Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

OSM3-like kinesin - putative

Species:

Leishmania infantum

UniProt:

A4HXF7_LEIIN

TriTrypDb:

LINF_170015000

Length:

940

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	7
GO:0099080	supramolecular complex	2	7
GO:0099081	supramolecular polymer	3	7
GO:0099512	supramolecular fiber	4	7
GO:0099513	polymeric cytoskeletal fiber	5	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0005929	cilium	4	1
GO:0032991	protein-containing complex	1	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HXF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXF7

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	8
GO:0007018	microtubule-based movement	3	8
GO:0009987	cellular process	1	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003774	cytoskeletal motor activity	1	8
GO:0003777	microtubule motor activity	2	8
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0005524	ATP binding	5	8
GO:0008017	microtubule binding	5	8
GO:0008092	cytoskeletal protein binding	3	8
GO:0015631	tubulin binding	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140657	ATP-dependent activity	1	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	565	569	PF00656	0.575
CLV_C14_Caspase3-7	799	803	PF00656	0.575
CLV_NRD_NRD_1	203	205	PF00675	0.344
CLV_NRD_NRD_1	613	615	PF00675	0.588
CLV_NRD_NRD_1	862	864	PF00675	0.552
CLV_NRD_NRD_1	878	880	PF00675	0.547
CLV_NRD_NRD_1	908	910	PF00675	0.532
CLV_NRD_NRD_1	927	929	PF00675	0.798
CLV_PCSK_KEX2_1	202	204	PF00082	0.345
CLV_PCSK_KEX2_1	556	558	PF00082	0.618
CLV_PCSK_KEX2_1	613	615	PF00082	0.584
CLV_PCSK_KEX2_1	811	813	PF00082	0.575
CLV_PCSK_KEX2_1	878	880	PF00082	0.547
CLV_PCSK_KEX2_1	907	909	PF00082	0.533
CLV_PCSK_KEX2_1	927	929	PF00082	0.746
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.618
CLV_PCSK_PC1ET2_1	811	813	PF00082	0.575
CLV_PCSK_SKI1_1	120	124	PF00082	0.469
CLV_PCSK_SKI1_1	156	160	PF00082	0.403
CLV_PCSK_SKI1_1	339	343	PF00082	0.343
CLV_PCSK_SKI1_1	369	373	PF00082	0.603
CLV_PCSK_SKI1_1	495	499	PF00082	0.587
CLV_PCSK_SKI1_1	532	536	PF00082	0.647
CLV_PCSK_SKI1_1	756	760	PF00082	0.465
CLV_PCSK_SKI1_1	832	836	PF00082	0.518
CLV_PCSK_SKI1_1	863	867	PF00082	0.557
CLV_PCSK_SKI1_1	920	924	PF00082	0.668
CLV_Separin_Metazoa	492	496	PF03568	0.653
DEG_APCC_DBOX_1	699	707	PF00400	0.531
DEG_APCC_KENBOX_2	24	28	PF00400	0.366
DEG_SPOP_SBC_1	136	140	PF00917	0.366
DOC_CKS1_1	470	475	PF01111	0.671
DOC_CYCLIN_RxL_1	753	760	PF00134	0.472
DOC_MAPK_gen_1	781	790	PF00069	0.594
DOC_MAPK_gen_1	869	876	PF00069	0.550
DOC_MAPK_MEF2A_6	161	168	PF00069	0.343
DOC_MAPK_MEF2A_6	265	274	PF00069	0.343
DOC_MAPK_MEF2A_6	32	39	PF00069	0.343
DOC_MAPK_MEF2A_6	342	349	PF00069	0.460
DOC_MAPK_MEF2A_6	391	399	PF00069	0.580
DOC_PP1_RVXF_1	309	316	PF00149	0.343
DOC_PP4_FxxP_1	470	473	PF00568	0.670
DOC_PP4_FxxP_1	75	78	PF00568	0.343
DOC_USP7_MATH_1	212	216	PF00917	0.335
DOC_USP7_MATH_1	238	242	PF00917	0.403
DOC_USP7_MATH_1	292	296	PF00917	0.362
DOC_USP7_MATH_1	402	406	PF00917	0.566
DOC_USP7_MATH_1	454	458	PF00917	0.581
DOC_USP7_MATH_1	562	566	PF00917	0.668
DOC_USP7_MATH_1	618	622	PF00917	0.700
DOC_USP7_MATH_1	645	649	PF00917	0.581
DOC_USP7_MATH_1	667	671	PF00917	0.593
DOC_USP7_MATH_1	731	735	PF00917	0.561
DOC_USP7_MATH_2	651	657	PF00917	0.655
DOC_USP7_UBL2_3	531	535	PF12436	0.683
DOC_USP7_UBL2_3	768	772	PF12436	0.461
DOC_USP7_UBL2_3	832	836	PF12436	0.523
DOC_WW_Pin1_4	293	298	PF00397	0.362
DOC_WW_Pin1_4	469	474	PF00397	0.674
LIG_14-3-3_CanoR_1	20	29	PF00244	0.461
LIG_14-3-3_CanoR_1	216	221	PF00244	0.403
LIG_14-3-3_CanoR_1	237	246	PF00244	0.420
LIG_14-3-3_CanoR_1	323	332	PF00244	0.403
LIG_14-3-3_CanoR_1	424	428	PF00244	0.517
LIG_14-3-3_CanoR_1	430	435	PF00244	0.511
LIG_14-3-3_CanoR_1	55	59	PF00244	0.343
LIG_14-3-3_CanoR_1	557	561	PF00244	0.619
LIG_14-3-3_CanoR_1	625	633	PF00244	0.685
LIG_14-3-3_CanoR_1	920	926	PF00244	0.686
LIG_14-3-3_CanoR_1	927	933	PF00244	0.682
LIG_Actin_WH2_2	506	523	PF00022	0.572
LIG_Actin_WH2_2	849	865	PF00022	0.546
LIG_APCC_ABBAyCdc20_2	689	695	PF00400	0.620
LIG_Clathr_ClatBox_1	431	435	PF01394	0.629
LIG_Clathr_ClatBox_1	787	791	PF01394	0.535
LIG_deltaCOP1_diTrp_1	461	470	PF00928	0.658
LIG_deltaCOP1_diTrp_1	54	58	PF00928	0.403
LIG_FHA_1	173	179	PF00498	0.409
LIG_FHA_1	226	232	PF00498	0.432
LIG_FHA_1	234	240	PF00498	0.352
LIG_FHA_1	297	303	PF00498	0.343
LIG_FHA_1	358	364	PF00498	0.497
LIG_FHA_1	376	382	PF00498	0.543
LIG_FHA_1	41	47	PF00498	0.403
LIG_FHA_1	427	433	PF00498	0.515
LIG_FHA_1	515	521	PF00498	0.693
LIG_FHA_1	625	631	PF00498	0.726
LIG_FHA_1	71	77	PF00498	0.355
LIG_FHA_1	78	84	PF00498	0.351
LIG_FHA_1	782	788	PF00498	0.542
LIG_FHA_2	228	234	PF00498	0.403
LIG_FHA_2	261	267	PF00498	0.343
LIG_FHA_2	277	283	PF00498	0.343
LIG_FHA_2	470	476	PF00498	0.583
LIG_FHA_2	487	493	PF00498	0.458
LIG_FHA_2	528	534	PF00498	0.627
LIG_FHA_2	580	586	PF00498	0.617
LIG_FHA_2	730	736	PF00498	0.680
LIG_FHA_2	737	743	PF00498	0.543
LIG_GBD_Chelix_1	362	370	PF00786	0.532
LIG_IRF3_LxIS_1	441	448	PF10401	0.660
LIG_LIR_Apic_2	73	78	PF02991	0.343
LIG_LIR_Gen_1	142	151	PF02991	0.395
LIG_LIR_Gen_1	219	225	PF02991	0.343
LIG_LIR_Gen_1	312	320	PF02991	0.343
LIG_LIR_Gen_1	464	473	PF02991	0.662
LIG_LIR_Gen_1	487	497	PF02991	0.445
LIG_LIR_Gen_1	57	66	PF02991	0.349
LIG_LIR_Gen_1	69	79	PF02991	0.343
LIG_LIR_Gen_1	690	698	PF02991	0.544
LIG_LIR_Nem_3	142	147	PF02991	0.395
LIG_LIR_Nem_3	219	224	PF02991	0.343
LIG_LIR_Nem_3	312	318	PF02991	0.343
LIG_LIR_Nem_3	464	470	PF02991	0.717
LIG_LIR_Nem_3	487	493	PF02991	0.447
LIG_LIR_Nem_3	57	61	PF02991	0.349
LIG_LIR_Nem_3	69	75	PF02991	0.362
LIG_LIR_Nem_3	690	696	PF02991	0.663
LIG_LIR_Nem_3	774	778	PF02991	0.608
LIG_PCNA_yPIPBox_3	111	123	PF02747	0.397
LIG_PCNA_yPIPBox_3	152	161	PF02747	0.343
LIG_Pex14_1	463	467	PF04695	0.651
LIG_Pex14_1	848	852	PF04695	0.548
LIG_PTB_Apo_2	60	67	PF02174	0.343
LIG_Rb_LxCxE_1	222	240	PF01857	0.403
LIG_REV1ctd_RIR_1	174	183	PF16727	0.397
LIG_SH2_GRB2like	373	376	PF00017	0.550
LIG_SH2_STAP1	724	728	PF00017	0.522
LIG_SH2_STAT3	581	584	PF00017	0.572
LIG_SH2_STAT5	144	147	PF00017	0.343
LIG_SH2_STAT5	469	472	PF00017	0.552
LIG_SH2_STAT5	581	584	PF00017	0.637
LIG_SH2_STAT5	775	778	PF00017	0.488
LIG_SH3_3	183	189	PF00018	0.359
LIG_SH3_3	627	633	PF00018	0.749
LIG_SUMO_SIM_par_1	42	48	PF11976	0.412
LIG_SUMO_SIM_par_1	650	659	PF11976	0.677
LIG_SUMO_SIM_par_1	784	791	PF11976	0.534
LIG_TRAF2_1	489	492	PF00917	0.599
LIG_TRAF2_1	508	511	PF00917	0.574
LIG_TRAF2_1	582	585	PF00917	0.572
LIG_TRAF2_1	865	868	PF00917	0.491
LIG_TRAF2_1	903	906	PF00917	0.577
LIG_TRFH_1	469	473	PF08558	0.672
LIG_UBA3_1	588	593	PF00899	0.641
LIG_WRC_WIRS_1	144	149	PF05994	0.343
MOD_CDK_SPxxK_3	469	476	PF00069	0.673
MOD_CK1_1	214	220	PF00069	0.357
MOD_CK1_1	260	266	PF00069	0.403
MOD_CK1_1	296	302	PF00069	0.362
MOD_CK1_1	448	454	PF00069	0.588
MOD_CK1_1	656	662	PF00069	0.636
MOD_CK1_1	688	694	PF00069	0.671
MOD_CK1_1	921	927	PF00069	0.721
MOD_CK1_1	99	105	PF00069	0.333
MOD_CK2_1	109	115	PF00069	0.397
MOD_CK2_1	143	149	PF00069	0.343
MOD_CK2_1	20	26	PF00069	0.403
MOD_CK2_1	260	266	PF00069	0.343
MOD_CK2_1	469	475	PF00069	0.582
MOD_CK2_1	486	492	PF00069	0.459
MOD_CK2_1	505	511	PF00069	0.615
MOD_CK2_1	520	526	PF00069	0.609
MOD_CK2_1	527	533	PF00069	0.556
MOD_CK2_1	579	585	PF00069	0.627
MOD_CK2_1	729	735	PF00069	0.595
MOD_CK2_1	736	742	PF00069	0.557
MOD_CK2_1	776	782	PF00069	0.511
MOD_CK2_1	880	886	PF00069	0.582
MOD_Cter_Amidation	1	4	PF01082	0.630
MOD_GlcNHglycan	259	262	PF01048	0.391
MOD_GlcNHglycan	274	277	PF01048	0.318
MOD_GlcNHglycan	449	453	PF01048	0.649
MOD_GlcNHglycan	620	623	PF01048	0.693
MOD_GlcNHglycan	636	639	PF01048	0.677
MOD_GlcNHglycan	647	650	PF01048	0.671
MOD_GlcNHglycan	658	661	PF01048	0.572
MOD_GlcNHglycan	820	823	PF01048	0.566
MOD_GlcNHglycan	920	923	PF01048	0.702
MOD_GlcNHglycan	96	99	PF01048	0.339
MOD_GSK3_1	135	142	PF00069	0.329
MOD_GSK3_1	212	219	PF00069	0.356
MOD_GSK3_1	233	240	PF00069	0.356
MOD_GSK3_1	272	279	PF00069	0.343
MOD_GSK3_1	292	299	PF00069	0.350
MOD_GSK3_1	323	330	PF00069	0.354
MOD_GSK3_1	412	419	PF00069	0.568
MOD_GSK3_1	426	433	PF00069	0.605
MOD_GSK3_1	634	641	PF00069	0.804
MOD_GSK3_1	736	743	PF00069	0.609
MOD_GSK3_1	814	821	PF00069	0.544
MOD_GSK3_1	927	934	PF00069	0.673
MOD_GSK3_1	99	106	PF00069	0.359
MOD_N-GLC_1	110	115	PF02516	0.397
MOD_N-GLC_1	270	275	PF02516	0.343
MOD_N-GLC_1	323	328	PF02516	0.357
MOD_N-GLC_1	400	405	PF02516	0.563
MOD_N-GLC_1	62	67	PF02516	0.341
MOD_N-GLC_1	87	92	PF02516	0.343
MOD_NEK2_1	109	114	PF00069	0.461
MOD_NEK2_1	143	148	PF00069	0.348
MOD_NEK2_1	272	277	PF00069	0.374
MOD_NEK2_1	302	307	PF00069	0.344
MOD_NEK2_1	325	330	PF00069	0.314
MOD_NEK2_1	484	489	PF00069	0.729
MOD_NEK2_1	520	525	PF00069	0.652
MOD_NEK2_1	534	539	PF00069	0.431
MOD_NEK2_1	654	659	PF00069	0.683
MOD_NEK2_1	706	711	PF00069	0.473
MOD_NEK2_1	776	781	PF00069	0.533
MOD_NEK2_1	79	84	PF00069	0.343
MOD_NEK2_1	87	92	PF00069	0.343
MOD_PIKK_1	436	442	PF00454	0.662
MOD_PIKK_1	454	460	PF00454	0.497
MOD_PIKK_1	520	526	PF00454	0.656
MOD_PIKK_1	64	70	PF00454	0.343
MOD_PK_1	216	222	PF00069	0.343
MOD_PK_1	556	562	PF00069	0.622
MOD_PK_1	636	642	PF00069	0.587
MOD_PKA_1	556	562	PF00069	0.638
MOD_PKA_1	927	933	PF00069	0.691
MOD_PKA_2	423	429	PF00069	0.575
MOD_PKA_2	54	60	PF00069	0.343
MOD_PKA_2	556	562	PF00069	0.731
MOD_PKA_2	624	630	PF00069	0.605
MOD_PKA_2	688	694	PF00069	0.555
MOD_PKA_2	926	932	PF00069	0.753
MOD_PKB_1	18	26	PF00069	0.403
MOD_PKB_1	202	210	PF00069	0.343
MOD_PKB_1	744	752	PF00069	0.559
MOD_Plk_1	110	116	PF00069	0.397
MOD_Plk_1	172	178	PF00069	0.403
MOD_Plk_1	270	276	PF00069	0.343
MOD_Plk_1	436	442	PF00069	0.617
MOD_Plk_1	505	511	PF00069	0.611
MOD_Plk_1	579	585	PF00069	0.714
MOD_Plk_1	62	68	PF00069	0.321
MOD_Plk_1	706	712	PF00069	0.536
MOD_Plk_1	736	742	PF00069	0.610
MOD_Plk_1	825	831	PF00069	0.559
MOD_Plk_1	87	93	PF00069	0.355
MOD_Plk_2-3	54	60	PF00069	0.343
MOD_Plk_4	139	145	PF00069	0.374
MOD_Plk_4	172	178	PF00069	0.345
MOD_Plk_4	216	222	PF00069	0.343
MOD_Plk_4	276	282	PF00069	0.343
MOD_Plk_4	296	302	PF00069	0.343
MOD_Plk_4	309	315	PF00069	0.343
MOD_Plk_4	45	51	PF00069	0.420
MOD_Plk_4	688	694	PF00069	0.555
MOD_Plk_4	79	85	PF00069	0.346
MOD_Plk_4	87	93	PF00069	0.343
MOD_Plk_4	921	927	PF00069	0.652
MOD_ProDKin_1	293	299	PF00069	0.362
MOD_ProDKin_1	469	475	PF00069	0.672
MOD_SUMO_for_1	371	374	PF00179	0.578
MOD_SUMO_for_1	548	551	PF00179	0.586
MOD_SUMO_for_1	680	683	PF00179	0.534
MOD_SUMO_for_1	704	707	PF00179	0.610
MOD_SUMO_for_1	903	906	PF00179	0.577
MOD_SUMO_rev_2	350	357	PF00179	0.493
MOD_SUMO_rev_2	515	523	PF00179	0.597
MOD_SUMO_rev_2	550	558	PF00179	0.666
MOD_SUMO_rev_2	580	589	PF00179	0.588
MOD_SUMO_rev_2	674	680	PF00179	0.546
MOD_SUMO_rev_2	723	729	PF00179	0.542
MOD_SUMO_rev_2	796	803	PF00179	0.574
MOD_SUMO_rev_2	849	856	PF00179	0.499
MOD_SUMO_rev_2	861	871	PF00179	0.523
TRG_DiLeu_BaEn_1	872	877	PF01217	0.544
TRG_DiLeu_BaEn_4	383	389	PF01217	0.550
TRG_DiLeu_BaEn_4	607	613	PF01217	0.595
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.631
TRG_DiLeu_LyEn_5	872	877	PF01217	0.544
TRG_ENDOCYTIC_2	144	147	PF00928	0.343
TRG_ENDOCYTIC_2	467	470	PF00928	0.679
TRG_ENDOCYTIC_2	693	696	PF00928	0.542
TRG_ENDOCYTIC_2	775	778	PF00928	0.606
TRG_ER_diArg_1	17	20	PF00400	0.344
TRG_ER_diArg_1	202	204	PF00400	0.344
TRG_ER_diArg_1	612	614	PF00400	0.577
TRG_ER_diArg_1	877	879	PF00400	0.528
TRG_ER_diArg_1	907	909	PF00400	0.678
TRG_ER_diArg_1	926	928	PF00400	0.587
TRG_NES_CRM1_1	387	400	PF08389	0.507
TRG_NES_CRM1_1	436	449	PF08389	0.575
TRG_NLS_MonoExtC_3	831	836	PF00514	0.510
TRG_NLS_MonoExtN_4	830	836	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	430	435	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	543	547	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.651
TRG_Pf-PMV_PEXEL_1	756	760	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	864	868	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L3	Leptomonas seymouri	68%	100%
A0A3Q8I9R7	Leishmania donovani	100%	100%
A0A3R7MU74	Trypanosoma rangeli	26%	84%
A4H925	Leishmania braziliensis	83%	99%
E9AR52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q0DV28	Oryza sativa subsp. japonica	30%	99%
Q4QEB1	Leishmania major	97%	100%
Q5W7C6	Oryza sativa subsp. japonica	32%	89%
V5B325	Trypanosoma cruzi	30%	100%
V5BFF1	Trypanosoma cruzi	56%	85%