N6-adenine methyltransferase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Probable N6-adenine methyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4HXB5_LEIIN

TriTrypDb:

LINF_170010500

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HXB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXB5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	9
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016278	lysine N-methyltransferase activity	6	12
GO:0016279	protein-lysine N-methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.502
CLV_NRD_NRD_1	246	248	PF00675	0.550
CLV_NRD_NRD_1	519	521	PF00675	0.425
CLV_NRD_NRD_1	77	79	PF00675	0.342
CLV_NRD_NRD_1	93	95	PF00675	0.310
CLV_PCSK_KEX2_1	248	250	PF00082	0.598
CLV_PCSK_KEX2_1	519	521	PF00082	0.540
CLV_PCSK_KEX2_1	77	79	PF00082	0.342
CLV_PCSK_KEX2_1	93	95	PF00082	0.310
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.644
CLV_PCSK_SKI1_1	147	151	PF00082	0.279
CLV_PCSK_SKI1_1	153	157	PF00082	0.252
CLV_PCSK_SKI1_1	161	165	PF00082	0.227
CLV_PCSK_SKI1_1	180	184	PF00082	0.241
CLV_PCSK_SKI1_1	381	385	PF00082	0.574
CLV_PCSK_SKI1_1	519	523	PF00082	0.448
CLV_PCSK_SKI1_1	530	534	PF00082	0.335
CLV_PCSK_SKI1_1	537	541	PF00082	0.320
DOC_CKS1_1	65	70	PF01111	0.452
DOC_CYCLIN_RxL_1	147	158	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.466
DOC_MAPK_FxFP_2	521	524	PF00069	0.452
DOC_MAPK_gen_1	371	379	PF00069	0.537
DOC_MAPK_gen_1	422	431	PF00069	0.477
DOC_MAPK_RevD_3	63	78	PF00069	0.542
DOC_PIKK_1	169	177	PF02985	0.542
DOC_PP1_RVXF_1	159	165	PF00149	0.452
DOC_PP4_FxxP_1	116	119	PF00568	0.452
DOC_PP4_FxxP_1	521	524	PF00568	0.508
DOC_USP7_MATH_1	24	28	PF00917	0.482
DOC_USP7_MATH_1	321	325	PF00917	0.725
DOC_USP7_MATH_1	334	338	PF00917	0.551
DOC_USP7_MATH_1	354	358	PF00917	0.302
DOC_USP7_MATH_1	397	401	PF00917	0.574
DOC_USP7_MATH_1	471	475	PF00917	0.770
DOC_USP7_UBL2_3	153	157	PF12436	0.488
DOC_USP7_UBL2_3	387	391	PF12436	0.640
DOC_WW_Pin1_4	452	457	PF00397	0.710
DOC_WW_Pin1_4	475	480	PF00397	0.673
DOC_WW_Pin1_4	64	69	PF00397	0.452
LIG_14-3-3_CanoR_1	147	156	PF00244	0.490
LIG_14-3-3_CanoR_1	234	242	PF00244	0.568
LIG_14-3-3_CanoR_1	26	30	PF00244	0.536
LIG_Actin_WH2_2	220	236	PF00022	0.453
LIG_APCC_ABBA_1	302	307	PF00400	0.605
LIG_BIR_III_4	472	476	PF00653	0.515
LIG_BRCT_BRCA1_1	68	72	PF00533	0.458
LIG_BRCT_BRCA1_1	95	99	PF00533	0.441
LIG_FHA_1	139	145	PF00498	0.450
LIG_FHA_1	149	155	PF00498	0.441
LIG_FHA_1	163	169	PF00498	0.423
LIG_FHA_1	285	291	PF00498	0.562
LIG_FHA_1	410	416	PF00498	0.431
LIG_FHA_1	65	71	PF00498	0.471
LIG_FHA_2	164	170	PF00498	0.452
LIG_FHA_2	321	327	PF00498	0.772
LIG_FHA_2	80	86	PF00498	0.539
LIG_Integrin_RGD_1	78	80	PF01839	0.327
LIG_LIR_Apic_2	115	119	PF02991	0.441
LIG_LIR_Apic_2	483	488	PF02991	0.481
LIG_LIR_Apic_2	518	524	PF02991	0.389
LIG_LIR_Gen_1	195	206	PF02991	0.441
LIG_LIR_Nem_3	108	114	PF02991	0.441
LIG_LIR_Nem_3	143	148	PF02991	0.455
LIG_LIR_Nem_3	186	191	PF02991	0.465
LIG_LIR_Nem_3	195	201	PF02991	0.424
LIG_LIR_Nem_3	294	298	PF02991	0.608
LIG_LIR_Nem_3	37	41	PF02991	0.476
LIG_LIR_Nem_3	483	489	PF02991	0.517
LIG_LIR_Nem_3	69	74	PF02991	0.465
LIG_LYPXL_S_1	187	191	PF13949	0.342
LIG_LYPXL_yS_3	188	191	PF13949	0.542
LIG_MLH1_MIPbox_1	68	72	PF16413	0.441
LIG_NRBOX	173	179	PF00104	0.466
LIG_NRP_CendR_1	540	543	PF00754	0.548
LIG_Pex14_2	183	187	PF04695	0.452
LIG_Pex14_2	38	42	PF04695	0.452
LIG_SH2_CRK	196	200	PF00017	0.452
LIG_SH2_SRC	196	199	PF00017	0.441
LIG_SH2_STAP1	101	105	PF00017	0.542
LIG_SH2_STAP1	342	346	PF00017	0.375
LIG_SH2_STAP1	489	493	PF00017	0.470
LIG_SH2_STAT3	101	104	PF00017	0.508
LIG_SH2_STAT5	111	114	PF00017	0.465
LIG_SH2_STAT5	132	135	PF00017	0.489
LIG_SH2_STAT5	148	151	PF00017	0.463
LIG_SH2_STAT5	198	201	PF00017	0.467
LIG_SH3_3	131	137	PF00018	0.484
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.391
LIG_TRAF2_1	509	512	PF00917	0.543
LIG_TYR_ITIM	194	199	PF00017	0.452
LIG_TYR_ITSM	184	191	PF00017	0.400
LIG_UBA3_1	532	540	PF00899	0.390
LIG_WRC_WIRS_1	184	189	PF05994	0.488
MOD_CK1_1	22	28	PF00069	0.587
MOD_CK1_1	399	405	PF00069	0.558
MOD_CK1_1	44	50	PF00069	0.441
MOD_CK1_1	452	458	PF00069	0.712
MOD_CK1_1	480	486	PF00069	0.675
MOD_CK1_1	66	72	PF00069	0.455
MOD_CK2_1	163	169	PF00069	0.441
MOD_CK2_1	233	239	PF00069	0.439
MOD_CK2_1	399	405	PF00069	0.551
MOD_GlcNHglycan	10	13	PF01048	0.709
MOD_GlcNHglycan	14	17	PF01048	0.659
MOD_GlcNHglycan	21	24	PF01048	0.539
MOD_GlcNHglycan	399	402	PF01048	0.519
MOD_GlcNHglycan	452	455	PF01048	0.713
MOD_GlcNHglycan	472	476	PF01048	0.598
MOD_GlcNHglycan	479	482	PF01048	0.627
MOD_GlcNHglycan	512	516	PF01048	0.363
MOD_GSK3_1	200	207	PF00069	0.523
MOD_GSK3_1	377	384	PF00069	0.509
MOD_GSK3_1	393	400	PF00069	0.535
MOD_GSK3_1	471	478	PF00069	0.708
MOD_GSK3_1	511	518	PF00069	0.359
MOD_GSK3_1	8	15	PF00069	0.656
MOD_N-GLC_1	169	174	PF02516	0.252
MOD_NEK2_1	162	167	PF00069	0.442
MOD_NEK2_1	183	188	PF00069	0.447
MOD_PIKK_1	1	7	PF00454	0.793
MOD_PIKK_1	87	93	PF00454	0.465
MOD_PKA_1	93	99	PF00069	0.544
MOD_PKA_2	233	239	PF00069	0.435
MOD_PKA_2	25	31	PF00069	0.540
MOD_PKA_2	44	50	PF00069	0.502
MOD_PKA_2	93	99	PF00069	0.529
MOD_Plk_1	169	175	PF00069	0.452
MOD_Plk_1	381	387	PF00069	0.503
MOD_Plk_4	163	169	PF00069	0.437
MOD_Plk_4	183	189	PF00069	0.356
MOD_Plk_4	300	306	PF00069	0.530
MOD_Plk_4	381	387	PF00069	0.438
MOD_Plk_4	480	486	PF00069	0.503
MOD_Plk_4	66	72	PF00069	0.465
MOD_ProDKin_1	452	458	PF00069	0.714
MOD_ProDKin_1	475	481	PF00069	0.668
MOD_ProDKin_1	64	70	PF00069	0.452
MOD_SUMO_for_1	34	37	PF00179	0.525
MOD_SUMO_rev_2	215	224	PF00179	0.417
TRG_DiLeu_BaEn_1	158	163	PF01217	0.542
TRG_ENDOCYTIC_2	188	191	PF00928	0.464
TRG_ENDOCYTIC_2	196	199	PF00928	0.423
TRG_ENDOCYTIC_2	500	503	PF00928	0.372
TRG_ER_diArg_1	346	349	PF00400	0.443
TRG_ER_diArg_1	519	521	PF00400	0.474
TRG_ER_diArg_1	92	94	PF00400	0.497
TRG_NES_CRM1_1	360	375	PF08389	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR6	Leptomonas seymouri	65%	100%
A0A0S4KEA9	Bodo saltans	39%	100%
A0A1X0NT88	Trypanosomatidae	43%	100%
A0A3Q8IDX6	Leishmania donovani	99%	100%
A0A422NXL8	Trypanosoma rangeli	45%	100%
A4H8Y5	Leishmania braziliensis	79%	99%
C9ZU02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AR11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QEF2	Leishmania major	92%	100%
V5BAJ7	Trypanosoma cruzi	42%	87%