Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

G-patch domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HXF9_LEIIN

TriTrypDb:

LINF_170015200

Length:

207

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HXF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXF9

Function

Biological processes
Term	Name	Level	Count
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0090069	regulation of ribosome biogenesis	5	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.704
CLV_C14_Caspase3-7	155	159	PF00656	0.705
CLV_C14_Caspase3-7	95	99	PF00656	0.733
CLV_NRD_NRD_1	120	122	PF00675	0.663
CLV_NRD_NRD_1	35	37	PF00675	0.369
CLV_NRD_NRD_1	75	77	PF00675	0.653
CLV_PCSK_KEX2_1	136	138	PF00082	0.718
CLV_PCSK_KEX2_1	160	162	PF00082	0.720
CLV_PCSK_KEX2_1	201	203	PF00082	0.572
CLV_PCSK_KEX2_1	35	37	PF00082	0.344
CLV_PCSK_KEX2_1	77	79	PF00082	0.600
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.718
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.720
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.652
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.600
CLV_PCSK_PC7_1	132	138	PF00082	0.764
CLV_PCSK_PC7_1	156	162	PF00082	0.684
CLV_PCSK_SKI1_1	176	180	PF00082	0.547
DEG_SPOP_SBC_1	106	110	PF00917	0.584
DEG_SPOP_SBC_1	113	117	PF00917	0.608
DOC_MAPK_gen_1	121	129	PF00069	0.553
DOC_USP7_MATH_1	113	117	PF00917	0.778
DOC_USP7_MATH_1	146	150	PF00917	0.732
DOC_USP7_UBL2_3	122	126	PF12436	0.726
DOC_USP7_UBL2_3	28	32	PF12436	0.380
DOC_USP7_UBL2_3	7	11	PF12436	0.444
DOC_USP7_UBL2_3	73	77	PF12436	0.557
DOC_WW_Pin1_4	138	143	PF00397	0.715
LIG_14-3-3_CanoR_1	140	146	PF00244	0.704
LIG_14-3-3_CanoR_1	172	179	PF00244	0.557
LIG_BIR_II_1	1	5	PF00653	0.547
LIG_FHA_1	57	63	PF00498	0.624
LIG_FHA_2	90	96	PF00498	0.660
LIG_LIR_Gen_1	29	38	PF02991	0.344
LIG_LIR_Gen_1	65	74	PF02991	0.463
LIG_LIR_Nem_3	29	33	PF02991	0.344
LIG_LIR_Nem_3	65	71	PF02991	0.520
LIG_SH2_CRK	68	72	PF00017	0.548
LIG_SH2_PTP2	30	33	PF00017	0.369
LIG_SH2_STAT5	30	33	PF00017	0.369
MOD_CK1_1	104	110	PF00069	0.719
MOD_CK1_1	111	117	PF00069	0.661
MOD_CK1_1	144	150	PF00069	0.658
MOD_CK1_1	159	165	PF00069	0.693
MOD_CK1_1	55	61	PF00069	0.583
MOD_CK2_1	159	165	PF00069	0.654
MOD_CK2_1	171	177	PF00069	0.533
MOD_CK2_1	90	96	PF00069	0.702
MOD_GlcNHglycan	1	4	PF01048	0.550
MOD_GlcNHglycan	110	113	PF01048	0.712
MOD_GlcNHglycan	117	120	PF01048	0.577
MOD_GlcNHglycan	148	151	PF01048	0.706
MOD_GlcNHglycan	23	27	PF01048	0.487
MOD_GSK3_1	101	108	PF00069	0.682
MOD_GSK3_1	111	118	PF00069	0.637
MOD_GSK3_1	138	145	PF00069	0.650
MOD_GSK3_1	22	29	PF00069	0.382
MOD_GSK3_1	52	59	PF00069	0.657
MOD_NEK2_1	56	61	PF00069	0.603
MOD_PIKK_1	66	72	PF00454	0.444
MOD_PKA_2	171	177	PF00069	0.579
MOD_PKA_2	79	85	PF00069	0.635
MOD_Plk_1	168	174	PF00069	0.570
MOD_Plk_4	26	32	PF00069	0.369
MOD_ProDKin_1	138	144	PF00069	0.715
MOD_SUMO_rev_2	114	123	PF00179	0.762
MOD_SUMO_rev_2	152	162	PF00179	0.766
TRG_ENDOCYTIC_2	30	33	PF00928	0.369
TRG_ENDOCYTIC_2	68	71	PF00928	0.520
TRG_ER_diArg_1	192	195	PF00400	0.588
TRG_NLS_MonoExtC_3	159	165	PF00514	0.719
TRG_NLS_MonoExtC_3	75	80	PF00514	0.648
TRG_NLS_MonoExtN_4	73	80	PF00514	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6K7	Leptomonas seymouri	52%	99%
A0A0S4J7Y3	Bodo saltans	36%	100%
A0A3S5H710	Leishmania donovani	100%	100%
A4H945	Leishmania braziliensis	74%	100%
C9ZP33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AR54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QEA9	Leishmania major	95%	100%
V5AQX6	Trypanosoma cruzi	42%	78%