LeishMANIAdb
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Putative META domain containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative META domain containing protein
Gene product:
META domain containing protein
Species:
Leishmania infantum
UniProt:
A4HXG5_LEIIN
TriTrypDb:
LINF_170015800
Length:
444

Annotations

Annotations by Jardim et al.

Membrane associated proteins, META domain containing META2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005829 cytosol 2 1
GO:0005929 cilium 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0110165 cellular anatomical entity 1 1
GO:0120025 plasma membrane bounded cell projection 3 1

Expansion

Sequence features

A4HXG5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXG5

Function

Biological processes
Term Name Level Count
GO:0006950 response to stress 2 1
GO:0006979 response to oxidative stress 3 1
GO:0009266 response to temperature stimulus 3 1
GO:0009408 response to heat 3 1
GO:0009628 response to abiotic stimulus 2 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034599 cellular response to oxidative stress 4 1
GO:0034605 cellular response to heat 4 1
GO:0042221 response to chemical 2 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
GO:0062197 cellular response to chemical stress 4 1
GO:0070887 cellular response to chemical stimulus 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 24 28 PF00082 0.325
CLV_PCSK_SKI1_1 328 332 PF00082 0.539
CLV_PCSK_SKI1_1 353 357 PF00082 0.443
CLV_PCSK_SKI1_1 373 377 PF00082 0.230
DOC_MAPK_MEF2A_6 243 250 PF00069 0.535
DOC_MAPK_MEF2A_6 412 419 PF00069 0.494
DOC_USP7_MATH_1 101 105 PF00917 0.357
DOC_USP7_MATH_1 178 182 PF00917 0.476
DOC_USP7_MATH_1 284 288 PF00917 0.482
DOC_USP7_MATH_1 71 75 PF00917 0.540
DOC_WW_Pin1_4 136 141 PF00397 0.419
DOC_WW_Pin1_4 66 71 PF00397 0.437
LIG_14-3-3_CanoR_1 219 226 PF00244 0.635
LIG_14-3-3_CanoR_1 386 392 PF00244 0.486
LIG_Actin_WH2_2 83 101 PF00022 0.494
LIG_AP2alpha_1 83 87 PF02296 0.494
LIG_BIR_III_2 440 444 PF00653 0.544
LIG_BRCT_BRCA1_1 103 107 PF00533 0.509
LIG_BRCT_BRCA1_1 189 193 PF00533 0.500
LIG_BRCT_BRCA1_1 79 83 PF00533 0.500
LIG_Clathr_ClatBox_1 182 186 PF01394 0.468
LIG_deltaCOP1_diTrp_1 371 376 PF00928 0.383
LIG_FHA_1 147 153 PF00498 0.432
LIG_FHA_1 21 27 PF00498 0.464
LIG_FHA_1 253 259 PF00498 0.444
LIG_FHA_1 263 269 PF00498 0.422
LIG_FHA_1 378 384 PF00498 0.519
LIG_FHA_2 1 7 PF00498 0.604
LIG_FHA_2 172 178 PF00498 0.372
LIG_FHA_2 291 297 PF00498 0.544
LIG_FHA_2 62 68 PF00498 0.535
LIG_GBD_Chelix_1 89 97 PF00786 0.421
LIG_Integrin_RGD_1 168 170 PF01839 0.437
LIG_LIR_Gen_1 104 113 PF02991 0.558
LIG_LIR_Gen_1 326 337 PF02991 0.572
LIG_LIR_Gen_1 85 93 PF02991 0.494
LIG_LIR_Nem_3 104 110 PF02991 0.368
LIG_LIR_Nem_3 326 332 PF02991 0.553
LIG_LIR_Nem_3 371 377 PF02991 0.408
LIG_LIR_Nem_3 85 90 PF02991 0.494
LIG_LRP6_Inhibitor_1 263 269 PF00058 0.437
LIG_Pex14_2 193 197 PF04695 0.500
LIG_Pex14_2 303 307 PF04695 0.397
LIG_Pex14_2 83 87 PF04695 0.426
LIG_PTB_Apo_2 349 356 PF02174 0.405
LIG_SH2_GRB2like 52 55 PF00017 0.500
LIG_SH2_STAT3 439 442 PF00017 0.476
LIG_SH2_STAT5 11 14 PF00017 0.494
LIG_SH2_STAT5 230 233 PF00017 0.441
LIG_SH2_STAT5 350 353 PF00017 0.458
LIG_SH2_STAT5 413 416 PF00017 0.570
LIG_SH3_3 246 252 PF00018 0.357
LIG_SUMO_SIM_anti_2 259 265 PF11976 0.573
LIG_SUMO_SIM_par_1 121 127 PF11976 0.637
LIG_SUMO_SIM_par_1 413 418 PF11976 0.486
LIG_TRAF2_1 130 133 PF00917 0.540
LIG_TRAF2_1 280 283 PF00917 0.500
LIG_TRAF2_1 293 296 PF00917 0.325
LIG_TRAF2_1 70 73 PF00917 0.500
LIG_WRC_WIRS_1 232 237 PF05994 0.494
MOD_CK1_1 111 117 PF00069 0.548
MOD_CK1_1 146 152 PF00069 0.538
MOD_CK1_1 60 66 PF00069 0.569
MOD_CK2_1 171 177 PF00069 0.397
MOD_CK2_1 277 283 PF00069 0.456
MOD_CK2_1 290 296 PF00069 0.340
MOD_CK2_1 392 398 PF00069 0.420
MOD_CK2_1 61 67 PF00069 0.519
MOD_GlcNHglycan 203 206 PF01048 0.476
MOD_GSK3_1 132 139 PF00069 0.552
MOD_GSK3_1 258 265 PF00069 0.397
MOD_GSK3_1 290 297 PF00069 0.420
MOD_GSK3_1 34 41 PF00069 0.485
MOD_GSK3_1 342 349 PF00069 0.493
MOD_GSK3_1 57 64 PF00069 0.440
MOD_N-GLC_1 101 106 PF02516 0.544
MOD_N-GLC_1 201 206 PF02516 0.494
MOD_N-GLC_1 377 382 PF02516 0.382
MOD_N-GLC_2 352 354 PF02516 0.437
MOD_NEK2_1 134 139 PF00069 0.422
MOD_NEK2_1 171 176 PF00069 0.471
MOD_NEK2_1 285 290 PF00069 0.423
MOD_NEK2_1 46 51 PF00069 0.471
MOD_NEK2_1 61 66 PF00069 0.319
MOD_NEK2_2 25 30 PF00069 0.494
MOD_PIKK_1 171 177 PF00454 0.500
MOD_PIKK_1 294 300 PF00454 0.437
MOD_PKA_2 108 114 PF00069 0.557
MOD_PKA_2 268 274 PF00069 0.458
MOD_PKA_2 387 393 PF00069 0.448
MOD_PKA_2 46 52 PF00069 0.463
MOD_Plk_1 101 107 PF00069 0.499
MOD_Plk_1 132 138 PF00069 0.459
MOD_Plk_1 178 184 PF00069 0.500
MOD_Plk_1 258 264 PF00069 0.491
MOD_Plk_1 294 300 PF00069 0.476
MOD_Plk_1 318 324 PF00069 0.394
MOD_Plk_1 415 421 PF00069 0.431
MOD_Plk_1 71 77 PF00069 0.453
MOD_Plk_4 101 107 PF00069 0.396
MOD_Plk_4 143 149 PF00069 0.380
MOD_Plk_4 178 184 PF00069 0.513
MOD_ProDKin_1 136 142 PF00069 0.419
MOD_ProDKin_1 66 72 PF00069 0.437
MOD_SUMO_for_1 355 358 PF00179 0.494
MOD_SUMO_rev_2 369 375 PF00179 0.445
TRG_DiLeu_BaEn_1 203 208 PF01217 0.486
TRG_DiLeu_BaEn_1 358 363 PF01217 0.494
TRG_DiLeu_BaEn_4 294 300 PF01217 0.500
TRG_ER_diArg_1 383 386 PF00400 0.519
TRG_NES_CRM1_1 77 92 PF08389 0.494
TRG_Pf-PMV_PEXEL_1 436 440 PF00026 0.437

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5L4 Leptomonas seymouri 61% 100%
A0A1X0NSU0 Trypanosomatidae 36% 100%
A0A3Q8IAQ3 Leishmania donovani 99% 100%
A0A422NH16 Trypanosoma rangeli 34% 100%
A4H951 Leishmania braziliensis 81% 100%
C9ZP52 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AR60 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QEA3 Leishmania major 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS