ATP pyrophosphate-lyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

receptor-type adenylate cyclase - putative

Species:

Leishmania infantum

UniProt:

A4HX86_LEIIN

TriTrypDb:

LINF_170007600

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0110165	cellular anatomical entity	1	8
GO:0016020	membrane	2	3

Expansion

Sequence features

A4HX86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX86

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006163	purine nucleotide metabolic process	5	8
GO:0006164	purine nucleotide biosynthetic process	6	8
GO:0006171	cAMP biosynthetic process	8	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006753	nucleoside phosphate metabolic process	4	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0007165	signal transduction	2	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009117	nucleotide metabolic process	5	8
GO:0009150	purine ribonucleotide metabolic process	6	8
GO:0009152	purine ribonucleotide biosynthetic process	7	8
GO:0009165	nucleotide biosynthetic process	6	8
GO:0009187	cyclic nucleotide metabolic process	6	8
GO:0009190	cyclic nucleotide biosynthetic process	7	8
GO:0009259	ribonucleotide metabolic process	5	8
GO:0009260	ribonucleotide biosynthetic process	6	8
GO:0009987	cellular process	1	8
GO:0018130	heterocycle biosynthetic process	4	8
GO:0019438	aromatic compound biosynthetic process	4	8
GO:0019637	organophosphate metabolic process	3	8
GO:0019693	ribose phosphate metabolic process	4	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034654	nucleobase-containing compound biosynthetic process	4	8
GO:0035556	intracellular signal transduction	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044271	cellular nitrogen compound biosynthetic process	4	8
GO:0044281	small molecule metabolic process	2	8
GO:0046058	cAMP metabolic process	7	8
GO:0046390	ribose phosphate biosynthetic process	5	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0052652	cyclic purine nucleotide metabolic process	6	8
GO:0055086	nucleobase-containing small molecule metabolic process	3	8
GO:0065007	biological regulation	1	8
GO:0071704	organic substance metabolic process	2	8
GO:0072521	purine-containing compound metabolic process	4	8
GO:0072522	purine-containing compound biosynthetic process	5	8
GO:0090407	organophosphate biosynthetic process	4	8
GO:1901135	carbohydrate derivative metabolic process	3	8
GO:1901137	carbohydrate derivative biosynthetic process	4	8
GO:1901293	nucleoside phosphate biosynthetic process	5	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901362	organic cyclic compound biosynthetic process	4	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016829	lyase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.343
CLV_MEL_PAP_1	77	83	PF00089	0.361
CLV_NRD_NRD_1	167	169	PF00675	0.573
CLV_NRD_NRD_1	331	333	PF00675	0.774
CLV_NRD_NRD_1	334	336	PF00675	0.762
CLV_PCSK_FUR_1	329	333	PF00082	0.776
CLV_PCSK_KEX2_1	167	169	PF00082	0.573
CLV_PCSK_KEX2_1	331	333	PF00082	0.778
CLV_PCSK_SKI1_1	264	268	PF00082	0.532
CLV_PCSK_SKI1_1	29	33	PF00082	0.436
DEG_Nend_UBRbox_2	1	2	PF02207	0.489
DOC_MAPK_RevD_3	154	168	PF00069	0.489
DOC_USP7_MATH_1	12	16	PF00917	0.343
DOC_USP7_MATH_1	266	270	PF00917	0.590
DOC_USP7_MATH_1	311	315	PF00917	0.689
DOC_USP7_MATH_1	323	327	PF00917	0.765
LIG_14-3-3_CanoR_1	14	22	PF00244	0.489
LIG_14-3-3_CanoR_1	246	253	PF00244	0.558
LIG_14-3-3_CanoR_1	264	269	PF00244	0.494
LIG_14-3-3_CanoR_1	64	70	PF00244	0.489
LIG_FHA_1	110	116	PF00498	0.361
LIG_FHA_1	26	32	PF00498	0.390
LIG_FHA_1	289	295	PF00498	0.720
LIG_FHA_1	35	41	PF00498	0.291
LIG_FHA_1	60	66	PF00498	0.343
LIG_FHA_2	172	178	PF00498	0.584
LIG_FHA_2	182	188	PF00498	0.583
LIG_FHA_2	2	8	PF00498	0.343
LIG_FHA_2	52	58	PF00498	0.479
LIG_GBD_Chelix_1	22	30	PF00786	0.489
LIG_LIR_Apic_2	56	61	PF02991	0.346
LIG_LIR_Gen_1	67	77	PF02991	0.489
LIG_LIR_Gen_1	89	99	PF02991	0.489
LIG_LIR_Nem_3	125	131	PF02991	0.447
LIG_LIR_Nem_3	216	221	PF02991	0.538
LIG_LIR_Nem_3	41	47	PF02991	0.319
LIG_LIR_Nem_3	67	73	PF02991	0.489
LIG_LIR_Nem_3	89	95	PF02991	0.356
LIG_LIR_Nem_3	96	102	PF02991	0.295
LIG_SH2_NCK_1	58	62	PF00017	0.489
LIG_SH2_NCK_1	92	96	PF00017	0.489
LIG_SH2_SRC	58	61	PF00017	0.343
LIG_SH2_SRC	92	95	PF00017	0.489
LIG_SH2_STAP1	70	74	PF00017	0.489
LIG_SH2_STAT5	253	256	PF00017	0.523
LIG_SH3_1	335	341	PF00018	0.747
LIG_SH3_3	236	242	PF00018	0.541
LIG_SH3_3	291	297	PF00018	0.771
LIG_SH3_3	335	341	PF00018	0.747
LIG_TRAF2_1	66	69	PF00917	0.489
LIG_TYR_ITIM	90	95	PF00017	0.489
LIG_WW_3	241	245	PF00397	0.650
MOD_CK1_1	15	21	PF00069	0.489
MOD_CK1_1	199	205	PF00069	0.550
MOD_CK1_1	303	309	PF00069	0.708
MOD_CK1_1	314	320	PF00069	0.600
MOD_CK2_1	129	135	PF00069	0.343
MOD_CK2_1	171	177	PF00069	0.614
MOD_CK2_1	63	69	PF00069	0.489
MOD_Cter_Amidation	165	168	PF01082	0.597
MOD_Cter_Amidation	333	336	PF01082	0.798
MOD_GlcNHglycan	14	17	PF01048	0.445
MOD_GlcNHglycan	190	193	PF01048	0.570
MOD_GlcNHglycan	313	316	PF01048	0.737
MOD_GlcNHglycan	321	324	PF01048	0.726
MOD_GlcNHglycan	325	328	PF01048	0.728
MOD_GSK3_1	1	8	PF00069	0.343
MOD_GSK3_1	181	188	PF00069	0.676
MOD_GSK3_1	195	202	PF00069	0.569
MOD_GSK3_1	242	249	PF00069	0.609
MOD_GSK3_1	319	326	PF00069	0.714
MOD_GSK3_1	59	66	PF00069	0.489
MOD_NEK2_1	196	201	PF00069	0.671
MOD_PIKK_1	266	272	PF00454	0.619
MOD_PKA_2	311	317	PF00069	0.697
MOD_PKA_2	339	345	PF00069	0.625
MOD_PKA_2	63	69	PF00069	0.489
MOD_PKB_1	244	252	PF00069	0.659
MOD_Plk_2-3	1	7	PF00069	0.343
MOD_Plk_4	300	306	PF00069	0.642
MOD_Plk_4	5	11	PF00069	0.343
TRG_DiLeu_BaEn_4	68	74	PF01217	0.489
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.769
TRG_DiLeu_LyEn_5	229	234	PF01217	0.595
TRG_ENDOCYTIC_2	44	47	PF00928	0.319
TRG_ENDOCYTIC_2	70	73	PF00928	0.489
TRG_ENDOCYTIC_2	92	95	PF00928	0.465
TRG_ER_diArg_1	243	246	PF00400	0.676
TRG_ER_diArg_1	328	331	PF00400	0.775
TRG_ER_diArg_1	77	80	PF00400	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J1Z5	Bodo saltans	31%	100%
A0A1X0NRC9	Trypanosomatidae	50%	81%
A0A3R7LH78	Trypanosoma rangeli	49%	66%
A0A422MX26	Trypanosoma rangeli	49%	95%
A0A422N092	Trypanosoma rangeli	50%	92%
A0A422NJL9	Trypanosoma rangeli	49%	68%
P26338	Trypanosoma equiperdum	50%	75%