Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXG0_LEIIN

TriTrypDb:

LINF_170015300

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXG0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.574
CLV_NRD_NRD_1	131	133	PF00675	0.640
CLV_NRD_NRD_1	435	437	PF00675	0.648
CLV_PCSK_KEX2_1	131	133	PF00082	0.640
CLV_PCSK_KEX2_1	435	437	PF00082	0.641
CLV_PCSK_SKI1_1	453	457	PF00082	0.632
DEG_SPOP_SBC_1	103	107	PF00917	0.627
DEG_SPOP_SBC_1	442	446	PF00917	0.651
DEG_SPOP_SBC_1	506	510	PF00917	0.620
DOC_MAPK_MEF2A_6	119	126	PF00069	0.628
DOC_USP7_MATH_1	12	16	PF00917	0.618
DOC_USP7_MATH_1	176	180	PF00917	0.651
DOC_USP7_MATH_1	208	212	PF00917	0.615
DOC_USP7_MATH_1	245	249	PF00917	0.715
DOC_USP7_MATH_1	305	309	PF00917	0.594
DOC_USP7_MATH_1	425	429	PF00917	0.725
DOC_USP7_MATH_1	437	441	PF00917	0.657
DOC_USP7_MATH_1	457	461	PF00917	0.585
DOC_USP7_MATH_1	57	61	PF00917	0.583
DOC_WW_Pin1_4	118	123	PF00397	0.604
DOC_WW_Pin1_4	182	187	PF00397	0.647
DOC_WW_Pin1_4	192	197	PF00397	0.653
DOC_WW_Pin1_4	259	264	PF00397	0.620
DOC_WW_Pin1_4	268	273	PF00397	0.640
DOC_WW_Pin1_4	310	315	PF00397	0.629
DOC_WW_Pin1_4	69	74	PF00397	0.696
DOC_WW_Pin1_4	77	82	PF00397	0.614
LIG_14-3-3_CanoR_1	191	196	PF00244	0.655
LIG_14-3-3_CanoR_1	354	361	PF00244	0.507
LIG_14-3-3_CanoR_1	443	452	PF00244	0.656
LIG_14-3-3_CanoR_1	497	501	PF00244	0.617
LIG_BRCT_BRCA1_1	122	126	PF00533	0.625
LIG_BRCT_BRCA1_1	520	524	PF00533	0.616
LIG_FHA_1	178	184	PF00498	0.664
LIG_FHA_1	224	230	PF00498	0.511
LIG_FHA_1	83	89	PF00498	0.632
LIG_FHA_2	22	28	PF00498	0.675
LIG_Integrin_isoDGR_2	539	541	PF01839	0.716
LIG_LIR_Gen_1	47	57	PF02991	0.564
LIG_LIR_Gen_1	521	529	PF02991	0.612
LIG_LIR_LC3C_4	99	104	PF02991	0.682
LIG_LIR_Nem_3	363	368	PF02991	0.773
LIG_LIR_Nem_3	47	52	PF02991	0.557
LIG_LIR_Nem_3	521	527	PF02991	0.613
LIG_Pex14_1	240	244	PF04695	0.693
LIG_SH2_PTP2	260	263	PF00017	0.621
LIG_SH2_STAT5	260	263	PF00017	0.621
LIG_SH2_STAT5	327	330	PF00017	0.643
LIG_SH3_3	1	7	PF00018	0.642
LIG_SH3_3	17	23	PF00018	0.585
LIG_SH3_3	180	186	PF00018	0.644
LIG_SH3_3	373	379	PF00018	0.601
LIG_SH3_3	412	418	PF00018	0.564
LIG_SH3_3	446	452	PF00018	0.630
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.526
LIG_TRAF2_1	19	22	PF00917	0.706
LIG_TRAF2_1	40	43	PF00917	0.565
MOD_CDK_SPK_2	268	273	PF00069	0.640
MOD_CK1_1	143	149	PF00069	0.553
MOD_CK1_1	179	185	PF00069	0.702
MOD_CK1_1	202	208	PF00069	0.635
MOD_CK1_1	223	229	PF00069	0.590
MOD_CK1_1	253	259	PF00069	0.802
MOD_CK1_1	271	277	PF00069	0.530
MOD_CK1_1	281	287	PF00069	0.627
MOD_CK1_1	310	316	PF00069	0.733
MOD_CK1_1	387	393	PF00069	0.711
MOD_CK1_1	480	486	PF00069	0.621
MOD_CK1_1	495	501	PF00069	0.612
MOD_CK1_1	518	524	PF00069	0.616
MOD_CK1_1	61	67	PF00069	0.544
MOD_CK1_1	82	88	PF00069	0.635
MOD_CK1_1	96	102	PF00069	0.601
MOD_CK2_1	486	492	PF00069	0.632
MOD_GlcNHglycan	110	113	PF01048	0.581
MOD_GlcNHglycan	142	145	PF01048	0.682
MOD_GlcNHglycan	160	163	PF01048	0.667
MOD_GlcNHglycan	172	175	PF01048	0.586
MOD_GlcNHglycan	204	207	PF01048	0.648
MOD_GlcNHglycan	210	213	PF01048	0.572
MOD_GlcNHglycan	273	276	PF01048	0.641
MOD_GlcNHglycan	300	303	PF01048	0.589
MOD_GlcNHglycan	386	389	PF01048	0.628
MOD_GlcNHglycan	437	440	PF01048	0.641
MOD_GlcNHglycan	445	448	PF01048	0.640
MOD_GlcNHglycan	482	485	PF01048	0.609
MOD_GlcNHglycan	487	491	PF01048	0.610
MOD_GlcNHglycan	509	512	PF01048	0.629
MOD_GlcNHglycan	60	63	PF01048	0.627
MOD_GlcNHglycan	81	84	PF01048	0.646
MOD_GlcNHglycan	99	102	PF01048	0.603
MOD_GSK3_1	104	111	PF00069	0.706
MOD_GSK3_1	172	179	PF00069	0.616
MOD_GSK3_1	289	296	PF00069	0.607
MOD_GSK3_1	322	329	PF00069	0.741
MOD_GSK3_1	339	346	PF00069	0.558
MOD_GSK3_1	427	434	PF00069	0.647
MOD_GSK3_1	437	444	PF00069	0.779
MOD_GSK3_1	486	493	PF00069	0.609
MOD_GSK3_1	507	514	PF00069	0.619
MOD_GSK3_1	515	522	PF00069	0.615
MOD_GSK3_1	57	64	PF00069	0.722
MOD_GSK3_1	69	76	PF00069	0.666
MOD_GSK3_1	93	100	PF00069	0.769
MOD_N-GLC_1	480	485	PF02516	0.609
MOD_N-GLC_1	511	516	PF02516	0.615
MOD_N-GLC_1	69	74	PF02516	0.712
MOD_NEK2_1	102	107	PF00069	0.714
MOD_NEK2_1	298	303	PF00069	0.654
MOD_NEK2_1	411	416	PF00069	0.587
MOD_NEK2_1	507	512	PF00069	0.623
MOD_NEK2_1	519	524	PF00069	0.616
MOD_PIKK_1	143	149	PF00454	0.553
MOD_PIKK_1	395	401	PF00454	0.645
MOD_PIKK_1	61	67	PF00454	0.543
MOD_PK_1	132	138	PF00069	0.626
MOD_PKA_1	435	441	PF00069	0.713
MOD_PKA_2	190	196	PF00069	0.654
MOD_PKA_2	340	346	PF00069	0.595
MOD_PKA_2	353	359	PF00069	0.571
MOD_PKA_2	435	441	PF00069	0.686
MOD_PKA_2	442	448	PF00069	0.619
MOD_PKA_2	496	502	PF00069	0.618
MOD_PKB_1	69	77	PF00069	0.730
MOD_Plk_1	220	226	PF00069	0.523
MOD_Plk_1	480	486	PF00069	0.638
MOD_Plk_1	515	521	PF00069	0.613
MOD_Plk_2-3	21	27	PF00069	0.642
MOD_Plk_4	120	126	PF00069	0.599
MOD_Plk_4	220	226	PF00069	0.523
MOD_Plk_4	293	299	PF00069	0.681
MOD_Plk_4	519	525	PF00069	0.615
MOD_ProDKin_1	118	124	PF00069	0.604
MOD_ProDKin_1	182	188	PF00069	0.648
MOD_ProDKin_1	192	198	PF00069	0.651
MOD_ProDKin_1	259	265	PF00069	0.621
MOD_ProDKin_1	268	274	PF00069	0.639
MOD_ProDKin_1	310	316	PF00069	0.628
MOD_ProDKin_1	69	75	PF00069	0.697
MOD_ProDKin_1	77	83	PF00069	0.614
MOD_SUMO_for_1	455	458	PF00179	0.705
TRG_DiLeu_BaEn_1	220	225	PF01217	0.524
TRG_DiLeu_BaEn_4	220	226	PF01217	0.523
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.521
TRG_ER_diArg_1	131	133	PF00400	0.640
TRG_ER_diArg_1	435	437	PF00400	0.719
TRG_ER_diArg_1	469	472	PF00400	0.615
TRG_ER_diArg_1	68	71	PF00400	0.727
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I516	Leptomonas seymouri	57%	97%
A0A3Q8IJG5	Leishmania donovani	100%	91%
A4H946	Leishmania braziliensis	85%	100%
E9AR55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QEA8	Leishmania major	96%	100%