	199	208	PF00899	0.351
LIG_WRC_WIRS_1	42	47	PF05994	0.304
MOD_CK1_1	183	189	PF00069	0.274
MOD_CK1_1	201	207	PF00069	0.210
MOD_CK1_1	328	334	PF00069	0.343
MOD_CK1_1	8	14	PF00069	0.638
MOD_CK2_1	124	130	PF00069	0.352
MOD_CK2_1	219	225	PF00069	0.352
MOD_Cter_Amidation	402	405	PF01082	0.393
MOD_GlcNHglycan	158	161	PF01048	0.378
MOD_GlcNHglycan	210	213	PF01048	0.365
MOD_GlcNHglycan	222	225	PF01048	0.392
MOD_GlcNHglycan	253	256	PF01048	0.349
MOD_GlcNHglycan	327	330	PF01048	0.412
MOD_GlcNHglycan	418	421	PF01048	0.687
MOD_GlcNHglycan	76	79	PF01048	0.453
MOD_GSK3_1	177	184	PF00069	0.263
MOD_GSK3_1	275	282	PF00069	0.222
MOD_GSK3_1	30	37	PF00069	0.510
MOD_GSK3_1	320	327	PF00069	0.421
MOD_N-GLC_1	320	325	PF02516	0.203
MOD_NEK2_1	155	160	PF00069	0.346
MOD_NEK2_1	177	182	PF00069	0.310
MOD_NEK2_1	275	280	PF00069	0.284
MOD_NEK2_1	372	377	PF00069	0.367
MOD_NEK2_1	380	385	PF00069	0.365
MOD_NEK2_1	74	79	PF00069	0.401
MOD_NEK2_2	124	129	PF00069	0.474
MOD_PIKK_1	309	315	PF00454	0.454
MOD_PK_1	304	310	PF00069	0.406
MOD_PKA_2	219	225	PF00069	0.186
MOD_PKA_2	237	243	PF00069	0.408
MOD_PKA_2	303	309	PF00069	0.395
MOD_PKA_2	380	386	PF00069	0.424
MOD_PKB_1	302	310	PF00069	0.203
MOD_Plk_2-3	130	136	PF00069	0.272
MOD_Plk_4	109	115	PF00069	0.369
MOD_Plk_4	177	183	PF00069	0.238
MOD_Plk_4	198	204	PF00069	0.343
MOD_Plk_4	335	341	PF00069	0.275
MOD_Plk_4	356	362	PF00069	0.299
MOD_Plk_4	372	378	PF00069	0.353
MOD_Plk_4	380	386	PF00069	0.375
MOD_Plk_4	69	75	PF00069	0.403
MOD_ProDKin_1	185	191	PF00069	0.319
MOD_ProDKin_1	329	335	PF00069	0.239
MOD_ProDKin_1	58	64	PF00069	0.330
MOD_SUMO_rev_2	93	102	PF00179	0.155
TRG_AP2beta_CARGO_1	140	149	PF09066	0.186
TRG_DiLeu_BaEn_4	225	231	PF01217	0.399
TRG_ENDOCYTIC_2	118	121	PF00928	0.249
TRG_ENDOCYTIC_2	384	387	PF00928	0.457
TRG_ENDOCYTIC_2	42	45	PF00928	0.312
TRG_ENDOCYTIC_2	80	83	PF00928	0.315
TRG_ER_diArg_1	148	151	PF00400	0.205
TRG_ER_diArg_1	19	22	PF00400	0.331
TRG_ER_diArg_1	227	230	PF00400	0.370
TRG_ER_diArg_1	301	304	PF00400	0.364
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.336
TRG_PTS1	428	431	PF00515	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	65%	100%
A0A0N0P3S4	Leptomonas seymouri	36%	100%
A0A0N1PA10	Leptomonas seymouri	30%	100%
A0A0N1PCQ2	Leptomonas seymouri	33%	100%
A0A0S4JQB3	Bodo saltans	30%	100%
A0A1X0NSR3	Trypanosomatidae	30%	96%
A0A1X0NSS6	Trypanosomatidae	33%	100%
A0A1X0NT85	Trypanosomatidae	34%	87%
A0A3Q8IAY1	Leishmania donovani	38%	100%
A0A3R7KKJ0	Trypanosoma rangeli	33%	100%
A0A3S5IRR1	Trypanosoma rangeli	37%	100%
A0A3S7WUJ3	Leishmania donovani	31%	100%
A0A3S7WUK0	Leishmania donovani	99%	100%
A0A3S7X1K2	Leishmania donovani	31%	100%
A0A422NS41	Trypanosoma rangeli	30%	100%
A4H956	Leishmania braziliensis	33%	95%
A4H959	Leishmania braziliensis	79%	99%
A4H960	Leishmania braziliensis	36%	100%
A4HGL0	Leishmania braziliensis	29%	87%
A4HXH8	Leishmania infantum	31%	91%
A4HXI2	Leishmania infantum	38%	100%
A4I3N6	Leishmania infantum	32%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	86%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	96%
Q4Q8A8	Leishmania major	31%	96%
Q4QE86	Leishmania major	37%	100%
Q4QE87	Leishmania major	92%	100%
Q4QE90	Leishmania major	31%	92%
Q54528	Streptomyces purpurascens	26%	100%
Q54809	Streptomyces peucetius	27%	100%
Q55217	Streptomyces sp. (strain C5)	27%	100%
V5AZB9	Trypanosoma cruzi	31%	100%
V5BER0	Trypanosoma cruzi	32%	100%
V5BNU9	Trypanosoma cruzi	34%	100%