Putative NADH-ubiquinone oxidoreductase, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase - mitochondrial - putative

Species:

Leishmania infantum

UniProt:

A4HX94_LEIIN

TriTrypDb:

LINF_170009000

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4HX94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX94

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	7	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0019646	aerobic electron transport chain	6	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051537	2 iron, 2 sulfur cluster binding	4	11
GO:0051540	metal cluster binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.242
CLV_C14_Caspase3-7	264	268	PF00656	0.454
CLV_NRD_NRD_1	233	235	PF00675	0.421
CLV_NRD_NRD_1	74	76	PF00675	0.281
CLV_PCSK_FUR_1	72	76	PF00082	0.242
CLV_PCSK_KEX2_1	233	235	PF00082	0.537
CLV_PCSK_KEX2_1	74	76	PF00082	0.259
CLV_PCSK_SKI1_1	101	105	PF00082	0.321
CLV_PCSK_SKI1_1	222	226	PF00082	0.428
DEG_Nend_UBRbox_1	1	4	PF02207	0.504
DEG_SPOP_SBC_1	15	19	PF00917	0.644
DOC_MAPK_DCC_7	75	85	PF00069	0.242
DOC_MAPK_gen_1	72	82	PF00069	0.242
DOC_MAPK_HePTP_8	149	161	PF00069	0.242
DOC_MAPK_MEF2A_6	152	161	PF00069	0.242
DOC_PP4_FxxP_1	247	250	PF00568	0.486
DOC_USP7_MATH_1	16	20	PF00917	0.559
DOC_USP7_MATH_1	5	9	PF00917	0.585
DOC_WW_Pin1_4	136	141	PF00397	0.242
LIG_14-3-3_CanoR_1	242	246	PF00244	0.487
LIG_14-3-3_CanoR_1	74	83	PF00244	0.276
LIG_BIR_III_2	259	263	PF00653	0.497
LIG_BIR_III_2	267	271	PF00653	0.560
LIG_BRCT_BRCA1_1	243	247	PF00533	0.529
LIG_FHA_1	241	247	PF00498	0.490
LIG_FHA_1	29	35	PF00498	0.634
LIG_FHA_1	77	83	PF00498	0.374
LIG_FHA_2	162	168	PF00498	0.242
LIG_FHA_2	169	175	PF00498	0.242
LIG_FHA_2	211	217	PF00498	0.436
LIG_FHA_2	41	47	PF00498	0.480
LIG_LIR_Apic_2	190	195	PF02991	0.242
LIG_LIR_Apic_2	232	238	PF02991	0.405
LIG_LIR_Apic_2	244	250	PF02991	0.419
LIG_LIR_Gen_1	118	128	PF02991	0.282
LIG_LIR_Gen_1	153	161	PF02991	0.242
LIG_LIR_Gen_1	199	206	PF02991	0.249
LIG_LIR_Gen_1	207	215	PF02991	0.232
LIG_LIR_Gen_1	56	67	PF02991	0.354
LIG_LIR_Nem_3	118	123	PF02991	0.282
LIG_LIR_Nem_3	153	159	PF02991	0.242
LIG_LIR_Nem_3	205	211	PF02991	0.257
LIG_LIR_Nem_3	56	62	PF02991	0.329
LIG_Pex14_2	119	123	PF04695	0.242
LIG_SH2_CRK	192	196	PF00017	0.242
LIG_SH2_GRB2like	156	159	PF00017	0.242
LIG_SH2_GRB2like	192	195	PF00017	0.321
LIG_SH2_GRB2like	45	48	PF00017	0.421
LIG_SH2_NCK_1	192	196	PF00017	0.242
LIG_SH2_NCK_1	235	239	PF00017	0.413
LIG_SH2_PTP2	93	96	PF00017	0.242
LIG_SH2_SRC	156	159	PF00017	0.242
LIG_SH2_SRC	235	238	PF00017	0.411
LIG_SH2_SRC	93	96	PF00017	0.242
LIG_SH2_STAT3	131	134	PF00017	0.242
LIG_SH2_STAT5	156	159	PF00017	0.242
LIG_SH2_STAT5	254	257	PF00017	0.452
LIG_SH2_STAT5	93	96	PF00017	0.242
LIG_SH3_3	179	185	PF00018	0.246
LIG_SH3_3	247	253	PF00018	0.426
LIG_SH3_3	65	71	PF00018	0.278
LIG_SUMO_SIM_par_1	164	174	PF11976	0.275
LIG_SUMO_SIM_par_1	185	191	PF11976	0.309
MOD_CK1_1	19	25	PF00069	0.681
MOD_CK1_1	190	196	PF00069	0.247
MOD_CK1_1	210	216	PF00069	0.113
MOD_CK2_1	168	174	PF00069	0.273
MOD_CK2_1	210	216	PF00069	0.385
MOD_Cter_Amidation	72	75	PF01082	0.374
MOD_GlcNHglycan	7	10	PF01048	0.573
MOD_GlcNHglycan	76	79	PF01048	0.256
MOD_GSK3_1	15	22	PF00069	0.612
MOD_N-GLC_1	196	201	PF02516	0.374
MOD_NEK2_1	135	140	PF00069	0.242
MOD_NEK2_1	150	155	PF00069	0.314
MOD_NEK2_1	161	166	PF00069	0.261
MOD_NEK2_1	28	33	PF00069	0.530
MOD_PIKK_1	225	231	PF00454	0.413
MOD_PKA_1	74	80	PF00069	0.248
MOD_PKA_2	241	247	PF00069	0.438
MOD_PKA_2	74	80	PF00069	0.255
MOD_PKB_1	72	80	PF00069	0.261
MOD_Plk_1	150	156	PF00069	0.318
MOD_Plk_1	196	202	PF00069	0.275
MOD_Plk_1	204	210	PF00069	0.210
MOD_Plk_1	45	51	PF00069	0.367
MOD_Plk_2-3	204	210	PF00069	0.261
MOD_Plk_4	115	121	PF00069	0.258
MOD_Plk_4	210	216	PF00069	0.318
MOD_Plk_4	241	247	PF00069	0.442
MOD_ProDKin_1	136	142	PF00069	0.242
MOD_SUMO_rev_2	257	266	PF00179	0.508
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.282
TRG_ENDOCYTIC_2	120	123	PF00928	0.242
TRG_ENDOCYTIC_2	156	159	PF00928	0.242
TRG_ENDOCYTIC_2	200	203	PF00928	0.245
TRG_ENDOCYTIC_2	59	62	PF00928	0.317
TRG_ENDOCYTIC_2	93	96	PF00928	0.242
TRG_ER_diArg_1	233	235	PF00400	0.523
TRG_ER_diArg_1	71	74	PF00400	0.279
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJN3	Leptomonas seymouri	81%	98%
A0A0S4KI12	Bodo saltans	70%	100%
A0A1X0NUP5	Trypanosomatidae	73%	100%
A0A3Q8ICR5	Leishmania donovani	100%	100%
A4H8X0	Leishmania braziliensis	91%	100%
C9ZTW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
E9AQZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
O22769	Arabidopsis thaliana	46%	100%
P04394	Bos taurus	47%	100%
P19234	Rattus norvegicus	48%	100%
P19404	Homo sapiens	46%	100%
P29914	Paracoccus denitrificans	37%	100%
P40915	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	39%	100%
P56909	Rhizobium meliloti (strain 1021)	36%	99%
Q0MQI7	Pongo pygmaeus	46%	100%
Q0MQI8	Gorilla gorilla gorilla	46%	100%
Q0MQI9	Pan troglodytes	46%	100%
Q20719	Caenorhabditis elegans	45%	100%
Q4QEG7	Leishmania major	97%	100%
Q54F10	Dictyostelium discoideum	45%	100%
Q9D6J6	Mus musculus	46%	100%
V5D8N1	Trypanosoma cruzi	76%	100%