DUF106-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXF0_LEIIN

TriTrypDb:

LINF_170014200

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HXF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.578
CLV_MEL_PAP_1	198	204	PF00089	0.388
CLV_NRD_NRD_1	358	360	PF00675	0.412
CLV_NRD_NRD_1	367	369	PF00675	0.370
CLV_NRD_NRD_1	388	390	PF00675	0.528
CLV_NRD_NRD_1	431	433	PF00675	0.344
CLV_PCSK_FUR_1	365	369	PF00082	0.402
CLV_PCSK_KEX2_1	323	325	PF00082	0.407
CLV_PCSK_KEX2_1	358	360	PF00082	0.395
CLV_PCSK_KEX2_1	367	369	PF00082	0.378
CLV_PCSK_KEX2_1	387	389	PF00082	0.534
CLV_PCSK_KEX2_1	90	92	PF00082	0.436
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.436
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.406
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.413
CLV_PCSK_SKI1_1	266	270	PF00082	0.325
CLV_PCSK_SKI1_1	304	308	PF00082	0.443
CLV_PCSK_SKI1_1	323	327	PF00082	0.384
CLV_PCSK_SKI1_1	336	340	PF00082	0.384
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DOC_CKS1_1	30	35	PF01111	0.393
DOC_CYCLIN_yCln2_LP_2	232	238	PF00134	0.410
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.435
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.401
DOC_MAPK_gen_1	213	223	PF00069	0.536
DOC_MAPK_gen_1	333	343	PF00069	0.590
DOC_MAPK_MEF2A_6	214	223	PF00069	0.494
DOC_MAPK_MEF2A_6	411	418	PF00069	0.600
DOC_PP1_RVXF_1	199	205	PF00149	0.594
DOC_PP1_RVXF_1	302	308	PF00149	0.619
DOC_PP1_RVXF_1	82	89	PF00149	0.543
DOC_PP2B_LxvP_1	130	133	PF13499	0.395
DOC_PP2B_LxvP_1	240	243	PF13499	0.428
DOC_PP2B_LxvP_1	47	50	PF13499	0.357
DOC_PP4_FxxP_1	247	250	PF00568	0.357
DOC_PP4_FxxP_1	280	283	PF00568	0.625
DOC_USP7_MATH_1	120	124	PF00917	0.417
DOC_USP7_MATH_1	169	173	PF00917	0.431
DOC_USP7_MATH_1	227	231	PF00917	0.428
DOC_USP7_UBL2_3	356	360	PF12436	0.655
DOC_WW_Pin1_4	148	153	PF00397	0.402
DOC_WW_Pin1_4	2	7	PF00397	0.609
DOC_WW_Pin1_4	29	34	PF00397	0.403
LIG_14-3-3_CanoR_1	103	109	PF00244	0.561
LIG_14-3-3_CanoR_1	196	204	PF00244	0.550
LIG_14-3-3_CanoR_1	368	374	PF00244	0.708
LIG_14-3-3_CanoR_1	387	392	PF00244	0.619
LIG_Actin_WH2_2	252	268	PF00022	0.402
LIG_APCC_ABBA_1	341	346	PF00400	0.626
LIG_APCC_ABBA_1	51	56	PF00400	0.400
LIG_Clathr_ClatBox_1	176	180	PF01394	0.410
LIG_FHA_1	108	114	PF00498	0.552
LIG_FHA_1	137	143	PF00498	0.383
LIG_FHA_1	180	186	PF00498	0.352
LIG_FHA_1	2	8	PF00498	0.664
LIG_FHA_1	235	241	PF00498	0.374
LIG_FHA_1	260	266	PF00498	0.355
LIG_FHA_1	313	319	PF00498	0.668
LIG_FHA_2	306	312	PF00498	0.616
LIG_FHA_2	388	394	PF00498	0.644
LIG_LIR_Gen_1	190	198	PF02991	0.408
LIG_LIR_Gen_1	75	83	PF02991	0.603
LIG_LIR_Nem_3	102	108	PF02991	0.610
LIG_LIR_Nem_3	190	195	PF02991	0.501
LIG_LIR_Nem_3	75	79	PF02991	0.548
LIG_MYND_1	250	254	PF01753	0.322
LIG_PCNA_yPIPBox_3	201	212	PF02747	0.544
LIG_RPA_C_Insects	86	101	PF08784	0.438
LIG_SH2_SRC	76	79	PF00017	0.408
LIG_SH2_STAP1	238	242	PF00017	0.512
LIG_SH2_STAP1	328	332	PF00017	0.480
LIG_SH2_STAT3	285	288	PF00017	0.497
LIG_SH2_STAT3	54	57	PF00017	0.451
LIG_SH2_STAT5	128	131	PF00017	0.359
LIG_SH2_STAT5	251	254	PF00017	0.315
LIG_SH2_STAT5	76	79	PF00017	0.539
LIG_SH3_3	280	286	PF00018	0.547
LIG_SH3_3	77	83	PF00018	0.435
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.499
LIG_SUMO_SIM_par_1	151	156	PF11976	0.445
LIG_TRAF2_1	398	401	PF00917	0.683
LIG_WRC_WIRS_1	105	110	PF05994	0.399
LIG_WRC_WIRS_1	137	142	PF05994	0.460
MOD_CDK_SPxxK_3	2	9	PF00069	0.504
MOD_CK1_1	107	113	PF00069	0.503
MOD_CK1_1	123	129	PF00069	0.336
MOD_CK1_1	164	170	PF00069	0.600
MOD_CK1_1	172	178	PF00069	0.394
MOD_CK1_1	260	266	PF00069	0.332
MOD_CK1_1	29	35	PF00069	0.553
MOD_CK1_1	379	385	PF00069	0.687
MOD_CK1_1	406	412	PF00069	0.657
MOD_CK2_1	391	397	PF00069	0.789
MOD_CK2_1	406	412	PF00069	0.592
MOD_GlcNHglycan	122	125	PF01048	0.383
MOD_GlcNHglycan	171	174	PF01048	0.643
MOD_GlcNHglycan	259	262	PF01048	0.427
MOD_GlcNHglycan	39	42	PF01048	0.407
MOD_GlcNHglycan	393	397	PF01048	0.756
MOD_GSK3_1	161	168	PF00069	0.557
MOD_GSK3_1	175	182	PF00069	0.369
MOD_GSK3_1	260	267	PF00069	0.344
MOD_GSK3_1	314	321	PF00069	0.632
MOD_GSK3_1	387	394	PF00069	0.663
MOD_GSK3_1	403	410	PF00069	0.569
MOD_N-GLC_1	270	275	PF02516	0.421
MOD_NEK2_1	1	6	PF00069	0.488
MOD_NEK2_1	12	17	PF00069	0.421
MOD_NEK2_1	153	158	PF00069	0.481
MOD_NEK2_1	165	170	PF00069	0.617
MOD_NEK2_1	257	262	PF00069	0.309
MOD_NEK2_1	305	310	PF00069	0.510
MOD_NEK2_1	369	374	PF00069	0.537
MOD_NEK2_1	37	42	PF00069	0.360
MOD_NEK2_1	391	396	PF00069	0.721
MOD_NEK2_2	187	192	PF00069	0.357
MOD_PIKK_1	196	202	PF00454	0.377
MOD_PIKK_1	318	324	PF00454	0.485
MOD_PIKK_1	379	385	PF00454	0.670
MOD_PKA_1	387	393	PF00069	0.516
MOD_PKA_2	387	393	PF00069	0.622
MOD_Plk_4	12	18	PF00069	0.357
MOD_Plk_4	123	129	PF00069	0.302
MOD_Plk_4	136	142	PF00069	0.402
MOD_Plk_4	172	178	PF00069	0.311
MOD_Plk_4	227	233	PF00069	0.309
MOD_Plk_4	264	270	PF00069	0.417
MOD_ProDKin_1	148	154	PF00069	0.497
MOD_ProDKin_1	2	8	PF00069	0.508
MOD_ProDKin_1	29	35	PF00069	0.498
TRG_ENDOCYTIC_2	76	79	PF00928	0.420
TRG_ER_diArg_1	367	369	PF00400	0.528
TRG_ER_diArg_1	386	389	PF00400	0.699
TRG_ER_diArg_1	426	429	PF00400	0.562
TRG_NLS_MonoCore_2	357	362	PF00514	0.526
TRG_NLS_MonoExtN_4	356	363	PF00514	0.526
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3N4	Leptomonas seymouri	61%	94%
A0A0S4KHH7	Bodo saltans	36%	90%
A0A1X0NTB3	Trypanosomatidae	48%	100%
A0A3S7WUI4	Leishmania donovani	100%	100%
A4H918	Leishmania braziliensis	84%	100%
C9ZP21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AR45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QEB8	Leishmania major	98%	100%
V5BFE7	Trypanosoma cruzi	46%	100%