Putative RNA-binding protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein - putative

Species:

Leishmania infantum

UniProt:

A4HXC9_LEIIN

TriTrypDb:

LINF_170011800

Length:

295

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA-binding

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXC9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.645
CLV_NRD_NRD_1	131	133	PF00675	0.483
CLV_NRD_NRD_1	146	148	PF00675	0.725
CLV_PCSK_FUR_1	92	96	PF00082	0.662
CLV_PCSK_KEX2_1	131	133	PF00082	0.611
CLV_PCSK_KEX2_1	146	148	PF00082	0.586
CLV_PCSK_KEX2_1	41	43	PF00082	0.598
CLV_PCSK_KEX2_1	94	96	PF00082	0.754
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.598
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.749
CLV_PCSK_SKI1_1	42	46	PF00082	0.482
DEG_APCC_DBOX_1	243	251	PF00400	0.513
DEG_APCC_DBOX_1	60	68	PF00400	0.530
DEG_COP1_1	130	139	PF00400	0.540
DEG_Nend_UBRbox_2	1	3	PF02207	0.512
DOC_CYCLIN_yClb3_PxF_3	204	210	PF00134	0.677
DOC_MAPK_gen_1	41	49	PF00069	0.457
DOC_MAPK_MEF2A_6	244	253	PF00069	0.534
DOC_MAPK_MEF2A_6	284	293	PF00069	0.486
DOC_MAPK_MEF2A_6	42	51	PF00069	0.442
DOC_PP2B_LxvP_1	180	183	PF13499	0.574
DOC_PP2B_LxvP_1	197	200	PF13499	0.612
DOC_PP4_FxxP_1	186	189	PF00568	0.748
DOC_PP4_FxxP_1	253	256	PF00568	0.562
DOC_USP7_MATH_1	165	169	PF00917	0.571
DOC_USP7_MATH_1	30	34	PF00917	0.484
DOC_USP7_UBL2_3	37	41	PF12436	0.536
DOC_WW_Pin1_4	77	82	PF00397	0.745
LIG_14-3-3_CanoR_1	11	18	PF00244	0.560
LIG_BIR_III_2	65	69	PF00653	0.531
LIG_EVH1_2	182	186	PF00568	0.577
LIG_FHA_1	280	286	PF00498	0.486
LIG_FHA_1	44	50	PF00498	0.471
LIG_FHA_2	138	144	PF00498	0.551
LIG_FHA_2	19	25	PF00498	0.526
LIG_FHA_2	48	54	PF00498	0.548
LIG_LIR_Gen_1	113	120	PF02991	0.665
LIG_LIR_Gen_1	12	22	PF02991	0.460
LIG_LIR_Gen_1	231	240	PF02991	0.546
LIG_LIR_Gen_1	45	56	PF02991	0.429
LIG_LIR_Nem_3	113	117	PF02991	0.653
LIG_LIR_Nem_3	12	18	PF02991	0.457
LIG_LIR_Nem_3	231	236	PF02991	0.472
LIG_LIR_Nem_3	24	28	PF02991	0.418
LIG_LIR_Nem_3	45	51	PF02991	0.413
LIG_MYND_1	205	209	PF01753	0.640
LIG_PROFILIN_1	199	205	PF00235	0.550
LIG_PTB_Apo_2	216	223	PF02174	0.496
LIG_SH2_STAT3	120	123	PF00017	0.680
LIG_SH2_STAT5	228	231	PF00017	0.529
LIG_SH3_2	201	206	PF14604	0.600
LIG_SH3_3	196	202	PF00018	0.671
LIG_SH3_3	280	286	PF00018	0.433
LIG_SH3_CIN85_PxpxPR_1	201	206	PF14604	0.600
LIG_SUMO_SIM_anti_2	246	251	PF11976	0.534
LIG_SUMO_SIM_par_1	273	280	PF11976	0.561
LIG_TRAF2_1	81	84	PF00917	0.747
LIG_WRC_WIRS_1	31	36	PF05994	0.587
LIG_WRC_WIRS_1	48	53	PF05994	0.543
LIG_WW_3	203	207	PF00397	0.656
MOD_CK1_1	279	285	PF00069	0.445
MOD_CK1_1	9	15	PF00069	0.550
MOD_CK1_1	93	99	PF00069	0.765
MOD_CK2_1	13	19	PF00069	0.505
MOD_CK2_1	137	143	PF00069	0.551
MOD_CK2_1	30	36	PF00069	0.458
MOD_GlcNHglycan	15	18	PF01048	0.556
MOD_GlcNHglycan	233	236	PF01048	0.358
MOD_GlcNHglycan	279	282	PF01048	0.429
MOD_GlcNHglycan	77	80	PF01048	0.645
MOD_GlcNHglycan	88	91	PF01048	0.674
MOD_GSK3_1	102	109	PF00069	0.651
MOD_GSK3_1	137	144	PF00069	0.734
MOD_GSK3_1	43	50	PF00069	0.532
MOD_GSK3_1	5	12	PF00069	0.544
MOD_GSK3_1	84	91	PF00069	0.711
MOD_N-GLC_1	159	164	PF02516	0.722
MOD_N-GLC_1	266	271	PF02516	0.383
MOD_NEK2_1	222	227	PF00069	0.562
MOD_NEK2_1	266	271	PF00069	0.586
MOD_NEK2_1	5	10	PF00069	0.538
MOD_NEK2_2	30	35	PF00069	0.489
MOD_PIKK_1	93	99	PF00454	0.581
MOD_PKA_2	10	16	PF00069	0.592
MOD_PKA_2	130	136	PF00069	0.706
MOD_Plk_1	18	24	PF00069	0.511
MOD_Plk_1	42	48	PF00069	0.488
MOD_Plk_4	43	49	PF00069	0.472
MOD_ProDKin_1	77	83	PF00069	0.750
MOD_SUMO_rev_2	105	110	PF00179	0.717
TRG_ER_diArg_1	146	149	PF00400	0.737
TRG_ER_diArg_1	172	175	PF00400	0.743
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZY5	Leptomonas seymouri	52%	100%
A0A1X0P0T6	Trypanosomatidae	36%	100%
A0A3Q8IAN2	Leishmania donovani	98%	98%
A0A3R7MFN4	Trypanosoma rangeli	36%	100%
A4H8Z8	Leishmania braziliensis	76%	100%
D0A4S0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AR24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QED9	Leishmania major	94%	100%
V5AZY6	Trypanosoma cruzi	37%	100%