LeishMANIAdb
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Str_synth domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Str_synth domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HXD7_LEIIN
TriTrypDb:
LINF_170012600
Length:
388

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXD7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXD7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016491 oxidoreductase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 234 236 PF00675 0.590
CLV_PCSK_KEX2_1 234 236 PF00082 0.587
CLV_PCSK_KEX2_1 99 101 PF00082 0.423
CLV_PCSK_PC1ET2_1 99 101 PF00082 0.423
CLV_PCSK_SKI1_1 138 142 PF00082 0.407
CLV_PCSK_SKI1_1 28 32 PF00082 0.481
CLV_PCSK_SKI1_1 313 317 PF00082 0.421
CLV_PCSK_SKI1_1 376 380 PF00082 0.424
CLV_Separin_Metazoa 383 387 PF03568 0.378
DEG_APCC_DBOX_1 233 241 PF00400 0.590
DEG_APCC_DBOX_1 375 383 PF00400 0.377
DEG_SPOP_SBC_1 243 247 PF00917 0.557
DOC_CYCLIN_RxL_1 25 33 PF00134 0.446
DOC_CYCLIN_yCln2_LP_2 226 232 PF00134 0.464
DOC_CYCLIN_yCln2_LP_2 264 270 PF00134 0.435
DOC_MAPK_gen_1 194 203 PF00069 0.448
DOC_MAPK_MEF2A_6 194 203 PF00069 0.448
DOC_PP1_RVXF_1 136 143 PF00149 0.409
DOC_PP2B_LxvP_1 226 229 PF13499 0.451
DOC_PP4_FxxP_1 116 119 PF00568 0.629
DOC_SPAK_OSR1_1 196 200 PF12202 0.447
DOC_USP7_MATH_1 181 185 PF00917 0.533
DOC_USP7_MATH_1 243 247 PF00917 0.627
DOC_USP7_UBL2_3 215 219 PF12436 0.468
DOC_USP7_UBL2_3 363 367 PF12436 0.489
LIG_14-3-3_CanoR_1 182 186 PF00244 0.452
LIG_14-3-3_CanoR_1 296 302 PF00244 0.492
LIG_APCC_ABBA_1 6 11 PF00400 0.425
LIG_BIR_II_1 1 5 PF00653 0.505
LIG_BIR_III_4 287 291 PF00653 0.459
LIG_BIR_III_4 81 85 PF00653 0.468
LIG_deltaCOP1_diTrp_1 78 85 PF00928 0.481
LIG_FHA_1 155 161 PF00498 0.485
LIG_FHA_1 31 37 PF00498 0.418
LIG_FHA_1 364 370 PF00498 0.477
LIG_FHA_2 175 181 PF00498 0.493
LIG_FHA_2 200 206 PF00498 0.405
LIG_FHA_2 257 263 PF00498 0.485
LIG_FHA_2 378 384 PF00498 0.354
LIG_Integrin_isoDGR_2 136 138 PF01839 0.439
LIG_Integrin_RGD_1 21 23 PF01839 0.502
LIG_Integrin_RGD_1 284 286 PF01839 0.490
LIG_LIR_Apic_2 113 119 PF02991 0.626
LIG_LYPXL_yS_3 121 124 PF13949 0.423
LIG_REV1ctd_RIR_1 139 149 PF16727 0.444
LIG_REV1ctd_RIR_1 209 216 PF16727 0.451
LIG_SH2_CRK 348 352 PF00017 0.408
LIG_SH2_STAT3 230 233 PF00017 0.444
LIG_SH2_STAT5 231 234 PF00017 0.453
LIG_SH2_STAT5 278 281 PF00017 0.458
LIG_SH2_STAT5 350 353 PF00017 0.445
LIG_SH3_3 116 122 PF00018 0.558
LIG_SH3_3 248 254 PF00018 0.539
LIG_SH3_3 84 90 PF00018 0.447
LIG_SUMO_SIM_anti_2 256 262 PF11976 0.482
LIG_SUMO_SIM_anti_2 266 276 PF11976 0.346
LIG_SUMO_SIM_anti_2 380 386 PF11976 0.357
LIG_SUMO_SIM_par_1 256 262 PF11976 0.482
LIG_TRAF2_1 177 180 PF00917 0.554
LIG_UBA3_1 210 219 PF00899 0.412
MOD_CK2_1 174 180 PF00069 0.545
MOD_CK2_1 181 187 PF00069 0.486
MOD_CK2_1 199 205 PF00069 0.232
MOD_CK2_1 243 249 PF00069 0.616
MOD_CK2_1 377 383 PF00069 0.355
MOD_GlcNHglycan 23 27 PF01048 0.488
MOD_GlcNHglycan 304 307 PF01048 0.489
MOD_GlcNHglycan 44 48 PF01048 0.478
MOD_GSK3_1 101 108 PF00069 0.470
MOD_GSK3_1 22 29 PF00069 0.504
MOD_GSK3_1 238 245 PF00069 0.587
MOD_N-GLC_1 243 248 PF02516 0.556
MOD_NEK2_1 124 129 PF00069 0.387
MOD_NEK2_1 13 18 PF00069 0.423
MOD_NEK2_1 30 35 PF00069 0.309
MOD_NEK2_1 43 48 PF00069 0.322
MOD_NEK2_2 26 31 PF00069 0.464
MOD_PKA_2 110 116 PF00069 0.578
MOD_PKA_2 181 187 PF00069 0.440
MOD_Plk_1 13 19 PF00069 0.460
MOD_Plk_1 43 49 PF00069 0.479
MOD_Plk_2-3 174 180 PF00069 0.515
MOD_Plk_2-3 187 193 PF00069 0.381
MOD_Plk_4 181 187 PF00069 0.521
MOD_Plk_4 253 259 PF00069 0.469
MOD_Plk_4 26 32 PF00069 0.490
MOD_SUMO_rev_2 248 257 PF00179 0.486
MOD_SUMO_rev_2 44 54 PF00179 0.390
TRG_DiLeu_BaEn_1 266 271 PF01217 0.438
TRG_DiLeu_BaEn_1 312 317 PF01217 0.432
TRG_DiLeu_LyEn_5 159 164 PF01217 0.457
TRG_ENDOCYTIC_2 121 124 PF00928 0.423
TRG_ENDOCYTIC_2 348 351 PF00928 0.478

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ICT3 Leishmania donovani 99% 100%
A0A3Q8IJF2 Leishmania donovani 100% 100%
A4H906 Leishmania braziliensis 76% 100%
E9AR32 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
N4WEA4 Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T) 30% 82%
Q4QED1 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS