LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HXG3_LEIIN
TriTrypDb:
LINF_170015600
Length:
117

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXG3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXG3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 104 106 PF00675 0.529
CLV_NRD_NRD_1 112 114 PF00675 0.529
CLV_NRD_NRD_1 36 38 PF00675 0.563
CLV_NRD_NRD_1 92 94 PF00675 0.494
CLV_PCSK_KEX2_1 104 106 PF00082 0.528
CLV_PCSK_KEX2_1 112 114 PF00082 0.532
CLV_PCSK_KEX2_1 38 40 PF00082 0.541
CLV_PCSK_KEX2_1 84 86 PF00082 0.586
CLV_PCSK_PC1ET2_1 38 40 PF00082 0.541
CLV_PCSK_PC1ET2_1 84 86 PF00082 0.586
CLV_PCSK_SKI1_1 7 11 PF00082 0.742
CLV_PCSK_SKI1_1 87 91 PF00082 0.518
DOC_USP7_UBL2_3 110 114 PF12436 0.623
DOC_USP7_UBL2_3 25 29 PF12436 0.695
DOC_USP7_UBL2_3 63 67 PF12436 0.706
DOC_USP7_UBL2_3 90 94 PF12436 0.525
DOC_WW_Pin1_4 24 29 PF00397 0.623
LIG_14-3-3_CanoR_1 45 52 PF00244 0.657
LIG_14-3-3_CanoR_1 7 13 PF00244 0.707
LIG_BRCT_BRCA1_1 74 78 PF00533 0.649
LIG_LIR_Gen_1 75 82 PF02991 0.655
LIG_LIR_Nem_3 75 81 PF02991 0.639
LIG_SUMO_SIM_anti_2 11 16 PF11976 0.748
MOD_CDK_SPK_2 24 29 PF00069 0.623
MOD_Cter_Amidation 23 26 PF01082 0.704
MOD_NEK2_1 31 36 PF00069 0.538
MOD_NEK2_1 52 57 PF00069 0.556
MOD_PKA_2 31 37 PF00069 0.556
MOD_PKA_2 44 50 PF00069 0.397
MOD_Plk_1 52 58 PF00069 0.559
MOD_ProDKin_1 24 30 PF00069 0.621
MOD_SUMO_for_1 59 62 PF00179 0.661
TRG_DiLeu_BaEn_4 53 59 PF01217 0.627
TRG_ER_diArg_1 103 105 PF00400 0.542
TRG_NLS_Bipartite_1 25 42 PF00514 0.654
TRG_NLS_MonoExtC_3 36 41 PF00514 0.643
TRG_NLS_MonoExtN_4 35 42 PF00514 0.563
TRG_Pf-PMV_PEXEL_1 104 109 PF00026 0.667

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4KMF1 Bodo saltans 47% 82%
A0A1X0NKS3 Trypanosomatidae 54% 98%
A0A3Q8IAX0 Leishmania donovani 100% 100%
A4H949 Leishmania braziliensis 82% 100%
C9ZNE7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 92%
E9AR58 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QEA5 Leishmania major 97% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS