LeishMANIAdb
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Thioredoxin domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Thioredoxin domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HXA9_LEIIN
TriTrypDb:
LINF_170008200
Length:
867

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 0
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXA9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXA9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 323 327 PF00656 0.472
CLV_C14_Caspase3-7 505 509 PF00656 0.552
CLV_C14_Caspase3-7 510 514 PF00656 0.561
CLV_C14_Caspase3-7 614 618 PF00656 0.622
CLV_C14_Caspase3-7 817 821 PF00656 0.582
CLV_MEL_PAP_1 499 505 PF00089 0.677
CLV_NRD_NRD_1 140 142 PF00675 0.445
CLV_NRD_NRD_1 389 391 PF00675 0.497
CLV_NRD_NRD_1 434 436 PF00675 0.498
CLV_NRD_NRD_1 536 538 PF00675 0.534
CLV_NRD_NRD_1 638 640 PF00675 0.600
CLV_NRD_NRD_1 709 711 PF00675 0.527
CLV_NRD_NRD_1 719 721 PF00675 0.518
CLV_NRD_NRD_1 732 734 PF00675 0.459
CLV_NRD_NRD_1 740 742 PF00675 0.574
CLV_NRD_NRD_1 790 792 PF00675 0.605
CLV_NRD_NRD_1 806 808 PF00675 0.621
CLV_NRD_NRD_1 832 834 PF00675 0.444
CLV_PCSK_FUR_1 707 711 PF00082 0.467
CLV_PCSK_FUR_1 738 742 PF00082 0.562
CLV_PCSK_FUR_1 829 833 PF00082 0.465
CLV_PCSK_KEX2_1 140 142 PF00082 0.445
CLV_PCSK_KEX2_1 389 391 PF00082 0.515
CLV_PCSK_KEX2_1 434 436 PF00082 0.498
CLV_PCSK_KEX2_1 535 537 PF00082 0.572
CLV_PCSK_KEX2_1 638 640 PF00082 0.652
CLV_PCSK_KEX2_1 709 711 PF00082 0.557
CLV_PCSK_KEX2_1 719 721 PF00082 0.505
CLV_PCSK_KEX2_1 730 732 PF00082 0.464
CLV_PCSK_KEX2_1 740 742 PF00082 0.577
CLV_PCSK_KEX2_1 790 792 PF00082 0.605
CLV_PCSK_KEX2_1 806 808 PF00082 0.621
CLV_PCSK_KEX2_1 829 831 PF00082 0.460
CLV_PCSK_KEX2_1 832 834 PF00082 0.444
CLV_PCSK_PC1ET2_1 719 721 PF00082 0.552
CLV_PCSK_PC1ET2_1 730 732 PF00082 0.424
CLV_PCSK_PC7_1 705 711 PF00082 0.472
CLV_PCSK_SKI1_1 162 166 PF00082 0.476
CLV_PCSK_SKI1_1 239 243 PF00082 0.544
CLV_PCSK_SKI1_1 248 252 PF00082 0.521
CLV_PCSK_SKI1_1 409 413 PF00082 0.393
CLV_PCSK_SKI1_1 570 574 PF00082 0.535
CLV_PCSK_SKI1_1 657 661 PF00082 0.559
CLV_PCSK_SKI1_1 850 854 PF00082 0.614
DEG_SPOP_SBC_1 311 315 PF00917 0.551
DOC_CDC14_PxL_1 216 224 PF14671 0.474
DOC_CKS1_1 179 184 PF01111 0.489
DOC_CYCLIN_yCln2_LP_2 11 17 PF00134 0.507
DOC_MAPK_gen_1 140 148 PF00069 0.439
DOC_MAPK_gen_1 535 543 PF00069 0.489
DOC_MAPK_MEF2A_6 140 147 PF00069 0.499
DOC_MAPK_MEF2A_6 535 543 PF00069 0.489
DOC_MAPK_MEF2A_6 86 95 PF00069 0.470
DOC_MAPK_NFAT4_5 140 148 PF00069 0.503
DOC_PP1_RVXF_1 407 413 PF00149 0.363
DOC_PP2B_LxvP_1 11 14 PF13499 0.513
DOC_PP2B_LxvP_1 335 338 PF13499 0.603
DOC_PP2B_PxIxI_1 538 544 PF00149 0.422
DOC_PP4_FxxP_1 179 182 PF00568 0.609
DOC_PP4_FxxP_1 52 55 PF00568 0.471
DOC_USP7_MATH_1 101 105 PF00917 0.393
DOC_USP7_MATH_1 189 193 PF00917 0.478
DOC_USP7_MATH_1 244 248 PF00917 0.592
DOC_USP7_MATH_1 253 257 PF00917 0.460
DOC_USP7_MATH_1 273 277 PF00917 0.372
DOC_USP7_MATH_1 311 315 PF00917 0.508
DOC_USP7_MATH_1 330 334 PF00917 0.544
DOC_USP7_MATH_1 41 45 PF00917 0.684
DOC_USP7_MATH_1 449 453 PF00917 0.696
DOC_USP7_MATH_1 498 502 PF00917 0.478
DOC_USP7_MATH_1 526 530 PF00917 0.601
DOC_USP7_MATH_1 577 581 PF00917 0.495
DOC_USP7_MATH_1 588 592 PF00917 0.377
DOC_USP7_MATH_1 622 626 PF00917 0.630
DOC_USP7_MATH_1 82 86 PF00917 0.581
DOC_WW_Pin1_4 174 179 PF00397 0.613
DOC_WW_Pin1_4 185 190 PF00397 0.457
DOC_WW_Pin1_4 224 229 PF00397 0.552
DOC_WW_Pin1_4 3 8 PF00397 0.563
DOC_WW_Pin1_4 333 338 PF00397 0.547
DOC_WW_Pin1_4 383 388 PF00397 0.508
DOC_WW_Pin1_4 460 465 PF00397 0.471
DOC_WW_Pin1_4 661 666 PF00397 0.572
DOC_WW_Pin1_4 695 700 PF00397 0.628
DOC_WW_Pin1_4 78 83 PF00397 0.588
LIG_14-3-3_CanoR_1 115 125 PF00244 0.437
LIG_14-3-3_CanoR_1 434 443 PF00244 0.525
LIG_14-3-3_CanoR_1 609 619 PF00244 0.574
LIG_14-3-3_CanoR_1 692 699 PF00244 0.676
LIG_14-3-3_CanoR_1 850 855 PF00244 0.611
LIG_Actin_RPEL_3 828 847 PF02755 0.422
LIG_Actin_WH2_2 394 411 PF00022 0.485
LIG_Actin_WH2_2 539 555 PF00022 0.496
LIG_AP2alpha_2 538 540 PF02296 0.487
LIG_APCC_ABBA_1 93 98 PF00400 0.407
LIG_BRCT_BRCA1_1 220 224 PF00533 0.483
LIG_BRCT_BRCA1_1 324 328 PF00533 0.597
LIG_BRCT_BRCA1_1 43 47 PF00533 0.574
LIG_BRCT_BRCA1_1 588 592 PF00533 0.431
LIG_CaM_IQ_9 401 417 PF13499 0.408
LIG_EH1_1 15 23 PF00400 0.454
LIG_FHA_1 153 159 PF00498 0.460
LIG_FHA_1 179 185 PF00498 0.519
LIG_FHA_1 213 219 PF00498 0.626
LIG_FHA_1 232 238 PF00498 0.488
LIG_FHA_1 383 389 PF00498 0.653
LIG_FHA_1 443 449 PF00498 0.536
LIG_FHA_1 79 85 PF00498 0.724
LIG_FHA_1 87 93 PF00498 0.434
LIG_FHA_2 341 347 PF00498 0.613
LIG_FHA_2 791 797 PF00498 0.580
LIG_FHA_2 851 857 PF00498 0.611
LIG_GBD_Chelix_1 428 436 PF00786 0.396
LIG_LIR_Apic_2 130 134 PF02991 0.413
LIG_LIR_Apic_2 177 182 PF02991 0.609
LIG_LIR_Apic_2 49 55 PF02991 0.555
LIG_LIR_Gen_1 192 203 PF02991 0.413
LIG_LIR_Gen_1 215 224 PF02991 0.494
LIG_LIR_Nem_3 192 198 PF02991 0.459
LIG_LIR_Nem_3 215 219 PF02991 0.485
LIG_LIR_Nem_3 256 262 PF02991 0.464
LIG_LIR_Nem_3 459 465 PF02991 0.615
LIG_LIR_Nem_3 538 543 PF02991 0.470
LIG_LIR_Nem_3 637 643 PF02991 0.615
LIG_NRBOX 141 147 PF00104 0.493
LIG_SH2_CRK 259 263 PF00017 0.476
LIG_SH2_CRK 549 553 PF00017 0.490
LIG_SH2_GRB2like 319 322 PF00017 0.547
LIG_SH2_PTP2 131 134 PF00017 0.439
LIG_SH2_PTP2 210 213 PF00017 0.483
LIG_SH2_SRC 131 134 PF00017 0.439
LIG_SH2_SRC 210 213 PF00017 0.483
LIG_SH2_SRC 319 322 PF00017 0.503
LIG_SH2_STAT3 655 658 PF00017 0.542
LIG_SH2_STAT5 131 134 PF00017 0.439
LIG_SH2_STAT5 195 198 PF00017 0.563
LIG_SH2_STAT5 210 213 PF00017 0.403
LIG_SH2_STAT5 319 322 PF00017 0.482
LIG_SH2_STAT5 598 601 PF00017 0.676
LIG_SH2_STAT5 633 636 PF00017 0.732
LIG_SH2_STAT5 655 658 PF00017 0.563
LIG_SH3_1 808 814 PF00018 0.579
LIG_SH3_3 1 7 PF00018 0.581
LIG_SH3_3 222 228 PF00018 0.552
LIG_SH3_3 34 40 PF00018 0.632
LIG_SH3_3 571 577 PF00018 0.475
LIG_SH3_3 786 792 PF00018 0.604
LIG_SH3_3 808 814 PF00018 0.579
LIG_SH3_3 85 91 PF00018 0.538
LIG_SUMO_SIM_anti_2 144 149 PF11976 0.495
LIG_SUMO_SIM_anti_2 492 498 PF11976 0.377
LIG_SUMO_SIM_anti_2 59 67 PF11976 0.461
LIG_SUMO_SIM_par_1 284 292 PF11976 0.477
LIG_SUMO_SIM_par_1 91 99 PF11976 0.412
LIG_TRAF2_1 528 531 PF00917 0.648
LIG_TRAF2_1 711 714 PF00917 0.493
LIG_TRAF2_1 767 770 PF00917 0.501
LIG_TRFH_1 216 220 PF08558 0.506
LIG_UBA3_1 397 402 PF00899 0.422
MOD_CDC14_SPxK_1 386 389 PF00782 0.491
MOD_CDK_SPxK_1 383 389 PF00069 0.500
MOD_CDK_SPxxK_3 383 390 PF00069 0.500
MOD_CDK_SPxxK_3 460 467 PF00069 0.462
MOD_CK1_1 172 178 PF00069 0.566
MOD_CK1_1 276 282 PF00069 0.461
MOD_CK1_1 322 328 PF00069 0.490
MOD_CK1_1 333 339 PF00069 0.539
MOD_CK1_1 340 346 PF00069 0.512
MOD_CK1_1 42 48 PF00069 0.616
MOD_CK1_1 6 12 PF00069 0.522
MOD_CK1_1 625 631 PF00069 0.564
MOD_CK1_1 671 677 PF00069 0.647
MOD_CK1_1 78 84 PF00069 0.627
MOD_CK1_1 861 867 PF00069 0.635
MOD_CK2_1 133 139 PF00069 0.430
MOD_CK2_1 191 197 PF00069 0.459
MOD_CK2_1 224 230 PF00069 0.544
MOD_CK2_1 340 346 PF00069 0.626
MOD_CK2_1 453 459 PF00069 0.718
MOD_CK2_1 565 571 PF00069 0.689
MOD_CK2_1 671 677 PF00069 0.642
MOD_CK2_1 695 701 PF00069 0.780
MOD_CK2_1 779 785 PF00069 0.748
MOD_CK2_1 850 856 PF00069 0.548
MOD_CK2_1 861 867 PF00069 0.570
MOD_Cter_Amidation 804 807 PF01082 0.656
MOD_DYRK1A_RPxSP_1 460 464 PF00069 0.468
MOD_GlcNHglycan 135 138 PF01048 0.498
MOD_GlcNHglycan 174 177 PF01048 0.582
MOD_GlcNHglycan 191 194 PF01048 0.396
MOD_GlcNHglycan 291 294 PF01048 0.477
MOD_GlcNHglycan 322 325 PF01048 0.567
MOD_GlcNHglycan 353 356 PF01048 0.537
MOD_GlcNHglycan 392 395 PF01048 0.456
MOD_GlcNHglycan 41 44 PF01048 0.609
MOD_GlcNHglycan 567 570 PF01048 0.623
MOD_GlcNHglycan 588 591 PF01048 0.505
MOD_GlcNHglycan 624 627 PF01048 0.686
MOD_GlcNHglycan 686 689 PF01048 0.773
MOD_GlcNHglycan 695 698 PF01048 0.705
MOD_GSK3_1 116 123 PF00069 0.461
MOD_GSK3_1 148 155 PF00069 0.616
MOD_GSK3_1 174 181 PF00069 0.548
MOD_GSK3_1 185 192 PF00069 0.588
MOD_GSK3_1 197 204 PF00069 0.376
MOD_GSK3_1 242 249 PF00069 0.710
MOD_GSK3_1 260 267 PF00069 0.401
MOD_GSK3_1 272 279 PF00069 0.481
MOD_GSK3_1 333 340 PF00069 0.536
MOD_GSK3_1 35 42 PF00069 0.642
MOD_GSK3_1 449 456 PF00069 0.620
MOD_GSK3_1 485 492 PF00069 0.481
MOD_GSK3_1 575 582 PF00069 0.399
MOD_GSK3_1 596 603 PF00069 0.657
MOD_GSK3_1 622 629 PF00069 0.713
MOD_GSK3_1 63 70 PF00069 0.544
MOD_GSK3_1 691 698 PF00069 0.674
MOD_GSK3_1 76 83 PF00069 0.569
MOD_LATS_1 690 696 PF00433 0.657
MOD_N-GLC_1 320 325 PF02516 0.514
MOD_N-GLC_1 382 387 PF02516 0.495
MOD_N-GLC_1 443 448 PF02516 0.502
MOD_N-GLC_1 660 665 PF02516 0.578
MOD_N-GLC_2 849 851 PF02516 0.601
MOD_NEK2_1 184 189 PF00069 0.547
MOD_NEK2_1 260 265 PF00069 0.451
MOD_NEK2_1 320 325 PF00069 0.565
MOD_NEK2_1 328 333 PF00069 0.528
MOD_NEK2_1 382 387 PF00069 0.521
MOD_NEK2_1 436 441 PF00069 0.489
MOD_NEK2_1 442 447 PF00069 0.488
MOD_NEK2_1 485 490 PF00069 0.536
MOD_NEK2_1 586 591 PF00069 0.487
MOD_NEK2_1 596 601 PF00069 0.510
MOD_NEK2_1 660 665 PF00069 0.614
MOD_NEK2_1 96 101 PF00069 0.497
MOD_NEK2_2 361 366 PF00069 0.490
MOD_PIKK_1 276 282 PF00454 0.457
MOD_PIKK_1 485 491 PF00454 0.488
MOD_PIKK_1 600 606 PF00454 0.550
MOD_PIKK_1 779 785 PF00454 0.636
MOD_PIKK_1 818 824 PF00454 0.553
MOD_PKA_1 790 796 PF00069 0.650
MOD_PKA_2 260 266 PF00069 0.475
MOD_PKA_2 414 420 PF00069 0.493
MOD_PKA_2 691 697 PF00069 0.681
MOD_PKA_2 790 796 PF00069 0.664
MOD_Plk_1 303 309 PF00069 0.520
MOD_Plk_1 443 449 PF00069 0.504
MOD_Plk_1 458 464 PF00069 0.493
MOD_Plk_4 121 127 PF00069 0.435
MOD_Plk_4 169 175 PF00069 0.495
MOD_Plk_4 191 197 PF00069 0.459
MOD_Plk_4 284 290 PF00069 0.538
MOD_Plk_4 437 443 PF00069 0.542
MOD_Plk_4 489 495 PF00069 0.429
MOD_Plk_4 56 62 PF00069 0.452
MOD_Plk_4 579 585 PF00069 0.534
MOD_Plk_4 588 594 PF00069 0.446
MOD_Plk_4 6 12 PF00069 0.637
MOD_Plk_4 858 864 PF00069 0.576
MOD_ProDKin_1 174 180 PF00069 0.614
MOD_ProDKin_1 185 191 PF00069 0.454
MOD_ProDKin_1 224 230 PF00069 0.544
MOD_ProDKin_1 3 9 PF00069 0.561
MOD_ProDKin_1 333 339 PF00069 0.540
MOD_ProDKin_1 383 389 PF00069 0.510
MOD_ProDKin_1 460 466 PF00069 0.461
MOD_ProDKin_1 661 667 PF00069 0.576
MOD_ProDKin_1 695 701 PF00069 0.622
MOD_ProDKin_1 78 84 PF00069 0.587
MOD_SUMO_for_1 765 768 PF00179 0.582
TRG_DiLeu_BaEn_1 233 238 PF01217 0.434
TRG_DiLeu_BaEn_4 713 719 PF01217 0.535
TRG_DiLeu_BaLyEn_6 138 143 PF01217 0.514
TRG_ENDOCYTIC_2 195 198 PF00928 0.446
TRG_ENDOCYTIC_2 259 262 PF00928 0.464
TRG_ENDOCYTIC_2 549 552 PF00928 0.445
TRG_ENDOCYTIC_2 633 636 PF00928 0.546
TRG_ENDOCYTIC_2 640 643 PF00928 0.605
TRG_ER_diArg_1 140 142 PF00400 0.445
TRG_ER_diArg_1 388 390 PF00400 0.544
TRG_ER_diArg_1 434 436 PF00400 0.498
TRG_ER_diArg_1 455 458 PF00400 0.570
TRG_ER_diArg_1 534 537 PF00400 0.560
TRG_ER_diArg_1 638 640 PF00400 0.600
TRG_ER_diArg_1 706 709 PF00400 0.562
TRG_ER_diArg_1 731 733 PF00400 0.512
TRG_ER_diArg_1 738 741 PF00400 0.568
TRG_ER_diArg_1 789 791 PF00400 0.608
TRG_ER_diArg_1 828 831 PF00400 0.467
TRG_ER_diArg_1 832 835 PF00400 0.467
TRG_NES_CRM1_1 476 489 PF08389 0.441
TRG_NLS_Bipartite_1 709 723 PF00514 0.483
TRG_NLS_Bipartite_1 790 811 PF00514 0.541
TRG_NLS_MonoExtC_3 806 811 PF00514 0.559
TRG_NLS_MonoExtN_4 806 811 PF00514 0.559
TRG_Pf-PMV_PEXEL_1 140 144 PF00026 0.442
TRG_Pf-PMV_PEXEL_1 832 836 PF00026 0.360

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2L9 Leptomonas seymouri 51% 100%
A0A3Q8IAS7 Leishmania donovani 100% 100%
A4H8W2 Leishmania braziliensis 74% 100%
E9AQY8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QEH5 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS