Uncharacterized protein

Quick info Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXF4_LEIIN

TriTrypDb:

LINF_170014600

Length:

647

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HXF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.518
CLV_NRD_NRD_1	164	166	PF00675	0.369
CLV_NRD_NRD_1	397	399	PF00675	0.485
CLV_NRD_NRD_1	447	449	PF00675	0.500
CLV_NRD_NRD_1	587	589	PF00675	0.490
CLV_PCSK_KEX2_1	397	399	PF00082	0.485
CLV_PCSK_KEX2_1	587	589	PF00082	0.480
CLV_PCSK_SKI1_1	260	264	PF00082	0.307
CLV_PCSK_SKI1_1	301	305	PF00082	0.719
CLV_PCSK_SKI1_1	397	401	PF00082	0.442
CLV_PCSK_SKI1_1	409	413	PF00082	0.426
CLV_PCSK_SKI1_1	612	616	PF00082	0.448
CLV_Separin_Metazoa	264	268	PF03568	0.383
DEG_APCC_DBOX_1	586	594	PF00400	0.349
DEG_Nend_UBRbox_3	1	3	PF02207	0.286
DEG_SPOP_SBC_1	105	109	PF00917	0.519
DEG_SPOP_SBC_1	430	434	PF00917	0.473
DOC_CKS1_1	252	257	PF01111	0.516
DOC_CKS1_1	410	415	PF01111	0.435
DOC_CKS1_1	69	74	PF01111	0.521
DOC_MAPK_gen_1	126	135	PF00069	0.409
DOC_MAPK_gen_1	165	175	PF00069	0.386
DOC_MAPK_gen_1	397	403	PF00069	0.450
DOC_MAPK_MEF2A_6	141	148	PF00069	0.316
DOC_MAPK_MEF2A_6	168	177	PF00069	0.395
DOC_PP1_RVXF_1	1	8	PF00149	0.419
DOC_PP1_RVXF_1	238	245	PF00149	0.422
DOC_PP2B_LxvP_1	10	13	PF13499	0.402
DOC_PP2B_LxvP_1	630	633	PF13499	0.374
DOC_PP4_FxxP_1	148	151	PF00568	0.276
DOC_PP4_FxxP_1	263	266	PF00568	0.374
DOC_USP7_MATH_1	106	110	PF00917	0.609
DOC_USP7_MATH_1	14	18	PF00917	0.540
DOC_USP7_MATH_1	160	164	PF00917	0.507
DOC_USP7_MATH_1	198	202	PF00917	0.489
DOC_USP7_MATH_1	203	207	PF00917	0.441
DOC_USP7_MATH_1	311	315	PF00917	0.543
DOC_USP7_MATH_1	430	434	PF00917	0.569
DOC_USP7_MATH_1	493	497	PF00917	0.482
DOC_WW_Pin1_4	110	115	PF00397	0.503
DOC_WW_Pin1_4	194	199	PF00397	0.434
DOC_WW_Pin1_4	251	256	PF00397	0.529
DOC_WW_Pin1_4	26	31	PF00397	0.554
DOC_WW_Pin1_4	301	306	PF00397	0.526
DOC_WW_Pin1_4	409	414	PF00397	0.445
DOC_WW_Pin1_4	498	503	PF00397	0.457
DOC_WW_Pin1_4	68	73	PF00397	0.518
LIG_14-3-3_CanoR_1	240	245	PF00244	0.422
LIG_14-3-3_CanoR_1	267	271	PF00244	0.394
LIG_14-3-3_CanoR_1	3	8	PF00244	0.355
LIG_14-3-3_CanoR_1	542	550	PF00244	0.457
LIG_14-3-3_CanoR_1	594	604	PF00244	0.432
LIG_Actin_WH2_2	258	273	PF00022	0.398
LIG_Actin_WH2_2	404	419	PF00022	0.460
LIG_BIR_III_4	293	297	PF00653	0.498
LIG_BIR_III_4	310	314	PF00653	0.410
LIG_BRCT_BRCA1_1	160	164	PF00533	0.462
LIG_BRCT_BRCA1_1	206	210	PF00533	0.400
LIG_BRCT_BRCA1_2	160	166	PF00533	0.342
LIG_Clathr_ClatBox_1	435	439	PF01394	0.430
LIG_DLG_GKlike_1	3	10	PF00625	0.339
LIG_FHA_1	105	111	PF00498	0.557
LIG_FHA_1	207	213	PF00498	0.322
LIG_FHA_1	360	366	PF00498	0.462
LIG_FHA_1	430	436	PF00498	0.494
LIG_FHA_1	69	75	PF00498	0.681
LIG_FHA_1	84	90	PF00498	0.439
LIG_FHA_2	252	258	PF00498	0.497
LIG_FHA_2	410	416	PF00498	0.443
LIG_FHA_2	55	61	PF00498	0.494
LIG_GBD_Chelix_1	328	336	PF00786	0.308
LIG_LIR_Apic_2	145	151	PF02991	0.272
LIG_LIR_Apic_2	249	255	PF02991	0.474
LIG_LIR_Apic_2	407	413	PF02991	0.429
LIG_LIR_Apic_2	513	517	PF02991	0.395
LIG_LIR_Gen_1	349	358	PF02991	0.373
LIG_LIR_Gen_1	6	14	PF02991	0.466
LIG_LIR_LC3C_4	325	330	PF02991	0.397
LIG_LIR_Nem_3	161	167	PF02991	0.384
LIG_LIR_Nem_3	214	218	PF02991	0.313
LIG_LIR_Nem_3	237	242	PF02991	0.522
LIG_LIR_Nem_3	349	353	PF02991	0.370
LIG_LIR_Nem_3	557	561	PF02991	0.300
LIG_LIR_Nem_3	6	10	PF02991	0.403
LIG_LIR_Nem_3	64	70	PF02991	0.523
LIG_MYND_1	223	227	PF01753	0.435
LIG_Pex14_1	235	239	PF04695	0.440
LIG_SH2_CRK	239	243	PF00017	0.534
LIG_SH2_CRK	43	47	PF00017	0.452
LIG_SH2_CRK	67	71	PF00017	0.568
LIG_SH2_NCK_1	252	256	PF00017	0.456
LIG_SH2_PTP2	350	353	PF00017	0.299
LIG_SH2_SRC	43	46	PF00017	0.453
LIG_SH2_STAP1	361	365	PF00017	0.409
LIG_SH2_STAP1	561	565	PF00017	0.345
LIG_SH2_STAT5	261	264	PF00017	0.305
LIG_SH2_STAT5	350	353	PF00017	0.319
LIG_SH2_STAT5	361	364	PF00017	0.351
LIG_SH2_STAT5	514	517	PF00017	0.394
LIG_SH3_1	43	49	PF00018	0.454
LIG_SH3_3	111	117	PF00018	0.449
LIG_SH3_3	148	154	PF00018	0.297
LIG_SH3_3	217	223	PF00018	0.423
LIG_SH3_3	245	251	PF00018	0.404
LIG_SH3_3	36	42	PF00018	0.562
LIG_SH3_3	43	49	PF00018	0.517
LIG_SH3_3	482	488	PF00018	0.343
LIG_SH3_3	599	605	PF00018	0.538
LIG_SH3_3	66	72	PF00018	0.506
LIG_SH3_5	554	558	PF00018	0.329
LIG_SUMO_SIM_anti_2	325	330	PF11976	0.331
LIG_SUMO_SIM_anti_2	349	356	PF11976	0.359
LIG_SUMO_SIM_anti_2	634	641	PF11976	0.377
LIG_SUMO_SIM_par_1	634	641	PF11976	0.377
LIG_TRAF2_1	191	194	PF00917	0.382
LIG_TRAF2_1	254	257	PF00917	0.541
LIG_TRAF2_1	284	287	PF00917	0.463
LIG_TRAF2_1	412	415	PF00917	0.445
LIG_TRAF2_1	61	64	PF00917	0.584
LIG_TYR_ITIM	348	353	PF00017	0.346
LIG_WRC_WIRS_1	212	217	PF05994	0.394
MOD_CDC14_SPxK_1	29	32	PF00782	0.493
MOD_CDK_SPxK_1	26	32	PF00069	0.492
MOD_CDK_SPxxK_3	498	505	PF00069	0.465
MOD_CK1_1	108	114	PF00069	0.495
MOD_CK1_1	15	21	PF00069	0.530
MOD_CK1_1	197	203	PF00069	0.552
MOD_CK1_1	204	210	PF00069	0.448
MOD_CK1_1	24	30	PF00069	0.582
MOD_CK1_1	366	372	PF00069	0.408
MOD_CK1_1	73	79	PF00069	0.541
MOD_CK1_1	83	89	PF00069	0.496
MOD_CK2_1	251	257	PF00069	0.474
MOD_CK2_1	349	355	PF00069	0.378
MOD_CK2_1	401	407	PF00069	0.488
MOD_CK2_1	409	415	PF00069	0.450
MOD_CK2_1	417	423	PF00069	0.559
MOD_CK2_1	444	450	PF00069	0.682
MOD_CK2_1	635	641	PF00069	0.308
MOD_Cter_Amidation	395	398	PF01082	0.503
MOD_GlcNHglycan	136	139	PF01048	0.319
MOD_GlcNHglycan	160	163	PF01048	0.470
MOD_GlcNHglycan	200	203	PF01048	0.530
MOD_GlcNHglycan	205	209	PF01048	0.469
MOD_GlcNHglycan	23	26	PF01048	0.698
MOD_GlcNHglycan	394	397	PF01048	0.575
MOD_GlcNHglycan	478	481	PF01048	0.581
MOD_GlcNHglycan	491	494	PF01048	0.397
MOD_GlcNHglycan	530	533	PF01048	0.407
MOD_GlcNHglycan	535	538	PF01048	0.338
MOD_GlcNHglycan	80	83	PF01048	0.598
MOD_GSK3_1	104	111	PF00069	0.564
MOD_GSK3_1	12	19	PF00069	0.538
MOD_GSK3_1	120	127	PF00069	0.425
MOD_GSK3_1	149	156	PF00069	0.340
MOD_GSK3_1	194	201	PF00069	0.422
MOD_GSK3_1	221	228	PF00069	0.414
MOD_GSK3_1	26	33	PF00069	0.620
MOD_GSK3_1	359	366	PF00069	0.382
MOD_GSK3_1	489	496	PF00069	0.455
MOD_GSK3_1	631	638	PF00069	0.388
MOD_N-GLC_1	330	335	PF02516	0.409
MOD_NEK2_1	242	247	PF00069	0.398
MOD_NEK2_1	278	283	PF00069	0.428
MOD_NEK2_1	444	449	PF00069	0.531
MOD_NEK2_1	528	533	PF00069	0.428
MOD_NEK2_2	160	165	PF00069	0.464
MOD_NEK2_2	266	271	PF00069	0.506
MOD_NEK2_2	469	474	PF00069	0.506
MOD_NEK2_2	493	498	PF00069	0.422
MOD_PIKK_1	330	336	PF00454	0.306
MOD_PIKK_1	452	458	PF00454	0.605
MOD_PKA_2	125	131	PF00069	0.519
MOD_PKA_2	266	272	PF00069	0.346
MOD_PKA_2	510	516	PF00069	0.433
MOD_Plk_1	322	328	PF00069	0.377
MOD_Plk_1	439	445	PF00069	0.541
MOD_Plk_1	469	475	PF00069	0.592
MOD_Plk_1	626	632	PF00069	0.402
MOD_Plk_2-3	322	328	PF00069	0.415
MOD_Plk_2-3	349	355	PF00069	0.354
MOD_Plk_2-3	635	641	PF00069	0.367
MOD_Plk_4	349	355	PF00069	0.342
MOD_Plk_4	431	437	PF00069	0.472
MOD_Plk_4	439	445	PF00069	0.529
MOD_Plk_4	510	516	PF00069	0.404
MOD_Plk_4	570	576	PF00069	0.376
MOD_Plk_4	635	641	PF00069	0.367
MOD_ProDKin_1	110	116	PF00069	0.495
MOD_ProDKin_1	194	200	PF00069	0.437
MOD_ProDKin_1	251	257	PF00069	0.521
MOD_ProDKin_1	26	32	PF00069	0.554
MOD_ProDKin_1	301	307	PF00069	0.526
MOD_ProDKin_1	409	415	PF00069	0.447
MOD_ProDKin_1	498	504	PF00069	0.452
MOD_ProDKin_1	68	74	PF00069	0.517
MOD_SUMO_rev_2	414	419	PF00179	0.463
TRG_DiLeu_BaEn_1	349	354	PF01217	0.354
TRG_ENDOCYTIC_2	239	242	PF00928	0.543
TRG_ENDOCYTIC_2	350	353	PF00928	0.355
TRG_ENDOCYTIC_2	67	70	PF00928	0.565
TRG_ER_diArg_1	397	399	PF00400	0.485
TRG_ER_diArg_1	586	588	PF00400	0.508
TRG_NES_CRM1_1	559	572	PF08389	0.299
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	581	585	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L1	Leptomonas seymouri	49%	84%
A0A1X0NSU7	Trypanosomatidae	29%	100%
A0A3S7WUG5	Leishmania donovani	99%	81%
A4H922	Leishmania braziliensis	73%	100%
E9AR49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QEB4	Leishmania major	89%	100%