LeishMANIAdb
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Cilia- and flagella-associated protein 206

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cilia- and flagella-associated protein 206
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HXB1_LEIIN
TriTrypDb:
LINF_170008400 *
Length:
402

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 4
GO:0005856 cytoskeleton 5 4
GO:0005929 cilium 4 4
GO:0042995 cell projection 2 4
GO:0043226 organelle 2 4
GO:0043227 membrane-bounded organelle 3 4
GO:0043228 non-membrane-bounded organelle 3 4
GO:0043229 intracellular organelle 3 4
GO:0043232 intracellular non-membrane-bounded organelle 4 4
GO:0110165 cellular anatomical entity 1 4
GO:0120025 plasma membrane bounded cell projection 3 4

Expansion

Sequence features

A4HXB1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXB1

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 4
GO:0016043 cellular component organization 3 4
GO:0030030 cell projection organization 4 4
GO:0071840 cellular component organization or biogenesis 2 4
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 59 63 PF00656 0.384
CLV_NRD_NRD_1 217 219 PF00675 0.629
CLV_NRD_NRD_1 325 327 PF00675 0.336
CLV_NRD_NRD_1 350 352 PF00675 0.563
CLV_NRD_NRD_1 359 361 PF00675 0.548
CLV_NRD_NRD_1 396 398 PF00675 0.393
CLV_PCSK_KEX2_1 217 219 PF00082 0.622
CLV_PCSK_KEX2_1 325 327 PF00082 0.336
CLV_PCSK_KEX2_1 350 352 PF00082 0.483
CLV_PCSK_SKI1_1 326 330 PF00082 0.347
CLV_PCSK_SKI1_1 51 55 PF00082 0.429
CLV_PCSK_SKI1_1 82 86 PF00082 0.401
CLV_Separin_Metazoa 269 273 PF03568 0.411
DEG_Nend_UBRbox_3 1 3 PF02207 0.436
DEG_SPOP_SBC_1 197 201 PF00917 0.511
DOC_CYCLIN_RxL_1 217 231 PF00134 0.372
DOC_CYCLIN_RxL_1 266 277 PF00134 0.412
DOC_MAPK_DCC_7 135 144 PF00069 0.349
DOC_MAPK_gen_1 135 144 PF00069 0.386
DOC_MAPK_gen_1 145 152 PF00069 0.353
DOC_MAPK_gen_1 325 331 PF00069 0.348
DOC_MAPK_MEF2A_6 135 144 PF00069 0.349
DOC_PP1_RVXF_1 221 228 PF00149 0.347
DOC_PP1_RVXF_1 48 55 PF00149 0.396
DOC_PP2B_LxvP_1 187 190 PF13499 0.437
DOC_USP7_MATH_1 114 118 PF00917 0.436
DOC_USP7_MATH_1 197 201 PF00917 0.511
DOC_USP7_MATH_1 26 30 PF00917 0.532
DOC_USP7_MATH_1 3 7 PF00917 0.401
DOC_USP7_MATH_1 84 88 PF00917 0.417
DOC_WW_Pin1_4 198 203 PF00397 0.548
DOC_WW_Pin1_4 33 38 PF00397 0.543
LIG_14-3-3_CanoR_1 338 347 PF00244 0.477
LIG_14-3-3_CanoR_1 386 396 PF00244 0.413
LIG_14-3-3_CanoR_1 82 91 PF00244 0.435
LIG_AP2alpha_2 241 243 PF02296 0.303
LIG_eIF4E_1 173 179 PF01652 0.326
LIG_FHA_1 182 188 PF00498 0.463
LIG_FHA_1 284 290 PF00498 0.529
LIG_FHA_1 304 310 PF00498 0.494
LIG_FHA_1 342 348 PF00498 0.498
LIG_FHA_1 388 394 PF00498 0.402
LIG_FHA_2 353 359 PF00498 0.501
LIG_FHA_2 96 102 PF00498 0.496
LIG_GBD_Chelix_1 281 289 PF00786 0.503
LIG_HCF-1_HBM_1 314 317 PF13415 0.347
LIG_KLC1_Yacidic_2 273 277 PF13176 0.441
LIG_LIR_Nem_3 241 246 PF02991 0.427
LIG_Pex14_2 318 322 PF04695 0.361
LIG_SH2_CRK 173 177 PF00017 0.378
LIG_SH2_CRK 4 8 PF00017 0.396
LIG_SH2_SRC 245 248 PF00017 0.316
LIG_SH2_SRC 275 278 PF00017 0.460
LIG_SH2_SRC 312 315 PF00017 0.405
LIG_SH2_STAP1 389 393 PF00017 0.426
LIG_SH2_STAP1 4 8 PF00017 0.396
LIG_SH2_STAP1 91 95 PF00017 0.491
LIG_SH2_STAT5 173 176 PF00017 0.314
LIG_SH2_STAT5 226 229 PF00017 0.378
LIG_SH2_STAT5 245 248 PF00017 0.384
LIG_SH2_STAT5 275 278 PF00017 0.441
LIG_SH2_STAT5 312 315 PF00017 0.405
LIG_SH2_STAT5 317 320 PF00017 0.340
LIG_SH2_STAT5 381 384 PF00017 0.382
LIG_SH2_STAT5 389 392 PF00017 0.409
LIG_SH3_3 108 114 PF00018 0.479
LIG_SH3_3 191 197 PF00018 0.448
LIG_SH3_3 49 55 PF00018 0.395
LIG_TRAF2_1 99 102 PF00917 0.435
MOD_CDC14_SPxK_1 201 204 PF00782 0.547
MOD_CDK_SPxK_1 198 204 PF00069 0.547
MOD_CK1_1 131 137 PF00069 0.359
MOD_CK1_1 195 201 PF00069 0.539
MOD_CK1_1 203 209 PF00069 0.413
MOD_CK1_1 287 293 PF00069 0.495
MOD_CK1_1 29 35 PF00069 0.537
MOD_CK1_1 301 307 PF00069 0.524
MOD_CK1_1 341 347 PF00069 0.444
MOD_CK2_1 388 394 PF00069 0.416
MOD_CK2_1 95 101 PF00069 0.446
MOD_CMANNOS 319 322 PF00535 0.344
MOD_GlcNHglycan 116 119 PF01048 0.410
MOD_GlcNHglycan 211 215 PF01048 0.466
MOD_GlcNHglycan 28 31 PF01048 0.533
MOD_GlcNHglycan 290 293 PF01048 0.538
MOD_GlcNHglycan 32 35 PF01048 0.519
MOD_GlcNHglycan 390 393 PF01048 0.436
MOD_GlcNHglycan 86 89 PF01048 0.541
MOD_GSK3_1 151 158 PF00069 0.425
MOD_GSK3_1 192 199 PF00069 0.595
MOD_GSK3_1 25 32 PF00069 0.532
MOD_GSK3_1 283 290 PF00069 0.515
MOD_GSK3_1 360 367 PF00069 0.525
MOD_GSK3_1 91 98 PF00069 0.442
MOD_NEK2_1 210 215 PF00069 0.331
MOD_NEK2_1 385 390 PF00069 0.420
MOD_NEK2_1 76 81 PF00069 0.375
MOD_PIKK_1 301 307 PF00454 0.504
MOD_PIKK_1 339 345 PF00454 0.475
MOD_PIKK_1 352 358 PF00454 0.484
MOD_PIKK_1 370 376 PF00454 0.560
MOD_PKA_1 360 366 PF00069 0.525
MOD_PKA_2 181 187 PF00069 0.465
MOD_PKA_2 283 289 PF00069 0.513
MOD_PKA_2 298 304 PF00069 0.545
MOD_PKA_2 385 391 PF00069 0.412
MOD_Plk_1 230 236 PF00069 0.293
MOD_Plk_1 91 97 PF00069 0.477
MOD_Plk_4 258 264 PF00069 0.443
MOD_Plk_4 3 9 PF00069 0.395
MOD_Plk_4 308 314 PF00069 0.438
MOD_Plk_4 76 82 PF00069 0.577
MOD_ProDKin_1 198 204 PF00069 0.547
MOD_ProDKin_1 33 39 PF00069 0.544
TRG_DiLeu_BaEn_1 10 15 PF01217 0.424
TRG_DiLeu_BaEn_1 124 129 PF01217 0.446
TRG_DiLeu_BaEn_4 101 107 PF01217 0.456
TRG_ENDOCYTIC_2 173 176 PF00928 0.372
TRG_ENDOCYTIC_2 226 229 PF00928 0.307
TRG_ENDOCYTIC_2 4 7 PF00928 0.397
TRG_ER_diArg_1 135 138 PF00400 0.396
TRG_ER_diArg_1 217 219 PF00400 0.631
TRG_ER_diArg_1 324 326 PF00400 0.336
TRG_ER_diArg_1 349 351 PF00400 0.476
TRG_Pf-PMV_PEXEL_1 272 277 PF00026 0.445

Homologs

Protein Taxonomy Sequence identity Coverage
A0A422NFB1 Trypanosoma rangeli 36% 100%
E9AQZ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS