LeishMANIAdb
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Putative mitogen-activated protein kinase kinase 3

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitogen-activated protein kinase kinase 3
Gene product:
mitogen-activated protein kinase kinase 3 - putative
Species:
Leishmania infantum
UniProt:
A4HX71_LEIIN
TriTrypDb:
LINF_170005700
Length:
553

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 27
NetGPI no yes: 0, no: 27
Cellular components
Term Name Level Count
GO:0005929 cilium 4 11
GO:0042995 cell projection 2 11
GO:0043226 organelle 2 13
GO:0043227 membrane-bounded organelle 3 13
GO:0110165 cellular anatomical entity 1 15
GO:0120025 plasma membrane bounded cell projection 3 11
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 4
GO:0005829 cytosol 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2

Expansion

Sequence features

A4HX71
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX71

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 28
GO:0006793 phosphorus metabolic process 3 28
GO:0006796 phosphate-containing compound metabolic process 4 28
GO:0006807 nitrogen compound metabolic process 2 28
GO:0008152 metabolic process 1 28
GO:0009987 cellular process 1 28
GO:0016310 phosphorylation 5 28
GO:0019538 protein metabolic process 3 28
GO:0036211 protein modification process 4 28
GO:0043170 macromolecule metabolic process 3 28
GO:0043412 macromolecule modification 4 28
GO:0044237 cellular metabolic process 2 28
GO:0044238 primary metabolic process 2 28
GO:0071704 organic substance metabolic process 2 28
GO:1901564 organonitrogen compound metabolic process 3 28
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0007165 signal transduction 2 3
GO:0022402 cell cycle process 2 1
GO:0035556 intracellular signal transduction 3 3
GO:0050789 regulation of biological process 2 3
GO:0050794 regulation of cellular process 3 3
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:0065007 biological regulation 1 3
GO:1903047 mitotic cell cycle process 3 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 28
GO:0003824 catalytic activity 1 28
GO:0004672 protein kinase activity 3 28
GO:0005488 binding 1 28
GO:0005524 ATP binding 5 28
GO:0016301 kinase activity 4 28
GO:0016740 transferase activity 2 28
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 28
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 28
GO:0017076 purine nucleotide binding 4 28
GO:0030554 adenyl nucleotide binding 5 28
GO:0032553 ribonucleotide binding 3 28
GO:0032555 purine ribonucleotide binding 4 28
GO:0032559 adenyl ribonucleotide binding 5 28
GO:0035639 purine ribonucleoside triphosphate binding 4 28
GO:0036094 small molecule binding 2 28
GO:0043167 ion binding 2 28
GO:0043168 anion binding 3 28
GO:0097159 organic cyclic compound binding 2 28
GO:0097367 carbohydrate derivative binding 2 28
GO:0140096 catalytic activity, acting on a protein 2 28
GO:1901265 nucleoside phosphate binding 3 28
GO:1901363 heterocyclic compound binding 2 28
GO:0004674 protein serine/threonine kinase activity 4 14
GO:0043169 cation binding 3 5
GO:0046872 metal ion binding 4 5
GO:0004707 MAP kinase activity 5 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 275 279 PF00656 0.343
CLV_C14_Caspase3-7 287 291 PF00656 0.397
CLV_NRD_NRD_1 129 131 PF00675 0.240
CLV_NRD_NRD_1 272 274 PF00675 0.286
CLV_NRD_NRD_1 293 295 PF00675 0.447
CLV_NRD_NRD_1 48 50 PF00675 0.244
CLV_NRD_NRD_1 547 549 PF00675 0.695
CLV_PCSK_KEX2_1 129 131 PF00082 0.259
CLV_PCSK_KEX2_1 272 274 PF00082 0.281
CLV_PCSK_KEX2_1 293 295 PF00082 0.595
CLV_PCSK_KEX2_1 48 50 PF00082 0.224
CLV_PCSK_KEX2_1 516 518 PF00082 0.647
CLV_PCSK_KEX2_1 547 549 PF00082 0.593
CLV_PCSK_KEX2_1 59 61 PF00082 0.292
CLV_PCSK_KEX2_1 63 65 PF00082 0.332
CLV_PCSK_PC1ET2_1 516 518 PF00082 0.647
CLV_PCSK_PC1ET2_1 59 61 PF00082 0.312
CLV_PCSK_PC1ET2_1 63 65 PF00082 0.312
CLV_PCSK_SKI1_1 12 16 PF00082 0.685
CLV_PCSK_SKI1_1 130 134 PF00082 0.254
CLV_PCSK_SKI1_1 150 154 PF00082 0.326
CLV_PCSK_SKI1_1 277 281 PF00082 0.250
CLV_PCSK_SKI1_1 28 32 PF00082 0.240
CLV_PCSK_SKI1_1 412 416 PF00082 0.429
DEG_APCC_DBOX_1 442 450 PF00400 0.376
DEG_Nend_UBRbox_2 1 3 PF02207 0.367
DEG_SPOP_SBC_1 360 364 PF00917 0.374
DOC_MAPK_gen_1 313 321 PF00069 0.497
DOC_MAPK_gen_1 529 537 PF00069 0.551
DOC_PP4_FxxP_1 192 195 PF00568 0.241
DOC_USP7_MATH_1 110 114 PF00917 0.355
DOC_USP7_MATH_1 361 365 PF00917 0.500
DOC_USP7_MATH_1 434 438 PF00917 0.464
DOC_USP7_UBL2_3 201 205 PF12436 0.355
DOC_USP7_UBL2_3 277 281 PF12436 0.245
DOC_USP7_UBL2_3 525 529 PF12436 0.539
DOC_USP7_UBL2_3 59 63 PF12436 0.262
DOC_WW_Pin1_4 473 478 PF00397 0.434
LIG_14-3-3_CanoR_1 129 139 PF00244 0.193
LIG_14-3-3_CanoR_1 272 280 PF00244 0.310
LIG_14-3-3_CanoR_1 293 298 PF00244 0.598
LIG_14-3-3_CanoR_1 443 452 PF00244 0.435
LIG_Actin_WH2_2 377 394 PF00022 0.396
LIG_Actin_WH2_2 397 414 PF00022 0.359
LIG_APCC_ABBAyCdc20_2 145 151 PF00400 0.227
LIG_BRCT_BRCA1_1 367 371 PF00533 0.301
LIG_Clathr_ClatBox_1 136 140 PF01394 0.227
LIG_FHA_1 131 137 PF00498 0.217
LIG_FHA_1 20 26 PF00498 0.530
LIG_FHA_1 233 239 PF00498 0.310
LIG_FHA_1 50 56 PF00498 0.479
LIG_FHA_1 66 72 PF00498 0.368
LIG_FHA_1 78 84 PF00498 0.280
LIG_FHA_2 361 367 PF00498 0.478
LIG_FHA_2 93 99 PF00498 0.261
LIG_LIR_Apic_2 189 195 PF02991 0.333
LIG_LIR_Apic_2 200 206 PF02991 0.333
LIG_LIR_Gen_1 26 35 PF02991 0.296
LIG_LIR_Gen_1 395 406 PF02991 0.335
LIG_LIR_LC3C_4 163 166 PF02991 0.359
LIG_LIR_Nem_3 2 6 PF02991 0.357
LIG_LIR_Nem_3 342 347 PF02991 0.356
LIG_LIR_Nem_3 349 353 PF02991 0.353
LIG_LIR_Nem_3 37 43 PF02991 0.364
LIG_LIR_Nem_3 395 401 PF02991 0.328
LIG_SH2_CRK 203 207 PF00017 0.307
LIG_SH2_CRK 268 272 PF00017 0.174
LIG_SH2_CRK 350 354 PF00017 0.418
LIG_SH2_SRC 108 111 PF00017 0.355
LIG_SH2_SRC 358 361 PF00017 0.336
LIG_SH2_STAT3 224 227 PF00017 0.220
LIG_SH2_STAT3 298 301 PF00017 0.494
LIG_SH2_STAT3 4 7 PF00017 0.491
LIG_SH2_STAT5 108 111 PF00017 0.420
LIG_SH2_STAT5 141 144 PF00017 0.434
LIG_SH2_STAT5 29 32 PF00017 0.404
LIG_SH2_STAT5 329 332 PF00017 0.305
LIG_SH2_STAT5 352 355 PF00017 0.355
LIG_SH2_STAT5 358 361 PF00017 0.366
LIG_SH3_2 524 529 PF14604 0.741
LIG_SH3_3 521 527 PF00018 0.600
LIG_SH3_3 532 538 PF00018 0.543
LIG_SUMO_SIM_anti_2 403 408 PF11976 0.394
LIG_SUMO_SIM_par_1 19 27 PF11976 0.358
LIG_SUMO_SIM_par_1 377 383 PF11976 0.344
LIG_TRAF2_1 244 247 PF00917 0.332
LIG_TYR_ITIM 266 271 PF00017 0.174
LIG_UBA3_1 327 332 PF00899 0.438
LIG_WRC_WIRS_1 467 472 PF05994 0.318
MOD_CK1_1 16 22 PF00069 0.476
MOD_CK1_1 419 425 PF00069 0.363
MOD_CK1_1 447 453 PF00069 0.344
MOD_CK1_1 460 466 PF00069 0.337
MOD_CK1_1 483 489 PF00069 0.545
MOD_CK1_1 491 497 PF00069 0.548
MOD_CK1_1 505 511 PF00069 0.555
MOD_CK1_1 518 524 PF00069 0.472
MOD_CK1_1 82 88 PF00069 0.322
MOD_CK2_1 121 127 PF00069 0.289
MOD_CK2_1 360 366 PF00069 0.304
MOD_GlcNHglycan 15 18 PF01048 0.566
MOD_GlcNHglycan 274 277 PF01048 0.368
MOD_GlcNHglycan 303 306 PF01048 0.535
MOD_GlcNHglycan 310 313 PF01048 0.416
MOD_GlcNHglycan 36 39 PF01048 0.379
MOD_GlcNHglycan 44 47 PF01048 0.301
MOD_GlcNHglycan 459 462 PF01048 0.352
MOD_GlcNHglycan 496 499 PF01048 0.727
MOD_GlcNHglycan 520 523 PF01048 0.702
MOD_GSK3_1 121 128 PF00069 0.306
MOD_GSK3_1 13 20 PF00069 0.505
MOD_GSK3_1 182 189 PF00069 0.326
MOD_GSK3_1 293 300 PF00069 0.630
MOD_GSK3_1 361 368 PF00069 0.410
MOD_GSK3_1 380 387 PF00069 0.414
MOD_GSK3_1 412 419 PF00069 0.328
MOD_GSK3_1 478 485 PF00069 0.517
MOD_GSK3_1 494 501 PF00069 0.479
MOD_GSK3_1 502 509 PF00069 0.545
MOD_N-GLC_1 121 126 PF02516 0.183
MOD_NEK2_1 171 176 PF00069 0.315
MOD_NEK2_1 384 389 PF00069 0.346
MOD_NEK2_1 480 485 PF00069 0.611
MOD_NEK2_1 502 507 PF00069 0.560
MOD_NEK2_1 6 11 PF00069 0.372
MOD_NEK2_1 92 97 PF00069 0.263
MOD_NEK2_2 186 191 PF00069 0.252
MOD_PIKK_1 130 136 PF00454 0.297
MOD_PIKK_1 157 163 PF00454 0.355
MOD_PIKK_1 260 266 PF00454 0.279
MOD_PIKK_1 297 303 PF00454 0.514
MOD_PIKK_1 444 450 PF00454 0.452
MOD_PIKK_1 491 497 PF00454 0.724
MOD_PKA_1 272 278 PF00069 0.266
MOD_PKA_1 293 299 PF00069 0.469
MOD_PKA_1 529 535 PF00069 0.668
MOD_PKA_2 272 278 PF00069 0.311
MOD_PKA_2 292 298 PF00069 0.388
MOD_PKA_2 47 53 PF00069 0.272
MOD_PKA_2 491 497 PF00069 0.503
MOD_Plk_1 365 371 PF00069 0.553
MOD_Plk_1 394 400 PF00069 0.342
MOD_Plk_1 498 504 PF00069 0.562
MOD_Plk_1 92 98 PF00069 0.259
MOD_Plk_2-3 380 386 PF00069 0.248
MOD_Plk_4 100 106 PF00069 0.304
MOD_Plk_4 171 177 PF00069 0.355
MOD_Plk_4 293 299 PF00069 0.638
MOD_Plk_4 402 408 PF00069 0.282
MOD_Plk_4 466 472 PF00069 0.433
MOD_Plk_4 498 504 PF00069 0.563
MOD_Plk_4 6 12 PF00069 0.607
MOD_Plk_4 79 85 PF00069 0.220
MOD_ProDKin_1 473 479 PF00069 0.448
MOD_SUMO_for_1 528 531 PF00179 0.532
MOD_SUMO_for_1 90 93 PF00179 0.355
TRG_DiLeu_BaEn_1 79 84 PF01217 0.272
TRG_DiLeu_BaEn_2 126 132 PF01217 0.332
TRG_DiLeu_BaLyEn_6 253 258 PF01217 0.195
TRG_DiLeu_BaLyEn_6 323 328 PF01217 0.404
TRG_DiLeu_BaLyEn_6 437 442 PF01217 0.472
TRG_ENDOCYTIC_2 268 271 PF00928 0.174
TRG_ENDOCYTIC_2 29 32 PF00928 0.262
TRG_ENDOCYTIC_2 341 344 PF00928 0.331
TRG_ENDOCYTIC_2 350 353 PF00928 0.396
TRG_ENDOCYTIC_2 40 43 PF00928 0.282
TRG_ER_diArg_1 129 131 PF00400 0.241
TRG_ER_diArg_1 242 245 PF00400 0.203
TRG_ER_diArg_1 271 273 PF00400 0.267
TRG_Pf-PMV_PEXEL_1 130 134 PF00026 0.220
TRG_Pf-PMV_PEXEL_1 326 331 PF00026 0.323

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2S2 Leptomonas seymouri 69% 99%
A0A0S4JTJ8 Bodo saltans 31% 100%
A0A1X0NTP1 Trypanosomatidae 49% 95%
A0A3Q8IB74 Leishmania donovani 30% 100%
A0A3Q8IH39 Leishmania donovani 27% 100%
A0A3Q8IIG1 Leishmania donovani 26% 100%
A0A3Q8INQ4 Leishmania donovani 29% 100%
A0A3Q8ITZ9 Leishmania donovani 25% 100%
A0A3Q8IVR8 Leishmania donovani 31% 100%
A0A3R7MKJ1 Trypanosoma rangeli 45% 100%
A0A3S5H528 Leishmania donovani 26% 100%
A0A3S5H5G0 Leishmania donovani 28% 100%
A0A3S5H6C8 Leishmania donovani 22% 100%
A0A3S5H7N7 Leishmania donovani 27% 100%
A0A3S7WQK7 Leishmania donovani 22% 100%
A0A3S7WR45 Leishmania donovani 27% 100%
A0A3S7WTN9 Leishmania donovani 32% 100%
A0A3S7WUE7 Leishmania donovani 100% 100%
A0A3S7X2W3 Leishmania donovani 29% 100%
A0A3S7X7Y2 Leishmania donovani 30% 100%
A0A3S7X933 Leishmania donovani 28% 100%
A0A3S7X9R4 Leishmania donovani 30% 100%
A0A451EJH2 Leishmania donovani 24% 100%
A4H3D2 Leishmania braziliensis 24% 100%
A4H3J3 Leishmania braziliensis 27% 100%
A4H459 Leishmania braziliensis 27% 100%
A4H5L7 Leishmania braziliensis 23% 100%
A4H601 Leishmania braziliensis 27% 100%
A4H8C4 Leishmania braziliensis 33% 100%
A4H8V2 Leishmania braziliensis 88% 100%
A4H9X5 Leishmania braziliensis 30% 100%
A4HAS1 Leishmania braziliensis 30% 100%
A4HED7 Leishmania braziliensis 30% 100%
A4HHN1 Leishmania braziliensis 29% 100%
A4HIM5 Leishmania braziliensis 26% 100%
A4HLJ9 Leishmania braziliensis 24% 100%
A4HMJ3 Leishmania braziliensis 29% 100%
A4HN71 Leishmania braziliensis 29% 100%
A4HRN3 Leishmania infantum 24% 100%
A4HRT2 Leishmania infantum 26% 100%
A4HSE2 Leishmania infantum 28% 100%
A4HTV4 Leishmania infantum 22% 100%
A4HTV5 Leishmania infantum 22% 100%
A4HUC8 Leishmania infantum 27% 100%
A4HUG1 Leishmania infantum 27% 100%
A4HWP5 Leishmania infantum 32% 100%
A4I1T4 Leishmania infantum 29% 100%
A4I435 Leishmania infantum 26% 100%
A4I4U6 Leishmania infantum 29% 100%
A4I5X0 Leishmania infantum 27% 100%
A4I910 Leishmania infantum 27% 100%
A4I9Y5 Leishmania infantum 30% 100%
A4IB73 Leishmania infantum 28% 100%
A4IBT4 Leishmania infantum 30% 100%
A4IBT9 Leishmania infantum 30% 100%
A4ICR2 Leishmania infantum 31% 100%
C9ZTU6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E8NHK0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9ACB1 Leishmania major 24% 100%
E9ACG8 Leishmania major 27% 100%
E9AEZ4 Leishmania major 29% 100%
E9AGS0 Leishmania infantum 30% 100%
E9AJJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AJJ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AMP2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AN28 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AN59 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AQF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9ARC8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9ARW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9ASJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B164 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B3X5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B650 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
O80673 Arabidopsis thaliana 30% 96%
P00518 Oryctolagus cuniculus 28% 100%
Q16816 Homo sapiens 28% 100%
Q4Q204 Leishmania major 31% 100%
Q4Q2Z2 Leishmania major 31% 100%
Q4Q449 Leishmania major 26% 100%
Q4Q701 Leishmania major 27% 100%
Q4Q9K2 Leishmania major 29% 100%
Q4QDK3 Leishmania major 30% 100%
Q4QEJ2 Leishmania major 97% 100%
Q4QF23 Leishmania major 32% 100%
Q4QH69 Leishmania major 25% 100%
Q4QHG6 Leishmania major 27% 100%
Q4QHJ8 Leishmania major 27% 100%
Q4QHY3 Leishmania major 22% 100%
Q4QJJ0 Leishmania major 28% 100%
Q6Z8C8 Oryza sativa subsp. japonica 28% 100%
Q9GNR4 Leishmania major 30% 100%
Q9LET1 Arabidopsis thaliana 30% 96%
Q9Y077 Leishmania major 29% 100%
V5BH88 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS