LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
GRAM domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HXE3_LEIIN
TriTrypDb:
LINF_170013200
Length:
657

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005789 endoplasmic reticulum membrane 4 1
GO:0005886 plasma membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0044232 organelle membrane contact site 2 1
GO:0140268 endoplasmic reticulum-plasma membrane contact site 3 1

Expansion

Sequence features

A4HXE3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXE3

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006869 lipid transport 5 1
GO:0009987 cellular process 1 1
GO:0015850 organic hydroxy compound transport 5 1
GO:0015918 sterol transport 6 1
GO:0032365 intracellular lipid transport 4 1
GO:0032366 intracellular sterol transport 5 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0071702 organic substance transport 4 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 1
GO:0005319 lipid transporter activity 2 1
GO:0005488 binding 1 1
GO:0005496 steroid binding 3 1
GO:0008289 lipid binding 2 1
GO:0015248 sterol transporter activity 3 1
GO:0032934 sterol binding 4 1
GO:0097159 organic cyclic compound binding 2 1
GO:0120013 lipid transfer activity 3 1
GO:0120015 sterol transfer activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 117 121 PF00656 0.535
CLV_C14_Caspase3-7 216 220 PF00656 0.317
CLV_C14_Caspase3-7 291 295 PF00656 0.269
CLV_C14_Caspase3-7 524 528 PF00656 0.383
CLV_NRD_NRD_1 184 186 PF00675 0.712
CLV_NRD_NRD_1 205 207 PF00675 0.517
CLV_NRD_NRD_1 30 32 PF00675 0.578
CLV_NRD_NRD_1 401 403 PF00675 0.481
CLV_NRD_NRD_1 538 540 PF00675 0.503
CLV_NRD_NRD_1 558 560 PF00675 0.735
CLV_PCSK_KEX2_1 205 207 PF00082 0.517
CLV_PCSK_KEX2_1 538 540 PF00082 0.465
CLV_PCSK_SKI1_1 169 173 PF00082 0.664
CLV_PCSK_SKI1_1 197 201 PF00082 0.653
CLV_PCSK_SKI1_1 205 209 PF00082 0.546
CLV_PCSK_SKI1_1 268 272 PF00082 0.559
CLV_PCSK_SKI1_1 378 382 PF00082 0.508
CLV_PCSK_SKI1_1 425 429 PF00082 0.516
CLV_PCSK_SKI1_1 448 452 PF00082 0.481
CLV_PCSK_SKI1_1 624 628 PF00082 0.460
DEG_APCC_DBOX_1 447 455 PF00400 0.388
DEG_APCC_DBOX_1 623 631 PF00400 0.612
DEG_Nend_Nbox_1 1 3 PF02207 0.325
DOC_CKS1_1 161 166 PF01111 0.471
DOC_CKS1_1 2 7 PF01111 0.381
DOC_CKS1_1 368 373 PF01111 0.438
DOC_CYCLIN_yCln2_LP_2 368 374 PF00134 0.304
DOC_CYCLIN_yCln2_LP_2 630 636 PF00134 0.517
DOC_MAPK_gen_1 262 272 PF00069 0.317
DOC_MAPK_MEF2A_6 453 462 PF00069 0.319
DOC_MAPK_MEF2A_6 574 581 PF00069 0.443
DOC_PP1_RVXF_1 5 11 PF00149 0.333
DOC_PP4_FxxP_1 244 247 PF00568 0.317
DOC_USP7_MATH_1 315 319 PF00917 0.542
DOC_USP7_MATH_1 340 344 PF00917 0.387
DOC_USP7_MATH_1 553 557 PF00917 0.535
DOC_USP7_MATH_1 566 570 PF00917 0.557
DOC_USP7_MATH_1 653 657 PF00917 0.462
DOC_USP7_MATH_1 93 97 PF00917 0.497
DOC_USP7_UBL2_3 308 312 PF12436 0.408
DOC_WW_Pin1_4 1 6 PF00397 0.413
DOC_WW_Pin1_4 127 132 PF00397 0.526
DOC_WW_Pin1_4 160 165 PF00397 0.592
DOC_WW_Pin1_4 243 248 PF00397 0.317
DOC_WW_Pin1_4 367 372 PF00397 0.434
DOC_WW_Pin1_4 567 572 PF00397 0.494
DOC_WW_Pin1_4 629 634 PF00397 0.633
LIG_14-3-3_CanoR_1 106 111 PF00244 0.462
LIG_14-3-3_CanoR_1 151 157 PF00244 0.517
LIG_14-3-3_CanoR_1 179 183 PF00244 0.496
LIG_14-3-3_CanoR_1 31 36 PF00244 0.392
LIG_14-3-3_CanoR_1 425 433 PF00244 0.306
LIG_14-3-3_CanoR_1 515 525 PF00244 0.340
LIG_14-3-3_CanoR_1 7 15 PF00244 0.382
LIG_14-3-3_CanoR_1 81 86 PF00244 0.466
LIG_Actin_WH2_2 265 282 PF00022 0.317
LIG_AP2alpha_1 473 477 PF02296 0.306
LIG_BRCT_BRCA1_1 283 287 PF00533 0.317
LIG_BRCT_BRCA1_1 605 609 PF00533 0.397
LIG_Clathr_ClatBox_1 269 273 PF01394 0.317
LIG_deltaCOP1_diTrp_1 406 412 PF00928 0.324
LIG_eIF4E_1 446 452 PF01652 0.388
LIG_FHA_1 105 111 PF00498 0.420
LIG_FHA_1 151 157 PF00498 0.527
LIG_FHA_1 161 167 PF00498 0.550
LIG_FHA_1 170 176 PF00498 0.410
LIG_FHA_1 212 218 PF00498 0.317
LIG_FHA_1 31 37 PF00498 0.374
LIG_FHA_1 390 396 PF00498 0.388
LIG_FHA_1 428 434 PF00498 0.281
LIG_FHA_1 457 463 PF00498 0.277
LIG_FHA_1 51 57 PF00498 0.294
LIG_FHA_1 629 635 PF00498 0.629
LIG_FHA_1 637 643 PF00498 0.292
LIG_FHA_1 650 656 PF00498 0.228
LIG_FHA_2 145 151 PF00498 0.501
LIG_FHA_2 198 204 PF00498 0.458
LIG_FHA_2 214 220 PF00498 0.382
LIG_FHA_2 289 295 PF00498 0.269
LIG_FHA_2 312 318 PF00498 0.509
LIG_FHA_2 327 333 PF00498 0.450
LIG_GBD_Chelix_1 532 540 PF00786 0.521
LIG_LIR_Apic_2 84 89 PF02991 0.452
LIG_LIR_Gen_1 238 249 PF02991 0.258
LIG_LIR_Gen_1 254 263 PF02991 0.258
LIG_LIR_Gen_1 273 283 PF02991 0.195
LIG_LIR_Gen_1 284 295 PF02991 0.237
LIG_LIR_Gen_1 345 354 PF02991 0.355
LIG_LIR_Gen_1 359 369 PF02991 0.337
LIG_LIR_Gen_1 49 60 PF02991 0.463
LIG_LIR_Gen_1 61 70 PF02991 0.283
LIG_LIR_Gen_1 652 657 PF02991 0.491
LIG_LIR_Nem_3 202 207 PF02991 0.287
LIG_LIR_Nem_3 238 244 PF02991 0.258
LIG_LIR_Nem_3 254 260 PF02991 0.258
LIG_LIR_Nem_3 273 279 PF02991 0.189
LIG_LIR_Nem_3 284 290 PF02991 0.216
LIG_LIR_Nem_3 345 350 PF02991 0.376
LIG_LIR_Nem_3 359 364 PF02991 0.348
LIG_LIR_Nem_3 445 449 PF02991 0.286
LIG_LIR_Nem_3 49 55 PF02991 0.345
LIG_LIR_Nem_3 527 532 PF02991 0.350
LIG_LIR_Nem_3 606 611 PF02991 0.368
LIG_LIR_Nem_3 61 67 PF02991 0.312
LIG_LIR_Nem_3 612 618 PF02991 0.511
LIG_LIR_Nem_3 652 657 PF02991 0.591
LIG_MLH1_MIPbox_1 605 609 PF16413 0.397
LIG_PDZ_Class_2 652 657 PF00595 0.573
LIG_Pex14_2 10 14 PF04695 0.351
LIG_Pex14_2 204 208 PF04695 0.317
LIG_Pex14_2 384 388 PF04695 0.281
LIG_Pex14_2 473 477 PF04695 0.306
LIG_SH2_CRK 529 533 PF00017 0.301
LIG_SH2_CRK 64 68 PF00017 0.369
LIG_SH2_GRB2like 136 139 PF00017 0.411
LIG_SH2_PTP2 2 5 PF00017 0.381
LIG_SH2_PTP2 276 279 PF00017 0.317
LIG_SH2_PTP2 576 579 PF00017 0.466
LIG_SH2_SRC 441 444 PF00017 0.340
LIG_SH2_SRC 576 579 PF00017 0.430
LIG_SH2_STAT5 136 139 PF00017 0.468
LIG_SH2_STAT5 2 5 PF00017 0.381
LIG_SH2_STAT5 276 279 PF00017 0.317
LIG_SH2_STAT5 443 446 PF00017 0.383
LIG_SH2_STAT5 503 506 PF00017 0.345
LIG_SH2_STAT5 576 579 PF00017 0.554
LIG_SH3_1 206 212 PF00018 0.317
LIG_SH3_1 408 414 PF00018 0.282
LIG_SH3_2 411 416 PF14604 0.317
LIG_SH3_3 125 131 PF00018 0.475
LIG_SH3_3 158 164 PF00018 0.506
LIG_SH3_3 206 212 PF00018 0.272
LIG_SH3_3 317 323 PF00018 0.503
LIG_SH3_3 408 414 PF00018 0.282
LIG_SH3_3 565 571 PF00018 0.514
LIG_SH3_3 572 578 PF00018 0.464
LIG_SH3_3 97 103 PF00018 0.461
LIG_SUMO_SIM_anti_2 16 24 PF11976 0.338
LIG_SUMO_SIM_anti_2 38 44 PF11976 0.350
LIG_SUMO_SIM_par_1 16 24 PF11976 0.403
LIG_SUMO_SIM_par_1 197 203 PF11976 0.398
LIG_SUMO_SIM_par_1 25 30 PF11976 0.345
LIG_SUMO_SIM_par_1 268 273 PF11976 0.282
LIG_SUMO_SIM_par_1 38 44 PF11976 0.364
LIG_SUMO_SIM_par_1 594 599 PF11976 0.384
LIG_WRC_WIRS_1 482 487 PF05994 0.317
LIG_WRC_WIRS_1 644 649 PF05994 0.379
MOD_CDK_SPxK_1 1 7 PF00069 0.379
MOD_CDK_SPxK_1 367 373 PF00069 0.438
MOD_CDK_SPxxK_3 567 574 PF00069 0.505
MOD_CK1_1 101 107 PF00069 0.447
MOD_CK1_1 123 129 PF00069 0.516
MOD_CK1_1 173 179 PF00069 0.466
MOD_CK1_1 281 287 PF00069 0.271
MOD_CK1_1 288 294 PF00069 0.242
MOD_CK1_1 318 324 PF00069 0.487
MOD_CK1_1 356 362 PF00069 0.386
MOD_CK1_1 490 496 PF00069 0.388
MOD_CK1_1 542 548 PF00069 0.435
MOD_CK1_1 614 620 PF00069 0.619
MOD_CK1_1 629 635 PF00069 0.680
MOD_CK1_1 91 97 PF00069 0.511
MOD_CK2_1 10 16 PF00069 0.390
MOD_CK2_1 197 203 PF00069 0.474
MOD_CK2_1 248 254 PF00069 0.359
MOD_CK2_1 326 332 PF00069 0.426
MOD_CK2_1 345 351 PF00069 0.252
MOD_CK2_1 566 572 PF00069 0.564
MOD_CK2_1 69 75 PF00069 0.387
MOD_CMANNOS 409 412 PF00535 0.481
MOD_GlcNHglycan 156 159 PF01048 0.762
MOD_GlcNHglycan 172 175 PF01048 0.627
MOD_GlcNHglycan 280 283 PF01048 0.527
MOD_GlcNHglycan 316 320 PF01048 0.719
MOD_GlcNHglycan 355 358 PF01048 0.692
MOD_GlcNHglycan 454 457 PF01048 0.529
MOD_GlcNHglycan 489 492 PF01048 0.544
MOD_GlcNHglycan 544 547 PF01048 0.726
MOD_GlcNHglycan 598 601 PF01048 0.403
MOD_GlcNHglycan 95 98 PF01048 0.720
MOD_GSK3_1 123 130 PF00069 0.538
MOD_GSK3_1 140 147 PF00069 0.482
MOD_GSK3_1 150 157 PF00069 0.479
MOD_GSK3_1 169 176 PF00069 0.384
MOD_GSK3_1 207 214 PF00069 0.359
MOD_GSK3_1 281 288 PF00069 0.262
MOD_GSK3_1 300 307 PF00069 0.214
MOD_GSK3_1 311 318 PF00069 0.446
MOD_GSK3_1 345 352 PF00069 0.366
MOD_GSK3_1 452 459 PF00069 0.391
MOD_GSK3_1 483 490 PF00069 0.344
MOD_GSK3_1 50 57 PF00069 0.368
MOD_GSK3_1 516 523 PF00069 0.387
MOD_GSK3_1 628 635 PF00069 0.633
MOD_GSK3_1 649 656 PF00069 0.388
MOD_GSK3_1 88 95 PF00069 0.502
MOD_GSK3_1 98 105 PF00069 0.461
MOD_N-GLC_1 120 125 PF02516 0.653
MOD_N-GLC_1 288 293 PF02516 0.479
MOD_N-GLC_1 591 596 PF02516 0.470
MOD_NEK2_1 10 15 PF00069 0.387
MOD_NEK2_1 156 161 PF00069 0.594
MOD_NEK2_1 227 232 PF00069 0.286
MOD_NEK2_1 235 240 PF00069 0.315
MOD_NEK2_1 248 253 PF00069 0.239
MOD_NEK2_1 285 290 PF00069 0.399
MOD_NEK2_1 304 309 PF00069 0.253
MOD_NEK2_1 326 331 PF00069 0.462
MOD_NEK2_1 427 432 PF00069 0.297
MOD_NEK2_1 452 457 PF00069 0.388
MOD_NEK2_1 506 511 PF00069 0.317
MOD_NEK2_1 55 60 PF00069 0.372
MOD_NEK2_1 596 601 PF00069 0.450
MOD_NEK2_1 603 608 PF00069 0.319
MOD_NEK2_1 609 614 PF00069 0.279
MOD_NEK2_1 66 71 PF00069 0.301
MOD_NEK2_2 494 499 PF00069 0.319
MOD_PIKK_1 120 126 PF00454 0.524
MOD_PIKK_1 156 162 PF00454 0.461
MOD_PIKK_1 173 179 PF00454 0.572
MOD_PIKK_1 235 241 PF00454 0.317
MOD_PIKK_1 345 351 PF00454 0.464
MOD_PIKK_1 463 469 PF00454 0.388
MOD_PIKK_1 483 489 PF00454 0.162
MOD_PIKK_1 58 64 PF00454 0.377
MOD_PK_1 106 112 PF00069 0.414
MOD_PKA_1 31 37 PF00069 0.414
MOD_PKA_1 402 408 PF00069 0.281
MOD_PKA_2 101 107 PF00069 0.553
MOD_PKA_2 150 156 PF00069 0.505
MOD_PKA_2 178 184 PF00069 0.517
MOD_PKA_2 30 36 PF00069 0.375
MOD_PKA_2 412 418 PF00069 0.351
MOD_Plk_1 177 183 PF00069 0.522
MOD_Plk_1 300 306 PF00069 0.269
MOD_Plk_1 359 365 PF00069 0.383
MOD_Plk_1 494 500 PF00069 0.388
MOD_Plk_1 50 56 PF00069 0.396
MOD_Plk_1 591 597 PF00069 0.470
MOD_Plk_2-3 144 150 PF00069 0.522
MOD_Plk_4 10 16 PF00069 0.417
MOD_Plk_4 31 37 PF00069 0.388
MOD_Plk_4 428 434 PF00069 0.306
MOD_Plk_4 506 512 PF00069 0.317
MOD_Plk_4 591 597 PF00069 0.475
MOD_Plk_4 603 609 PF00069 0.379
MOD_Plk_4 611 617 PF00069 0.442
MOD_Plk_4 66 72 PF00069 0.337
MOD_Plk_4 81 87 PF00069 0.423
MOD_ProDKin_1 1 7 PF00069 0.413
MOD_ProDKin_1 127 133 PF00069 0.525
MOD_ProDKin_1 160 166 PF00069 0.593
MOD_ProDKin_1 243 249 PF00069 0.317
MOD_ProDKin_1 367 373 PF00069 0.438
MOD_ProDKin_1 567 573 PF00069 0.493
MOD_ProDKin_1 629 635 PF00069 0.629
MOD_SUMO_rev_2 24 34 PF00179 0.375
MOD_SUMO_rev_2 250 257 PF00179 0.291
MOD_SUMO_rev_2 261 270 PF00179 0.258
MOD_SUMO_rev_2 331 339 PF00179 0.476
MOD_SUMO_rev_2 396 405 PF00179 0.306
MOD_SUMO_rev_2 569 575 PF00179 0.456
TRG_DiLeu_BaEn_3 16 22 PF01217 0.377
TRG_ENDOCYTIC_2 276 279 PF00928 0.317
TRG_ENDOCYTIC_2 441 444 PF00928 0.312
TRG_ENDOCYTIC_2 449 452 PF00928 0.250
TRG_ENDOCYTIC_2 503 506 PF00928 0.345
TRG_ENDOCYTIC_2 529 532 PF00928 0.321
TRG_ENDOCYTIC_2 576 579 PF00928 0.466
TRG_ENDOCYTIC_2 64 67 PF00928 0.364
TRG_ER_diArg_1 204 206 PF00400 0.317
TRG_ER_diArg_1 538 540 PF00400 0.266

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NSV7 Trypanosomatidae 40% 92%
A0A3R7LZ26 Trypanosoma rangeli 40% 100%
A0A3S7WUF7 Leishmania donovani 100% 100%
A4H911 Leishmania braziliensis 81% 100%
E9AR38 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QEC5 Leishmania major 93% 100%
V5B9G2 Trypanosoma cruzi 38% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS