Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HX99_LEIIN

TriTrypDb:

LINF_170009500

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HX99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.660
CLV_NRD_NRD_1	303	305	PF00675	0.672
CLV_NRD_NRD_1	309	311	PF00675	0.569
CLV_NRD_NRD_1	5	7	PF00675	0.621
CLV_NRD_NRD_1	66	68	PF00675	0.404
CLV_PCSK_FUR_1	304	308	PF00082	0.639
CLV_PCSK_FUR_1	75	79	PF00082	0.595
CLV_PCSK_KEX2_1	303	305	PF00082	0.768
CLV_PCSK_KEX2_1	306	308	PF00082	0.802
CLV_PCSK_KEX2_1	309	311	PF00082	0.565
CLV_PCSK_KEX2_1	5	7	PF00082	0.621
CLV_PCSK_KEX2_1	66	68	PF00082	0.404
CLV_PCSK_KEX2_1	77	79	PF00082	0.591
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.591
CLV_PCSK_PC7_1	303	309	PF00082	0.743
DOC_MAPK_gen_1	75	84	PF00069	0.439
DOC_PP2B_LxvP_1	278	281	PF13499	0.579
DOC_SPAK_OSR1_1	60	64	PF12202	0.410
DOC_USP7_MATH_1	159	163	PF00917	0.617
DOC_USP7_MATH_1	56	60	PF00917	0.485
DOC_WW_Pin1_4	223	228	PF00397	0.728
DOC_WW_Pin1_4	235	240	PF00397	0.611
DOC_WW_Pin1_4	24	29	PF00397	0.689
DOC_WW_Pin1_4	48	53	PF00397	0.699
LIG_14-3-3_CanoR_1	201	211	PF00244	0.627
LIG_14-3-3_CanoR_1	216	223	PF00244	0.560
LIG_14-3-3_CanoR_1	307	313	PF00244	0.584
LIG_BIR_III_2	11	15	PF00653	0.542
LIG_BRCT_BRCA1_1	218	222	PF00533	0.565
LIG_FHA_2	21	27	PF00498	0.611
LIG_FHA_2	238	244	PF00498	0.721
LIG_LIR_Gen_1	59	65	PF02991	0.405
LIG_LIR_Nem_3	320	326	PF02991	0.491
LIG_LIR_Nem_3	59	64	PF02991	0.406
LIG_PDZ_Class_3	322	327	PF00595	0.504
LIG_Pex14_2	61	65	PF04695	0.403
LIG_Rb_pABgroove_1	86	94	PF01858	0.452
LIG_RPA_C_Fungi	55	67	PF08784	0.457
LIG_SH2_SRC	152	155	PF00017	0.640
LIG_SH2_STAP1	152	156	PF00017	0.587
LIG_SH2_STAP1	187	191	PF00017	0.553
LIG_SH2_STAP1	20	24	PF00017	0.613
LIG_SH2_STAT5	90	93	PF00017	0.456
LIG_SH3_3	233	239	PF00018	0.767
LIG_SH3_3	277	283	PF00018	0.657
LIG_SH3_CIN85_PxpxPR_1	279	284	PF14604	0.619
LIG_TRAF2_1	151	154	PF00917	0.687
MOD_CDK_SPxK_1	223	229	PF00069	0.693
MOD_CDK_SPxxK_3	24	31	PF00069	0.670
MOD_CDK_SPxxK_3	48	55	PF00069	0.518
MOD_CK1_1	178	184	PF00069	0.611
MOD_CK1_1	228	234	PF00069	0.646
MOD_CK1_1	237	243	PF00069	0.730
MOD_CK1_1	265	271	PF00069	0.617
MOD_CK1_1	311	317	PF00069	0.583
MOD_CK1_1	68	74	PF00069	0.592
MOD_CK2_1	237	243	PF00069	0.723
MOD_Cter_Amidation	3	6	PF01082	0.629
MOD_GlcNHglycan	177	180	PF01048	0.743
MOD_GlcNHglycan	182	185	PF01048	0.690
MOD_GlcNHglycan	68	71	PF01048	0.476
MOD_GSK3_1	170	177	PF00069	0.641
MOD_GSK3_1	183	190	PF00069	0.583
MOD_GSK3_1	20	27	PF00069	0.578
MOD_GSK3_1	221	228	PF00069	0.728
MOD_GSK3_1	44	51	PF00069	0.617
MOD_N-GLC_1	160	165	PF02516	0.768
MOD_N-GLC_2	133	135	PF02516	0.381
MOD_N-GLC_2	296	298	PF02516	0.581
MOD_NEK2_1	222	227	PF00069	0.650
MOD_NEK2_1	65	70	PF00069	0.475
MOD_PIKK_1	216	222	PF00454	0.564
MOD_PK_1	260	266	PF00069	0.703
MOD_PK_1	308	314	PF00069	0.571
MOD_PKA_1	308	314	PF00069	0.666
MOD_PKA_1	66	72	PF00069	0.493
MOD_PKA_2	209	215	PF00069	0.664
MOD_PKA_2	228	234	PF00069	0.630
MOD_PKA_2	308	314	PF00069	0.579
MOD_PKA_2	65	71	PF00069	0.475
MOD_PKB_1	306	314	PF00069	0.684
MOD_Plk_1	86	92	PF00069	0.397
MOD_Plk_4	86	92	PF00069	0.387
MOD_ProDKin_1	223	229	PF00069	0.732
MOD_ProDKin_1	235	241	PF00069	0.609
MOD_ProDKin_1	24	30	PF00069	0.690
MOD_ProDKin_1	48	54	PF00069	0.693
MOD_SUMO_for_1	76	79	PF00179	0.592
TRG_DiLeu_BaEn_4	142	148	PF01217	0.432
TRG_ER_diArg_1	303	306	PF00400	0.745
TRG_ER_diArg_1	307	310	PF00400	0.775
TRG_ER_diArg_1	65	67	PF00400	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9Y1	Leptomonas seymouri	35%	100%
A0A3S7WUB2	Leishmania donovani	98%	99%
A4H8X5	Leishmania braziliensis	64%	100%
E9AR01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QEG2	Leishmania major	84%	100%