Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4HXG9_LEIIN

TriTrypDb:

LINF_170016200

Length:

477

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, acyl transferase lysophosphatidylglycerol acyl transferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0012505	endomembrane system	2	1
GO:0016020	membrane	2	10
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HXG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXG9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0036149	phosphatidylinositol acyl-chain remodeling	7	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046488	phosphatidylinositol metabolic process	6	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.555
CLV_NRD_NRD_1	194	196	PF00675	0.270
CLV_NRD_NRD_1	387	389	PF00675	0.382
CLV_NRD_NRD_1	462	464	PF00675	0.385
CLV_NRD_NRD_1	470	472	PF00675	0.423
CLV_PCSK_FUR_1	460	464	PF00082	0.382
CLV_PCSK_KEX2_1	194	196	PF00082	0.298
CLV_PCSK_KEX2_1	387	389	PF00082	0.363
CLV_PCSK_KEX2_1	462	464	PF00082	0.385
CLV_PCSK_PC7_1	383	389	PF00082	0.404
CLV_PCSK_SKI1_1	157	161	PF00082	0.225
CLV_PCSK_SKI1_1	178	182	PF00082	0.242
CLV_PCSK_SKI1_1	239	243	PF00082	0.348
CLV_PCSK_SKI1_1	338	342	PF00082	0.279
CLV_PCSK_SKI1_1	359	363	PF00082	0.305
CLV_PCSK_SKI1_1	37	41	PF00082	0.542
CLV_PCSK_SKI1_1	434	438	PF00082	0.409
CLV_PCSK_SKI1_1	449	453	PF00082	0.360
CLV_PCSK_SKI1_1	462	466	PF00082	0.449
DEG_APCC_DBOX_1	416	424	PF00400	0.334
DEG_APCC_DBOX_1	60	68	PF00400	0.358
DEG_MDM2_SWIB_1	415	423	PF02201	0.336
DEG_Nend_UBRbox_1	1	4	PF02207	0.624
DEG_SCF_FBW7_1	450	456	PF00400	0.530
DOC_CDC14_PxL_1	164	172	PF14671	0.553
DOC_CKS1_1	450	455	PF01111	0.536
DOC_CYCLIN_RxL_1	106	114	PF00134	0.586
DOC_CYCLIN_RxL_1	175	183	PF00134	0.496
DOC_CYCLIN_RxL_1	332	343	PF00134	0.539
DOC_MAPK_gen_1	293	299	PF00069	0.568
DOC_MAPK_gen_1	387	395	PF00069	0.528
DOC_MAPK_JIP1_4	280	286	PF00069	0.603
DOC_MAPK_MEF2A_6	261	270	PF00069	0.547
DOC_PP1_RVXF_1	134	140	PF00149	0.459
DOC_PP1_RVXF_1	193	200	PF00149	0.523
DOC_PP2B_LxvP_1	117	120	PF13499	0.567
DOC_PP2B_PxIxI_1	206	212	PF00149	0.525
DOC_USP7_UBL2_3	161	165	PF12436	0.508
DOC_WW_Pin1_4	203	208	PF00397	0.534
DOC_WW_Pin1_4	216	221	PF00397	0.534
DOC_WW_Pin1_4	405	410	PF00397	0.323
DOC_WW_Pin1_4	449	454	PF00397	0.537
LIG_14-3-3_CanoR_1	150	160	PF00244	0.565
LIG_14-3-3_CanoR_1	417	426	PF00244	0.326
LIG_Actin_RPEL_3	410	429	PF02755	0.272
LIG_Actin_WH2_2	435	451	PF00022	0.470
LIG_APCC_ABBA_1	209	214	PF00400	0.467
LIG_CaM_IQ_9	455	471	PF13499	0.633
LIG_deltaCOP1_diTrp_1	138	146	PF00928	0.448
LIG_FHA_1	147	153	PF00498	0.468
LIG_FHA_1	204	210	PF00498	0.477
LIG_FHA_1	244	250	PF00498	0.461
LIG_FHA_1	25	31	PF00498	0.432
LIG_FHA_1	326	332	PF00498	0.571
LIG_FHA_1	346	352	PF00498	0.418
LIG_FHA_1	420	426	PF00498	0.409
LIG_FHA_2	80	86	PF00498	0.554
LIG_LIR_Apic_2	273	277	PF02991	0.598
LIG_LIR_Gen_1	108	117	PF02991	0.576
LIG_LIR_Gen_1	138	147	PF02991	0.448
LIG_LIR_Gen_1	445	455	PF02991	0.557
LIG_LIR_Gen_1	78	87	PF02991	0.571
LIG_LIR_Nem_3	108	113	PF02991	0.608
LIG_LIR_Nem_3	142	146	PF02991	0.480
LIG_LIR_Nem_3	175	180	PF02991	0.457
LIG_LIR_Nem_3	408	414	PF02991	0.387
LIG_LIR_Nem_3	445	450	PF02991	0.546
LIG_LIR_Nem_3	78	84	PF02991	0.551
LIG_MAD2	115	123	PF02301	0.606
LIG_PCNA_PIPBox_1	193	202	PF02747	0.496
LIG_Pex14_1	139	143	PF04695	0.473
LIG_Pex14_1	385	389	PF04695	0.601
LIG_Pex14_2	177	181	PF04695	0.440
LIG_Pex14_2	414	418	PF04695	0.384
LIG_REV1ctd_RIR_1	412	421	PF16727	0.447
LIG_SH2_CRK	274	278	PF00017	0.609
LIG_SH2_CRK	390	394	PF00017	0.577
LIG_SH2_NCK_1	81	85	PF00017	0.508
LIG_SH2_STAP1	141	145	PF00017	0.553
LIG_SH2_STAP1	229	233	PF00017	0.534
LIG_SH2_STAP1	272	276	PF00017	0.506
LIG_SH2_STAT3	389	392	PF00017	0.592
LIG_SH2_STAT5	110	113	PF00017	0.606
LIG_SH2_STAT5	141	144	PF00017	0.556
LIG_SH2_STAT5	145	148	PF00017	0.562
LIG_SH2_STAT5	158	161	PF00017	0.352
LIG_SH2_STAT5	179	182	PF00017	0.452
LIG_SH2_STAT5	272	275	PF00017	0.510
LIG_SH2_STAT5	34	37	PF00017	0.393
LIG_SH2_STAT5	38	41	PF00017	0.401
LIG_SH2_STAT5	412	415	PF00017	0.442
LIG_SH2_STAT5	447	450	PF00017	0.572
LIG_SH2_STAT5	63	66	PF00017	0.382
LIG_SH2_STAT5	81	84	PF00017	0.392
LIG_SH3_2	120	125	PF14604	0.545
LIG_SH3_3	113	119	PF00018	0.511
LIG_SH3_3	230	236	PF00018	0.473
LIG_SH3_3	238	244	PF00018	0.425
LIG_SH3_3	378	384	PF00018	0.613
LIG_SH3_3	396	402	PF00018	0.204
LIG_SH3_3	447	453	PF00018	0.591
LIG_SUMO_SIM_anti_2	205	212	PF11976	0.537
LIG_SUMO_SIM_anti_2	26	33	PF11976	0.311
LIG_SUMO_SIM_par_1	246	254	PF11976	0.538
LIG_TRAF2_1	321	324	PF00917	0.625
LIG_TYR_ITIM	79	84	PF00017	0.490
LIG_UBA3_1	152	161	PF00899	0.553
LIG_UBA3_1	30	37	PF00899	0.361
LIG_UBA3_1	457	466	PF00899	0.478
LIG_WRC_WIRS_1	140	145	PF05994	0.553
MOD_CK2_1	20	26	PF00069	0.452
MOD_GSK3_1	20	27	PF00069	0.333
MOD_GSK3_1	266	273	PF00069	0.474
MOD_GSK3_1	449	456	PF00069	0.601
MOD_GSK3_1	75	82	PF00069	0.362
MOD_NEK2_1	1	6	PF00069	0.554
MOD_NEK2_1	146	151	PF00069	0.521
MOD_NEK2_1	180	185	PF00069	0.533
MOD_NEK2_1	24	29	PF00069	0.308
MOD_NEK2_1	298	303	PF00069	0.563
MOD_NEK2_1	340	345	PF00069	0.487
MOD_NEK2_1	59	64	PF00069	0.362
MOD_NEK2_1	75	80	PF00069	0.300
MOD_NEK2_2	20	25	PF00069	0.331
MOD_NEK2_2	96	101	PF00069	0.627
MOD_PIKK_1	118	124	PF00454	0.589
MOD_PIKK_1	223	229	PF00454	0.523
MOD_PKA_2	244	250	PF00069	0.459
MOD_PKA_2	49	55	PF00069	0.366
MOD_Plk_1	282	288	PF00069	0.601
MOD_Plk_1	453	459	PF00069	0.585
MOD_Plk_4	139	145	PF00069	0.553
MOD_Plk_4	419	425	PF00069	0.259
MOD_Plk_4	442	448	PF00069	0.535
MOD_Plk_4	453	459	PF00069	0.540
MOD_Plk_4	79	85	PF00069	0.502
MOD_ProDKin_1	203	209	PF00069	0.534
MOD_ProDKin_1	216	222	PF00069	0.534
MOD_ProDKin_1	405	411	PF00069	0.323
MOD_ProDKin_1	449	455	PF00069	0.536
MOD_SUMO_rev_2	162	167	PF00179	0.520
TRG_AP2beta_CARGO_1	175	184	PF09066	0.525
TRG_DiLeu_BaEn_1	337	342	PF01217	0.551
TRG_DiLeu_BaEn_4	263	269	PF01217	0.530
TRG_ENDOCYTIC_2	110	113	PF00928	0.600
TRG_ENDOCYTIC_2	141	144	PF00928	0.511
TRG_ENDOCYTIC_2	179	182	PF00928	0.455
TRG_ENDOCYTIC_2	390	393	PF00928	0.579
TRG_ENDOCYTIC_2	411	414	PF00928	0.318
TRG_ENDOCYTIC_2	447	450	PF00928	0.580
TRG_ENDOCYTIC_2	81	84	PF00928	0.504
TRG_ER_diArg_1	193	195	PF00400	0.470
TRG_ER_diArg_1	386	388	PF00400	0.600
TRG_ER_diArg_1	460	463	PF00400	0.615
TRG_ER_diLys_1	472	477	PF00400	0.674
TRG_Pf-PMV_PEXEL_1	109	114	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKC7	Leptomonas seymouri	59%	100%
A0A0S4J7G6	Bodo saltans	31%	100%
A0A1X0NU94	Trypanosomatidae	38%	100%
A0A3Q8IE09	Leishmania donovani	100%	100%
A0A422NH08	Trypanosoma rangeli	42%	100%
A4H937	Leishmania braziliensis	77%	100%
C9ZP55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AR64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QE99	Leishmania major	96%	100%
Q5F3X0	Gallus gallus	28%	100%
V5BF39	Trypanosoma cruzi	39%	100%