Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HX93_LEIIN

TriTrypDb:

LINF_170008900

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HX93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX93

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.632
CLV_NRD_NRD_1	230	232	PF00675	0.721
CLV_NRD_NRD_1	248	250	PF00675	0.412
CLV_NRD_NRD_1	290	292	PF00675	0.716
CLV_NRD_NRD_1	337	339	PF00675	0.686
CLV_NRD_NRD_1	523	525	PF00675	0.669
CLV_NRD_NRD_1	536	538	PF00675	0.564
CLV_NRD_NRD_1	610	612	PF00675	0.597
CLV_NRD_NRD_1	676	678	PF00675	0.694
CLV_PCSK_KEX2_1	248	250	PF00082	0.562
CLV_PCSK_KEX2_1	290	292	PF00082	0.716
CLV_PCSK_KEX2_1	337	339	PF00082	0.686
CLV_PCSK_KEX2_1	536	538	PF00082	0.610
CLV_PCSK_KEX2_1	610	612	PF00082	0.597
CLV_PCSK_SKI1_1	17	21	PF00082	0.685
CLV_PCSK_SKI1_1	232	236	PF00082	0.714
CLV_PCSK_SKI1_1	493	497	PF00082	0.726
CLV_PCSK_SKI1_1	524	528	PF00082	0.630
CLV_PCSK_SKI1_1	536	540	PF00082	0.480
CLV_PCSK_SKI1_1	596	600	PF00082	0.551
CLV_PCSK_SKI1_1	646	650	PF00082	0.625
CLV_PCSK_SKI1_1	743	747	PF00082	0.549
CLV_PCSK_SKI1_1	764	768	PF00082	0.534
CLV_Separin_Metazoa	521	525	PF03568	0.634
DEG_COP1_1	78	86	PF00400	0.674
DEG_SCF_FBW7_1	346	353	PF00400	0.744
DEG_SCF_FBW7_1	381	388	PF00400	0.661
DEG_SCF_FBW7_2	83	89	PF00400	0.741
DOC_CKS1_1	159	164	PF01111	0.687
DOC_CKS1_1	23	28	PF01111	0.589
DOC_CKS1_1	647	652	PF01111	0.718
DOC_CKS1_1	77	82	PF01111	0.725
DOC_CKS1_1	83	88	PF01111	0.721
DOC_CYCLIN_RxL_1	532	545	PF00134	0.619
DOC_CYCLIN_RxL_1	739	748	PF00134	0.444
DOC_MAPK_gen_1	14	22	PF00069	0.656
DOC_MAPK_gen_1	337	343	PF00069	0.684
DOC_MAPK_gen_1	456	465	PF00069	0.808
DOC_PP1_RVXF_1	767	774	PF00149	0.641
DOC_PP2B_LxvP_1	120	123	PF13499	0.748
DOC_PP2B_LxvP_1	20	23	PF13499	0.694
DOC_PP2B_LxvP_1	325	328	PF13499	0.753
DOC_PP2B_LxvP_1	343	346	PF13499	0.593
DOC_PP4_FxxP_1	710	713	PF00568	0.573
DOC_USP7_MATH_1	121	125	PF00917	0.745
DOC_USP7_MATH_1	193	197	PF00917	0.689
DOC_USP7_MATH_1	227	231	PF00917	0.663
DOC_USP7_MATH_1	257	261	PF00917	0.640
DOC_USP7_MATH_1	27	31	PF00917	0.703
DOC_USP7_MATH_1	3	7	PF00917	0.620
DOC_USP7_MATH_1	312	316	PF00917	0.683
DOC_USP7_MATH_1	350	354	PF00917	0.758
DOC_USP7_MATH_1	358	362	PF00917	0.800
DOC_USP7_MATH_1	375	379	PF00917	0.531
DOC_USP7_MATH_1	438	442	PF00917	0.828
DOC_USP7_MATH_1	510	514	PF00917	0.791
DOC_USP7_MATH_1	55	59	PF00917	0.768
DOC_USP7_MATH_1	564	568	PF00917	0.823
DOC_USP7_MATH_1	582	586	PF00917	0.766
DOC_USP7_MATH_1	587	591	PF00917	0.761
DOC_USP7_MATH_1	630	634	PF00917	0.645
DOC_USP7_MATH_1	685	689	PF00917	0.718
DOC_USP7_MATH_1	700	704	PF00917	0.760
DOC_WW_Pin1_4	103	108	PF00397	0.748
DOC_WW_Pin1_4	127	132	PF00397	0.748
DOC_WW_Pin1_4	158	163	PF00397	0.728
DOC_WW_Pin1_4	22	27	PF00397	0.622
DOC_WW_Pin1_4	318	323	PF00397	0.716
DOC_WW_Pin1_4	341	346	PF00397	0.797
DOC_WW_Pin1_4	381	386	PF00397	0.661
DOC_WW_Pin1_4	471	476	PF00397	0.726
DOC_WW_Pin1_4	500	505	PF00397	0.774
DOC_WW_Pin1_4	51	56	PF00397	0.621
DOC_WW_Pin1_4	553	558	PF00397	0.654
DOC_WW_Pin1_4	572	577	PF00397	0.741
DOC_WW_Pin1_4	646	651	PF00397	0.805
DOC_WW_Pin1_4	652	657	PF00397	0.766
DOC_WW_Pin1_4	686	691	PF00397	0.740
DOC_WW_Pin1_4	696	701	PF00397	0.720
DOC_WW_Pin1_4	76	81	PF00397	0.826
DOC_WW_Pin1_4	82	87	PF00397	0.729
DOC_WW_Pin1_4	96	101	PF00397	0.515
LIG_14-3-3_CanoR_1	105	111	PF00244	0.768
LIG_14-3-3_CanoR_1	408	412	PF00244	0.720
LIG_14-3-3_CanoR_1	459	464	PF00244	0.733
LIG_14-3-3_CanoR_1	546	553	PF00244	0.698
LIG_14-3-3_CanoR_1	610	614	PF00244	0.625
LIG_14-3-3_CanoR_1	624	630	PF00244	0.633
LIG_14-3-3_CanoR_1	686	690	PF00244	0.684
LIG_14-3-3_CanoR_1	728	736	PF00244	0.573
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_BIR_III_4	154	158	PF00653	0.842
LIG_BIR_III_4	39	43	PF00653	0.707
LIG_BRCT_BRCA1_1	566	570	PF00533	0.734
LIG_BRCT_BRCA1_1	633	637	PF00533	0.695
LIG_CaM_IQ_9	538	554	PF13499	0.683
LIG_FHA_1	51	57	PF00498	0.739
LIG_FHA_1	554	560	PF00498	0.742
LIG_FHA_1	637	643	PF00498	0.719
LIG_FHA_1	67	73	PF00498	0.731
LIG_FHA_1	700	706	PF00498	0.632
LIG_FHA_1	731	737	PF00498	0.661
LIG_FHA_2	666	672	PF00498	0.830
LIG_FHA_2	752	758	PF00498	0.560
LIG_LIR_Gen_1	384	393	PF02991	0.634
LIG_LIR_Nem_3	261	267	PF02991	0.673
LIG_LIR_Nem_3	384	390	PF02991	0.585
LIG_LIR_Nem_3	740	745	PF02991	0.561
LIG_LIR_Nem_3	762	766	PF02991	0.544
LIG_LIR_Nem_3	772	776	PF02991	0.562
LIG_PCNA_yPIPBox_3	592	603	PF02747	0.496
LIG_SH2_CRK	742	746	PF00017	0.660
LIG_SH2_CRK	763	767	PF00017	0.567
LIG_SH3_2	270	275	PF14604	0.721
LIG_SH3_2	332	337	PF14604	0.833
LIG_SH3_2	576	581	PF14604	0.761
LIG_SH3_3	176	182	PF00018	0.809
LIG_SH3_3	20	26	PF00018	0.606
LIG_SH3_3	267	273	PF00018	0.719
LIG_SH3_3	306	312	PF00018	0.608
LIG_SH3_3	321	327	PF00018	0.707
LIG_SH3_3	329	335	PF00018	0.805
LIG_SH3_3	469	475	PF00018	0.668
LIG_SH3_3	49	55	PF00018	0.843
LIG_SH3_3	498	504	PF00018	0.744
LIG_SH3_3	573	579	PF00018	0.768
LIG_SH3_3	80	86	PF00018	0.739
LIG_SH3_4	299	306	PF00018	0.767
LIG_SUMO_SIM_anti_2	461	469	PF11976	0.714
LIG_SUMO_SIM_par_1	18	25	PF11976	0.716
LIG_SUMO_SIM_par_1	665	673	PF11976	0.755
LIG_TRAF2_1	165	168	PF00917	0.635
LIG_TRAF2_1	484	487	PF00917	0.670
LIG_TRAF2_1	612	615	PF00917	0.693
LIG_TRAF2_1	668	671	PF00917	0.621
LIG_TRAF2_1	713	716	PF00917	0.598
LIG_TRAF2_1	754	757	PF00917	0.579
LIG_WW_3	185	189	PF00397	0.640
LIG_WW_3	93	97	PF00397	0.734
MOD_CDC14_SPxK_1	578	581	PF00782	0.814
MOD_CDC14_SPxK_1	689	692	PF00782	0.702
MOD_CDK_SPK_2	572	577	PF00069	0.720
MOD_CDK_SPxK_1	575	581	PF00069	0.765
MOD_CDK_SPxK_1	686	692	PF00069	0.705
MOD_CDK_SPxxK_3	341	348	PF00069	0.684
MOD_CDK_SPxxK_3	96	103	PF00069	0.771
MOD_CK1_1	106	112	PF00069	0.764
MOD_CK1_1	136	142	PF00069	0.777
MOD_CK1_1	196	202	PF00069	0.581
MOD_CK1_1	280	286	PF00069	0.620
MOD_CK1_1	315	321	PF00069	0.755
MOD_CK1_1	361	367	PF00069	0.786
MOD_CK1_1	368	374	PF00069	0.696
MOD_CK1_1	439	445	PF00069	0.845
MOD_CK1_1	447	453	PF00069	0.676
MOD_CK1_1	458	464	PF00069	0.598
MOD_CK1_1	50	56	PF00069	0.712
MOD_CK1_1	528	534	PF00069	0.677
MOD_CK1_1	545	551	PF00069	0.528
MOD_CK1_1	571	577	PF00069	0.819
MOD_CK1_1	580	586	PF00069	0.797
MOD_CK1_1	59	65	PF00069	0.786
MOD_CK1_1	591	597	PF00069	0.650
MOD_CK1_1	609	615	PF00069	0.390
MOD_CK1_1	631	637	PF00069	0.672
MOD_CK1_1	730	736	PF00069	0.520
MOD_CK2_1	227	233	PF00069	0.642
MOD_CK2_1	609	615	PF00069	0.692
MOD_CK2_1	665	671	PF00069	0.756
MOD_CK2_1	751	757	PF00069	0.483
MOD_CK2_1	96	102	PF00069	0.747
MOD_DYRK1A_RPxSP_1	502	506	PF00069	0.733
MOD_DYRK1A_RPxSP_1	686	690	PF00069	0.613
MOD_DYRK1A_RPxSP_1	96	100	PF00069	0.846
MOD_GlcNHglycan	123	126	PF01048	0.761
MOD_GlcNHglycan	127	130	PF01048	0.741
MOD_GlcNHglycan	154	158	PF01048	0.842
MOD_GlcNHglycan	162	165	PF01048	0.767
MOD_GlcNHglycan	188	191	PF01048	0.767
MOD_GlcNHglycan	197	201	PF01048	0.567
MOD_GlcNHglycan	279	282	PF01048	0.674
MOD_GlcNHglycan	305	308	PF01048	0.800
MOD_GlcNHglycan	312	315	PF01048	0.640
MOD_GlcNHglycan	317	320	PF01048	0.559
MOD_GlcNHglycan	352	355	PF01048	0.747
MOD_GlcNHglycan	373	376	PF01048	0.721
MOD_GlcNHglycan	377	380	PF01048	0.710
MOD_GlcNHglycan	411	414	PF01048	0.655
MOD_GlcNHglycan	512	515	PF01048	0.731
MOD_GlcNHglycan	564	567	PF01048	0.809
MOD_GlcNHglycan	57	61	PF01048	0.754
MOD_GlcNHglycan	584	587	PF01048	0.774
MOD_GlcNHglycan	630	633	PF01048	0.689
MOD_GlcNHglycan	702	705	PF01048	0.571
MOD_GlcNHglycan	730	733	PF01048	0.569
MOD_GSK3_1	121	128	PF00069	0.774
MOD_GSK3_1	136	143	PF00069	0.767
MOD_GSK3_1	192	199	PF00069	0.635
MOD_GSK3_1	27	34	PF00069	0.813
MOD_GSK3_1	280	287	PF00069	0.739
MOD_GSK3_1	303	310	PF00069	0.824
MOD_GSK3_1	346	353	PF00069	0.744
MOD_GSK3_1	361	368	PF00069	0.783
MOD_GSK3_1	371	378	PF00069	0.712
MOD_GSK3_1	381	388	PF00069	0.464
MOD_GSK3_1	403	410	PF00069	0.706
MOD_GSK3_1	436	443	PF00069	0.803
MOD_GSK3_1	444	451	PF00069	0.589
MOD_GSK3_1	455	462	PF00069	0.809
MOD_GSK3_1	47	54	PF00069	0.522
MOD_GSK3_1	496	503	PF00069	0.825
MOD_GSK3_1	528	535	PF00069	0.568
MOD_GSK3_1	55	62	PF00069	0.738
MOD_GSK3_1	562	569	PF00069	0.713
MOD_GSK3_1	571	578	PF00069	0.827
MOD_GSK3_1	587	594	PF00069	0.700
MOD_GSK3_1	652	659	PF00069	0.799
MOD_GSK3_1	694	701	PF00069	0.800
MOD_GSK3_1	726	733	PF00069	0.565
MOD_LATS_1	282	288	PF00433	0.633
MOD_N-GLC_1	133	138	PF02516	0.776
MOD_N-GLC_1	447	452	PF02516	0.794
MOD_N-GLC_1	47	52	PF02516	0.765
MOD_N-GLC_1	532	537	PF02516	0.614
MOD_N-GLC_1	542	547	PF02516	0.662
MOD_N-GLC_1	694	699	PF02516	0.768
MOD_NEK2_1	133	138	PF00069	0.718
MOD_NEK2_1	140	145	PF00069	0.726
MOD_NEK2_1	363	368	PF00069	0.674
MOD_NEK2_1	407	412	PF00069	0.707
MOD_NEK2_1	496	501	PF00069	0.823
MOD_NEK2_1	547	552	PF00069	0.798
MOD_NEK2_1	637	642	PF00069	0.752
MOD_NEK2_1	726	731	PF00069	0.531
MOD_NEK2_2	403	408	PF00069	0.689
MOD_PIKK_1	155	161	PF00454	0.632
MOD_PIKK_1	284	290	PF00454	0.845
MOD_PIKK_1	496	502	PF00454	0.847
MOD_PIKK_1	548	554	PF00454	0.731
MOD_PIKK_1	588	594	PF00454	0.706
MOD_PIKK_1	730	736	PF00454	0.644
MOD_PK_1	459	465	PF00069	0.812
MOD_PK_1	491	497	PF00069	0.709
MOD_PKA_2	212	218	PF00069	0.528
MOD_PKA_2	336	342	PF00069	0.769
MOD_PKA_2	358	364	PF00069	0.651
MOD_PKA_2	407	413	PF00069	0.725
MOD_PKA_2	439	445	PF00069	0.773
MOD_PKA_2	455	461	PF00069	0.717
MOD_PKA_2	545	551	PF00069	0.670
MOD_PKA_2	580	586	PF00069	0.765
MOD_PKA_2	609	615	PF00069	0.570
MOD_PKA_2	685	691	PF00069	0.652
MOD_PKA_2	727	733	PF00069	0.573
MOD_PKB_1	96	104	PF00069	0.713
MOD_Plk_1	133	139	PF00069	0.728
MOD_Plk_1	364	370	PF00069	0.803
MOD_Plk_1	447	453	PF00069	0.777
MOD_Plk_1	47	53	PF00069	0.802
MOD_Plk_1	542	548	PF00069	0.705
MOD_Plk_4	170	176	PF00069	0.635
MOD_Plk_4	28	34	PF00069	0.683
MOD_Plk_4	3	9	PF00069	0.677
MOD_Plk_4	358	364	PF00069	0.766
MOD_Plk_4	368	374	PF00069	0.649
MOD_Plk_4	461	467	PF00069	0.716
MOD_Plk_4	68	74	PF00069	0.833
MOD_ProDKin_1	103	109	PF00069	0.747
MOD_ProDKin_1	127	133	PF00069	0.749
MOD_ProDKin_1	158	164	PF00069	0.728
MOD_ProDKin_1	22	28	PF00069	0.625
MOD_ProDKin_1	318	324	PF00069	0.716
MOD_ProDKin_1	341	347	PF00069	0.796
MOD_ProDKin_1	381	387	PF00069	0.657
MOD_ProDKin_1	471	477	PF00069	0.729
MOD_ProDKin_1	500	506	PF00069	0.773
MOD_ProDKin_1	51	57	PF00069	0.623
MOD_ProDKin_1	553	559	PF00069	0.657
MOD_ProDKin_1	572	578	PF00069	0.740
MOD_ProDKin_1	646	652	PF00069	0.805
MOD_ProDKin_1	686	692	PF00069	0.742
MOD_ProDKin_1	696	702	PF00069	0.716
MOD_ProDKin_1	76	82	PF00069	0.830
MOD_ProDKin_1	96	102	PF00069	0.517
MOD_SUMO_rev_2	752	760	PF00179	0.647
TRG_DiLeu_BaEn_1	615	620	PF01217	0.653
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.717
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.825
TRG_ENDOCYTIC_2	742	745	PF00928	0.506
TRG_ENDOCYTIC_2	763	766	PF00928	0.539
TRG_ER_diArg_1	248	251	PF00400	0.583
TRG_ER_diArg_1	289	291	PF00400	0.715
TRG_ER_diArg_1	95	98	PF00400	0.741
TRG_NES_CRM1_1	233	247	PF08389	0.618
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.732
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	525	529	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	537	542	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	743	748	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4I6	Leptomonas seymouri	35%	85%
A0A3S7WUB6	Leishmania donovani	99%	100%
A4H8W9	Leishmania braziliensis	60%	100%
E9AQZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4QEG8	Leishmania major	90%	100%