LeishMANIAdb
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Serine/threonine-protein kinase PLK

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein kinase PLK
Gene product:
polo-like protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4HXE5_LEIIN
TriTrypDb:
LINF_170013700
Length:
701

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000922 spindle pole 2 1
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0005813 centrosome 3 1
GO:0005815 microtubule organizing center 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HXE5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXE5

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0000278 mitotic cell cycle 3 1
GO:0007049 cell cycle 2 1
GO:0010564 regulation of cell cycle process 5 1
GO:0032465 regulation of cytokinesis 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051302 regulation of cell division 4 1
GO:0051726 regulation of cell cycle 4 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0004674 protein serine/threonine kinase activity 4 10
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 14 18 PF00656 0.427
CLV_C14_Caspase3-7 267 271 PF00656 0.347
CLV_C14_Caspase3-7 477 481 PF00656 0.558
CLV_NRD_NRD_1 138 140 PF00675 0.337
CLV_NRD_NRD_1 198 200 PF00675 0.245
CLV_NRD_NRD_1 345 347 PF00675 0.649
CLV_NRD_NRD_1 666 668 PF00675 0.265
CLV_NRD_NRD_1 99 101 PF00675 0.323
CLV_PCSK_KEX2_1 138 140 PF00082 0.339
CLV_PCSK_KEX2_1 200 202 PF00082 0.245
CLV_PCSK_KEX2_1 255 257 PF00082 0.263
CLV_PCSK_KEX2_1 345 347 PF00082 0.649
CLV_PCSK_KEX2_1 620 622 PF00082 0.308
CLV_PCSK_KEX2_1 665 667 PF00082 0.267
CLV_PCSK_KEX2_1 99 101 PF00082 0.263
CLV_PCSK_PC1ET2_1 200 202 PF00082 0.245
CLV_PCSK_PC1ET2_1 255 257 PF00082 0.377
CLV_PCSK_PC1ET2_1 620 622 PF00082 0.308
CLV_PCSK_SKI1_1 167 171 PF00082 0.288
CLV_PCSK_SKI1_1 362 366 PF00082 0.645
CLV_PCSK_SKI1_1 371 375 PF00082 0.530
CLV_PCSK_SKI1_1 555 559 PF00082 0.247
CLV_PCSK_SKI1_1 569 573 PF00082 0.180
CLV_PCSK_SKI1_1 575 579 PF00082 0.267
CLV_PCSK_SKI1_1 655 659 PF00082 0.209
CLV_PCSK_SKI1_1 689 693 PF00082 0.376
CLV_PCSK_SKI1_1 99 103 PF00082 0.288
CLV_Separin_Metazoa 372 376 PF03568 0.603
DEG_APCC_DBOX_1 286 294 PF00400 0.263
DEG_APCC_DBOX_1 370 378 PF00400 0.584
DEG_Nend_UBRbox_2 1 3 PF02207 0.678
DEG_SCF_FBW7_1 305 312 PF00400 0.473
DEG_SCF_FBW7_1 403 408 PF00400 0.532
DEG_SPOP_SBC_1 19 23 PF00917 0.666
DEG_SPOP_SBC_1 610 614 PF00917 0.514
DOC_CKS1_1 306 311 PF01111 0.524
DOC_CKS1_1 402 407 PF01111 0.532
DOC_CKS1_1 659 664 PF01111 0.440
DOC_CYCLIN_yCln2_LP_2 307 313 PF00134 0.530
DOC_MAPK_gen_1 114 123 PF00069 0.263
DOC_MAPK_gen_1 167 176 PF00069 0.364
DOC_MAPK_gen_1 620 631 PF00069 0.443
DOC_MAPK_gen_1 665 671 PF00069 0.504
DOC_MAPK_gen_1 99 109 PF00069 0.263
DOC_MAPK_MEF2A_6 345 352 PF00069 0.565
DOC_PP1_RVXF_1 518 524 PF00149 0.504
DOC_PP2B_LxvP_1 307 310 PF13499 0.463
DOC_PP2B_LxvP_1 318 321 PF13499 0.517
DOC_PP2B_LxvP_1 365 368 PF13499 0.586
DOC_PP4_FxxP_1 316 319 PF00568 0.623
DOC_SPAK_OSR1_1 139 143 PF12202 0.263
DOC_USP7_MATH_1 20 24 PF00917 0.570
DOC_USP7_MATH_1 32 36 PF00917 0.444
DOC_USP7_MATH_1 330 334 PF00917 0.581
DOC_USP7_MATH_1 610 614 PF00917 0.570
DOC_USP7_MATH_1 670 674 PF00917 0.394
DOC_USP7_UBL2_3 86 90 PF12436 0.288
DOC_WW_Pin1_4 203 208 PF00397 0.245
DOC_WW_Pin1_4 280 285 PF00397 0.365
DOC_WW_Pin1_4 299 304 PF00397 0.297
DOC_WW_Pin1_4 305 310 PF00397 0.398
DOC_WW_Pin1_4 387 392 PF00397 0.672
DOC_WW_Pin1_4 401 406 PF00397 0.595
DOC_WW_Pin1_4 417 422 PF00397 0.608
DOC_WW_Pin1_4 437 442 PF00397 0.664
DOC_WW_Pin1_4 584 589 PF00397 0.535
DOC_WW_Pin1_4 594 599 PF00397 0.287
DOC_WW_Pin1_4 658 663 PF00397 0.440
LIG_14-3-3_CanoR_1 138 143 PF00244 0.288
LIG_14-3-3_CanoR_1 294 299 PF00244 0.323
LIG_14-3-3_CanoR_1 435 441 PF00244 0.667
LIG_14-3-3_CanoR_1 464 470 PF00244 0.548
LIG_14-3-3_CanoR_1 555 561 PF00244 0.533
LIG_14-3-3_CanoR_1 583 588 PF00244 0.515
LIG_14-3-3_CanoR_1 606 610 PF00244 0.612
LIG_14-3-3_CanoR_1 655 660 PF00244 0.409
LIG_14-3-3_CanoR_1 665 670 PF00244 0.409
LIG_14-3-3_CanoR_1 686 692 PF00244 0.420
LIG_14-3-3_CanoR_1 79 83 PF00244 0.323
LIG_BRCT_BRCA1_1 612 616 PF00533 0.611
LIG_eIF4E_1 117 123 PF01652 0.377
LIG_EVH1_2 309 313 PF00568 0.495
LIG_FHA_1 143 149 PF00498 0.263
LIG_FHA_1 20 26 PF00498 0.599
LIG_FHA_1 226 232 PF00498 0.301
LIG_FHA_1 235 241 PF00498 0.257
LIG_FHA_1 275 281 PF00498 0.377
LIG_FHA_1 425 431 PF00498 0.750
LIG_FHA_1 517 523 PF00498 0.409
LIG_FHA_1 525 531 PF00498 0.409
LIG_FHA_1 635 641 PF00498 0.422
LIG_FHA_1 666 672 PF00498 0.414
LIG_FHA_1 686 692 PF00498 0.231
LIG_FHA_1 69 75 PF00498 0.347
LIG_FHA_2 110 116 PF00498 0.263
LIG_FHA_2 12 18 PF00498 0.604
LIG_FHA_2 128 134 PF00498 0.263
LIG_FHA_2 287 293 PF00498 0.245
LIG_FHA_2 610 616 PF00498 0.547
LIG_FHA_2 674 680 PF00498 0.566
LIG_LIR_Apic_2 206 212 PF02991 0.288
LIG_LIR_Apic_2 315 319 PF02991 0.672
LIG_LIR_Apic_2 658 662 PF02991 0.431
LIG_LIR_Gen_1 115 123 PF02991 0.323
LIG_LIR_Gen_1 144 155 PF02991 0.288
LIG_LIR_Gen_1 312 321 PF02991 0.571
LIG_LIR_Gen_1 531 541 PF02991 0.388
LIG_LIR_Gen_1 613 623 PF02991 0.465
LIG_LIR_Gen_1 690 701 PF02991 0.439
LIG_LIR_Nem_3 115 120 PF02991 0.263
LIG_LIR_Nem_3 144 150 PF02991 0.288
LIG_LIR_Nem_3 251 257 PF02991 0.251
LIG_LIR_Nem_3 312 316 PF02991 0.530
LIG_LIR_Nem_3 531 536 PF02991 0.388
LIG_LIR_Nem_3 574 580 PF02991 0.458
LIG_LIR_Nem_3 613 619 PF02991 0.462
LIG_LIR_Nem_3 651 657 PF02991 0.504
LIG_LIR_Nem_3 690 696 PF02991 0.420
LIG_MYND_1 305 309 PF01753 0.450
LIG_NRBOX 130 136 PF00104 0.377
LIG_NRBOX 234 240 PF00104 0.245
LIG_Pex14_2 109 113 PF04695 0.263
LIG_SH2_CRK 236 240 PF00017 0.261
LIG_SH2_CRK 254 258 PF00017 0.178
LIG_SH2_CRK 262 266 PF00017 0.377
LIG_SH2_CRK 533 537 PF00017 0.388
LIG_SH2_CRK 659 663 PF00017 0.440
LIG_SH2_CRK 693 697 PF00017 0.486
LIG_SH2_NCK_1 659 663 PF00017 0.431
LIG_SH2_PTP2 147 150 PF00017 0.323
LIG_SH2_PTP2 209 212 PF00017 0.245
LIG_SH2_STAP1 236 240 PF00017 0.301
LIG_SH2_STAP1 72 76 PF00017 0.290
LIG_SH2_STAT5 118 121 PF00017 0.317
LIG_SH2_STAT5 147 150 PF00017 0.345
LIG_SH2_STAT5 209 212 PF00017 0.245
LIG_SH2_STAT5 236 239 PF00017 0.263
LIG_SH2_STAT5 576 579 PF00017 0.336
LIG_SH2_STAT5 580 583 PF00017 0.354
LIG_SH2_STAT5 618 621 PF00017 0.338
LIG_SH2_STAT5 659 662 PF00017 0.409
LIG_SH3_2 601 606 PF14604 0.596
LIG_SH3_3 237 243 PF00018 0.245
LIG_SH3_3 300 306 PF00018 0.406
LIG_SH3_3 353 359 PF00018 0.664
LIG_SH3_3 370 376 PF00018 0.594
LIG_SH3_3 378 384 PF00018 0.572
LIG_SH3_3 385 391 PF00018 0.537
LIG_SH3_3 404 410 PF00018 0.692
LIG_SH3_3 481 487 PF00018 0.530
LIG_SH3_3 519 525 PF00018 0.422
LIG_SH3_3 595 601 PF00018 0.511
LIG_SH3_4 27 34 PF00018 0.511
LIG_SH3_CIN85_PxpxPR_1 601 606 PF14604 0.533
LIG_TRAF2_2 244 249 PF00917 0.245
LIG_TYR_ITIM 234 239 PF00017 0.263
LIG_TYR_ITIM 691 696 PF00017 0.476
LIG_UBA3_1 131 136 PF00899 0.288
LIG_WRC_WIRS_1 110 115 PF05994 0.263
LIG_WRC_WIRS_1 313 318 PF05994 0.575
LIG_WW_3 603 607 PF00397 0.541
MOD_CDC14_SPxK_1 587 590 PF00782 0.499
MOD_CDK_SPK_2 387 392 PF00069 0.710
MOD_CDK_SPK_2 417 422 PF00069 0.613
MOD_CDK_SPxK_1 584 590 PF00069 0.570
MOD_CDK_SPxxK_3 280 287 PF00069 0.377
MOD_CDK_SPxxK_3 658 665 PF00069 0.440
MOD_CK1_1 297 303 PF00069 0.584
MOD_CK1_1 312 318 PF00069 0.570
MOD_CK1_1 559 565 PF00069 0.546
MOD_CK1_1 634 640 PF00069 0.420
MOD_CK1_1 66 72 PF00069 0.377
MOD_CK1_1 673 679 PF00069 0.423
MOD_CK1_1 93 99 PF00069 0.323
MOD_CK2_1 138 144 PF00069 0.309
MOD_CK2_1 18 24 PF00069 0.567
MOD_CK2_1 32 38 PF00069 0.400
MOD_CK2_1 673 679 PF00069 0.604
MOD_Cter_Amidation 663 666 PF01082 0.304
MOD_DYRK1A_RPxSP_1 417 421 PF00069 0.610
MOD_GlcNHglycan 153 156 PF01048 0.444
MOD_GlcNHglycan 332 335 PF01048 0.704
MOD_GlcNHglycan 342 345 PF01048 0.575
MOD_GlcNHglycan 40 44 PF01048 0.525
MOD_GlcNHglycan 422 425 PF01048 0.675
MOD_GlcNHglycan 432 435 PF01048 0.586
MOD_GlcNHglycan 662 665 PF01048 0.265
MOD_GSK3_1 138 145 PF00069 0.272
MOD_GSK3_1 199 206 PF00069 0.247
MOD_GSK3_1 216 223 PF00069 0.359
MOD_GSK3_1 294 301 PF00069 0.325
MOD_GSK3_1 305 312 PF00069 0.372
MOD_GSK3_1 326 333 PF00069 0.600
MOD_GSK3_1 336 343 PF00069 0.509
MOD_GSK3_1 401 408 PF00069 0.649
MOD_GSK3_1 420 427 PF00069 0.674
MOD_GSK3_1 504 511 PF00069 0.504
MOD_GSK3_1 605 612 PF00069 0.590
MOD_N-GLC_1 515 520 PF02516 0.215
MOD_N-GLC_1 634 639 PF02516 0.222
MOD_NEK2_1 109 114 PF00069 0.296
MOD_NEK2_1 298 303 PF00069 0.553
MOD_NEK2_1 39 44 PF00069 0.583
MOD_NEK2_1 465 470 PF00069 0.395
MOD_NEK2_1 515 520 PF00069 0.415
MOD_NEK2_1 631 636 PF00069 0.409
MOD_NEK2_1 685 690 PF00069 0.465
MOD_NEK2_2 32 37 PF00069 0.506
MOD_PIKK_1 142 148 PF00454 0.263
MOD_PIKK_1 274 280 PF00454 0.395
MOD_PIKK_1 488 494 PF00454 0.465
MOD_PK_1 138 144 PF00069 0.237
MOD_PKA_1 138 144 PF00069 0.377
MOD_PKA_1 199 205 PF00069 0.245
MOD_PKA_1 569 575 PF00069 0.462
MOD_PKA_1 665 671 PF00069 0.504
MOD_PKA_2 138 144 PF00069 0.299
MOD_PKA_2 286 292 PF00069 0.288
MOD_PKA_2 504 510 PF00069 0.422
MOD_PKA_2 605 611 PF00069 0.600
MOD_PKA_2 631 637 PF00069 0.409
MOD_PKA_2 665 671 PF00069 0.409
MOD_PKA_2 685 691 PF00069 0.230
MOD_PKA_2 78 84 PF00069 0.323
MOD_Plk_1 250 256 PF00069 0.384
MOD_Plk_1 634 640 PF00069 0.422
MOD_Plk_1 93 99 PF00069 0.364
MOD_Plk_2-3 127 133 PF00069 0.377
MOD_Plk_4 127 133 PF00069 0.273
MOD_Plk_4 234 240 PF00069 0.302
MOD_Plk_4 286 292 PF00069 0.254
MOD_Plk_4 294 300 PF00069 0.261
MOD_Plk_4 32 38 PF00069 0.402
MOD_Plk_4 576 582 PF00069 0.364
MOD_Plk_4 687 693 PF00069 0.380
MOD_ProDKin_1 203 209 PF00069 0.245
MOD_ProDKin_1 280 286 PF00069 0.365
MOD_ProDKin_1 299 305 PF00069 0.288
MOD_ProDKin_1 387 393 PF00069 0.672
MOD_ProDKin_1 401 407 PF00069 0.593
MOD_ProDKin_1 417 423 PF00069 0.606
MOD_ProDKin_1 437 443 PF00069 0.667
MOD_ProDKin_1 584 590 PF00069 0.528
MOD_ProDKin_1 594 600 PF00069 0.299
MOD_ProDKin_1 658 664 PF00069 0.440
MOD_SUMO_for_1 536 539 PF00179 0.504
MOD_SUMO_for_1 551 554 PF00179 0.504
MOD_SUMO_rev_2 162 171 PF00179 0.381
MOD_SUMO_rev_2 192 202 PF00179 0.245
MOD_SUMO_rev_2 213 219 PF00179 0.377
MOD_SUMO_rev_2 562 572 PF00179 0.500
TRG_ENDOCYTIC_2 118 121 PF00928 0.270
TRG_ENDOCYTIC_2 147 150 PF00928 0.323
TRG_ENDOCYTIC_2 236 239 PF00928 0.261
TRG_ENDOCYTIC_2 254 257 PF00928 0.178
TRG_ENDOCYTIC_2 533 536 PF00928 0.388
TRG_ENDOCYTIC_2 693 696 PF00928 0.482
TRG_ER_diArg_1 137 139 PF00400 0.278
TRG_ER_diArg_1 665 667 PF00400 0.497
TRG_ER_diArg_1 99 101 PF00400 0.323
TRG_NES_CRM1_1 133 144 PF08389 0.377
TRG_NES_CRM1_1 179 192 PF08389 0.289
TRG_Pf-PMV_PEXEL_1 273 278 PF00026 0.377
TRG_Pf-PMV_PEXEL_1 621 626 PF00026 0.457

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I191 Leptomonas seymouri 73% 95%
A0A0S4JMY6 Bodo saltans 48% 91%
A0A1X0NTN5 Trypanosomatidae 50% 92%
A0A3Q8IAR8 Leishmania donovani 100% 100%
A0A422N3U8 Trypanosoma rangeli 48% 97%
A4H913 Leishmania braziliensis 92% 99%
C9ZTW0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AR40 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
P0C8M8 Zea mays 38% 100%
P32562 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 99%
P50528 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
P53351 Mus musculus 30% 100%
Q4FZD7 Mus musculus 29% 100%
Q4QEC3 Leishmania major 97% 100%
Q9R012 Rattus norvegicus 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS