Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXA4_LEIIN

TriTrypDb:

LINF_170010000

Length:

800

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HXA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.568
CLV_C14_Caspase3-7	519	523	PF00656	0.705
CLV_C14_Caspase3-7	55	59	PF00656	0.702
CLV_C14_Caspase3-7	754	758	PF00656	0.646
CLV_NRD_NRD_1	208	210	PF00675	0.473
CLV_NRD_NRD_1	321	323	PF00675	0.453
CLV_NRD_NRD_1	330	332	PF00675	0.441
CLV_NRD_NRD_1	37	39	PF00675	0.416
CLV_NRD_NRD_1	525	527	PF00675	0.515
CLV_NRD_NRD_1	724	726	PF00675	0.350
CLV_PCSK_FUR_1	206	210	PF00082	0.463
CLV_PCSK_FUR_1	319	323	PF00082	0.440
CLV_PCSK_KEX2_1	208	210	PF00082	0.470
CLV_PCSK_KEX2_1	321	323	PF00082	0.453
CLV_PCSK_KEX2_1	330	332	PF00082	0.441
CLV_PCSK_KEX2_1	37	39	PF00082	0.526
CLV_PCSK_KEX2_1	524	526	PF00082	0.517
CLV_PCSK_KEX2_1	724	726	PF00082	0.350
CLV_PCSK_SKI1_1	101	105	PF00082	0.394
CLV_PCSK_SKI1_1	14	18	PF00082	0.415
CLV_PCSK_SKI1_1	244	248	PF00082	0.447
CLV_PCSK_SKI1_1	734	738	PF00082	0.398
DEG_APCC_DBOX_1	100	108	PF00400	0.588
DEG_APCC_DBOX_1	116	124	PF00400	0.553
DEG_SCF_FBW7_1	510	516	PF00400	0.709
DOC_CKS1_1	469	474	PF01111	0.676
DOC_CKS1_1	510	515	PF01111	0.711
DOC_CYCLIN_RxL_1	11	21	PF00134	0.659
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.629
DOC_CYCLIN_yCln2_LP_2	485	491	PF00134	0.743
DOC_PP2B_LxvP_1	248	251	PF13499	0.615
DOC_PP2B_LxvP_1	485	488	PF13499	0.741
DOC_PP2B_LxvP_1	703	706	PF13499	0.582
DOC_PP2B_LxvP_1	77	80	PF13499	0.765
DOC_USP7_MATH_1	266	270	PF00917	0.720
DOC_USP7_MATH_1	336	340	PF00917	0.618
DOC_USP7_MATH_1	356	360	PF00917	0.615
DOC_USP7_MATH_1	376	380	PF00917	0.594
DOC_USP7_MATH_1	462	466	PF00917	0.715
DOC_USP7_MATH_1	473	477	PF00917	0.697
DOC_USP7_MATH_1	478	482	PF00917	0.664
DOC_USP7_MATH_1	52	56	PF00917	0.745
DOC_USP7_MATH_1	580	584	PF00917	0.715
DOC_USP7_MATH_1	59	63	PF00917	0.675
DOC_USP7_MATH_1	69	73	PF00917	0.613
DOC_USP7_MATH_1	8	12	PF00917	0.610
DOC_USP7_MATH_1	86	90	PF00917	0.595
DOC_USP7_MATH_2	370	376	PF00917	0.736
DOC_WW_Pin1_4	211	216	PF00397	0.762
DOC_WW_Pin1_4	272	277	PF00397	0.703
DOC_WW_Pin1_4	283	288	PF00397	0.607
DOC_WW_Pin1_4	391	396	PF00397	0.709
DOC_WW_Pin1_4	431	436	PF00397	0.700
DOC_WW_Pin1_4	443	448	PF00397	0.633
DOC_WW_Pin1_4	458	463	PF00397	0.660
DOC_WW_Pin1_4	468	473	PF00397	0.688
DOC_WW_Pin1_4	474	479	PF00397	0.644
DOC_WW_Pin1_4	480	485	PF00397	0.721
DOC_WW_Pin1_4	494	499	PF00397	0.631
DOC_WW_Pin1_4	500	505	PF00397	0.701
DOC_WW_Pin1_4	509	514	PF00397	0.763
DOC_WW_Pin1_4	535	540	PF00397	0.688
DOC_WW_Pin1_4	571	576	PF00397	0.672
DOC_WW_Pin1_4	62	67	PF00397	0.731
DOC_WW_Pin1_4	88	93	PF00397	0.685
LIG_14-3-3_CanoR_1	117	121	PF00244	0.556
LIG_14-3-3_CanoR_1	131	141	PF00244	0.575
LIG_14-3-3_CanoR_1	330	336	PF00244	0.689
LIG_14-3-3_CanoR_1	350	355	PF00244	0.582
LIG_14-3-3_CanoR_1	361	370	PF00244	0.663
LIG_14-3-3_CanoR_1	37	42	PF00244	0.645
LIG_14-3-3_CanoR_1	391	395	PF00244	0.677
LIG_14-3-3_CanoR_1	454	462	PF00244	0.738
LIG_14-3-3_CanoR_1	524	533	PF00244	0.717
LIG_14-3-3_CanoR_1	556	561	PF00244	0.694
LIG_14-3-3_CanoR_1	734	739	PF00244	0.654
LIG_BRCT_BRCA1_1	439	443	PF00533	0.740
LIG_BRCT_BRCA1_2	439	445	PF00533	0.709
LIG_CaM_IQ_9	311	327	PF13499	0.627
LIG_CtBP_PxDLS_1	280	284	PF00389	0.659
LIG_CtBP_PxDLS_1	575	579	PF00389	0.641
LIG_CtBP_PxDLS_1	81	85	PF00389	0.603
LIG_DLG_GKlike_1	37	45	PF00625	0.650
LIG_EH1_1	639	647	PF00400	0.670
LIG_EVH1_1	77	81	PF00568	0.708
LIG_FHA_1	293	299	PF00498	0.608
LIG_FHA_1	344	350	PF00498	0.716
LIG_FHA_1	535	541	PF00498	0.762
LIG_FHA_1	713	719	PF00498	0.565
LIG_FHA_2	335	341	PF00498	0.708
LIG_FHA_2	590	596	PF00498	0.638
LIG_FHA_2	94	100	PF00498	0.639
LIG_HP1_1	86	90	PF01393	0.692
LIG_Integrin_RGD_1	755	757	PF01839	0.463
LIG_KLC1_Yacidic_2	668	673	PF13176	0.706
LIG_LIR_Apic_2	677	683	PF02991	0.605
LIG_LIR_Gen_1	109	120	PF02991	0.605
LIG_LIR_Gen_1	237	246	PF02991	0.622
LIG_LIR_Gen_1	599	608	PF02991	0.682
LIG_LIR_Gen_1	650	658	PF02991	0.594
LIG_LIR_Gen_1	668	676	PF02991	0.587
LIG_LIR_Gen_1	686	694	PF02991	0.577
LIG_LIR_Gen_1	772	782	PF02991	0.302
LIG_LIR_LC3C_4	383	387	PF02991	0.732
LIG_LIR_Nem_3	109	115	PF02991	0.665
LIG_LIR_Nem_3	163	167	PF02991	0.532
LIG_LIR_Nem_3	237	241	PF02991	0.637
LIG_LIR_Nem_3	554	560	PF02991	0.634
LIG_LIR_Nem_3	599	604	PF02991	0.700
LIG_LIR_Nem_3	650	656	PF02991	0.585
LIG_LIR_Nem_3	668	674	PF02991	0.581
LIG_LIR_Nem_3	686	690	PF02991	0.569
LIG_LIR_Nem_3	772	777	PF02991	0.302
LIG_LIR_Nem_3	91	97	PF02991	0.619
LIG_Pex14_1	112	116	PF04695	0.599
LIG_Pex14_2	139	143	PF04695	0.565
LIG_Pex14_2	243	247	PF04695	0.642
LIG_Pex14_2	779	783	PF04695	0.302
LIG_SH2_CRK	164	168	PF00017	0.533
LIG_SH2_CRK	680	684	PF00017	0.591
LIG_SH2_CRK	774	778	PF00017	0.302
LIG_SH2_SRC	7	10	PF00017	0.618
LIG_SH2_STAP1	565	569	PF00017	0.634
LIG_SH2_STAP1	774	778	PF00017	0.363
LIG_SH2_STAT3	354	357	PF00017	0.705
LIG_SH2_STAT5	106	109	PF00017	0.533
LIG_SH2_STAT5	354	357	PF00017	0.705
LIG_SH2_STAT5	671	674	PF00017	0.699
LIG_SH2_STAT5	680	683	PF00017	0.595
LIG_SH2_STAT5	774	777	PF00017	0.302
LIG_SH2_STAT5	95	98	PF00017	0.639
LIG_SH3_3	253	259	PF00018	0.661
LIG_SH3_3	425	431	PF00018	0.732
LIG_SH3_3	466	472	PF00018	0.718
LIG_SH3_3	72	78	PF00018	0.832
LIG_Sin3_3	710	717	PF02671	0.568
LIG_SUMO_SIM_anti_2	425	430	PF11976	0.699
LIG_SUMO_SIM_anti_2	643	648	PF11976	0.666
LIG_SUMO_SIM_par_1	383	390	PF11976	0.732
LIG_SUMO_SIM_par_1	86	91	PF11976	0.736
LIG_TRAF2_1	44	47	PF00917	0.672
LIG_TRAF2_1	666	669	PF00917	0.580
LIG_TRAF2_1	675	678	PF00917	0.615
LIG_TRAF2_1	719	722	PF00917	0.567
LIG_TYR_ITIM	651	656	PF00017	0.597
LIG_UBA3_1	16	20	PF00899	0.616
LIG_WRC_WIRS_1	235	240	PF05994	0.641
LIG_WRC_WIRS_1	684	689	PF05994	0.615
MOD_CDK_SPK_2	447	452	PF00069	0.652
MOD_CDK_SPK_2	494	499	PF00069	0.673
MOD_CDK_SPxxK_3	447	454	PF00069	0.657
MOD_CK1_1	234	240	PF00069	0.786
MOD_CK1_1	269	275	PF00069	0.725
MOD_CK1_1	279	285	PF00069	0.786
MOD_CK1_1	288	294	PF00069	0.628
MOD_CK1_1	334	340	PF00069	0.671
MOD_CK1_1	390	396	PF00069	0.666
MOD_CK1_1	40	46	PF00069	0.706
MOD_CK1_1	458	464	PF00069	0.748
MOD_CK1_1	476	482	PF00069	0.623
MOD_CK1_1	516	522	PF00069	0.797
MOD_CK1_1	599	605	PF00069	0.681
MOD_CK1_1	609	615	PF00069	0.728
MOD_CK1_1	62	68	PF00069	0.642
MOD_CK1_1	630	636	PF00069	0.638
MOD_CK1_1	772	778	PF00069	0.302
MOD_CK2_1	3	9	PF00069	0.633
MOD_CK2_1	40	46	PF00069	0.679
MOD_CK2_1	692	698	PF00069	0.556
MOD_CK2_1	93	99	PF00069	0.602
MOD_Cter_Amidation	522	525	PF01082	0.502
MOD_GlcNHglycan	215	218	PF01048	0.538
MOD_GlcNHglycan	364	367	PF01048	0.513
MOD_GlcNHglycan	374	377	PF01048	0.486
MOD_GlcNHglycan	378	381	PF01048	0.451
MOD_GlcNHglycan	406	409	PF01048	0.482
MOD_GlcNHglycan	46	50	PF01048	0.490
MOD_GlcNHglycan	507	510	PF01048	0.524
MOD_GlcNHglycan	515	518	PF01048	0.491
MOD_GlcNHglycan	548	551	PF01048	0.519
MOD_GlcNHglycan	582	585	PF01048	0.502
MOD_GlcNHglycan	60	64	PF01048	0.424
MOD_GlcNHglycan	608	611	PF01048	0.445
MOD_GlcNHglycan	614	617	PF01048	0.464
MOD_GlcNHglycan	629	632	PF01048	0.463
MOD_GlcNHglycan	67	70	PF01048	0.503
MOD_GlcNHglycan	694	697	PF01048	0.367
MOD_GlcNHglycan	71	74	PF01048	0.482
MOD_GlcNHglycan	715	718	PF01048	0.369
MOD_GSK3_1	131	138	PF00069	0.578
MOD_GSK3_1	262	269	PF00069	0.698
MOD_GSK3_1	270	277	PF00069	0.731
MOD_GSK3_1	279	286	PF00069	0.782
MOD_GSK3_1	288	295	PF00069	0.667
MOD_GSK3_1	3	10	PF00069	0.628
MOD_GSK3_1	364	371	PF00069	0.697
MOD_GSK3_1	37	44	PF00069	0.663
MOD_GSK3_1	372	379	PF00069	0.673
MOD_GSK3_1	387	394	PF00069	0.665
MOD_GSK3_1	437	444	PF00069	0.687
MOD_GSK3_1	457	464	PF00069	0.755
MOD_GSK3_1	473	480	PF00069	0.659
MOD_GSK3_1	500	507	PF00069	0.675
MOD_GSK3_1	509	516	PF00069	0.672
MOD_GSK3_1	552	559	PF00069	0.665
MOD_GSK3_1	608	615	PF00069	0.661
MOD_GSK3_1	61	68	PF00069	0.680
MOD_N-GLC_1	132	137	PF02516	0.386
MOD_N-GLC_1	391	396	PF02516	0.517
MOD_N-GLC_1	494	499	PF02516	0.497
MOD_N-GLC_1	500	505	PF02516	0.476
MOD_N-GLC_1	535	540	PF02516	0.454
MOD_N-GLC_1	596	601	PF02516	0.485
MOD_N-GLC_2	748	750	PF02516	0.485
MOD_NEK2_1	111	116	PF00069	0.598
MOD_NEK2_1	262	267	PF00069	0.699
MOD_NEK2_1	290	295	PF00069	0.614
MOD_NEK2_1	343	348	PF00069	0.704
MOD_NEK2_1	349	354	PF00069	0.649
MOD_NEK2_1	362	367	PF00069	0.608
MOD_NEK2_1	385	390	PF00069	0.733
MOD_NEK2_1	437	442	PF00069	0.720
MOD_NEK2_1	505	510	PF00069	0.715
MOD_NEK2_1	67	72	PF00069	0.714
MOD_NEK2_1	790	795	PF00069	0.382
MOD_NEK2_2	356	361	PF00069	0.707
MOD_NMyristoyl	1	7	PF02799	0.643
MOD_PIKK_1	229	235	PF00454	0.692
MOD_PIKK_1	274	280	PF00454	0.751
MOD_PIKK_1	288	294	PF00454	0.622
MOD_PKA_1	37	43	PF00069	0.631
MOD_PKA_1	524	530	PF00069	0.717
MOD_PKA_2	116	122	PF00069	0.559
MOD_PKA_2	349	355	PF00069	0.653
MOD_PKA_2	362	368	PF00069	0.709
MOD_PKA_2	37	43	PF00069	0.646
MOD_PKA_2	390	396	PF00069	0.676
MOD_PKA_2	524	530	PF00069	0.749
MOD_PKA_2	53	59	PF00069	0.687
MOD_PKB_1	348	356	PF00069	0.714
MOD_Plk_1	135	141	PF00069	0.580
MOD_Plk_1	270	276	PF00069	0.700
MOD_Plk_1	676	682	PF00069	0.609
MOD_Plk_1	772	778	PF00069	0.302
MOD_Plk_1	8	14	PF00069	0.645
MOD_Plk_2-3	93	99	PF00069	0.602
MOD_Plk_4	111	117	PF00069	0.611
MOD_Plk_4	234	240	PF00069	0.646
MOD_Plk_4	285	291	PF00069	0.686
MOD_Plk_4	350	356	PF00069	0.712
MOD_Plk_4	364	370	PF00069	0.633
MOD_Plk_4	633	639	PF00069	0.674
MOD_Plk_4	640	646	PF00069	0.631
MOD_Plk_4	772	778	PF00069	0.302
MOD_ProDKin_1	211	217	PF00069	0.762
MOD_ProDKin_1	272	278	PF00069	0.704
MOD_ProDKin_1	283	289	PF00069	0.605
MOD_ProDKin_1	391	397	PF00069	0.710
MOD_ProDKin_1	431	437	PF00069	0.701
MOD_ProDKin_1	443	449	PF00069	0.634
MOD_ProDKin_1	458	464	PF00069	0.662
MOD_ProDKin_1	468	474	PF00069	0.689
MOD_ProDKin_1	480	486	PF00069	0.721
MOD_ProDKin_1	494	500	PF00069	0.643
MOD_ProDKin_1	509	515	PF00069	0.764
MOD_ProDKin_1	535	541	PF00069	0.687
MOD_ProDKin_1	571	577	PF00069	0.672
MOD_ProDKin_1	62	68	PF00069	0.731
MOD_ProDKin_1	88	94	PF00069	0.685
MOD_SUMO_for_1	19	22	PF00179	0.607
TRG_DiLeu_BaEn_4	677	683	PF01217	0.621
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.713
TRG_DiLeu_BaLyEn_6	686	691	PF01217	0.572
TRG_ENDOCYTIC_2	164	167	PF00928	0.530
TRG_ENDOCYTIC_2	653	656	PF00928	0.582
TRG_ENDOCYTIC_2	671	674	PF00928	0.585
TRG_ENDOCYTIC_2	774	777	PF00928	0.302
TRG_ENDOCYTIC_2	787	790	PF00928	0.468
TRG_ENDOCYTIC_2	94	97	PF00928	0.594
TRG_ER_diArg_1	205	208	PF00400	0.679
TRG_ER_diArg_1	325	328	PF00400	0.653
TRG_ER_diArg_1	330	333	PF00400	0.648
TRG_ER_diArg_1	36	38	PF00400	0.621
TRG_ER_diArg_1	360	363	PF00400	0.672
TRG_ER_diArg_1	524	526	PF00400	0.836
TRG_ER_diArg_1	723	725	PF00400	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRJ8	Leptomonas seymouri	47%	100%
A0A3Q8IAP9	Leishmania donovani	100%	100%
A4H8Y0	Leishmania braziliensis	68%	99%
E9AR06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QEF7	Leishmania major	91%	100%