Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXD9_LEIIN

TriTrypDb:

LINF_170012800

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	192	194	PF00675	0.453
CLV_NRD_NRD_1	253	255	PF00675	0.571
CLV_NRD_NRD_1	303	305	PF00675	0.488
CLV_NRD_NRD_1	350	352	PF00675	0.404
CLV_NRD_NRD_1	4	6	PF00675	0.636
CLV_NRD_NRD_1	94	96	PF00675	0.576
CLV_PCSK_FUR_1	92	96	PF00082	0.528
CLV_PCSK_KEX2_1	252	254	PF00082	0.578
CLV_PCSK_KEX2_1	303	305	PF00082	0.488
CLV_PCSK_KEX2_1	4	6	PF00082	0.629
CLV_PCSK_KEX2_1	92	94	PF00082	0.580
CLV_PCSK_SKI1_1	198	202	PF00082	0.394
CLV_PCSK_SKI1_1	224	228	PF00082	0.610
DEG_COP1_1	148	156	PF00400	0.492
DEG_Nend_UBRbox_3	1	3	PF02207	0.604
DEG_SCF_FBW7_2	73	79	PF00400	0.585
DOC_CKS1_1	115	120	PF01111	0.549
DOC_CKS1_1	326	331	PF01111	0.468
DOC_CKS1_1	73	78	PF01111	0.590
DOC_CYCLIN_RxL_1	92	102	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.629
DOC_MAPK_DCC_7	136	144	PF00069	0.516
DOC_MAPK_gen_1	112	121	PF00069	0.483
DOC_MAPK_gen_1	351	360	PF00069	0.396
DOC_MAPK_gen_1	92	99	PF00069	0.630
DOC_PP2B_LxvP_1	434	437	PF13499	0.622
DOC_PP2B_LxvP_1	438	441	PF13499	0.596
DOC_USP7_MATH_1	122	126	PF00917	0.658
DOC_USP7_MATH_1	163	167	PF00917	0.472
DOC_USP7_MATH_1	216	220	PF00917	0.588
DOC_USP7_MATH_1	271	275	PF00917	0.435
DOC_USP7_MATH_1	399	403	PF00917	0.559
DOC_USP7_MATH_1	8	12	PF00917	0.621
DOC_USP7_MATH_2	143	149	PF00917	0.583
DOC_USP7_UBL2_3	190	194	PF12436	0.423
DOC_USP7_UBL2_3	423	427	PF12436	0.591
DOC_USP7_UBL2_3	60	64	PF12436	0.623
DOC_WW_Pin1_4	114	119	PF00397	0.681
DOC_WW_Pin1_4	259	264	PF00397	0.558
DOC_WW_Pin1_4	325	330	PF00397	0.486
DOC_WW_Pin1_4	395	400	PF00397	0.584
DOC_WW_Pin1_4	402	407	PF00397	0.553
DOC_WW_Pin1_4	72	77	PF00397	0.706
LIG_14-3-3_CanoR_1	114	118	PF00244	0.643
LIG_14-3-3_CanoR_1	127	135	PF00244	0.568
LIG_14-3-3_CanoR_1	173	178	PF00244	0.447
LIG_14-3-3_CanoR_1	193	197	PF00244	0.271
LIG_14-3-3_CanoR_1	383	389	PF00244	0.594
LIG_14-3-3_CanoR_1	69	74	PF00244	0.706
LIG_CSL_BTD_1	438	441	PF09270	0.566
LIG_CtBP_PxDLS_1	118	122	PF00389	0.549
LIG_FHA_1	417	423	PF00498	0.557
LIG_FHA_2	115	121	PF00498	0.632
LIG_FHA_2	244	250	PF00498	0.600
LIG_FHA_2	344	350	PF00498	0.414
LIG_FHA_2	36	42	PF00498	0.631
LIG_GBD_Chelix_1	314	322	PF00786	0.498
LIG_LIR_Apic_2	79	85	PF02991	0.649
LIG_PCNA_yPIPBox_3	40	52	PF02747	0.594
LIG_Pex14_2	280	284	PF04695	0.386
LIG_SH2_NCK_1	17	21	PF00017	0.640
LIG_SH2_NCK_1	27	31	PF00017	0.484
LIG_SH2_STAT3	308	311	PF00017	0.416
LIG_SH2_STAT5	168	171	PF00017	0.477
LIG_SH2_STAT5	308	311	PF00017	0.499
LIG_SH2_STAT5	331	334	PF00017	0.448
LIG_SH2_STAT5	62	65	PF00017	0.778
LIG_SH3_1	151	157	PF00018	0.482
LIG_SH3_3	112	118	PF00018	0.551
LIG_SH3_3	132	138	PF00018	0.772
LIG_SH3_3	151	157	PF00018	0.359
LIG_SH3_3	210	216	PF00018	0.556
LIG_SH3_3	239	245	PF00018	0.568
LIG_SH3_3	317	323	PF00018	0.434
LIG_SH3_3	70	76	PF00018	0.609
LIG_TRFH_1	393	397	PF08558	0.560
MOD_CDC14_SPxK_1	262	265	PF00782	0.549
MOD_CDK_SPxK_1	259	265	PF00069	0.566
MOD_CDK_SPxK_1	72	78	PF00069	0.706
MOD_CK1_1	219	225	PF00069	0.632
MOD_CK1_1	28	34	PF00069	0.621
MOD_CK1_1	370	376	PF00069	0.486
MOD_CK1_1	400	406	PF00069	0.679
MOD_CK1_1	410	416	PF00069	0.535
MOD_CK1_1	72	78	PF00069	0.674
MOD_CK2_1	114	120	PF00069	0.633
MOD_CK2_1	243	249	PF00069	0.604
MOD_CK2_1	343	349	PF00069	0.375
MOD_CK2_1	35	41	PF00069	0.636
MOD_DYRK1A_RPxSP_1	114	118	PF00069	0.548
MOD_GlcNHglycan	124	127	PF01048	0.646
MOD_GlcNHglycan	147	150	PF01048	0.611
MOD_GlcNHglycan	17	20	PF01048	0.632
MOD_GlcNHglycan	370	373	PF01048	0.538
MOD_GSK3_1	163	170	PF00069	0.469
MOD_GSK3_1	364	371	PF00069	0.489
MOD_GSK3_1	395	402	PF00069	0.568
MOD_GSK3_1	407	414	PF00069	0.565
MOD_GSK3_1	9	16	PF00069	0.533
MOD_GSK3_1	95	102	PF00069	0.660
MOD_LATS_1	381	387	PF00433	0.532
MOD_N-GLC_1	340	345	PF02516	0.412
MOD_NEK2_1	129	134	PF00069	0.688
MOD_NEK2_1	147	152	PF00069	0.420
MOD_NEK2_1	407	412	PF00069	0.677
MOD_NEK2_2	35	40	PF00069	0.735
MOD_PIKK_1	271	277	PF00454	0.416
MOD_PIKK_1	343	349	PF00454	0.394
MOD_PK_1	173	179	PF00069	0.498
MOD_PK_1	69	75	PF00069	0.590
MOD_PKA_1	351	357	PF00069	0.397
MOD_PKA_2	113	119	PF00069	0.539
MOD_PKA_2	192	198	PF00069	0.454
MOD_PKA_2	243	249	PF00069	0.790
MOD_PKA_2	302	308	PF00069	0.494
MOD_PKB_1	171	179	PF00069	0.494
MOD_PKB_1	93	101	PF00069	0.580
MOD_Plk_1	95	101	PF00069	0.658
MOD_Plk_4	163	169	PF00069	0.469
MOD_Plk_4	192	198	PF00069	0.404
MOD_Plk_4	364	370	PF00069	0.491
MOD_Plk_4	47	53	PF00069	0.555
MOD_ProDKin_1	114	120	PF00069	0.679
MOD_ProDKin_1	259	265	PF00069	0.562
MOD_ProDKin_1	325	331	PF00069	0.478
MOD_ProDKin_1	395	401	PF00069	0.587
MOD_ProDKin_1	402	408	PF00069	0.554
MOD_ProDKin_1	72	78	PF00069	0.706
MOD_SUMO_rev_2	155	163	PF00179	0.488
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.580
TRG_ER_diArg_1	252	254	PF00400	0.578
TRG_ER_diArg_1	3	5	PF00400	0.647
TRG_ER_diArg_1	303	306	PF00400	0.497
TRG_ER_diArg_1	52	55	PF00400	0.533
TRG_ER_diArg_1	91	94	PF00400	0.608
TRG_NES_CRM1_1	275	287	PF08389	0.439
TRG_NES_CRM1_1	325	337	PF08389	0.466
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3E0	Leptomonas seymouri	44%	92%
A0A3S5H708	Leishmania donovani	98%	100%
E9AR34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QEC9	Leishmania major	83%	99%