LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4HXC3_LEIIN
TriTrypDb:
LINF_170011200
Length:
909

Annotations

Annotations by Jardim et al.

Protein kinase, kinase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HXC3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXC3

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0004674 protein serine/threonine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 172 176 PF00656 0.781
CLV_C14_Caspase3-7 64 68 PF00656 0.725
CLV_MEL_PAP_1 285 291 PF00089 0.432
CLV_NRD_NRD_1 208 210 PF00675 0.767
CLV_NRD_NRD_1 211 213 PF00675 0.788
CLV_NRD_NRD_1 279 281 PF00675 0.454
CLV_NRD_NRD_1 291 293 PF00675 0.333
CLV_NRD_NRD_1 451 453 PF00675 0.492
CLV_NRD_NRD_1 52 54 PF00675 0.634
CLV_NRD_NRD_1 591 593 PF00675 0.402
CLV_NRD_NRD_1 685 687 PF00675 0.269
CLV_NRD_NRD_1 74 76 PF00675 0.704
CLV_NRD_NRD_1 873 875 PF00675 0.297
CLV_NRD_NRD_1 92 94 PF00675 0.667
CLV_PCSK_FUR_1 209 213 PF00082 0.686
CLV_PCSK_KEX2_1 208 210 PF00082 0.774
CLV_PCSK_KEX2_1 211 213 PF00082 0.793
CLV_PCSK_KEX2_1 279 281 PF00082 0.448
CLV_PCSK_KEX2_1 451 453 PF00082 0.490
CLV_PCSK_KEX2_1 591 593 PF00082 0.402
CLV_PCSK_KEX2_1 685 687 PF00082 0.269
CLV_PCSK_KEX2_1 74 76 PF00082 0.707
CLV_PCSK_KEX2_1 746 748 PF00082 0.269
CLV_PCSK_KEX2_1 872 874 PF00082 0.294
CLV_PCSK_KEX2_1 92 94 PF00082 0.648
CLV_PCSK_PC1ET2_1 746 748 PF00082 0.269
CLV_PCSK_PC1ET2_1 872 874 PF00082 0.294
CLV_PCSK_PC7_1 275 281 PF00082 0.581
CLV_PCSK_PC7_1 869 875 PF00082 0.324
CLV_PCSK_SKI1_1 223 227 PF00082 0.780
CLV_PCSK_SKI1_1 267 271 PF00082 0.474
CLV_PCSK_SKI1_1 280 284 PF00082 0.413
CLV_PCSK_SKI1_1 292 296 PF00082 0.487
CLV_PCSK_SKI1_1 520 524 PF00082 0.606
CLV_PCSK_SKI1_1 634 638 PF00082 0.328
CLV_PCSK_SKI1_1 644 648 PF00082 0.222
CLV_PCSK_SKI1_1 687 691 PF00082 0.386
CLV_PCSK_SKI1_1 705 709 PF00082 0.269
CLV_PCSK_SKI1_1 722 726 PF00082 0.317
CLV_PCSK_SKI1_1 832 836 PF00082 0.290
CLV_PCSK_SKI1_1 873 877 PF00082 0.314
CLV_Separin_Metazoa 797 801 PF03568 0.383
DEG_APCC_DBOX_1 704 712 PF00400 0.312
DEG_SCF_FBW7_1 81 86 PF00400 0.551
DEG_SPOP_SBC_1 191 195 PF00917 0.657
DOC_CYCLIN_RxL_1 517 527 PF00134 0.578
DOC_CYCLIN_RxL_1 575 586 PF00134 0.467
DOC_MAPK_gen_1 257 266 PF00069 0.630
DOC_MAPK_gen_1 380 389 PF00069 0.723
DOC_MAPK_gen_1 634 642 PF00069 0.331
DOC_MAPK_gen_1 690 699 PF00069 0.302
DOC_MAPK_gen_1 722 731 PF00069 0.269
DOC_MAPK_gen_1 853 860 PF00069 0.403
DOC_MAPK_gen_1 872 880 PF00069 0.205
DOC_MAPK_MEF2A_6 260 268 PF00069 0.595
DOC_MAPK_MEF2A_6 853 862 PF00069 0.304
DOC_PP1_RVXF_1 265 271 PF00149 0.486
DOC_PP4_FxxP_1 793 796 PF00568 0.307
DOC_USP7_MATH_1 108 112 PF00917 0.616
DOC_USP7_MATH_1 187 191 PF00917 0.659
DOC_USP7_MATH_1 232 236 PF00917 0.719
DOC_USP7_MATH_1 27 31 PF00917 0.641
DOC_USP7_MATH_1 271 275 PF00917 0.466
DOC_USP7_MATH_1 360 364 PF00917 0.707
DOC_USP7_MATH_1 401 405 PF00917 0.740
DOC_USP7_MATH_1 539 543 PF00917 0.702
DOC_USP7_MATH_1 557 561 PF00917 0.500
DOC_USP7_MATH_2 202 208 PF00917 0.573
DOC_WW_Pin1_4 12 17 PF00397 0.729
DOC_WW_Pin1_4 23 28 PF00397 0.717
DOC_WW_Pin1_4 336 341 PF00397 0.776
DOC_WW_Pin1_4 342 347 PF00397 0.738
DOC_WW_Pin1_4 36 41 PF00397 0.662
DOC_WW_Pin1_4 405 410 PF00397 0.633
DOC_WW_Pin1_4 47 52 PF00397 0.617
DOC_WW_Pin1_4 489 494 PF00397 0.783
DOC_WW_Pin1_4 507 512 PF00397 0.629
DOC_WW_Pin1_4 513 518 PF00397 0.759
DOC_WW_Pin1_4 769 774 PF00397 0.421
DOC_WW_Pin1_4 787 792 PF00397 0.195
DOC_WW_Pin1_4 79 84 PF00397 0.776
DOC_WW_Pin1_4 896 901 PF00397 0.497
DOC_WW_Pin1_4 903 908 PF00397 0.559
LIG_14-3-3_CanoR_1 292 300 PF00244 0.506
LIG_14-3-3_CanoR_1 385 390 PF00244 0.608
LIG_14-3-3_CanoR_1 498 505 PF00244 0.564
LIG_14-3-3_CanoR_1 591 596 PF00244 0.469
LIG_14-3-3_CanoR_1 873 881 PF00244 0.285
LIG_APCC_ABBA_1 669 674 PF00400 0.269
LIG_BRCT_BRCA1_1 564 568 PF00533 0.549
LIG_BRCT_BRCA1_1 789 793 PF00533 0.432
LIG_DLG_GKlike_1 385 393 PF00625 0.591
LIG_FHA_1 198 204 PF00498 0.576
LIG_FHA_1 41 47 PF00498 0.619
LIG_FHA_1 499 505 PF00498 0.707
LIG_FHA_1 525 531 PF00498 0.704
LIG_FHA_1 577 583 PF00498 0.552
LIG_FHA_1 657 663 PF00498 0.357
LIG_FHA_1 702 708 PF00498 0.402
LIG_FHA_2 131 137 PF00498 0.597
LIG_FHA_2 175 181 PF00498 0.624
LIG_FHA_2 293 299 PF00498 0.536
LIG_FHA_2 311 317 PF00498 0.565
LIG_FHA_2 601 607 PF00498 0.402
LIG_FHA_2 874 880 PF00498 0.249
LIG_FHA_2 885 891 PF00498 0.372
LIG_LIR_Apic_2 790 796 PF02991 0.309
LIG_LIR_Gen_1 314 324 PF02991 0.517
LIG_LIR_Nem_3 295 300 PF02991 0.375
LIG_LIR_Nem_3 314 320 PF02991 0.389
LIG_LIR_Nem_3 600 604 PF02991 0.318
LIG_LIR_Nem_3 670 675 PF02991 0.402
LIG_LRP6_Inhibitor_1 19 25 PF00058 0.616
LIG_MLH1_MIPbox_1 789 793 PF16413 0.432
LIG_MYND_1 349 353 PF01753 0.532
LIG_Pex14_2 835 839 PF04695 0.390
LIG_Pex14_2 863 867 PF04695 0.249
LIG_PTB_Apo_2 441 448 PF02174 0.551
LIG_PTB_Phospho_1 441 447 PF10480 0.545
LIG_REV1ctd_RIR_1 860 869 PF16727 0.250
LIG_SH2_GRB2like 442 445 PF00017 0.551
LIG_SH2_NCK_1 442 446 PF00017 0.593
LIG_SH2_SRC 713 716 PF00017 0.269
LIG_SH2_STAP1 442 446 PF00017 0.544
LIG_SH2_STAP1 703 707 PF00017 0.287
LIG_SH2_STAT3 655 658 PF00017 0.269
LIG_SH2_STAT3 703 706 PF00017 0.269
LIG_SH2_STAT5 281 284 PF00017 0.530
LIG_SH2_STAT5 300 303 PF00017 0.375
LIG_SH2_STAT5 439 442 PF00017 0.451
LIG_SH2_STAT5 447 450 PF00017 0.486
LIG_SH2_STAT5 703 706 PF00017 0.308
LIG_SH2_STAT5 713 716 PF00017 0.287
LIG_SH2_STAT5 805 808 PF00017 0.390
LIG_SH3_1 14 20 PF00018 0.606
LIG_SH3_3 14 20 PF00018 0.608
LIG_SH3_3 334 340 PF00018 0.728
LIG_SH3_3 343 349 PF00018 0.729
LIG_SH3_3 43 49 PF00018 0.684
LIG_SH3_3 475 481 PF00018 0.582
LIG_SH3_3 511 517 PF00018 0.786
LIG_SH3_3 78 84 PF00018 0.628
LIG_SH3_3 785 791 PF00018 0.256
LIG_SH3_3 894 900 PF00018 0.561
LIG_SUMO_SIM_anti_2 696 702 PF11976 0.287
LIG_SUMO_SIM_anti_2 876 882 PF11976 0.276
LIG_SUMO_SIM_par_1 198 207 PF11976 0.575
LIG_SUMO_SIM_par_1 42 50 PF11976 0.614
LIG_TRAF2_1 145 148 PF00917 0.703
LIG_TRAF2_1 163 166 PF00917 0.699
LIG_TRAF2_1 772 775 PF00917 0.290
LIG_TRAF2_1 892 895 PF00917 0.560
LIG_TRFH_1 405 409 PF08558 0.595
LIG_TYR_ITSM 601 608 PF00017 0.402
LIG_UBA3_1 642 649 PF00899 0.269
LIG_UBA3_1 730 738 PF00899 0.287
LIG_UBA3_1 834 843 PF00899 0.310
MOD_CDC14_SPxK_1 50 53 PF00782 0.588
MOD_CDK_SPK_2 405 410 PF00069 0.551
MOD_CDK_SPxK_1 47 53 PF00069 0.589
MOD_CDK_SPxxK_3 47 54 PF00069 0.618
MOD_CDK_SPxxK_3 489 496 PF00069 0.606
MOD_CDK_SPxxK_3 513 520 PF00069 0.573
MOD_CK1_1 110 116 PF00069 0.700
MOD_CK1_1 190 196 PF00069 0.801
MOD_CK1_1 207 213 PF00069 0.727
MOD_CK1_1 235 241 PF00069 0.739
MOD_CK1_1 30 36 PF00069 0.568
MOD_CK1_1 339 345 PF00069 0.620
MOD_CK1_1 363 369 PF00069 0.757
MOD_CK1_1 376 382 PF00069 0.655
MOD_CK1_1 39 45 PF00069 0.634
MOD_CK1_1 417 423 PF00069 0.590
MOD_CK1_1 431 437 PF00069 0.456
MOD_CK1_1 467 473 PF00069 0.588
MOD_CK1_1 489 495 PF00069 0.650
MOD_CK1_1 529 535 PF00069 0.730
MOD_CK1_1 560 566 PF00069 0.531
MOD_CK1_1 600 606 PF00069 0.360
MOD_CK1_1 680 686 PF00069 0.402
MOD_CK1_1 86 92 PF00069 0.587
MOD_CK1_1 899 905 PF00069 0.551
MOD_CK2_1 130 136 PF00069 0.784
MOD_CK2_1 142 148 PF00069 0.775
MOD_CK2_1 160 166 PF00069 0.584
MOD_CK2_1 175 181 PF00069 0.554
MOD_CK2_1 420 426 PF00069 0.562
MOD_CK2_1 539 545 PF00069 0.644
MOD_CK2_1 600 606 PF00069 0.347
MOD_CK2_1 769 775 PF00069 0.460
MOD_CK2_1 873 879 PF00069 0.253
MOD_CK2_1 899 905 PF00069 0.697
MOD_Cter_Amidation 216 219 PF01082 0.767
MOD_DYRK1A_RPxSP_1 79 83 PF00069 0.558
MOD_GlcNHglycan 189 192 PF01048 0.655
MOD_GlcNHglycan 195 198 PF01048 0.587
MOD_GlcNHglycan 215 218 PF01048 0.585
MOD_GlcNHglycan 235 238 PF01048 0.771
MOD_GlcNHglycan 29 32 PF01048 0.569
MOD_GlcNHglycan 389 392 PF01048 0.601
MOD_GlcNHglycan 419 422 PF01048 0.643
MOD_GlcNHglycan 431 434 PF01048 0.608
MOD_GlcNHglycan 473 476 PF01048 0.652
MOD_GlcNHglycan 505 508 PF01048 0.752
MOD_GlcNHglycan 531 534 PF01048 0.769
MOD_GlcNHglycan 559 562 PF01048 0.617
MOD_GlcNHglycan 56 59 PF01048 0.731
MOD_GlcNHglycan 731 734 PF01048 0.347
MOD_GSK3_1 106 113 PF00069 0.646
MOD_GSK3_1 170 177 PF00069 0.767
MOD_GSK3_1 185 192 PF00069 0.799
MOD_GSK3_1 193 200 PF00069 0.722
MOD_GSK3_1 213 220 PF00069 0.591
MOD_GSK3_1 228 235 PF00069 0.716
MOD_GSK3_1 23 30 PF00069 0.732
MOD_GSK3_1 32 39 PF00069 0.599
MOD_GSK3_1 332 339 PF00069 0.630
MOD_GSK3_1 385 392 PF00069 0.626
MOD_GSK3_1 401 408 PF00069 0.576
MOD_GSK3_1 411 418 PF00069 0.624
MOD_GSK3_1 467 474 PF00069 0.715
MOD_GSK3_1 503 510 PF00069 0.699
MOD_GSK3_1 54 61 PF00069 0.724
MOD_GSK3_1 695 702 PF00069 0.275
MOD_GSK3_1 783 790 PF00069 0.256
MOD_GSK3_1 79 86 PF00069 0.655
MOD_GSK3_1 899 906 PF00069 0.728
MOD_N-GLC_1 360 365 PF02516 0.562
MOD_N-GLC_1 393 398 PF02516 0.611
MOD_N-GLC_1 458 463 PF02516 0.547
MOD_N-GLC_1 568 573 PF02516 0.479
MOD_NEK2_1 3 8 PF00069 0.734
MOD_NEK2_1 387 392 PF00069 0.740
MOD_NEK2_1 411 416 PF00069 0.626
MOD_NEK2_1 458 463 PF00069 0.584
MOD_NEK2_1 523 528 PF00069 0.601
MOD_NEK2_1 568 573 PF00069 0.467
MOD_NEK2_1 576 581 PF00069 0.468
MOD_NEK2_1 642 647 PF00069 0.260
MOD_NEK2_1 695 700 PF00069 0.278
MOD_NEK2_1 742 747 PF00069 0.296
MOD_NEK2_1 783 788 PF00069 0.390
MOD_PIKK_1 119 125 PF00454 0.659
MOD_PIKK_1 218 224 PF00454 0.594
MOD_PIKK_1 30 36 PF00454 0.740
MOD_PIKK_1 389 395 PF00454 0.583
MOD_PIKK_1 606 612 PF00454 0.331
MOD_PIKK_1 899 905 PF00454 0.697
MOD_PK_1 591 597 PF00069 0.402
MOD_PKA_1 218 224 PF00069 0.765
MOD_PKA_1 292 298 PF00069 0.524
MOD_PKA_1 591 597 PF00069 0.402
MOD_PKA_1 873 879 PF00069 0.290
MOD_PKA_2 207 213 PF00069 0.774
MOD_PKA_2 440 446 PF00069 0.481
MOD_PKA_2 591 597 PF00069 0.421
MOD_PKA_2 839 845 PF00069 0.304
MOD_PKA_2 868 874 PF00069 0.279
MOD_PKB_1 383 391 PF00069 0.538
MOD_Plk_1 411 417 PF00069 0.676
MOD_Plk_1 458 464 PF00069 0.553
MOD_Plk_1 568 574 PF00069 0.487
MOD_Plk_1 620 626 PF00069 0.390
MOD_Plk_2-3 132 138 PF00069 0.628
MOD_Plk_2-3 142 148 PF00069 0.699
MOD_Plk_2-3 175 181 PF00069 0.666
MOD_Plk_2-3 310 316 PF00069 0.415
MOD_Plk_4 332 338 PF00069 0.674
MOD_Plk_4 395 401 PF00069 0.714
MOD_Plk_4 420 426 PF00069 0.583
MOD_Plk_4 431 437 PF00069 0.471
MOD_Plk_4 458 464 PF00069 0.735
MOD_Plk_4 591 597 PF00069 0.399
MOD_Plk_4 600 606 PF00069 0.317
MOD_Plk_4 650 656 PF00069 0.402
MOD_Plk_4 783 789 PF00069 0.253
MOD_ProDKin_1 12 18 PF00069 0.731
MOD_ProDKin_1 23 29 PF00069 0.715
MOD_ProDKin_1 336 342 PF00069 0.776
MOD_ProDKin_1 36 42 PF00069 0.662
MOD_ProDKin_1 405 411 PF00069 0.623
MOD_ProDKin_1 47 53 PF00069 0.617
MOD_ProDKin_1 489 495 PF00069 0.779
MOD_ProDKin_1 507 513 PF00069 0.629
MOD_ProDKin_1 769 775 PF00069 0.421
MOD_ProDKin_1 787 793 PF00069 0.195
MOD_ProDKin_1 79 85 PF00069 0.775
MOD_ProDKin_1 896 902 PF00069 0.508
MOD_ProDKin_1 903 909 PF00069 0.563
MOD_SUMO_for_1 636 639 PF00179 0.331
MOD_SUMO_rev_2 423 432 PF00179 0.664
MOD_SUMO_rev_2 47 55 PF00179 0.659
MOD_SUMO_rev_2 606 615 PF00179 0.269
MOD_SUMO_rev_2 732 740 PF00179 0.269
TRG_ENDOCYTIC_2 605 608 PF00928 0.269
TRG_ENDOCYTIC_2 98 101 PF00928 0.551
TRG_ER_diArg_1 208 211 PF00400 0.598
TRG_ER_diArg_1 278 280 PF00400 0.454
TRG_ER_diArg_1 590 592 PF00400 0.506
TRG_ER_diArg_1 684 686 PF00400 0.269
TRG_NES_CRM1_1 318 334 PF08389 0.425
TRG_NES_CRM1_1 570 586 PF08389 0.529
TRG_NES_CRM1_1 810 820 PF08389 0.333
TRG_NLS_MonoExtN_4 869 876 PF00514 0.290
TRG_Pf-PMV_PEXEL_1 891 895 PF00026 0.535

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5H5 Leptomonas seymouri 51% 69%
A0A1X0NSX9 Trypanosomatidae 43% 96%
A0A3R7M724 Trypanosoma rangeli 44% 100%
A0A3S5H705 Leishmania donovani 97% 100%
C9ZU16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AI55 Leishmania braziliensis 64% 100%
E9AR18 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 99%
Q4QEE5 Leishmania major 93% 100%
V5B639 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS