Acyl-CoA-binding domain-containing protein 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyl CoA binding protein - putative

Species:

Leishmania infantum

UniProt:

A4HXD5_LEIIN

TriTrypDb:

LINF_170012400

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXD5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	7
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0008289	lipid binding	2	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0033218	amide binding	2	7
GO:0036094	small molecule binding	2	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0120227	acyl-CoA binding	3	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:1901567	fatty acid derivative binding	3	7
GO:1901681	sulfur compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.611
CLV_C14_Caspase3-7	41	45	PF00656	0.436
CLV_NRD_NRD_1	100	102	PF00675	0.411
CLV_NRD_NRD_1	123	125	PF00675	0.539
CLV_NRD_NRD_1	326	328	PF00675	0.744
CLV_NRD_NRD_1	338	340	PF00675	0.696
CLV_NRD_NRD_1	47	49	PF00675	0.513
CLV_NRD_NRD_1	8	10	PF00675	0.591
CLV_PCSK_FUR_1	327	331	PF00082	0.742
CLV_PCSK_KEX2_1	227	229	PF00082	0.411
CLV_PCSK_KEX2_1	268	270	PF00082	0.730
CLV_PCSK_KEX2_1	329	331	PF00082	0.648
CLV_PCSK_KEX2_1	337	339	PF00082	0.647
CLV_PCSK_KEX2_1	494	496	PF00082	0.681
CLV_PCSK_KEX2_1	8	10	PF00082	0.595
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.411
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.730
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.650
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.611
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.677
CLV_PCSK_SKI1_1	104	108	PF00082	0.513
CLV_PCSK_SKI1_1	173	177	PF00082	0.389
CLV_PCSK_SKI1_1	232	236	PF00082	0.504
CLV_PCSK_SKI1_1	264	268	PF00082	0.635
CLV_PCSK_SKI1_1	494	498	PF00082	0.651
CLV_PCSK_SKI1_1	71	75	PF00082	0.387
DEG_Nend_Nbox_1	1	3	PF02207	0.754
DEG_SPOP_SBC_1	432	436	PF00917	0.678
DOC_CDC14_PxL_1	437	445	PF14671	0.507
DOC_CKS1_1	184	189	PF01111	0.513
DOC_MAPK_gen_1	108	116	PF00069	0.389
DOC_MAPK_gen_1	465	472	PF00069	0.588
DOC_MAPK_MEF2A_6	110	118	PF00069	0.401
DOC_MAPK_MEF2A_6	465	472	PF00069	0.588
DOC_PP1_RVXF_1	137	144	PF00149	0.637
DOC_PP1_RVXF_1	61	67	PF00149	0.411
DOC_PP4_FxxP_1	29	32	PF00568	0.578
DOC_USP7_MATH_1	305	309	PF00917	0.661
DOC_USP7_MATH_1	408	412	PF00917	0.584
DOC_USP7_MATH_1	450	454	PF00917	0.774
DOC_USP7_MATH_1	457	461	PF00917	0.657
DOC_USP7_MATH_1	477	481	PF00917	0.638
DOC_USP7_UBL2_3	232	236	PF12436	0.606
DOC_USP7_UBL2_3	264	268	PF12436	0.737
DOC_USP7_UBL2_3	329	333	PF12436	0.693
DOC_USP7_UBL2_3	471	475	PF12436	0.728
DOC_USP7_UBL2_3	484	488	PF12436	0.665
DOC_WW_Pin1_4	183	188	PF00397	0.513
DOC_WW_Pin1_4	435	440	PF00397	0.696
LIG_14-3-3_CanoR_1	124	130	PF00244	0.686
LIG_BIR_III_4	292	296	PF00653	0.624
LIG_BRCT_BRCA1_1	21	25	PF00533	0.648
LIG_deltaCOP1_diTrp_1	137	143	PF00928	0.539
LIG_deltaCOP1_diTrp_1	90	95	PF00928	0.411
LIG_FHA_2	268	274	PF00498	0.608
LIG_FHA_2	284	290	PF00498	0.605
LIG_FHA_2	308	314	PF00498	0.620
LIG_FHA_2	364	370	PF00498	0.798
LIG_FHA_2	387	393	PF00498	0.661
LIG_FHA_2	72	78	PF00498	0.411
LIG_KLC1_Yacidic_2	113	117	PF13176	0.347
LIG_LIR_Apic_2	128	134	PF02991	0.714
LIG_LIR_Apic_2	28	32	PF02991	0.579
LIG_LIR_Gen_1	113	123	PF02991	0.411
LIG_LIR_Gen_1	137	147	PF02991	0.529
LIG_LIR_Gen_1	213	221	PF02991	0.411
LIG_LIR_Gen_1	344	353	PF02991	0.569
LIG_LIR_Nem_3	11	17	PF02991	0.680
LIG_LIR_Nem_3	113	118	PF02991	0.411
LIG_LIR_Nem_3	137	143	PF02991	0.539
LIG_LIR_Nem_3	192	198	PF02991	0.413
LIG_LIR_Nem_3	213	218	PF02991	0.411
LIG_LIR_Nem_3	344	348	PF02991	0.564
LIG_LIR_Nem_3	90	94	PF02991	0.411
LIG_MAD2	454	462	PF02301	0.687
LIG_MYND_3	440	444	PF01753	0.625
LIG_Pex14_2	25	29	PF04695	0.595
LIG_Pex14_2	66	70	PF04695	0.513
LIG_REV1ctd_RIR_1	3	11	PF16727	0.644
LIG_SH2_NCK_1	36	40	PF00017	0.513
LIG_SH2_PTP2	115	118	PF00017	0.383
LIG_SH2_PTP2	345	348	PF00017	0.564
LIG_SH2_STAP1	212	216	PF00017	0.411
LIG_SH2_STAP1	36	40	PF00017	0.513
LIG_SH2_STAT5	115	118	PF00017	0.411
LIG_SH2_STAT5	159	162	PF00017	0.329
LIG_SH2_STAT5	230	233	PF00017	0.411
LIG_SH2_STAT5	243	246	PF00017	0.573
LIG_SH2_STAT5	345	348	PF00017	0.752
LIG_SH2_STAT5	46	49	PF00017	0.411
LIG_SH3_3	14	20	PF00018	0.709
LIG_SH3_3	241	247	PF00018	0.574
LIG_SH3_3	29	35	PF00018	0.503
LIG_SH3_3	351	357	PF00018	0.582
LIG_SH3_3	79	85	PF00018	0.415
LIG_TRAF2_1	286	289	PF00917	0.685
LIG_TRAF2_1	320	323	PF00917	0.673
LIG_TRAF2_1	39	42	PF00917	0.436
LIG_UBA3_1	149	155	PF00899	0.472
LIG_ULM_U2AF65_1	193	198	PF00076	0.338
LIG_WRC_WIRS_1	2	7	PF05994	0.610
LIG_WRC_WIRS_1	306	311	PF05994	0.676
MOD_CDK_SPxxK_3	435	442	PF00069	0.583
MOD_CK1_1	200	206	PF00069	0.397
MOD_CK1_1	262	268	PF00069	0.716
MOD_CK1_1	359	365	PF00069	0.714
MOD_CK2_1	283	289	PF00069	0.699
MOD_CK2_1	296	302	PF00069	0.434
MOD_CK2_1	307	313	PF00069	0.554
MOD_CK2_1	363	369	PF00069	0.814
MOD_CK2_1	455	461	PF00069	0.744
MOD_Cter_Amidation	325	328	PF01082	0.656
MOD_Cter_Amidation	6	9	PF01082	0.752
MOD_GlcNHglycan	134	137	PF01048	0.680
MOD_GlcNHglycan	236	239	PF01048	0.545
MOD_GlcNHglycan	261	264	PF01048	0.623
MOD_GlcNHglycan	410	413	PF01048	0.692
MOD_GlcNHglycan	419	422	PF01048	0.710
MOD_GlcNHglycan	444	448	PF01048	0.730
MOD_GSK3_1	258	265	PF00069	0.640
MOD_GSK3_1	356	363	PF00069	0.757
MOD_GSK3_1	428	435	PF00069	0.655
MOD_N-GLC_1	178	183	PF02516	0.389
MOD_N-GLC_2	398	400	PF02516	0.678
MOD_NEK2_1	1	6	PF00069	0.604
MOD_NEK2_1	443	448	PF00069	0.695
MOD_PKA_1	267	273	PF00069	0.610
MOD_PKA_2	200	206	PF00069	0.438
MOD_Plk_1	363	369	PF00069	0.758
MOD_Plk_1	428	434	PF00069	0.617
MOD_Plk_4	1	7	PF00069	0.624
MOD_Plk_4	125	131	PF00069	0.593
MOD_Plk_4	19	25	PF00069	0.586
MOD_Plk_4	296	302	PF00069	0.669
MOD_Plk_4	341	347	PF00069	0.558
MOD_Plk_4	65	71	PF00069	0.390
MOD_Plk_4	83	89	PF00069	0.411
MOD_ProDKin_1	183	189	PF00069	0.513
MOD_ProDKin_1	435	441	PF00069	0.696
MOD_SUMO_for_1	357	360	PF00179	0.734
MOD_SUMO_for_1	441	444	PF00179	0.664
MOD_SUMO_for_1	464	467	PF00179	0.677
MOD_SUMO_rev_2	11	17	PF00179	0.638
MOD_SUMO_rev_2	75	85	PF00179	0.417
TRG_ENDOCYTIC_2	115	118	PF00928	0.411
TRG_ENDOCYTIC_2	195	198	PF00928	0.411
TRG_ENDOCYTIC_2	345	348	PF00928	0.564
TRG_ENDOCYTIC_2	67	70	PF00928	0.472
TRG_ENDOCYTIC_2	94	97	PF00928	0.513
TRG_ER_diArg_1	198	201	PF00400	0.393
TRG_NES_CRM1_1	289	302	PF08389	0.606
TRG_NLS_Bipartite_1	327	341	PF00514	0.614
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	382	387	PF00026	0.739

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F7	Leptomonas seymouri	46%	100%
A0A3Q8IDY9	Leishmania donovani	100%	100%
A4H904	Leishmania braziliensis	69%	99%
E9AR30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QED3	Leishmania major	91%	100%