Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXA6_LEIIN

TriTrypDb:

LINF_170007900

Length:

641

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	318	322	PF00656	0.526
CLV_C14_Caspase3-7	637	641	PF00656	0.610
CLV_MEL_PAP_1	120	126	PF00089	0.571
CLV_NRD_NRD_1	115	117	PF00675	0.501
CLV_NRD_NRD_1	175	177	PF00675	0.552
CLV_NRD_NRD_1	565	567	PF00675	0.471
CLV_PCSK_KEX2_1	115	117	PF00082	0.501
CLV_PCSK_KEX2_1	175	177	PF00082	0.552
CLV_PCSK_KEX2_1	565	567	PF00082	0.505
CLV_PCSK_KEX2_1	596	598	PF00082	0.733
CLV_PCSK_KEX2_1	631	633	PF00082	0.604
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.733
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.604
CLV_PCSK_SKI1_1	195	199	PF00082	0.501
CLV_PCSK_SKI1_1	246	250	PF00082	0.527
CLV_PCSK_SKI1_1	328	332	PF00082	0.678
DEG_APCC_DBOX_1	327	335	PF00400	0.673
DEG_APCC_DBOX_1	565	573	PF00400	0.587
DEG_Nend_UBRbox_1	1	4	PF02207	0.487
DEG_SPOP_SBC_1	379	383	PF00917	0.689
DEG_SPOP_SBC_1	419	423	PF00917	0.712
DEG_SPOP_SBC_1	503	507	PF00917	0.631
DOC_CDC14_PxL_1	289	297	PF14671	0.573
DOC_CYCLIN_yCln2_LP_2	294	297	PF00134	0.368
DOC_MAPK_HePTP_8	65	77	PF00069	0.571
DOC_MAPK_MEF2A_6	230	237	PF00069	0.525
DOC_MAPK_MEF2A_6	68	77	PF00069	0.540
DOC_PP2B_LxvP_1	294	297	PF13499	0.512
DOC_PP2B_LxvP_1	469	472	PF13499	0.788
DOC_PP4_FxxP_1	537	540	PF00568	0.565
DOC_PP4_FxxP_1	614	617	PF00568	0.697
DOC_USP7_MATH_1	10	14	PF00917	0.736
DOC_USP7_MATH_1	255	259	PF00917	0.527
DOC_USP7_MATH_1	29	33	PF00917	0.556
DOC_USP7_MATH_1	380	384	PF00917	0.701
DOC_USP7_MATH_1	419	423	PF00917	0.707
DOC_USP7_MATH_1	472	476	PF00917	0.759
DOC_USP7_MATH_1	49	53	PF00917	0.651
DOC_USP7_MATH_1	503	507	PF00917	0.711
DOC_USP7_MATH_1	586	590	PF00917	0.571
DOC_USP7_MATH_1	92	96	PF00917	0.720
DOC_USP7_UBL2_3	570	574	PF12436	0.638
DOC_WW_Pin1_4	407	412	PF00397	0.540
LIG_14-3-3_CanoR_1	101	110	PF00244	0.620
LIG_14-3-3_CanoR_1	242	248	PF00244	0.450
LIG_14-3-3_CanoR_1	333	341	PF00244	0.583
LIG_BIR_III_4	90	94	PF00653	0.626
LIG_BRCT_BRCA1_1	350	354	PF00533	0.403
LIG_BRCT_BRCA1_1	356	360	PF00533	0.460
LIG_BRCT_BRCA1_1	514	518	PF00533	0.531
LIG_BRCT_BRCA1_1	622	626	PF00533	0.585
LIG_Clathr_ClatBox_1	225	229	PF01394	0.445
LIG_Clathr_ClatBox_1	633	637	PF01394	0.599
LIG_Dynein_DLC8_1	331	337	PF01221	0.526
LIG_EH1_1	436	444	PF00400	0.468
LIG_EVH1_2	411	415	PF00568	0.478
LIG_FHA_1	139	145	PF00498	0.528
LIG_FHA_1	206	212	PF00498	0.396
LIG_FHA_1	43	49	PF00498	0.664
LIG_FHA_1	464	470	PF00498	0.727
LIG_FHA_1	582	588	PF00498	0.519
LIG_FHA_1	625	631	PF00498	0.508
LIG_FHA_2	133	139	PF00498	0.588
LIG_FHA_2	196	202	PF00498	0.705
LIG_FHA_2	550	556	PF00498	0.631
LIG_LIR_Apic_2	534	540	PF02991	0.555
LIG_LIR_Apic_2	611	617	PF02991	0.678
LIG_LIR_Gen_1	208	217	PF02991	0.558
LIG_LIR_Gen_1	357	367	PF02991	0.519
LIG_LIR_Gen_1	553	563	PF02991	0.639
LIG_LIR_Nem_3	122	127	PF02991	0.527
LIG_LIR_Nem_3	162	166	PF02991	0.405
LIG_LIR_Nem_3	172	177	PF02991	0.406
LIG_LIR_Nem_3	208	213	PF02991	0.541
LIG_LIR_Nem_3	218	222	PF02991	0.366
LIG_LIR_Nem_3	357	363	PF02991	0.518
LIG_LIR_Nem_3	55	60	PF02991	0.511
LIG_LIR_Nem_3	553	559	PF02991	0.571
LIG_LYPXL_yS_3	3	6	PF13949	0.698
LIG_MYND_1	293	297	PF01753	0.610
LIG_MYND_1	4	8	PF01753	0.595
LIG_NRBOX	221	227	PF00104	0.493
LIG_PDZ_Class_2	636	641	PF00595	0.601
LIG_Pex14_1	620	624	PF04695	0.498
LIG_Rb_LxCxE_1	221	241	PF01857	0.502
LIG_REV1ctd_RIR_1	435	445	PF16727	0.551
LIG_SH2_CRK	63	67	PF00017	0.579
LIG_SH2_NCK_1	118	122	PF00017	0.574
LIG_SH2_PTP2	210	213	PF00017	0.399
LIG_SH2_STAT5	166	169	PF00017	0.418
LIG_SH2_STAT5	210	213	PF00017	0.399
LIG_SH2_STAT5	403	406	PF00017	0.518
LIG_SH3_1	406	412	PF00018	0.516
LIG_SH3_3	137	143	PF00018	0.739
LIG_SH3_3	265	271	PF00018	0.408
LIG_SH3_3	287	293	PF00018	0.451
LIG_SH3_3	406	412	PF00018	0.450
LIG_SH3_3	55	61	PF00018	0.506
LIG_SH3_3	81	87	PF00018	0.684
LIG_SUMO_SIM_par_1	632	638	PF11976	0.582
LIG_TYR_ITIM	60	65	PF00017	0.630
MOD_CK1_1	150	156	PF00069	0.719
MOD_CK1_1	241	247	PF00069	0.434
MOD_CK1_1	339	345	PF00069	0.544
MOD_CK1_1	347	353	PF00069	0.433
MOD_CK1_1	382	388	PF00069	0.731
MOD_CK1_1	410	416	PF00069	0.680
MOD_CK1_1	422	428	PF00069	0.481
MOD_CK1_1	473	479	PF00069	0.726
MOD_CK1_1	495	501	PF00069	0.676
MOD_CK1_1	504	510	PF00069	0.476
MOD_CK1_1	512	518	PF00069	0.471
MOD_CK1_1	52	58	PF00069	0.638
MOD_CK1_1	589	595	PF00069	0.740
MOD_CK2_1	132	138	PF00069	0.594
MOD_CK2_1	549	555	PF00069	0.640
MOD_CK2_1	64	70	PF00069	0.560
MOD_CMANNOS	283	286	PF00535	0.488
MOD_GlcNHglycan	149	152	PF01048	0.664
MOD_GlcNHglycan	177	180	PF01048	0.443
MOD_GlcNHglycan	191	194	PF01048	0.641
MOD_GlcNHglycan	221	225	PF01048	0.541
MOD_GlcNHglycan	25	28	PF01048	0.769
MOD_GlcNHglycan	310	313	PF01048	0.735
MOD_GlcNHglycan	323	326	PF01048	0.550
MOD_GlcNHglycan	341	344	PF01048	0.555
MOD_GlcNHglycan	384	387	PF01048	0.761
MOD_GlcNHglycan	422	425	PF01048	0.722
MOD_GlcNHglycan	480	483	PF01048	0.746
MOD_GlcNHglycan	51	54	PF01048	0.705
MOD_GlcNHglycan	514	517	PF01048	0.541
MOD_GlcNHglycan	588	592	PF01048	0.673
MOD_GlcNHglycan	78	82	PF01048	0.659
MOD_GlcNHglycan	94	97	PF01048	0.648
MOD_GSK3_1	10	17	PF00069	0.656
MOD_GSK3_1	128	135	PF00069	0.536
MOD_GSK3_1	149	156	PF00069	0.661
MOD_GSK3_1	237	244	PF00069	0.455
MOD_GSK3_1	332	339	PF00069	0.531
MOD_GSK3_1	344	351	PF00069	0.364
MOD_GSK3_1	378	385	PF00069	0.760
MOD_GSK3_1	418	425	PF00069	0.708
MOD_GSK3_1	472	479	PF00069	0.738
MOD_GSK3_1	488	495	PF00069	0.549
MOD_GSK3_1	49	56	PF00069	0.641
MOD_GSK3_1	577	584	PF00069	0.685
MOD_GSK3_1	620	627	PF00069	0.578
MOD_GSK3_1	73	80	PF00069	0.599
MOD_NEK2_1	136	141	PF00069	0.664
MOD_NEK2_1	237	242	PF00069	0.433
MOD_NEK2_1	344	349	PF00069	0.452
MOD_NEK2_1	354	359	PF00069	0.440
MOD_NEK2_1	384	389	PF00069	0.758
MOD_NEK2_1	427	432	PF00069	0.645
MOD_NEK2_1	437	442	PF00069	0.501
MOD_NEK2_1	488	493	PF00069	0.741
MOD_NEK2_1	509	514	PF00069	0.606
MOD_NEK2_1	624	629	PF00069	0.570
MOD_PIKK_1	12	18	PF00454	0.649
MOD_PIKK_1	156	162	PF00454	0.579
MOD_PIKK_1	241	247	PF00454	0.436
MOD_PIKK_1	332	338	PF00454	0.516
MOD_PK_1	123	129	PF00069	0.484
MOD_PKA_1	175	181	PF00069	0.448
MOD_PKA_2	175	181	PF00069	0.436
MOD_PKA_2	241	247	PF00069	0.455
MOD_PKA_2	332	338	PF00069	0.516
MOD_PKA_2	512	518	PF00069	0.555
MOD_PKA_2	524	530	PF00069	0.520
MOD_Plk_1	220	226	PF00069	0.511
MOD_Plk_1	73	79	PF00069	0.619
MOD_Plk_2-3	549	555	PF00069	0.619
MOD_Plk_2-3	568	574	PF00069	0.474
MOD_Plk_4	123	129	PF00069	0.481
MOD_Plk_4	205	211	PF00069	0.549
MOD_Plk_4	492	498	PF00069	0.715
MOD_ProDKin_1	407	413	PF00069	0.554
MOD_SUMO_rev_2	564	572	PF00179	0.597
TRG_AP2beta_CARGO_1	172	181	PF09066	0.424
TRG_DiLeu_BaEn_1	229	234	PF01217	0.503
TRG_DiLeu_BaEn_1	270	275	PF01217	0.527
TRG_DiLeu_BaEn_1	448	453	PF01217	0.578
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.716
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.464
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.508
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.493
TRG_DiLeu_BaLyEn_6	629	634	PF01217	0.597
TRG_ENDOCYTIC_2	210	213	PF00928	0.543
TRG_ENDOCYTIC_2	3	6	PF00928	0.698
TRG_ENDOCYTIC_2	62	65	PF00928	0.508
TRG_ER_diArg_1	115	117	PF00400	0.501
TRG_ER_diArg_1	174	176	PF00400	0.554
TRG_ER_diArg_1	597	600	PF00400	0.692
TRG_NLS_MonoExtC_3	595	601	PF00514	0.773
TRG_NLS_MonoExtN_4	594	600	PF00514	0.728
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTE1	Leptomonas seymouri	37%	100%
A0A3S5H6Z9	Leishmania donovani	100%	96%
A0A3S5IR37	Trypanosoma rangeli	29%	100%
A4H8V9	Leishmania braziliensis	70%	100%
C9ZTV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AQY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QEH8	Leishmania major	88%	100%
V5D8P0	Trypanosoma cruzi	27%	100%