Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXC7_LEIIN

TriTrypDb:

LINF_170011600

Length:

1064

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	495	499	PF00656	0.734
CLV_MEL_PAP_1	125	131	PF00089	0.509
CLV_NRD_NRD_1	447	449	PF00675	0.836
CLV_NRD_NRD_1	563	565	PF00675	0.814
CLV_NRD_NRD_1	60	62	PF00675	0.802
CLV_NRD_NRD_1	642	644	PF00675	0.574
CLV_NRD_NRD_1	75	77	PF00675	0.587
CLV_NRD_NRD_1	90	92	PF00675	0.694
CLV_NRD_NRD_1	990	992	PF00675	0.803
CLV_PCSK_FUR_1	445	449	PF00082	0.778
CLV_PCSK_KEX2_1	447	449	PF00082	0.836
CLV_PCSK_KEX2_1	563	565	PF00082	0.814
CLV_PCSK_KEX2_1	60	62	PF00082	0.802
CLV_PCSK_KEX2_1	642	644	PF00082	0.574
CLV_PCSK_KEX2_1	723	725	PF00082	0.632
CLV_PCSK_KEX2_1	75	77	PF00082	0.587
CLV_PCSK_KEX2_1	90	92	PF00082	0.694
CLV_PCSK_KEX2_1	952	954	PF00082	0.609
CLV_PCSK_KEX2_1	989	991	PF00082	0.800
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.632
CLV_PCSK_PC1ET2_1	952	954	PF00082	0.553
CLV_PCSK_PC7_1	443	449	PF00082	0.795
CLV_PCSK_PC7_1	86	92	PF00082	0.639
CLV_PCSK_SKI1_1	155	159	PF00082	0.579
CLV_PCSK_SKI1_1	221	225	PF00082	0.636
CLV_PCSK_SKI1_1	516	520	PF00082	0.818
CLV_PCSK_SKI1_1	538	542	PF00082	0.776
CLV_PCSK_SKI1_1	662	666	PF00082	0.556
CLV_PCSK_SKI1_1	741	745	PF00082	0.642
CLV_PCSK_SKI1_1	842	846	PF00082	0.633
CLV_PCSK_SKI1_1	888	892	PF00082	0.639
CLV_PCSK_SKI1_1	994	998	PF00082	0.720
DEG_APCC_DBOX_1	758	766	PF00400	0.583
DEG_APCC_DBOX_1	802	810	PF00400	0.637
DEG_SCF_FBW7_1	16	23	PF00400	0.772
DEG_SCF_FBW7_1	465	471	PF00400	0.824
DEG_SPOP_SBC_1	11	15	PF00917	0.771
DEG_SPOP_SBC_1	595	599	PF00917	0.757
DOC_ANK_TNKS_1	747	754	PF00023	0.453
DOC_CKS1_1	465	470	PF01111	0.826
DOC_CKS1_1	624	629	PF01111	0.727
DOC_CYCLIN_RxL_1	152	162	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	388	394	PF00134	0.633
DOC_MAPK_gen_1	188	196	PF00069	0.596
DOC_MAPK_gen_1	485	494	PF00069	0.817
DOC_MAPK_gen_1	652	660	PF00069	0.428
DOC_MAPK_gen_1	952	959	PF00069	0.599
DOC_MAPK_MEF2A_6	221	228	PF00069	0.646
DOC_PP2B_LxvP_1	309	312	PF13499	0.636
DOC_USP7_MATH_1	1035	1039	PF00917	0.599
DOC_USP7_MATH_1	146	150	PF00917	0.699
DOC_USP7_MATH_1	20	24	PF00917	0.660
DOC_USP7_MATH_1	255	259	PF00917	0.816
DOC_USP7_MATH_1	272	276	PF00917	0.465
DOC_USP7_MATH_1	279	283	PF00917	0.658
DOC_USP7_MATH_1	285	289	PF00917	0.639
DOC_USP7_MATH_1	33	37	PF00917	0.620
DOC_USP7_MATH_1	397	401	PF00917	0.699
DOC_USP7_MATH_1	460	464	PF00917	0.849
DOC_USP7_MATH_1	468	472	PF00917	0.737
DOC_USP7_MATH_1	757	761	PF00917	0.608
DOC_USP7_MATH_1	770	774	PF00917	0.527
DOC_USP7_MATH_1	847	851	PF00917	0.468
DOC_USP7_MATH_1	872	876	PF00917	0.445
DOC_USP7_MATH_1	9	13	PF00917	0.795
DOC_USP7_MATH_1	970	974	PF00917	0.674
DOC_USP7_UBL2_3	952	956	PF12436	0.549
DOC_WW_Pin1_4	1014	1019	PF00397	0.791
DOC_WW_Pin1_4	1058	1063	PF00397	0.669
DOC_WW_Pin1_4	144	149	PF00397	0.717
DOC_WW_Pin1_4	16	21	PF00397	0.666
DOC_WW_Pin1_4	281	286	PF00397	0.793
DOC_WW_Pin1_4	341	346	PF00397	0.805
DOC_WW_Pin1_4	351	356	PF00397	0.655
DOC_WW_Pin1_4	370	375	PF00397	0.536
DOC_WW_Pin1_4	377	382	PF00397	0.749
DOC_WW_Pin1_4	390	395	PF00397	0.553
DOC_WW_Pin1_4	406	411	PF00397	0.826
DOC_WW_Pin1_4	464	469	PF00397	0.844
DOC_WW_Pin1_4	527	532	PF00397	0.849
DOC_WW_Pin1_4	597	602	PF00397	0.840
DOC_WW_Pin1_4	623	628	PF00397	0.681
DOC_WW_Pin1_4	67	72	PF00397	0.769
DOC_WW_Pin1_4	7	12	PF00397	0.716
DOC_WW_Pin1_4	74	79	PF00397	0.682
DOC_WW_Pin1_4	775	780	PF00397	0.738
LIG_14-3-3_CanoR_1	1058	1062	PF00244	0.718
LIG_14-3-3_CanoR_1	128	137	PF00244	0.687
LIG_14-3-3_CanoR_1	22	28	PF00244	0.776
LIG_14-3-3_CanoR_1	47	54	PF00244	0.771
LIG_14-3-3_CanoR_1	684	692	PF00244	0.582
LIG_14-3-3_CanoR_1	695	704	PF00244	0.424
LIG_14-3-3_CanoR_1	759	763	PF00244	0.579
LIG_14-3-3_CanoR_1	910	918	PF00244	0.575
LIG_14-3-3_CanoR_1	994	1004	PF00244	0.806
LIG_Actin_WH2_2	795	812	PF00022	0.544
LIG_Actin_WH2_2	855	872	PF00022	0.621
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_BRCT_BRCA1_1	125	129	PF00533	0.641
LIG_Clathr_ClatBox_1	733	737	PF01394	0.638
LIG_EVH1_1	291	295	PF00568	0.817
LIG_FHA_1	1047	1053	PF00498	0.654
LIG_FHA_1	114	120	PF00498	0.692
LIG_FHA_1	304	310	PF00498	0.826
LIG_FHA_1	333	339	PF00498	0.734
LIG_FHA_1	465	471	PF00498	0.740
LIG_FHA_1	598	604	PF00498	0.761
LIG_FHA_1	659	665	PF00498	0.590
LIG_FHA_1	889	895	PF00498	0.642
LIG_FHA_2	470	476	PF00498	0.766
LIG_FHA_2	502	508	PF00498	0.764
LIG_FHA_2	624	630	PF00498	0.691
LIG_FHA_2	745	751	PF00498	0.669
LIG_FHA_2	830	836	PF00498	0.606
LIG_FHA_2	880	886	PF00498	0.542
LIG_GBD_Chelix_1	798	806	PF00786	0.574
LIG_IRF3_LxIS_1	1039	1045	PF10401	0.465
LIG_LIR_Apic_2	142	148	PF02991	0.698
LIG_LIR_Apic_2	305	311	PF02991	0.642
LIG_LIR_Apic_2	357	363	PF02991	0.665
LIG_LIR_Gen_1	156	166	PF02991	0.624
LIG_LIR_Gen_1	320	330	PF02991	0.653
LIG_LIR_Gen_1	343	351	PF02991	0.715
LIG_LIR_Gen_1	656	665	PF02991	0.608
LIG_LIR_Nem_3	156	161	PF02991	0.628
LIG_LIR_Nem_3	288	294	PF02991	0.815
LIG_LIR_Nem_3	320	326	PF02991	0.709
LIG_LIR_Nem_3	343	349	PF02991	0.719
LIG_LIR_Nem_3	656	660	PF02991	0.513
LIG_MYND_1	292	296	PF01753	0.811
LIG_PCNA_yPIPBox_3	707	719	PF02747	0.618
LIG_PTB_Apo_2	508	515	PF02174	0.806
LIG_PTB_Phospho_1	508	514	PF10480	0.807
LIG_RPA_C_Fungi	258	270	PF08784	0.674
LIG_SH2_CRK	1036	1040	PF00017	0.652
LIG_SH2_CRK	346	350	PF00017	0.811
LIG_SH2_CRK	360	364	PF00017	0.608
LIG_SH2_CRK	621	625	PF00017	0.723
LIG_SH2_CRK	657	661	PF00017	0.419
LIG_SH2_SRC	200	203	PF00017	0.629
LIG_SH2_STAP1	115	119	PF00017	0.599
LIG_SH2_STAP1	925	929	PF00017	0.618
LIG_SH2_STAT3	619	622	PF00017	0.730
LIG_SH2_STAT5	115	118	PF00017	0.695
LIG_SH2_STAT5	241	244	PF00017	0.666
LIG_SH2_STAT5	308	311	PF00017	0.827
LIG_SH2_STAT5	346	349	PF00017	0.815
LIG_SH2_STAT5	619	622	PF00017	0.730
LIG_SH3_1	308	314	PF00018	0.634
LIG_SH3_1	621	627	PF00018	0.716
LIG_SH3_3	289	295	PF00018	0.799
LIG_SH3_3	308	314	PF00018	0.580
LIG_SH3_3	371	377	PF00018	0.804
LIG_SH3_3	388	394	PF00018	0.587
LIG_SH3_3	481	487	PF00018	0.796
LIG_SH3_3	5	11	PF00018	0.761
LIG_SH3_3	621	627	PF00018	0.748
LIG_SUMO_SIM_par_1	732	737	PF11976	0.640
LIG_TRAF2_1	179	182	PF00917	0.641
LIG_TRAF2_1	354	357	PF00917	0.624
LIG_TRAF2_1	630	633	PF00917	0.666
LIG_TRAF2_1	882	885	PF00917	0.631
LIG_TRAF2_1	896	899	PF00917	0.430
LIG_TRAF2_2	311	316	PF00917	0.624
LIG_TYR_ITIM	655	660	PF00017	0.514
LIG_WW_2	292	295	PF00397	0.812
LIG_WW_3	253	257	PF00397	0.719
MOD_CDC14_SPxK_1	15	18	PF00782	0.683
MOD_CDK_SPxK_1	12	18	PF00069	0.754
MOD_CDK_SPxK_1	74	80	PF00069	0.768
MOD_CDK_SPxxK_3	406	413	PF00069	0.790
MOD_CK1_1	117	123	PF00069	0.735
MOD_CK1_1	127	133	PF00069	0.558
MOD_CK1_1	23	29	PF00069	0.618
MOD_CK1_1	275	281	PF00069	0.694
MOD_CK1_1	344	350	PF00069	0.687
MOD_CK1_1	380	386	PF00069	0.853
MOD_CK1_1	393	399	PF00069	0.632
MOD_CK1_1	464	470	PF00069	0.790
MOD_CK1_1	522	528	PF00069	0.833
MOD_CK1_1	529	535	PF00069	0.719
MOD_CK1_1	602	608	PF00069	0.810
MOD_CK1_1	613	619	PF00069	0.748
MOD_CK1_1	683	689	PF00069	0.580
MOD_CK1_1	7	13	PF00069	0.776
MOD_CK1_1	775	781	PF00069	0.664
MOD_CK1_1	84	90	PF00069	0.805
MOD_CK1_1	854	860	PF00069	0.532
MOD_CK1_1	913	919	PF00069	0.608
MOD_CK2_1	144	150	PF00069	0.684
MOD_CK2_1	350	356	PF00069	0.747
MOD_CK2_1	469	475	PF00069	0.692
MOD_CK2_1	501	507	PF00069	0.765
MOD_CK2_1	623	629	PF00069	0.700
MOD_CK2_1	744	750	PF00069	0.656
MOD_CK2_1	758	764	PF00069	0.442
MOD_CK2_1	829	835	PF00069	0.611
MOD_CK2_1	837	843	PF00069	0.481
MOD_CK2_1	879	885	PF00069	0.551
MOD_CK2_1	893	899	PF00069	0.443
MOD_CK2_1	920	926	PF00069	0.626
MOD_Cter_Amidation	561	564	PF01082	0.768
MOD_DYRK1A_RPxSP_1	1058	1062	PF00069	0.663
MOD_DYRK1A_RPxSP_1	390	394	PF00069	0.757
MOD_GlcNHglycan	1006	1009	PF01048	0.745
MOD_GlcNHglycan	1044	1047	PF01048	0.602
MOD_GlcNHglycan	129	132	PF01048	0.658
MOD_GlcNHglycan	257	260	PF01048	0.741
MOD_GlcNHglycan	274	277	PF01048	0.508
MOD_GlcNHglycan	281	284	PF01048	0.717
MOD_GlcNHglycan	287	290	PF01048	0.646
MOD_GlcNHglycan	349	352	PF01048	0.656
MOD_GlcNHglycan	385	388	PF01048	0.794
MOD_GlcNHglycan	395	398	PF01048	0.689
MOD_GlcNHglycan	399	402	PF01048	0.629
MOD_GlcNHglycan	50	53	PF01048	0.780
MOD_GlcNHglycan	524	527	PF01048	0.834
MOD_GlcNHglycan	543	546	PF01048	0.528
MOD_GlcNHglycan	553	556	PF01048	0.714
MOD_GlcNHglycan	685	688	PF01048	0.589
MOD_GlcNHglycan	772	775	PF01048	0.708
MOD_GlcNHglycan	818	823	PF01048	0.608
MOD_GlcNHglycan	853	856	PF01048	0.511
MOD_GlcNHglycan	86	89	PF01048	0.769
MOD_GlcNHglycan	870	873	PF01048	0.356
MOD_GlcNHglycan	912	915	PF01048	0.605
MOD_GlcNHglycan	974	977	PF01048	0.692
MOD_GSK3_1	1004	1011	PF00069	0.749
MOD_GSK3_1	1021	1028	PF00069	0.551
MOD_GSK3_1	1042	1049	PF00069	0.646
MOD_GSK3_1	111	118	PF00069	0.738
MOD_GSK3_1	123	130	PF00069	0.541
MOD_GSK3_1	140	147	PF00069	0.579
MOD_GSK3_1	16	23	PF00069	0.692
MOD_GSK3_1	255	262	PF00069	0.744
MOD_GSK3_1	275	282	PF00069	0.537
MOD_GSK3_1	283	290	PF00069	0.684
MOD_GSK3_1	294	301	PF00069	0.532
MOD_GSK3_1	337	344	PF00069	0.791
MOD_GSK3_1	347	354	PF00069	0.671
MOD_GSK3_1	379	386	PF00069	0.842
MOD_GSK3_1	393	400	PF00069	0.627
MOD_GSK3_1	460	467	PF00069	0.853
MOD_GSK3_1	516	523	PF00069	0.758
MOD_GSK3_1	525	532	PF00069	0.695
MOD_GSK3_1	551	558	PF00069	0.770
MOD_GSK3_1	587	594	PF00069	0.802
MOD_GSK3_1	595	602	PF00069	0.544
MOD_GSK3_1	603	610	PF00069	0.685
MOD_GSK3_1	7	14	PF00069	0.775
MOD_GSK3_1	765	772	PF00069	0.651
MOD_GSK3_1	847	854	PF00069	0.531
MOD_GSK3_1	868	875	PF00069	0.474
MOD_GSK3_1	913	920	PF00069	0.619
MOD_GSK3_1	927	934	PF00069	0.421
MOD_N-GLC_1	1008	1013	PF02516	0.542
MOD_N-GLC_1	303	308	PF02516	0.731
MOD_N-GLC_1	461	466	PF02516	0.731
MOD_N-GLC_1	502	507	PF02516	0.715
MOD_N-GLC_2	667	669	PF02516	0.545
MOD_NEK2_1	1010	1015	PF00069	0.535
MOD_NEK2_1	1042	1047	PF00069	0.646
MOD_NEK2_1	1052	1057	PF00069	0.525
MOD_NEK2_1	129	134	PF00069	0.667
MOD_NEK2_1	349	354	PF00069	0.637
MOD_NEK2_1	4	9	PF00069	0.759
MOD_NEK2_1	411	416	PF00069	0.735
MOD_NEK2_1	521	526	PF00069	0.825
MOD_NEK2_1	541	546	PF00069	0.515
MOD_NEK2_1	603	608	PF00069	0.772
MOD_NEK2_1	736	741	PF00069	0.635
MOD_NEK2_1	758	763	PF00069	0.637
MOD_NEK2_1	769	774	PF00069	0.574
MOD_NEK2_1	829	834	PF00069	0.635
MOD_PIKK_1	129	135	PF00454	0.629
MOD_PIKK_1	726	732	PF00454	0.633
MOD_PIKK_1	893	899	PF00454	0.586
MOD_PIKK_1	917	923	PF00454	0.625
MOD_PK_1	927	933	PF00069	0.433
MOD_PKA_1	990	996	PF00069	0.754
MOD_PKA_2	1042	1048	PF00069	0.645
MOD_PKA_2	1057	1063	PF00069	0.497
MOD_PKA_2	127	133	PF00069	0.673
MOD_PKA_2	21	27	PF00069	0.776
MOD_PKA_2	255	261	PF00069	0.734
MOD_PKA_2	46	52	PF00069	0.783
MOD_PKA_2	683	689	PF00069	0.596
MOD_PKA_2	758	764	PF00069	0.582
MOD_PKA_2	990	996	PF00069	0.810
MOD_PKB_1	138	146	PF00069	0.674
MOD_PKB_1	886	894	PF00069	0.645
MOD_Plk_1	461	467	PF00069	0.731
MOD_Plk_1	818	824	PF00069	0.607
MOD_Plk_1	902	908	PF00069	0.613
MOD_Plk_1	927	933	PF00069	0.433
MOD_Plk_4	344	350	PF00069	0.717
MOD_Plk_4	461	467	PF00069	0.819
MOD_ProDKin_1	1014	1020	PF00069	0.790
MOD_ProDKin_1	1058	1064	PF00069	0.680
MOD_ProDKin_1	144	150	PF00069	0.712
MOD_ProDKin_1	16	22	PF00069	0.664
MOD_ProDKin_1	281	287	PF00069	0.794
MOD_ProDKin_1	341	347	PF00069	0.806
MOD_ProDKin_1	351	357	PF00069	0.658
MOD_ProDKin_1	370	376	PF00069	0.533
MOD_ProDKin_1	377	383	PF00069	0.750
MOD_ProDKin_1	390	396	PF00069	0.553
MOD_ProDKin_1	406	412	PF00069	0.826
MOD_ProDKin_1	464	470	PF00069	0.843
MOD_ProDKin_1	527	533	PF00069	0.848
MOD_ProDKin_1	597	603	PF00069	0.841
MOD_ProDKin_1	623	629	PF00069	0.678
MOD_ProDKin_1	67	73	PF00069	0.770
MOD_ProDKin_1	7	13	PF00069	0.715
MOD_ProDKin_1	74	80	PF00069	0.684
MOD_ProDKin_1	775	781	PF00069	0.730
MOD_SUMO_for_1	1022	1025	PF00179	0.692
MOD_SUMO_for_1	172	175	PF00179	0.579
MOD_SUMO_for_1	996	999	PF00179	0.714
MOD_SUMO_rev_2	316	323	PF00179	0.746
MOD_SUMO_rev_2	699	709	PF00179	0.611
TRG_DiLeu_BaEn_1	219	224	PF01217	0.638
TRG_DiLeu_BaEn_1	946	951	PF01217	0.631
TRG_DiLeu_BaEn_4	219	225	PF01217	0.638
TRG_DiLeu_BaEn_4	633	639	PF01217	0.653
TRG_DiLeu_BaEn_4	646	652	PF01217	0.432
TRG_DiLeu_BaEn_4	884	890	PF01217	0.587
TRG_ENDOCYTIC_2	1036	1039	PF00928	0.656
TRG_ENDOCYTIC_2	346	349	PF00928	0.723
TRG_ENDOCYTIC_2	657	660	PF00928	0.607
TRG_ENDOCYTIC_2	954	957	PF00928	0.545
TRG_ER_diArg_1	445	448	PF00400	0.776
TRG_ER_diArg_1	491	494	PF00400	0.765
TRG_ER_diArg_1	59	61	PF00400	0.810
TRG_ER_diArg_1	641	643	PF00400	0.582
TRG_ER_diArg_1	831	834	PF00400	0.644
TRG_ER_diArg_1	886	889	PF00400	0.646
TRG_ER_diArg_1	989	991	PF00400	0.671
TRG_NES_CRM1_1	649	663	PF08389	0.578
TRG_NES_CRM1_1	877	893	PF08389	0.452
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	642	646	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	695	700	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	910	915	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUD7	Leishmania donovani	100%	100%
A4H8Z6	Leishmania braziliensis	71%	99%
E9AR22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QEE1	Leishmania major	91%	100%