Dus domain-containing protein

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dihydrouridine synthase (Dus) - putative

Species:

Leishmania infantum

UniProt:

A4HXA2_LEIIN

TriTrypDb:

LINF_170009800

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HXA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXA2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	11
GO:0017150	tRNA dihydrouridine synthase activity	5	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0106413	dihydrouridine synthase activity	4	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	585	589	PF00656	0.479
CLV_NRD_NRD_1	251	253	PF00675	0.170
CLV_NRD_NRD_1	284	286	PF00675	0.170
CLV_NRD_NRD_1	399	401	PF00675	0.170
CLV_NRD_NRD_1	504	506	PF00675	0.244
CLV_PCSK_FUR_1	115	119	PF00082	0.429
CLV_PCSK_KEX2_1	117	119	PF00082	0.372
CLV_PCSK_KEX2_1	179	181	PF00082	0.676
CLV_PCSK_KEX2_1	251	253	PF00082	0.170
CLV_PCSK_KEX2_1	284	286	PF00082	0.170
CLV_PCSK_KEX2_1	343	345	PF00082	0.149
CLV_PCSK_KEX2_1	504	506	PF00082	0.262
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.385
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.676
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.149
CLV_PCSK_SKI1_1	121	125	PF00082	0.487
CLV_PCSK_SKI1_1	230	234	PF00082	0.295
CLV_PCSK_SKI1_1	236	240	PF00082	0.246
CLV_PCSK_SKI1_1	32	36	PF00082	0.520
CLV_PCSK_SKI1_1	331	335	PF00082	0.183
CLV_PCSK_SKI1_1	453	457	PF00082	0.170
CLV_PCSK_SKI1_1	504	508	PF00082	0.260
DEG_APCC_DBOX_1	539	547	PF00400	0.296
DEG_MDM2_SWIB_1	506	514	PF02201	0.230
DEG_ODPH_VHL_1	239	250	PF01847	0.383
DEG_SCF_FBW7_1	195	200	PF00400	0.587
DOC_AGCK_PIF_2	407	412	PF00069	0.456
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	456	462	PF00134	0.370
DOC_MAPK_RevD_3	237	252	PF00069	0.210
DOC_PP4_FxxP_1	108	111	PF00568	0.439
DOC_USP7_MATH_1	14	18	PF00917	0.663
DOC_USP7_MATH_1	167	171	PF00917	0.691
DOC_USP7_MATH_1	224	228	PF00917	0.487
DOC_USP7_MATH_1	68	72	PF00917	0.517
DOC_WW_Pin1_4	137	142	PF00397	0.710
DOC_WW_Pin1_4	193	198	PF00397	0.664
DOC_WW_Pin1_4	372	377	PF00397	0.422
DOC_WW_Pin1_4	570	575	PF00397	0.335
LIG_14-3-3_CanoR_1	182	191	PF00244	0.657
LIG_14-3-3_CanoR_1	211	219	PF00244	0.509
LIG_14-3-3_CanoR_1	225	230	PF00244	0.303
LIG_14-3-3_CanoR_1	252	258	PF00244	0.426
LIG_14-3-3_CanoR_1	274	283	PF00244	0.401
LIG_14-3-3_CanoR_1	384	389	PF00244	0.349
LIG_14-3-3_CanoR_1	46	55	PF00244	0.492
LIG_14-3-3_CanoR_1	498	507	PF00244	0.276
LIG_14-3-3_CanoR_1	557	565	PF00244	0.299
LIG_14-3-3_CanoR_1	69	73	PF00244	0.464
LIG_APCC_ABBAyCdc20_2	458	464	PF00400	0.370
LIG_BIR_II_1	1	5	PF00653	0.589
LIG_BIR_III_4	73	77	PF00653	0.513
LIG_BRCT_BRCA1_1	316	320	PF00533	0.383
LIG_deltaCOP1_diTrp_1	509	513	PF00928	0.230
LIG_DLG_GKlike_1	225	232	PF00625	0.250
LIG_Dynein_DLC8_1	209	215	PF01221	0.503
LIG_eIF4E_1	517	523	PF01652	0.241
LIG_FHA_1	198	204	PF00498	0.699
LIG_FHA_1	20	26	PF00498	0.620
LIG_FHA_1	343	349	PF00498	0.462
LIG_FHA_1	373	379	PF00498	0.349
LIG_FHA_2	163	169	PF00498	0.718
LIG_FHA_2	211	217	PF00498	0.578
LIG_FHA_2	260	266	PF00498	0.371
LIG_FHA_2	583	589	PF00498	0.562
LIG_LIR_Apic_2	61	65	PF02991	0.404
LIG_LIR_Gen_1	278	287	PF02991	0.384
LIG_LIR_Gen_1	317	328	PF02991	0.361
LIG_LIR_Gen_1	509	518	PF02991	0.235
LIG_LIR_Gen_1	554	563	PF02991	0.269
LIG_LIR_Nem_3	278	283	PF02991	0.370
LIG_LIR_Nem_3	317	323	PF02991	0.361
LIG_LIR_Nem_3	509	513	PF02991	0.230
LIG_LIR_Nem_3	554	558	PF02991	0.270
LIG_PCNA_PIPBox_1	226	235	PF02747	0.244
LIG_PCNA_yPIPBox_3	220	233	PF02747	0.417
LIG_Pex14_2	316	320	PF04695	0.401
LIG_Pex14_2	506	510	PF04695	0.229
LIG_PTB_Apo_2	244	251	PF02174	0.386
LIG_PTB_Apo_2	406	413	PF02174	0.370
LIG_PTB_Phospho_1	406	412	PF10480	0.370
LIG_SH2_GRB2like	581	584	PF00017	0.441
LIG_SH2_NCK_1	581	585	PF00017	0.536
LIG_SH2_PTP2	517	520	PF00017	0.232
LIG_SH2_SRC	517	520	PF00017	0.232
LIG_SH2_STAP1	404	408	PF00017	0.370
LIG_SH2_STAT3	412	415	PF00017	0.462
LIG_SH2_STAT5	404	407	PF00017	0.370
LIG_SH2_STAT5	412	415	PF00017	0.370
LIG_SH2_STAT5	517	520	PF00017	0.232
LIG_SH2_STAT5	581	584	PF00017	0.503
LIG_SH2_STAT5	62	65	PF00017	0.394
LIG_SH3_3	1	7	PF00018	0.691
LIG_SH3_3	235	241	PF00018	0.284
LIG_SH3_3	295	301	PF00018	0.370
LIG_SH3_3	33	39	PF00018	0.685
LIG_SH3_3	8	14	PF00018	0.712
LIG_TRAF2_1	185	188	PF00917	0.592
LIG_TRFH_1	107	111	PF08558	0.450
LIG_UBA3_1	461	466	PF00899	0.383
LIG_WW_1	534	537	PF00397	0.314
MOD_CDK_SPK_2	570	575	PF00069	0.335
MOD_CDK_SPxxK_3	137	144	PF00069	0.602
MOD_CDK_SPxxK_3	570	577	PF00069	0.359
MOD_CK1_1	140	146	PF00069	0.761
MOD_CK1_1	158	164	PF00069	0.434
MOD_CK1_1	17	23	PF00069	0.530
MOD_CK1_1	278	284	PF00069	0.383
MOD_CK1_1	314	320	PF00069	0.370
MOD_CK1_1	548	554	PF00069	0.405
MOD_CK2_1	162	168	PF00069	0.702
MOD_CK2_1	182	188	PF00069	0.627
MOD_CK2_1	201	207	PF00069	0.594
MOD_CK2_1	210	216	PF00069	0.555
MOD_CK2_1	25	31	PF00069	0.569
MOD_CK2_1	259	265	PF00069	0.371
MOD_CK2_1	471	477	PF00069	0.383
MOD_GlcNHglycan	148	151	PF01048	0.666
MOD_GlcNHglycan	181	185	PF01048	0.624
MOD_GlcNHglycan	312	316	PF01048	0.176
MOD_GlcNHglycan	334	337	PF01048	0.170
MOD_GlcNHglycan	466	469	PF01048	0.245
MOD_GSK3_1	14	21	PF00069	0.510
MOD_GSK3_1	151	158	PF00069	0.693
MOD_GSK3_1	189	196	PF00069	0.631
MOD_GSK3_1	197	204	PF00069	0.665
MOD_GSK3_1	206	213	PF00069	0.586
MOD_GSK3_1	542	549	PF00069	0.284
MOD_GSK3_1	575	582	PF00069	0.403
MOD_N-GLC_1	582	587	PF02516	0.373
MOD_NEK2_1	296	301	PF00069	0.471
MOD_NEK2_1	311	316	PF00069	0.483
MOD_NEK2_2	391	396	PF00069	0.401
MOD_PIKK_1	210	216	PF00454	0.540
MOD_PIKK_1	93	99	PF00454	0.527
MOD_PKA_2	210	216	PF00069	0.527
MOD_PKA_2	224	230	PF00069	0.280
MOD_PKA_2	383	389	PF00069	0.497
MOD_PKA_2	402	408	PF00069	0.308
MOD_PKA_2	556	562	PF00069	0.291
MOD_PKA_2	68	74	PF00069	0.497
MOD_PKB_1	180	188	PF00069	0.675
MOD_Plk_1	215	221	PF00069	0.530
MOD_Plk_1	259	265	PF00069	0.384
MOD_Plk_1	278	284	PF00069	0.438
MOD_Plk_2-3	429	435	PF00069	0.383
MOD_Plk_4	25	31	PF00069	0.621
MOD_Plk_4	509	515	PF00069	0.231
MOD_Plk_4	542	548	PF00069	0.287
MOD_ProDKin_1	137	143	PF00069	0.708
MOD_ProDKin_1	193	199	PF00069	0.662
MOD_ProDKin_1	372	378	PF00069	0.422
MOD_ProDKin_1	570	576	PF00069	0.343
MOD_SUMO_for_1	58	61	PF00179	0.320
MOD_SUMO_rev_2	463	467	PF00179	0.370
TRG_DiLeu_BaEn_1	31	36	PF01217	0.572
TRG_DiLeu_BaEn_1	542	547	PF01217	0.308
TRG_DiLeu_BaEn_2	103	109	PF01217	0.444
TRG_DiLeu_BaEn_2	508	514	PF01217	0.229
TRG_DiLeu_BaEn_2	87	93	PF01217	0.650
TRG_ENDOCYTIC_2	318	321	PF00928	0.370
TRG_ENDOCYTIC_2	404	407	PF00928	0.370
TRG_ENDOCYTIC_2	517	520	PF00928	0.234
TRG_ER_diArg_1	250	252	PF00400	0.370
TRG_ER_diArg_1	283	285	PF00400	0.370
TRG_ER_diArg_1	504	506	PF00400	0.262
TRG_NES_CRM1_1	509	524	PF08389	0.244
TRG_NLS_MonoExtN_4	398	404	PF00514	0.383
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	505	509	PF00026	0.236

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYR2	Leptomonas seymouri	77%	98%
A0A0S4JKI3	Bodo saltans	54%	94%
A0A1X0NSY5	Trypanosomatidae	62%	100%
A0A3S5H702	Leishmania donovani	100%	100%
A0A422NXR8	Trypanosoma rangeli	63%	100%
A1CNY3	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	40%	82%
A1D1U0	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	40%	82%
A2QAU6	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	42%	80%
A4H8X8	Leishmania braziliensis	85%	99%
A4RLF4	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	42%	81%
A5DBS1	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	40%	98%
A6QYC6	Ajellomyces capsulatus (strain NAm1 / WU24)	41%	80%
A6RMI1	Botryotinia fuckeliana (strain B05.10)	42%	79%
A7EKL8	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	42%	79%
C9ZTX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AR04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q0CZL3	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	42%	83%
Q0U9D6	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	40%	81%
Q1E2F4	Coccidioides immitis (strain RS)	41%	82%
Q2HDP2	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	43%	83%
Q2UL89	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	42%	82%
Q4P1U2	Ustilago maydis (strain 521 / FGSC 9021)	45%	69%
Q4QEF9	Leishmania major	94%	100%
Q4WRX4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	41%	82%
Q5BF62	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	40%	83%
Q6C4K3	Yarrowia lipolytica (strain CLIB 122 / E 150)	39%	96%
Q6CWM0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	40%	89%
Q757E3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	40%	92%
Q7SG01	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	42%	81%
Q7XT07	Oryza sativa subsp. japonica	46%	87%
Q96G46	Homo sapiens	51%	92%
Q9T0J6	Arabidopsis thaliana	40%	86%
Q9UTH9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	96%