Methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Methyltransferase

Gene product:

Putative methyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4HXF2_LEIIN

TriTrypDb:

LINF_170014400

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXF2

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	448	452	PF00656	0.671
CLV_NRD_NRD_1	364	366	PF00675	0.432
CLV_NRD_NRD_1	434	436	PF00675	0.779
CLV_NRD_NRD_1	469	471	PF00675	0.569
CLV_PCSK_FUR_1	432	436	PF00082	0.683
CLV_PCSK_KEX2_1	364	366	PF00082	0.432
CLV_PCSK_KEX2_1	432	434	PF00082	0.735
CLV_PCSK_KEX2_1	469	471	PF00082	0.566
CLV_PCSK_SKI1_1	118	122	PF00082	0.400
CLV_PCSK_SKI1_1	192	196	PF00082	0.583
CLV_Separin_Metazoa	429	433	PF03568	0.601
DEG_Nend_Nbox_1	1	3	PF02207	0.398
DEG_SPOP_SBC_1	229	233	PF00917	0.638
DEG_SPOP_SBC_1	71	75	PF00917	0.376
DOC_ANK_TNKS_1	436	443	PF00023	0.662
DOC_CKS1_1	243	248	PF01111	0.453
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.312
DOC_PP1_RVXF_1	390	396	PF00149	0.400
DOC_PP2B_LxvP_1	210	213	PF13499	0.393
DOC_PP2B_LxvP_1	79	82	PF13499	0.312
DOC_PP4_FxxP_1	425	428	PF00568	0.627
DOC_USP7_MATH_1	154	158	PF00917	0.448
DOC_USP7_MATH_1	213	217	PF00917	0.430
DOC_USP7_MATH_1	223	227	PF00917	0.257
DOC_USP7_MATH_1	229	233	PF00917	0.620
DOC_USP7_MATH_1	30	34	PF00917	0.466
DOC_USP7_MATH_1	352	356	PF00917	0.525
DOC_USP7_MATH_1	418	422	PF00917	0.767
DOC_USP7_MATH_1	455	459	PF00917	0.764
DOC_USP7_MATH_1	71	75	PF00917	0.450
DOC_USP7_UBL2_3	162	166	PF12436	0.412
DOC_WW_Pin1_4	179	184	PF00397	0.672
DOC_WW_Pin1_4	238	243	PF00397	0.644
DOC_WW_Pin1_4	8	13	PF00397	0.409
LIG_14-3-3_CanoR_1	111	121	PF00244	0.284
LIG_14-3-3_CanoR_1	184	190	PF00244	0.613
LIG_14-3-3_CanoR_1	201	207	PF00244	0.363
LIG_14-3-3_CanoR_1	333	343	PF00244	0.543
LIG_14-3-3_CanoR_1	392	401	PF00244	0.387
LIG_14-3-3_CanoR_1	60	70	PF00244	0.366
LIG_BIR_III_2	472	476	PF00653	0.546
LIG_BRCT_BRCA1_1	189	193	PF00533	0.463
LIG_BRCT_BRCA1_1	421	425	PF00533	0.671
LIG_eIF4E_1	268	274	PF01652	0.435
LIG_FHA_1	189	195	PF00498	0.536
LIG_FHA_1	232	238	PF00498	0.529
LIG_FHA_1	323	329	PF00498	0.494
LIG_FHA_1	372	378	PF00498	0.417
LIG_FHA_2	267	273	PF00498	0.321
LIG_FHA_2	274	280	PF00498	0.348
LIG_FHA_2	394	400	PF00498	0.422
LIG_FHA_2	446	452	PF00498	0.659
LIG_Integrin_RGD_1	470	472	PF01839	0.543
LIG_LIR_Apic_2	18	24	PF02991	0.455
LIG_LIR_Apic_2	254	260	PF02991	0.382
LIG_LIR_Apic_2	422	428	PF02991	0.622
LIG_LIR_Gen_1	245	255	PF02991	0.388
LIG_LIR_Gen_1	295	304	PF02991	0.367
LIG_LIR_Gen_1	321	331	PF02991	0.447
LIG_LIR_Gen_1	358	367	PF02991	0.349
LIG_LIR_Gen_1	64	71	PF02991	0.227
LIG_LIR_Nem_3	10	16	PF02991	0.350
LIG_LIR_Nem_3	245	250	PF02991	0.377
LIG_LIR_Nem_3	262	266	PF02991	0.251
LIG_LIR_Nem_3	295	301	PF02991	0.366
LIG_LIR_Nem_3	321	327	PF02991	0.456
LIG_LIR_Nem_3	358	362	PF02991	0.349
LIG_LIR_Nem_3	64	70	PF02991	0.288
LIG_Pex14_2	148	152	PF04695	0.383
LIG_SH2_CRK	257	261	PF00017	0.429
LIG_SH2_PTP2	249	252	PF00017	0.422
LIG_SH2_PTP2	359	362	PF00017	0.428
LIG_SH2_STAT5	249	252	PF00017	0.366
LIG_SH2_STAT5	268	271	PF00017	0.193
LIG_SH2_STAT5	359	362	PF00017	0.394
LIG_SH3_2	428	433	PF14604	0.625
LIG_SH3_3	424	430	PF00018	0.812
LIG_SH3_3	6	12	PF00018	0.357
LIG_SH3_3	79	85	PF00018	0.312
LIG_SUMO_SIM_par_1	226	235	PF11976	0.386
LIG_TRFH_1	67	71	PF08558	0.300
LIG_TYR_ITIM	357	362	PF00017	0.442
LIG_WW_3	429	433	PF00397	0.625
MOD_CDK_SPK_2	179	184	PF00069	0.534
MOD_CDK_SPxK_1	238	244	PF00069	0.466
MOD_CK1_1	205	211	PF00069	0.379
MOD_CK1_1	231	237	PF00069	0.683
MOD_CK1_1	338	344	PF00069	0.471
MOD_CK1_1	355	361	PF00069	0.427
MOD_CK1_1	72	78	PF00069	0.414
MOD_CK2_1	266	272	PF00069	0.321
MOD_CK2_1	338	344	PF00069	0.475
MOD_CK2_1	393	399	PF00069	0.398
MOD_GlcNHglycan	213	216	PF01048	0.513
MOD_GlcNHglycan	340	343	PF01048	0.593
MOD_GlcNHglycan	41	44	PF01048	0.400
MOD_GlcNHglycan	410	413	PF01048	0.707
MOD_GlcNHglycan	421	424	PF01048	0.686
MOD_GlcNHglycan	55	58	PF01048	0.312
MOD_GlcNHglycan	75	78	PF01048	0.262
MOD_GSK3_1	201	208	PF00069	0.455
MOD_GSK3_1	228	235	PF00069	0.628
MOD_GSK3_1	238	245	PF00069	0.442
MOD_GSK3_1	334	341	PF00069	0.457
MOD_GSK3_1	69	76	PF00069	0.437
MOD_N-GLC_1	185	190	PF02516	0.550
MOD_N-GLC_1	31	36	PF02516	0.360
MOD_N-GLC_2	285	287	PF02516	0.324
MOD_NEK2_1	193	198	PF00069	0.435
MOD_NEK2_1	206	211	PF00069	0.315
MOD_NEK2_1	266	271	PF00069	0.324
MOD_NEK2_1	273	278	PF00069	0.333
MOD_NEK2_1	31	36	PF00069	0.426
MOD_NEK2_1	51	56	PF00069	0.284
MOD_PKA_1	433	439	PF00069	0.638
MOD_PKA_2	388	394	PF00069	0.343
MOD_PKA_2	408	414	PF00069	0.746
MOD_PKA_2	433	439	PF00069	0.782
MOD_Plk_1	185	191	PF00069	0.451
MOD_Plk_1	31	37	PF00069	0.404
MOD_Plk_4	155	161	PF00069	0.441
MOD_Plk_4	202	208	PF00069	0.461
MOD_Plk_4	352	358	PF00069	0.427
MOD_ProDKin_1	179	185	PF00069	0.674
MOD_ProDKin_1	238	244	PF00069	0.637
MOD_ProDKin_1	8	14	PF00069	0.409
MOD_SUMO_for_1	218	221	PF00179	0.374
MOD_SUMO_for_1	401	404	PF00179	0.530
MOD_SUMO_rev_2	303	311	PF00179	0.310
TRG_ENDOCYTIC_2	13	16	PF00928	0.368
TRG_ENDOCYTIC_2	249	252	PF00928	0.370
TRG_ENDOCYTIC_2	359	362	PF00928	0.428
TRG_ENDOCYTIC_2	368	371	PF00928	0.464
TRG_ER_diArg_1	392	395	PF00400	0.440
TRG_ER_diArg_1	431	434	PF00400	0.784
TRG_NES_CRM1_1	119	132	PF08389	0.422
TRG_NES_CRM1_1	163	175	PF08389	0.425
TRG_NLS_MonoExtC_3	464	469	PF00514	0.724
TRG_NLS_MonoExtN_4	465	470	PF00514	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWR5	Leptomonas seymouri	59%	100%
A0A1X0NSU1	Trypanosomatidae	40%	100%
A0A3S7WUF8	Leishmania donovani	100%	100%
A0A422N4P6	Trypanosoma rangeli	41%	100%
A4H920	Leishmania braziliensis	80%	99%
C9ZP24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AR47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QEB6	Leishmania major	93%	100%