Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4HX90_LEIIN

TriTrypDb:

LINF_170008600

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13
GO:1990904	ribonucleoprotein complex	2	13

Expansion

Sequence features

A4HX90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX90

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	3
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.574
CLV_NRD_NRD_1	166	168	PF00675	0.683
CLV_NRD_NRD_1	209	211	PF00675	0.692
CLV_NRD_NRD_1	86	88	PF00675	0.595
CLV_PCSK_KEX2_1	434	436	PF00082	0.548
CLV_PCSK_KEX2_1	5	7	PF00082	0.740
CLV_PCSK_KEX2_1	86	88	PF00082	0.595
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.548
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.727
CLV_PCSK_SKI1_1	21	25	PF00082	0.631
CLV_PCSK_SKI1_1	227	231	PF00082	0.713
CLV_PCSK_SKI1_1	275	279	PF00082	0.707
CLV_PCSK_SKI1_1	396	400	PF00082	0.453
CLV_PCSK_SKI1_1	557	561	PF00082	0.553
CLV_PCSK_SKI1_1	598	602	PF00082	0.447
DEG_SCF_TRCP1_1	222	228	PF00400	0.617
DOC_CDC14_PxL_1	55	63	PF14671	0.620
DOC_CKS1_1	267	272	PF01111	0.687
DOC_CYCLIN_RxL_1	393	400	PF00134	0.516
DOC_MAPK_DCC_7	522	530	PF00069	0.434
DOC_MAPK_gen_1	86	96	PF00069	0.528
DOC_MAPK_MEF2A_6	175	183	PF00069	0.487
DOC_PP1_RVXF_1	540	546	PF00149	0.463
DOC_PP2B_LxvP_1	115	118	PF13499	0.633
DOC_PP4_FxxP_1	401	404	PF00568	0.581
DOC_USP7_MATH_1	146	150	PF00917	0.768
DOC_USP7_MATH_1	307	311	PF00917	0.596
DOC_USP7_MATH_1	336	340	PF00917	0.414
DOC_USP7_MATH_1	37	41	PF00917	0.608
DOC_USP7_MATH_1	379	383	PF00917	0.525
DOC_USP7_MATH_1	46	50	PF00917	0.601
DOC_USP7_MATH_1	466	470	PF00917	0.586
DOC_USP7_MATH_1	62	66	PF00917	0.607
DOC_USP7_MATH_1	69	73	PF00917	0.717
DOC_USP7_UBL2_3	271	275	PF12436	0.654
DOC_WW_Pin1_4	13	18	PF00397	0.610
DOC_WW_Pin1_4	142	147	PF00397	0.767
DOC_WW_Pin1_4	152	157	PF00397	0.678
DOC_WW_Pin1_4	248	253	PF00397	0.622
DOC_WW_Pin1_4	266	271	PF00397	0.626
DOC_WW_Pin1_4	326	331	PF00397	0.456
DOC_WW_Pin1_4	369	374	PF00397	0.521
DOC_WW_Pin1_4	452	457	PF00397	0.501
DOC_WW_Pin1_4	523	528	PF00397	0.537
DOC_WW_Pin1_4	67	72	PF00397	0.666
DOC_WW_Pin1_4	74	79	PF00397	0.564
LIG_14-3-3_CanoR_1	306	312	PF00244	0.595
LIG_14-3-3_CanoR_1	6	11	PF00244	0.636
LIG_14-3-3_CanoR_1	86	96	PF00244	0.652
LIG_AP2alpha_1	601	605	PF02296	0.419
LIG_APCC_ABBA_1	187	192	PF00400	0.521
LIG_BIR_III_2	68	72	PF00653	0.568
LIG_BRCT_BRCA1_1	118	122	PF00533	0.798
LIG_BRCT_BRCA1_1	367	371	PF00533	0.511
LIG_EH_1	32	36	PF12763	0.586
LIG_EH1_1	310	318	PF00400	0.489
LIG_FHA_1	145	151	PF00498	0.771
LIG_FHA_1	384	390	PF00498	0.515
LIG_FHA_1	392	398	PF00498	0.452
LIG_FHA_1	554	560	PF00498	0.375
LIG_FHA_1	7	13	PF00498	0.687
LIG_FHA_2	263	269	PF00498	0.547
LIG_FHA_2	441	447	PF00498	0.438
LIG_FHA_2	573	579	PF00498	0.475
LIG_FXI_DFP_1	235	239	PF00024	0.682
LIG_LIR_Apic_2	400	404	PF02991	0.581
LIG_LIR_Gen_1	119	127	PF02991	0.565
LIG_LIR_Gen_1	173	183	PF02991	0.481
LIG_LIR_Gen_1	234	242	PF02991	0.686
LIG_LIR_Gen_1	480	490	PF02991	0.556
LIG_LIR_Gen_1	554	562	PF02991	0.448
LIG_LIR_Nem_3	173	179	PF02991	0.483
LIG_LIR_Nem_3	234	238	PF02991	0.635
LIG_LIR_Nem_3	244	250	PF02991	0.690
LIG_LIR_Nem_3	438	442	PF02991	0.537
LIG_LIR_Nem_3	480	485	PF02991	0.470
LIG_LIR_Nem_3	554	558	PF02991	0.485
LIG_LIR_Nem_3	603	608	PF02991	0.379
LIG_MAD2	396	404	PF02301	0.360
LIG_PCNA_PIPBox_1	424	433	PF02747	0.519
LIG_PCNA_yPIPBox_3	417	431	PF02747	0.501
LIG_Pex14_2	601	605	PF04695	0.419
LIG_SH2_CRK	176	180	PF00017	0.501
LIG_SH2_SRC	190	193	PF00017	0.530
LIG_SH2_STAP1	190	194	PF00017	0.519
LIG_SH2_STAP1	42	46	PF00017	0.803
LIG_SH2_STAT5	377	380	PF00017	0.504
LIG_SH2_STAT5	442	445	PF00017	0.487
LIG_SH2_STAT5	460	463	PF00017	0.569
LIG_SH2_STAT5	496	499	PF00017	0.416
LIG_SH2_STAT5	569	572	PF00017	0.426
LIG_SH2_STAT5	589	592	PF00017	0.427
LIG_SH2_STAT5	609	612	PF00017	0.339
LIG_SH3_3	106	112	PF00018	0.637
LIG_SH3_3	246	252	PF00018	0.612
LIG_SH3_3	301	307	PF00018	0.509
LIG_SH3_3	31	37	PF00018	0.677
LIG_SUMO_SIM_par_1	569	575	PF11976	0.386
LIG_SUMO_SIM_par_1	90	97	PF11976	0.572
LIG_TRAF2_1	182	185	PF00917	0.545
LIG_WRC_WIRS_1	232	237	PF05994	0.684
LIG_WRC_WIRS_1	308	313	PF05994	0.572
LIG_WRC_WIRS_1	398	403	PF05994	0.456
MOD_CDK_SPK_2	266	271	PF00069	0.631
MOD_CDK_SPK_2	74	79	PF00069	0.564
MOD_CDK_SPxxK_3	369	376	PF00069	0.370
MOD_CK1_1	131	137	PF00069	0.628
MOD_CK1_1	141	147	PF00069	0.623
MOD_CK1_1	16	22	PF00069	0.727
MOD_CK1_1	220	226	PF00069	0.766
MOD_CK1_1	251	257	PF00069	0.690
MOD_CK1_1	40	46	PF00069	0.725
MOD_CK1_1	474	480	PF00069	0.450
MOD_CK1_1	495	501	PF00069	0.404
MOD_CK1_1	92	98	PF00069	0.540
MOD_CK2_1	12	18	PF00069	0.620
MOD_CK2_1	179	185	PF00069	0.566
MOD_CK2_1	193	199	PF00069	0.552
MOD_CK2_1	262	268	PF00069	0.617
MOD_CK2_1	326	332	PF00069	0.455
MOD_CK2_1	379	385	PF00069	0.360
MOD_CK2_1	440	446	PF00069	0.409
MOD_CK2_1	45	51	PF00069	0.735
MOD_CK2_1	502	508	PF00069	0.392
MOD_CK2_1	523	529	PF00069	0.449
MOD_CK2_1	572	578	PF00069	0.433
MOD_Cter_Amidation	208	211	PF01082	0.662
MOD_GlcNHglycan	135	139	PF01048	0.700
MOD_GlcNHglycan	162	165	PF01048	0.532
MOD_GlcNHglycan	222	225	PF01048	0.712
MOD_GlcNHglycan	367	370	PF01048	0.418
MOD_GlcNHglycan	420	423	PF01048	0.395
MOD_GlcNHglycan	462	465	PF01048	0.377
MOD_GlcNHglycan	473	476	PF01048	0.490
MOD_GlcNHglycan	514	517	PF01048	0.443
MOD_GlcNHglycan	548	551	PF01048	0.410
MOD_GlcNHglycan	64	67	PF01048	0.632
MOD_GlcNHglycan	71	74	PF01048	0.733
MOD_GlcNHglycan	96	99	PF01048	0.704
MOD_GSK3_1	12	19	PF00069	0.782
MOD_GSK3_1	134	141	PF00069	0.614
MOD_GSK3_1	142	149	PF00069	0.621
MOD_GSK3_1	218	225	PF00069	0.694
MOD_GSK3_1	262	269	PF00069	0.671
MOD_GSK3_1	275	282	PF00069	0.642
MOD_GSK3_1	326	333	PF00069	0.417
MOD_GSK3_1	36	43	PF00069	0.771
MOD_GSK3_1	365	372	PF00069	0.397
MOD_GSK3_1	379	386	PF00069	0.326
MOD_GSK3_1	462	469	PF00069	0.453
MOD_GSK3_1	473	480	PF00069	0.439
MOD_GSK3_1	490	497	PF00069	0.379
MOD_GSK3_1	502	509	PF00069	0.372
MOD_GSK3_1	517	524	PF00069	0.455
MOD_GSK3_1	530	537	PF00069	0.647
MOD_GSK3_1	88	95	PF00069	0.699
MOD_LATS_1	114	120	PF00433	0.793
MOD_N-GLC_1	280	285	PF02516	0.650
MOD_N-GLC_1	440	445	PF02516	0.334
MOD_NEK2_1	12	17	PF00069	0.644
MOD_NEK2_1	294	299	PF00069	0.737
MOD_NEK2_1	430	435	PF00069	0.430
MOD_NEK2_1	492	497	PF00069	0.371
MOD_NEK2_1	543	548	PF00069	0.415
MOD_NEK2_1	601	606	PF00069	0.423
MOD_NEK2_1	61	66	PF00069	0.733
MOD_NEK2_1	88	93	PF00069	0.678
MOD_NEK2_2	37	42	PF00069	0.612
MOD_NEK2_2	466	471	PF00069	0.370
MOD_PK_1	89	95	PF00069	0.582
MOD_PKA_2	128	134	PF00069	0.779
MOD_PKA_2	262	268	PF00069	0.600
MOD_PKA_2	88	94	PF00069	0.668
MOD_PKB_1	87	95	PF00069	0.525
MOD_Plk_1	341	347	PF00069	0.448
MOD_Plk_1	383	389	PF00069	0.313
MOD_Plk_1	466	472	PF00069	0.328
MOD_Plk_1	506	512	PF00069	0.475
MOD_Plk_4	128	134	PF00069	0.725
MOD_Plk_4	262	268	PF00069	0.669
MOD_Plk_4	362	368	PF00069	0.421
MOD_Plk_4	37	43	PF00069	0.778
MOD_Plk_4	383	389	PF00069	0.334
MOD_Plk_4	506	512	PF00069	0.475
MOD_Plk_4	53	59	PF00069	0.686
MOD_Plk_4	89	95	PF00069	0.686
MOD_ProDKin_1	13	19	PF00069	0.610
MOD_ProDKin_1	142	148	PF00069	0.769
MOD_ProDKin_1	152	158	PF00069	0.676
MOD_ProDKin_1	248	254	PF00069	0.622
MOD_ProDKin_1	266	272	PF00069	0.629
MOD_ProDKin_1	326	332	PF00069	0.455
MOD_ProDKin_1	369	375	PF00069	0.372
MOD_ProDKin_1	452	458	PF00069	0.345
MOD_ProDKin_1	523	529	PF00069	0.546
MOD_ProDKin_1	67	73	PF00069	0.666
MOD_ProDKin_1	74	80	PF00069	0.563
MOD_SUMO_rev_2	368	378	PF00179	0.355
TRG_DiLeu_BaEn_2	183	189	PF01217	0.544
TRG_ENDOCYTIC_2	176	179	PF00928	0.647
TRG_ENDOCYTIC_2	190	193	PF00928	0.531
TRG_ER_diArg_1	86	89	PF00400	0.594
TRG_NLS_MonoExtN_4	2	9	PF00514	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I384	Leptomonas seymouri	68%	86%
A0A1X0NT03	Trypanosomatidae	47%	100%
A0A3Q8IDW5	Leishmania donovani	100%	88%
A0A3Q8IGX5	Leishmania donovani	28%	100%
A0A3R7NBP1	Trypanosoma rangeli	54%	100%
A4H8W6	Leishmania braziliensis	69%	100%
A4ICS7	Leishmania infantum	27%	100%
C9ZTV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AQZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9ASH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4QEH1	Leishmania major	93%	100%