J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HXB9_LEIIN

TriTrypDb:

LINF_170010900

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0031207	Sec62/Sec63 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

A4HXB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXB9

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006613	cotranslational protein targeting to membrane	6	1
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	1
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0008320	protein transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022884	macromolecule transmembrane transporter activity	3	1
GO:0140318	protein transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.539
CLV_NRD_NRD_1	18	20	PF00675	0.416
CLV_NRD_NRD_1	202	204	PF00675	0.427
CLV_NRD_NRD_1	317	319	PF00675	0.369
CLV_NRD_NRD_1	80	82	PF00675	0.483
CLV_PCSK_KEX2_1	116	118	PF00082	0.508
CLV_PCSK_KEX2_1	18	20	PF00082	0.416
CLV_PCSK_KEX2_1	202	204	PF00082	0.395
CLV_PCSK_KEX2_1	317	319	PF00082	0.355
CLV_PCSK_KEX2_1	80	82	PF00082	0.482
CLV_PCSK_PC7_1	113	119	PF00082	0.497
CLV_PCSK_SKI1_1	24	28	PF00082	0.440
CLV_PCSK_SKI1_1	313	317	PF00082	0.338
CLV_PCSK_SKI1_1	61	65	PF00082	0.497
CLV_Separin_Metazoa	229	233	PF03568	0.583
DEG_Nend_Nbox_1	1	3	PF02207	0.703
DEG_SPOP_SBC_1	46	50	PF00917	0.716
DOC_CKS1_1	239	244	PF01111	0.573
DOC_PP2B_LxvP_1	65	68	PF13499	0.638
DOC_USP7_MATH_1	151	155	PF00917	0.475
DOC_USP7_MATH_1	300	304	PF00917	0.605
DOC_USP7_MATH_1	46	50	PF00917	0.779
DOC_USP7_MATH_1	53	57	PF00917	0.737
DOC_WW_Pin1_4	194	199	PF00397	0.560
DOC_WW_Pin1_4	238	243	PF00397	0.563
DOC_WW_Pin1_4	308	313	PF00397	0.540
DOC_WW_Pin1_4	38	43	PF00397	0.728
DOC_WW_Pin1_4	96	101	PF00397	0.673
LIG_14-3-3_CanoR_1	205	215	PF00244	0.560
LIG_14-3-3_CanoR_1	232	237	PF00244	0.582
LIG_14-3-3_CanoR_1	4	11	PF00244	0.686
LIG_14-3-3_CanoR_1	61	66	PF00244	0.746
LIG_14-3-3_CanoR_1	80	90	PF00244	0.717
LIG_BRCT_BRCA1_1	268	272	PF00533	0.351
LIG_deltaCOP1_diTrp_1	305	315	PF00928	0.545
LIG_FHA_1	153	159	PF00498	0.476
LIG_FHA_1	176	182	PF00498	0.450
LIG_FHA_1	25	31	PF00498	0.787
LIG_FHA_1	52	58	PF00498	0.753
LIG_FHA_2	105	111	PF00498	0.696
LIG_FHA_2	123	129	PF00498	0.727
LIG_LIR_Gen_1	243	251	PF02991	0.429
LIG_LIR_Gen_1	269	280	PF02991	0.363
LIG_LIR_Nem_3	201	207	PF02991	0.593
LIG_LIR_Nem_3	210	216	PF02991	0.556
LIG_LIR_Nem_3	243	248	PF02991	0.450
LIG_LIR_Nem_3	269	275	PF02991	0.356
LIG_MLH1_MIPbox_1	268	272	PF16413	0.391
LIG_NRBOX	276	282	PF00104	0.350
LIG_Pex14_2	214	218	PF04695	0.551
LIG_Pex14_2	260	264	PF04695	0.324
LIG_SH2_CRK	204	208	PF00017	0.572
LIG_SH2_CRK	216	220	PF00017	0.534
LIG_SH2_CRK	90	94	PF00017	0.665
LIG_SH2_NCK_1	191	195	PF00017	0.460
LIG_SH2_STAP1	296	300	PF00017	0.355
LIG_SH2_STAP1	304	308	PF00017	0.520
LIG_SH2_STAT5	213	216	PF00017	0.539
LIG_SH2_STAT5	255	258	PF00017	0.383
LIG_SUMO_SIM_anti_2	54	61	PF11976	0.659
LIG_TRAF2_1	106	109	PF00917	0.624
LIG_TYR_ITAM	188	207	PF00017	0.562
LIG_TYR_ITIM	160	165	PF00017	0.460
LIG_Vh1_VBS_1	266	284	PF01044	0.344
MOD_CDK_SPK_2	308	313	PF00069	0.538
MOD_CDK_SPK_2	96	101	PF00069	0.715
MOD_CK1_1	154	160	PF00069	0.492
MOD_CK1_1	33	39	PF00069	0.696
MOD_CK1_1	41	47	PF00069	0.673
MOD_CK2_1	104	110	PF00069	0.700
MOD_CMANNOS	236	239	PF00535	0.373
MOD_GlcNHglycan	12	15	PF01048	0.546
MOD_GlcNHglycan	138	141	PF01048	0.524
MOD_GlcNHglycan	242	245	PF01048	0.342
MOD_GlcNHglycan	43	46	PF01048	0.486
MOD_GlcNHglycan	73	76	PF01048	0.506
MOD_GlcNHglycan	84	87	PF01048	0.437
MOD_GSK3_1	132	139	PF00069	0.675
MOD_GSK3_1	192	199	PF00069	0.467
MOD_GSK3_1	24	31	PF00069	0.760
MOD_GSK3_1	3	10	PF00069	0.722
MOD_GSK3_1	41	48	PF00069	0.654
MOD_GSK3_1	66	73	PF00069	0.730
MOD_NEK2_1	266	271	PF00069	0.334
MOD_NEK2_1	280	285	PF00069	0.317
MOD_NEK2_1	294	299	PF00069	0.310
MOD_NEK2_1	3	8	PF00069	0.714
MOD_NEK2_1	47	52	PF00069	0.715
MOD_PIKK_1	152	158	PF00454	0.516
MOD_PIKK_1	208	214	PF00454	0.549
MOD_PKA_1	116	122	PF00069	0.739
MOD_PKA_2	116	122	PF00069	0.713
MOD_PKA_2	3	9	PF00069	0.734
MOD_Plk_4	266	272	PF00069	0.352
MOD_Plk_4	280	286	PF00069	0.344
MOD_Plk_4	294	300	PF00069	0.270
MOD_Plk_4	53	59	PF00069	0.706
MOD_ProDKin_1	194	200	PF00069	0.560
MOD_ProDKin_1	238	244	PF00069	0.559
MOD_ProDKin_1	308	314	PF00069	0.537
MOD_ProDKin_1	38	44	PF00069	0.728
MOD_ProDKin_1	96	102	PF00069	0.673
TRG_ENDOCYTIC_2	162	165	PF00928	0.460
TRG_ENDOCYTIC_2	191	194	PF00928	0.460
TRG_ENDOCYTIC_2	204	207	PF00928	0.579
TRG_ENDOCYTIC_2	215	218	PF00928	0.540
TRG_ENDOCYTIC_2	261	264	PF00928	0.328
TRG_ENDOCYTIC_2	296	299	PF00928	0.325
TRG_ENDOCYTIC_2	90	93	PF00928	0.670
TRG_ER_diArg_1	116	118	PF00400	0.714
TRG_ER_diArg_1	158	161	PF00400	0.460
TRG_ER_diArg_1	202	204	PF00400	0.627
TRG_ER_diArg_1	316	318	PF00400	0.566
TRG_ER_diArg_1	80	82	PF00400	0.680
TRG_Pf-PMV_PEXEL_1	205	210	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK95	Leptomonas seymouri	76%	100%
A0A0S4J1V7	Bodo saltans	58%	100%
A0A1X0NSX2	Trypanosomatidae	63%	100%
A0A3Q8ICS4	Leishmania donovani	99%	90%
A0A3R7MRU2	Trypanosoma rangeli	67%	100%
A4H8Y9	Leishmania braziliensis	88%	100%
C9ZU12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AR15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QEE8	Leishmania major	96%	100%