LeishMANIAdb
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ATP pyrophosphate-lyase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATP pyrophosphate-lyase
Gene product:
receptor-type adenylate cyclase - putative
Species:
Leishmania infantum
UniProt:
A4HX85_LEIIN
TriTrypDb:
LINF_170007800 *
Length:
1399

Annotations

LeishMANIAdb annotations

Carries an ATP pyrophosphate-lyase domain on its cytoplasmic segment. Likely acts as a receptor for some unknown extracellular stimulus. Extremely expanded kinetoplastid protein family.. Expressed in the insect stage (promastigote) but not in the mammalian host stage of the parasite life cycle.. Localization: Cell surface (by feature)

Annotations by Jardim et al.

Receptors, Receptor-type adenylate cyclase b RAC-B2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 57
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 46, no: 27
NetGPI no yes: 0, no: 73
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 68
GO:0110165 cellular anatomical entity 1 74
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Expansion

Sequence features

A4HX85
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX85

Function

Biological processes
TermNameLevelCount
GO:0006139 nucleobase-containing compound metabolic process 3 74
GO:0006163 purine nucleotide metabolic process 5 74
GO:0006164 purine nucleotide biosynthetic process 6 74
GO:0006171 cAMP biosynthetic process 8 74
GO:0006725 cellular aromatic compound metabolic process 3 74
GO:0006753 nucleoside phosphate metabolic process 4 74
GO:0006793 phosphorus metabolic process 3 74
GO:0006796 phosphate-containing compound metabolic process 4 74
GO:0006807 nitrogen compound metabolic process 2 74
GO:0007165 signal transduction 2 74
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 63
GO:0016829 lyase activity 2 63
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 383 387 PF00656 0.550
CLV_C14_Caspase3-7 983 987 PF00656 0.531
CLV_MEL_PAP_1 1056 1062 PF00089 0.322
CLV_NRD_NRD_1 1146 1148 PF00675 0.446
CLV_NRD_NRD_1 1314 1316 PF00675 0.630
CLV_NRD_NRD_1 1353 1355 PF00675 0.676
CLV_NRD_NRD_1 1383 1385 PF00675 0.488
CLV_NRD_NRD_1 207 209 PF00675 0.661
CLV_NRD_NRD_1 660 662 PF00675 0.559
CLV_NRD_NRD_1 801 803 PF00675 0.687
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P457 Leptomonas seymouri 26% 100%
A0A1X0P171 Trypanosomatidae 32% 100%
A0A3Q8IJB0 Leishmania donovani 97% 100%
A0A3R7R8G4 Trypanosoma rangeli 30% 100%
A0A3S5H6Z8 Leishmania donovani 97% 100%
A0A3S7WU91 Leishmania donovani 66% 99%
A0A3S7WU94 Leishmania donovani 54% 100%
A0A3S7WU95 Leishmania donovani 91% 100%
A0A3S7XB85 Leishmania donovani 27% 99%
A4H8U6 Leishmania braziliensis 55% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS