Tetratricopeptide repeat protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXD0_LEIIN

TriTrypDb:

LINF_170011900

Length:

221

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXD0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.503
CLV_NRD_NRD_1	10	12	PF00675	0.671
CLV_NRD_NRD_1	58	60	PF00675	0.691
CLV_PCSK_KEX2_1	10	12	PF00082	0.671
CLV_PCSK_KEX2_1	58	60	PF00082	0.628
CLV_PCSK_SKI1_1	132	136	PF00082	0.531
CLV_PCSK_SKI1_1	59	63	PF00082	0.522
DOC_MAPK_gen_1	58	64	PF00069	0.625
DOC_PP2B_LxvP_1	6	9	PF13499	0.778
DOC_USP7_MATH_1	12	16	PF00917	0.614
DOC_USP7_MATH_1	47	51	PF00917	0.684
DOC_USP7_MATH_1	86	90	PF00917	0.605
DOC_WW_Pin1_4	1	6	PF00397	0.734
DOC_WW_Pin1_4	75	80	PF00397	0.676
LIG_14-3-3_CanoR_1	10	20	PF00244	0.717
LIG_14-3-3_CanoR_1	139	148	PF00244	0.472
LIG_14-3-3_CanoR_1	178	187	PF00244	0.489
LIG_14-3-3_CanoR_1	192	199	PF00244	0.329
LIG_14-3-3_CanoR_1	85	95	PF00244	0.600
LIG_Actin_WH2_2	24	40	PF00022	0.600
LIG_BIR_III_2	125	129	PF00653	0.539
LIG_BRCT_BRCA1_1	141	145	PF00533	0.466
LIG_BRCT_BRCA1_1	193	197	PF00533	0.512
LIG_deltaCOP1_diTrp_1	191	197	PF00928	0.489
LIG_FHA_1	107	113	PF00498	0.545
LIG_GBD_Chelix_1	140	148	PF00786	0.567
LIG_LIR_Gen_1	174	183	PF02991	0.461
LIG_LIR_Nem_3	142	148	PF02991	0.444
LIG_LIR_Nem_3	170	176	PF02991	0.473
LIG_MYND_3	198	202	PF01753	0.568
LIG_NRBOX	15	21	PF00104	0.585
LIG_PCNA_PIPBox_1	137	146	PF02747	0.589
LIG_PCNA_yPIPBox_3	10	20	PF02747	0.617
LIG_Pex14_1	193	197	PF04695	0.478
LIG_Rb_pABgroove_1	139	147	PF01858	0.475
LIG_SH2_CRK	124	128	PF00017	0.531
LIG_SH2_STAP1	176	180	PF00017	0.497
LIG_SH2_STAT5	27	30	PF00017	0.493
LIG_SH3_3	20	26	PF00018	0.564
LIG_TRAF2_1	128	131	PF00917	0.637
LIG_TRAF2_1	165	168	PF00917	0.526
MOD_CK1_1	4	10	PF00069	0.672
MOD_CK2_1	162	168	PF00069	0.545
MOD_CK2_1	171	177	PF00069	0.502
MOD_CK2_1	86	92	PF00069	0.598
MOD_GlcNHglycan	118	121	PF01048	0.537
MOD_GlcNHglycan	151	154	PF01048	0.468
MOD_GlcNHglycan	180	183	PF01048	0.559
MOD_GlcNHglycan	193	196	PF01048	0.374
MOD_GlcNHglycan	49	52	PF01048	0.691
MOD_GlcNHglycan	89	92	PF01048	0.608
MOD_N-GLC_1	106	111	PF02516	0.624
MOD_NEK2_2	171	176	PF00069	0.562
MOD_PIKK_1	80	86	PF00454	0.747
MOD_PKA_2	191	197	PF00069	0.480
MOD_Plk_1	130	136	PF00069	0.573
MOD_ProDKin_1	1	7	PF00069	0.732
MOD_ProDKin_1	75	81	PF00069	0.672
MOD_SUMO_rev_2	110	120	PF00179	0.642
MOD_SUMO_rev_2	125	134	PF00179	0.461
TRG_DiLeu_BaEn_4	130	136	PF01217	0.538
TRG_ENDOCYTIC_2	124	127	PF00928	0.547
TRG_ENDOCYTIC_2	176	179	PF00928	0.568
TRG_ER_diArg_1	57	59	PF00400	0.676
TRG_ER_diArg_1	9	11	PF00400	0.770
TRG_NES_CRM1_1	146	161	PF08389	0.597
TRG_NES_CRM1_1	196	209	PF08389	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6A6	Leptomonas seymouri	66%	79%
A0A3S5H706	Leishmania donovani	99%	100%
A4H8Z9	Leishmania braziliensis	81%	100%
E9AR25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QED8	Leishmania major	94%	100%