LeishMANIAdb
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Ysine decarboxylase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ysine decarboxylase-like protein
Gene product:
ysine decarboxylase-like protein
Species:
Leishmania infantum
UniProt:
A4HXF6_LEIIN
TriTrypDb:
LINF_170014900
Length:
322

Annotations

Annotations by Jardim et al.

Amino acid metabolism, Ysine decarboxylase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005829 cytosol 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HXF6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXF6

Function

Biological processes
Term Name Level Count
GO:0006725 cellular aromatic compound metabolic process 3 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0008152 metabolic process 1 9
GO:0009058 biosynthetic process 2 9
GO:0009308 amine metabolic process 4 9
GO:0009690 cytokinin metabolic process 3 9
GO:0009691 cytokinin biosynthetic process 4 9
GO:0009987 cellular process 1 9
GO:0010817 regulation of hormone levels 3 9
GO:0042445 hormone metabolic process 2 9
GO:0042446 hormone biosynthetic process 3 9
GO:0044237 cellular metabolic process 2 9
GO:0044249 cellular biosynthetic process 3 9
GO:0046483 heterocycle metabolic process 3 9
GO:0065007 biological regulation 1 9
GO:0065008 regulation of biological quality 2 9
GO:0071704 organic substance metabolic process 2 9
GO:1901564 organonitrogen compound metabolic process 3 9
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0016787 hydrolase activity 2 9
GO:0016798 hydrolase activity, acting on glycosyl bonds 3 1
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 216 218 PF00675 0.304
CLV_PCSK_SKI1_1 127 131 PF00082 0.394
DOC_MAPK_gen_1 254 262 PF00069 0.509
DOC_PP1_RVXF_1 216 223 PF00149 0.504
DOC_PP2B_PxIxI_1 254 260 PF00149 0.555
DOC_PP4_FxxP_1 265 268 PF00568 0.503
DOC_PP4_FxxP_1 306 309 PF00568 0.431
DOC_USP7_MATH_1 107 111 PF00917 0.679
DOC_USP7_MATH_1 212 216 PF00917 0.549
DOC_USP7_UBL2_3 148 152 PF12436 0.478
DOC_WW_Pin1_4 308 313 PF00397 0.464
LIG_14-3-3_CanoR_1 207 214 PF00244 0.524
LIG_14-3-3_CanoR_1 62 67 PF00244 0.591
LIG_AP2alpha_1 20 24 PF02296 0.571
LIG_AP2alpha_1 265 269 PF02296 0.513
LIG_AP2alpha_2 267 269 PF02296 0.503
LIG_BRCT_BRCA1_1 218 222 PF00533 0.511
LIG_FHA_1 166 172 PF00498 0.419
LIG_FHA_1 38 44 PF00498 0.545
LIG_FHA_1 6 12 PF00498 0.529
LIG_FHA_2 211 217 PF00498 0.515
LIG_FHA_2 235 241 PF00498 0.504
LIG_FHA_2 293 299 PF00498 0.504
LIG_GSK3_LRP6_1 308 314 PF00069 0.506
LIG_LIR_Apic_2 263 268 PF02991 0.503
LIG_LIR_Apic_2 305 309 PF02991 0.443
LIG_LIR_Gen_1 237 245 PF02991 0.504
LIG_LIR_Gen_1 267 277 PF02991 0.513
LIG_LIR_Gen_1 284 294 PF02991 0.526
LIG_LIR_Gen_1 61 69 PF02991 0.571
LIG_LIR_Gen_1 97 107 PF02991 0.661
LIG_LIR_Nem_3 22 27 PF02991 0.545
LIG_LIR_Nem_3 237 241 PF02991 0.530
LIG_LIR_Nem_3 263 269 PF02991 0.545
LIG_LIR_Nem_3 284 290 PF02991 0.569
LIG_LIR_Nem_3 68 72 PF02991 0.588
LIG_LIR_Nem_3 97 102 PF02991 0.528
LIG_Pex14_2 20 24 PF04695 0.529
LIG_Pex14_2 265 269 PF04695 0.505
LIG_SH2_CRK 99 103 PF00017 0.557
LIG_SH2_GRB2like 99 102 PF00017 0.527
LIG_SH2_NCK_1 209 213 PF00017 0.555
LIG_SH2_NCK_1 99 103 PF00017 0.557
LIG_SH2_STAP1 143 147 PF00017 0.438
LIG_SH2_STAP1 99 103 PF00017 0.557
LIG_SH2_STAT5 143 146 PF00017 0.445
LIG_SH2_STAT5 153 156 PF00017 0.387
LIG_SH2_STAT5 209 212 PF00017 0.555
LIG_SH2_STAT5 57 60 PF00017 0.531
LIG_SH3_3 196 202 PF00018 0.503
LIG_SH3_3 226 232 PF00018 0.528
LIG_SH3_3 288 294 PF00018 0.504
LIG_SH3_3 304 310 PF00018 0.576
LIG_SUMO_SIM_anti_2 239 246 PF11976 0.507
LIG_SUMO_SIM_anti_2 295 302 PF11976 0.489
LIG_SUMO_SIM_par_1 239 246 PF11976 0.504
LIG_TRAF2_1 90 93 PF00917 0.501
LIG_TYR_ITIM 55 60 PF00017 0.524
LIG_TYR_ITSM 95 102 PF00017 0.507
LIG_WRC_WIRS_1 235 240 PF05994 0.529
LIG_WRC_WIRS_1 303 308 PF05994 0.500
MOD_CK1_1 197 203 PF00069 0.543
MOD_CK1_1 311 317 PF00069 0.529
MOD_CK2_1 192 198 PF00069 0.626
MOD_CK2_1 210 216 PF00069 0.426
MOD_CK2_1 234 240 PF00069 0.504
MOD_CK2_1 292 298 PF00069 0.504
MOD_GlcNHglycan 136 139 PF01048 0.576
MOD_GlcNHglycan 198 202 PF01048 0.342
MOD_GlcNHglycan 75 78 PF01048 0.444
MOD_GSK3_1 113 120 PF00069 0.631
MOD_GSK3_1 208 215 PF00069 0.530
MOD_GSK3_1 308 315 PF00069 0.613
MOD_GSK3_1 97 104 PF00069 0.622
MOD_NEK2_1 316 321 PF00069 0.650
MOD_NEK2_2 5 10 PF00069 0.559
MOD_PIKK_1 101 107 PF00454 0.663
MOD_PIKK_1 141 147 PF00454 0.487
MOD_PK_1 185 191 PF00069 0.571
MOD_PKA_2 216 222 PF00069 0.509
MOD_PKA_2 61 67 PF00069 0.531
MOD_Plk_2-3 117 123 PF00069 0.475
MOD_Plk_4 216 222 PF00069 0.511
MOD_Plk_4 224 230 PF00069 0.504
MOD_Plk_4 302 308 PF00069 0.554
MOD_Plk_4 312 318 PF00069 0.490
MOD_Plk_4 94 100 PF00069 0.486
MOD_ProDKin_1 308 314 PF00069 0.470
MOD_SUMO_rev_2 156 161 PF00179 0.484
MOD_SUMO_rev_2 215 220 PF00179 0.511
MOD_SUMO_rev_2 279 287 PF00179 0.508
MOD_SUMO_rev_2 92 97 PF00179 0.515
TRG_DiLeu_BaLyEn_6 120 125 PF01217 0.578
TRG_ENDOCYTIC_2 57 60 PF00928 0.571
TRG_ENDOCYTIC_2 63 66 PF00928 0.571
TRG_ENDOCYTIC_2 99 102 PF00928 0.643
TRG_Pf-PMV_PEXEL_1 274 279 PF00026 0.355

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC81 Leptomonas seymouri 70% 100%
A0A1X0NSV2 Trypanosomatidae 46% 94%
A0A3Q8IDZ9 Leishmania donovani 100% 100%
A0A422MP54 Trypanosoma rangeli 48% 100%
A4H924 Leishmania braziliensis 86% 100%
E9AR51 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QEB2 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS