Cystathionine beta-synthase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cystathionine beta-synthase

Species:

Leishmania infantum

UniProt:

A4HX92_LEIIN

TriTrypDb:

LINF_170008800

Length:

359

Annotations

Annotations by Jardim et al.

Amino acid metabolism, Cystathionine beta-synthase CYSB

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	yes	yes: 1
Forrest at al. (metacyclic)	yes	yes: 1
Forrest at al. (procyclic)	yes	yes: 1
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HX92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX92

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	10
GO:0000097	sulfur amino acid biosynthetic process	5	10
GO:0006082	organic acid metabolic process	3	10
GO:0006520	amino acid metabolic process	3	10
GO:0006534	cysteine metabolic process	5	10
GO:0006535	cysteine biosynthetic process from serine	7	10
GO:0006563	L-serine metabolic process	6	10
GO:0006790	sulfur compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008652	amino acid biosynthetic process	4	10
GO:0009058	biosynthetic process	2	10
GO:0009069	serine family amino acid metabolic process	5	10
GO:0009070	serine family amino acid biosynthetic process	6	10
GO:0009987	cellular process	1	10
GO:0016053	organic acid biosynthetic process	4	10
GO:0019344	cysteine biosynthetic process	6	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044272	sulfur compound biosynthetic process	4	10
GO:0044281	small molecule metabolic process	2	10
GO:0044283	small molecule biosynthetic process	3	10
GO:0046394	carboxylic acid biosynthetic process	5	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:1901605	alpha-amino acid metabolic process	4	10
GO:1901607	alpha-amino acid biosynthetic process	5	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004122	cystathionine beta-synthase activity	5	6
GO:0016829	lyase activity	2	6
GO:0016835	carbon-oxygen lyase activity	3	6
GO:0016836	hydro-lyase activity	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.300
CLV_NRD_NRD_1	142	144	PF00675	0.276
CLV_NRD_NRD_1	247	249	PF00675	0.390
CLV_PCSK_KEX2_1	142	144	PF00082	0.258
CLV_PCSK_SKI1_1	199	203	PF00082	0.258
CLV_PCSK_SKI1_1	253	257	PF00082	0.258
CLV_PCSK_SKI1_1	350	354	PF00082	0.509
DOC_MAPK_DCC_7	200	210	PF00069	0.252
DOC_MAPK_gen_1	145	153	PF00069	0.310
DOC_MAPK_gen_1	53	62	PF00069	0.269
DOC_MAPK_MEF2A_6	202	210	PF00069	0.258
DOC_MAPK_MEF2A_6	95	103	PF00069	0.258
DOC_PP4_FxxP_1	45	48	PF00568	0.258
DOC_USP7_MATH_1	215	219	PF00917	0.258
DOC_USP7_MATH_1	48	52	PF00917	0.291
DOC_WW_Pin1_4	18	23	PF00397	0.258
DOC_WW_Pin1_4	2	7	PF00397	0.454
LIG_APCC_ABBA_1	267	272	PF00400	0.323
LIG_deltaCOP1_diTrp_1	318	327	PF00928	0.449
LIG_FHA_1	19	25	PF00498	0.258
LIG_FHA_2	167	173	PF00498	0.258
LIG_LIR_Apic_2	154	159	PF02991	0.245
LIG_LIR_Apic_2	44	48	PF02991	0.258
LIG_LIR_Gen_1	147	156	PF02991	0.258
LIG_LIR_Gen_1	336	344	PF02991	0.379
LIG_LIR_Nem_3	147	153	PF02991	0.258
LIG_LIR_Nem_3	336	340	PF02991	0.375
LIG_SH2_CRK	156	160	PF00017	0.258
LIG_SH2_CRK	239	243	PF00017	0.258
LIG_SH2_CRK	337	341	PF00017	0.515
LIG_SH2_CRK	97	101	PF00017	0.276
LIG_SH2_GRB2like	156	159	PF00017	0.336
LIG_SH2_NCK_1	156	160	PF00017	0.322
LIG_SH2_PTP2	150	153	PF00017	0.276
LIG_SH2_STAT5	150	153	PF00017	0.284
LIG_SH2_STAT5	156	159	PF00017	0.308
LIG_SH2_STAT5	250	253	PF00017	0.365
LIG_SH3_1	156	162	PF00018	0.245
LIG_SH3_3	156	162	PF00018	0.245
LIG_SH3_3	220	226	PF00018	0.269
LIG_SH3_3	329	335	PF00018	0.407
LIG_SUMO_SIM_anti_2	207	212	PF11976	0.297
LIG_TRAF2_1	169	172	PF00917	0.258
LIG_TYR_ITIM	237	242	PF00017	0.258
MOD_CDK_SPK_2	2	7	PF00069	0.443
MOD_CDK_SPxxK_3	18	25	PF00069	0.258
MOD_CK1_1	280	286	PF00069	0.304
MOD_CK1_1	81	87	PF00069	0.258
MOD_CK2_1	166	172	PF00069	0.258
MOD_GlcNHglycan	2	5	PF01048	0.596
MOD_GlcNHglycan	280	283	PF01048	0.258
MOD_GlcNHglycan	355	358	PF01048	0.552
MOD_GlcNHglycan	80	83	PF01048	0.361
MOD_GSK3_1	110	117	PF00069	0.409
MOD_GSK3_1	77	84	PF00069	0.278
MOD_LATS_1	109	115	PF00433	0.336
MOD_N-GLC_1	66	71	PF02516	0.353
MOD_NEK2_1	99	104	PF00069	0.329
MOD_NEK2_2	48	53	PF00069	0.258
MOD_PK_1	71	77	PF00069	0.390
MOD_PKA_1	105	111	PF00069	0.276
MOD_PKA_2	333	339	PF00069	0.380
MOD_Plk_1	111	117	PF00069	0.303
MOD_Plk_1	125	131	PF00069	0.294
MOD_Plk_2-3	259	265	PF00069	0.258
MOD_Plk_4	133	139	PF00069	0.258
MOD_Plk_4	215	221	PF00069	0.282
MOD_Plk_4	71	77	PF00069	0.261
MOD_ProDKin_1	18	24	PF00069	0.258
MOD_ProDKin_1	2	8	PF00069	0.451
MOD_SUMO_for_1	340	343	PF00179	0.596
MOD_SUMO_for_1	352	355	PF00179	0.395
MOD_SUMO_for_1	41	44	PF00179	0.262
MOD_SUMO_rev_2	244	251	PF00179	0.390
MOD_SUMO_rev_2	343	349	PF00179	0.490
TRG_DiLeu_BaEn_1	272	277	PF01217	0.336
TRG_ENDOCYTIC_2	150	153	PF00928	0.258
TRG_ENDOCYTIC_2	239	242	PF00928	0.258
TRG_ENDOCYTIC_2	337	340	PF00928	0.388
TRG_ENDOCYTIC_2	97	100	PF00928	0.281
TRG_ER_diArg_1	142	145	PF00400	0.276
TRG_NES_CRM1_1	203	214	PF08389	0.300
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.276
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.276
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4H0	Leptomonas seymouri	82%	100%
A0A0N0P4U0	Leptomonas seymouri	36%	100%
A0A0S4IP22	Bodo saltans	29%	78%
A0A0S4JDZ7	Bodo saltans	34%	100%
A0A0S4JNJ6	Bodo saltans	65%	95%
A0A1X0NVD2	Trypanosomatidae	72%	100%
A0A1X0P4R1	Trypanosomatidae	38%	100%
A0A3S5H833	Leishmania donovani	36%	100%
A0A3S7WUC4	Leishmania donovani	100%	100%
A0A422N6U8	Trypanosoma rangeli	75%	96%
A1B8Z2	Paracoccus denitrificans (strain Pd 1222)	23%	100%
A4HPM6	Leishmania braziliensis	35%	100%
A4ID39	Leishmania infantum	36%	100%
A5INY7	Staphylococcus aureus (strain JH9)	30%	100%
A5U908	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	27%	98%
A6QDA0	Staphylococcus aureus (strain Newman)	30%	100%
A6TXQ1	Staphylococcus aureus (strain JH1)	30%	100%
A7WX68	Staphylococcus aureus (strain Mu3 / ATCC 700698)	30%	100%
A8YZ41	Staphylococcus aureus (strain USA300 / TCH1516)	30%	100%
C1FW07	Unknown prokaryotic organism	29%	76%
D0A7T9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	99%
D0K799	Staphylococcus aureus (strain ED98)	30%	100%
D1GUM7	Staphylococcus aureus (strain TW20 / 0582)	30%	100%
D2N3G7	Staphylococcus aureus (strain MRSA ST398 / isolate S0385)	30%	100%
D2Z027	Streptomyces lavendulae	35%	100%
D3ERF5	Staphylococcus aureus (strain 04-02981)	30%	100%
E3PY97	Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / CCUG 9281 / NCIMB 10654 / HF)	28%	77%
E9AQZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9ATD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
F4K5T2	Arabidopsis thaliana	37%	100%
O01592	Caenorhabditis elegans	36%	100%
O05393	Bacillus subtilis (strain 168)	38%	100%
O22682	Arabidopsis thaliana	32%	89%
O23733	Brassica juncea	44%	100%
O23735	Brassica juncea	45%	100%
O32978	Mycobacterium leprae (strain TN)	42%	100%
O34476	Bacillus subtilis (strain 168)	41%	100%
O45679	Caenorhabditis elegans	38%	100%
O59701	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
O67507	Aquifex aeolicus (strain VF5)	36%	100%
O69652	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	98%
O81154	Solanum tuberosum	42%	100%
O81155	Solanum tuberosum	39%	93%
P09123	Bacillus sp. (strain ULM1)	26%	100%
P0A1E3	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	38%	100%
P0A1E4	Salmonella typhi	38%	100%
P0A535	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	41%	100%
P0ABK5	Escherichia coli (strain K12)	37%	100%
P0ABK6	Escherichia coli O157:H7	37%	100%
P16703	Escherichia coli (strain K12)	38%	100%
P29848	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	40%	100%
P31300	Capsicum annuum	38%	96%
P32260	Spinacia oleracea	41%	94%
P32582	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	71%
P37887	Bacillus subtilis (strain 168)	41%	100%
P38076	Triticum aestivum	40%	100%
P45040	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	39%	100%
P46794	Dictyostelium discoideum	56%	72%
P47998	Arabidopsis thaliana	44%	100%
P47999	Arabidopsis thaliana	43%	92%
P50867	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	97%
P53206	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	91%
P55708	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	33%	100%
P56067	Helicobacter pylori (strain ATCC 700392 / 26695)	33%	100%
P57171	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	33%	100%
P63870	Staphylococcus aureus (strain Mu50 / ATCC 700699)	37%	100%
P63871	Staphylococcus aureus (strain N315)	37%	100%
P63872	Staphylococcus aureus (strain MW2)	37%	100%
P63874	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	32%	100%
P71128	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	34%	100%
P73410	Synechocystis sp. (strain PCC 6803 / Kazusa)	38%	100%
P80608	Zea mays	39%	100%
P87131	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	91%
P9WP50	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	44%	77%
P9WP51	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	44%	77%
P9WP52	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	100%
P9WP53	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	100%
P9WP54	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	41%	100%
P9WP55	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	41%	100%
Q00834	Spinacia oleracea	42%	100%
Q10725	Ralstonia pickettii	26%	100%
Q1KLZ1	Malus domestica	34%	96%
Q1KLZ2	Malus domestica	34%	95%
Q2FKE3	Staphylococcus aureus (strain USA300)	30%	100%
Q2G1N3	Staphylococcus aureus (strain NCTC 8325 / PS 47)	30%	100%
Q2V0C9	Apis mellifera	54%	71%
Q2YUU0	Staphylococcus aureus (strain bovine RF122 / ET3-1)	31%	100%
Q43153	Spinacia oleracea	35%	98%
Q43317	Citrullus lanatus	43%	100%
Q43725	Arabidopsis thaliana	41%	83%
Q44004	Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)	30%	100%
Q4Q159	Leishmania major	37%	100%
Q4QEG9	Leishmania major	97%	100%
Q54CN7	Dictyostelium discoideum	34%	95%
Q58860	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	26%	89%
Q59447	Flavobacterium sp. (strain K3-15 / DSM ID92-509)	37%	100%
Q59966	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	37%	100%
Q5BD67	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	84%
Q5HIG2	Staphylococcus aureus (strain COL)	37%	100%
Q5HJQ3	Staphylococcus aureus (strain COL)	30%	100%
Q5HRP1	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	39%	100%
Q5XAQ3	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	36%	100%
Q6GBX5	Staphylococcus aureus (strain MSSA476)	37%	100%
Q6GD09	Staphylococcus aureus (strain MSSA476)	30%	100%
Q6GJF8	Staphylococcus aureus (strain MRSA252)	37%	100%
Q6GKI9	Staphylococcus aureus (strain MRSA252)	30%	100%
Q76MX2	Solanum tuberosum	33%	100%
Q79FV4	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	97%
Q7A1Z6	Staphylococcus aureus (strain MW2)	30%	100%
Q7DDL5	Neisseria meningitidis serogroup B (strain MC58)	41%	100%
Q7RYW6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	95%
Q7SHQ1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	79%
Q8CMT6	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	39%	100%
Q8KA48	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	38%	100%
Q8XSQ0	Ralstonia solanacearum (strain GMI1000)	30%	100%
Q93244	Caenorhabditis elegans	42%	100%
Q932K9	Staphylococcus aureus (strain Mu50 / ATCC 700699)	30%	100%
Q99X99	Staphylococcus aureus (strain N315)	30%	100%
Q9FS29	Solanum tuberosum	32%	100%
Q9I526	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	40%	100%
Q9S6Z7	Arabidopsis thaliana	38%	100%
Q9S757	Arabidopsis thaliana	33%	98%
Q9SXS7	Arabidopsis thaliana	38%	100%
Q9XEA6	Oryza sativa subsp. japonica	41%	100%
Q9XEA8	Oryza sativa subsp. japonica	43%	100%
Q9YBL2	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	26%	92%
Q9ZMW6	Helicobacter pylori (strain J99 / ATCC 700824)	34%	100%
V5BWY7	Trypanosoma cruzi	37%	100%