Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXG4_LEIIN

TriTrypDb:

LINF_170015700

Length:

144

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.731
CLV_PCSK_KEX2_1	69	71	PF00082	0.811
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.725
CLV_PCSK_SKI1_1	28	32	PF00082	0.759
DEG_MDM2_SWIB_1	7	14	PF02201	0.783
DOC_CKS1_1	120	125	PF01111	0.746
DOC_USP7_MATH_1	57	61	PF00917	0.683
DOC_USP7_MATH_1	68	72	PF00917	0.625
DOC_USP7_MATH_1	79	83	PF00917	0.769
DOC_USP7_MATH_1	90	94	PF00917	0.646
DOC_USP7_UBL2_3	20	24	PF12436	0.723
DOC_WW_Pin1_4	119	124	PF00397	0.746
LIG_14-3-3_CanoR_1	28	35	PF00244	0.706
LIG_14-3-3_CanoR_1	56	62	PF00244	0.729
LIG_14-3-3_CanoR_1	70	75	PF00244	0.597
LIG_BIR_II_1	1	5	PF00653	0.761
LIG_BRCT_BRCA1_1	3	7	PF00533	0.676
LIG_BRCT_BRCA1_1	70	74	PF00533	0.740
LIG_FHA_1	16	22	PF00498	0.638
LIG_FHA_2	14	20	PF00498	0.780
LIG_LIR_Apic_2	33	38	PF02991	0.777
LIG_LIR_Gen_1	106	116	PF02991	0.734
LIG_LIR_Nem_3	94	100	PF02991	0.740
LIG_Pex14_2	3	7	PF04695	0.754
LIG_PTB_Apo_2	36	43	PF02174	0.544
LIG_PTB_Phospho_1	36	42	PF10480	0.547
LIG_SH2_CRK	140	144	PF00017	0.773
LIG_SH2_CRK	35	39	PF00017	0.762
LIG_SH2_CRK	42	46	PF00017	0.654
LIG_SH2_CRK	97	101	PF00017	0.744
LIG_SH2_GRB2like	35	38	PF00017	0.765
LIG_SH2_NCK_1	35	39	PF00017	0.762
LIG_SH2_SRC	35	38	PF00017	0.765
LIG_SH2_STAP1	105	109	PF00017	0.709
LIG_SH2_STAT3	127	130	PF00017	0.867
LIG_SH2_STAT5	105	108	PF00017	0.742
LIG_SH2_STAT5	121	124	PF00017	0.682
LIG_SH2_STAT5	127	130	PF00017	0.780
MOD_CK1_1	13	19	PF00069	0.596
MOD_CK1_1	2	8	PF00069	0.760
MOD_CK1_1	47	53	PF00069	0.786
MOD_CK2_1	13	19	PF00069	0.777
MOD_GlcNHglycan	57	60	PF01048	0.767
MOD_GlcNHglycan	81	84	PF01048	0.793
MOD_GSK3_1	47	54	PF00069	0.784
MOD_GSK3_1	57	64	PF00069	0.651
MOD_N-GLC_1	79	84	PF02516	0.750
MOD_NEK2_1	1	6	PF00069	0.733
MOD_NEK2_1	55	60	PF00069	0.723
MOD_NEK2_1	61	66	PF00069	0.648
MOD_PIKK_1	103	109	PF00454	0.662
MOD_PK_1	44	50	PF00069	0.703
MOD_PKA_2	51	57	PF00069	0.791
MOD_ProDKin_1	119	125	PF00069	0.745
TRG_DiLeu_BaEn_1	25	30	PF01217	0.795
TRG_ENDOCYTIC_2	109	112	PF00928	0.644
TRG_ENDOCYTIC_2	140	143	PF00928	0.775
TRG_ENDOCYTIC_2	97	100	PF00928	0.758

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IAS9	Leishmania donovani	99%	100%
A4H950	Leishmania braziliensis	53%	89%
E9AR59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QEA4	Leishmania major	90%	100%