ER membrane protein complex subunit 2

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat - putative

Species:

Leishmania infantum

UniProt:

A4HXA8_LEIIN

TriTrypDb:

LINF_170008100

Length:

317

Annotations

Annotations by Jardim et al.

ER/Golgi Proteins, ER Membrane complex EMC2 Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0072546	EMC complex	3	12
GO:0098796	membrane protein complex	2	12
GO:0140534	endoplasmic reticulum protein-containing complex	2	12

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HXA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.465
CLV_MEL_PAP_1	91	97	PF00089	0.427
CLV_NRD_NRD_1	297	299	PF00675	0.455
CLV_PCSK_KEX2_1	229	231	PF00082	0.391
CLV_PCSK_KEX2_1	297	299	PF00082	0.455
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.434
CLV_PCSK_SKI1_1	200	204	PF00082	0.366
CLV_PCSK_SKI1_1	26	30	PF00082	0.340
CLV_PCSK_SKI1_1	43	47	PF00082	0.335
CLV_Separin_Metazoa	264	268	PF03568	0.386
DOC_CYCLIN_RxL_1	101	111	PF00134	0.429
DOC_CYCLIN_RxL_1	39	50	PF00134	0.460
DOC_MAPK_gen_1	94	102	PF00069	0.393
DOC_USP7_MATH_1	53	57	PF00917	0.453
DOC_WW_Pin1_4	11	16	PF00397	0.418
LIG_14-3-3_CanoR_1	101	108	PF00244	0.377
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_BIR_III_2	180	184	PF00653	0.376
LIG_BRCT_BRCA1_1	241	245	PF00533	0.456
LIG_eIF4E_1	204	210	PF01652	0.434
LIG_eIF4E_1	239	245	PF01652	0.449
LIG_FHA_1	283	289	PF00498	0.435
LIG_FHA_1	301	307	PF00498	0.400
LIG_FHA_1	47	53	PF00498	0.345
LIG_FHA_1	83	89	PF00498	0.444
LIG_FHA_2	12	18	PF00498	0.430
LIG_FHA_2	162	168	PF00498	0.499
LIG_FHA_2	170	176	PF00498	0.384
LIG_FHA_2	182	188	PF00498	0.319
LIG_Integrin_RGD_1	178	180	PF01839	0.450
LIG_LIR_Gen_1	172	181	PF02991	0.450
LIG_LIR_Gen_1	214	225	PF02991	0.452
LIG_LIR_Gen_1	66	76	PF02991	0.335
LIG_LIR_Gen_1	85	95	PF02991	0.420
LIG_LIR_Nem_3	172	176	PF02991	0.390
LIG_LIR_Nem_3	184	188	PF02991	0.284
LIG_LIR_Nem_3	214	220	PF02991	0.431
LIG_LIR_Nem_3	62	68	PF02991	0.341
LIG_LIR_Nem_3	85	90	PF02991	0.371
LIG_NRBOX	190	196	PF00104	0.451
LIG_PTB_Apo_2	187	194	PF02174	0.320
LIG_PTB_Apo_2	210	217	PF02174	0.369
LIG_PTB_Phospho_1	187	193	PF10480	0.316
LIG_PTB_Phospho_1	210	216	PF10480	0.367
LIG_SH2_GRB2like	87	90	PF00017	0.448
LIG_SH2_PTP2	173	176	PF00017	0.386
LIG_SH2_SRC	173	176	PF00017	0.471
LIG_SH2_STAP1	123	127	PF00017	0.422
LIG_SH2_STAP1	239	243	PF00017	0.322
LIG_SH2_STAP1	68	72	PF00017	0.308
LIG_SH2_STAT5	163	166	PF00017	0.366
LIG_SH2_STAT5	173	176	PF00017	0.476
LIG_SH2_STAT5	193	196	PF00017	0.345
LIG_SH2_STAT5	216	219	PF00017	0.341
LIG_SH2_STAT5	312	315	PF00017	0.474
LIG_SH2_STAT5	87	90	PF00017	0.343
LIG_SUMO_SIM_par_1	26	32	PF11976	0.443
MOD_CK1_1	57	63	PF00069	0.483
MOD_CK1_1	6	12	PF00069	0.469
MOD_CK2_1	169	175	PF00069	0.384
MOD_CK2_1	181	187	PF00069	0.328
MOD_CK2_1	57	63	PF00069	0.430
MOD_Cter_Amidation	95	98	PF01082	0.484
MOD_GlcNHglycan	140	143	PF01048	0.339
MOD_GlcNHglycan	270	273	PF01048	0.466
MOD_GlcNHglycan	306	309	PF01048	0.330
MOD_GlcNHglycan	35	38	PF01048	0.473
MOD_GlcNHglycan	56	59	PF01048	0.462
MOD_GSK3_1	300	307	PF00069	0.367
MOD_GSK3_1	53	60	PF00069	0.414
MOD_GSK3_1	96	103	PF00069	0.461
MOD_N-GLC_1	212	217	PF02516	0.484
MOD_N-GLC_1	249	254	PF02516	0.421
MOD_N-GLC_1	82	87	PF02516	0.440
MOD_NEK2_1	244	249	PF00069	0.496
MOD_NEK2_1	90	95	PF00069	0.472
MOD_NEK2_2	292	297	PF00069	0.442
MOD_NEK2_2	96	101	PF00069	0.356
MOD_PIKK_1	237	243	PF00454	0.438
MOD_PIKK_1	244	250	PF00454	0.481
MOD_PIKK_1	280	286	PF00454	0.495
MOD_PKA_2	100	106	PF00069	0.437
MOD_PKA_2	138	144	PF00069	0.313
MOD_PKA_2	33	39	PF00069	0.416
MOD_Plk_1	212	218	PF00069	0.358
MOD_Plk_1	82	88	PF00069	0.435
MOD_Plk_4	169	175	PF00069	0.393
MOD_Plk_4	212	218	PF00069	0.413
MOD_Plk_4	239	245	PF00069	0.422
MOD_Plk_4	82	88	PF00069	0.355
MOD_ProDKin_1	11	17	PF00069	0.411
MOD_SUMO_rev_2	12	21	PF00179	0.423
TRG_ENDOCYTIC_2	123	126	PF00928	0.341
TRG_ENDOCYTIC_2	173	176	PF00928	0.435
TRG_ENDOCYTIC_2	185	188	PF00928	0.254
TRG_ENDOCYTIC_2	68	71	PF00928	0.312
TRG_ENDOCYTIC_2	87	90	PF00928	0.343
TRG_ER_diArg_1	296	298	PF00400	0.456
TRG_NES_CRM1_1	63	77	PF08389	0.389
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYX7	Leptomonas seymouri	83%	100%
A0A0S4J0N8	Bodo saltans	42%	100%
A0A1X0NTH4	Trypanosomatidae	55%	100%
A0A3R7KD80	Trypanosoma rangeli	51%	100%
A0A3S7WUH2	Leishmania donovani	100%	100%
A4H8W1	Leishmania braziliensis	92%	100%
B0BNG0	Rattus norvegicus	27%	100%
C9ZTV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
E9AQY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q15006	Homo sapiens	27%	100%
Q4QEH6	Leishmania major	97%	100%
Q5E993	Bos taurus	27%	100%
Q5M7J9	Xenopus tropicalis	31%	100%
Q5R882	Pongo abelii	27%	100%
Q6INS3	Xenopus laevis	29%	100%
Q6TGY8	Danio rerio	30%	100%
Q8AVU9	Xenopus laevis	28%	100%
Q9CRD2	Mus musculus	27%	100%
V5B876	Trypanosoma cruzi	51%	100%