LeishMANIAdb
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Separase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Separase
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HX65_LEIIN
TriTrypDb:
LINF_170005000
Length:
774

Annotations

Annotations by Jardim et al.

Translation, eukaryotic translation initiation factor 3 subunit a

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 2
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 4
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005852 eukaryotic translation initiation factor 3 complex 2 12
GO:0032991 protein-containing complex 1 12
GO:0005737 cytoplasm 2 1
GO:0043614 multi-eIF complex 3 1
GO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e 3 1
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m 3 1
GO:0110165 cellular anatomical entity 1 1
GO:1990904 ribonucleoprotein complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HX65
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX65

Function

Biological processes
Term Name Level Count
GO:0001732 formation of cytoplasmic translation initiation complex 7 1
GO:0002183 cytoplasmic translational initiation 4 1
GO:0002188 translation reinitiation 5 1
GO:0006413 translational initiation 3 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0022618 ribonucleoprotein complex assembly 6 1
GO:0043933 protein-containing complex organization 4 1
GO:0044237 cellular metabolic process 2 1
GO:0065003 protein-containing complex assembly 5 1
GO:0071826 ribonucleoprotein complex subunit organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 10
GO:0003723 RNA binding 4 1
GO:0003729 mRNA binding 5 1
GO:0003743 translation initiation factor activity 4 10
GO:0005488 binding 1 10
GO:0008135 translation factor activity, RNA binding 3 10
GO:0045182 translation regulator activity 1 10
GO:0090079 translation regulator activity, nucleic acid binding 2 10
GO:0097159 organic cyclic compound binding 2 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 29 33 PF00656 0.435
CLV_C14_Caspase3-7 490 494 PF00656 0.539
CLV_NRD_NRD_1 151 153 PF00675 0.520
CLV_NRD_NRD_1 590 592 PF00675 0.583
CLV_NRD_NRD_1 606 608 PF00675 0.521
CLV_NRD_NRD_1 626 628 PF00675 0.431
CLV_NRD_NRD_1 663 665 PF00675 0.540
CLV_NRD_NRD_1 669 671 PF00675 0.565
CLV_NRD_NRD_1 690 692 PF00675 0.491
CLV_NRD_NRD_1 718 720 PF00675 0.489
CLV_NRD_NRD_1 723 725 PF00675 0.555
CLV_NRD_NRD_1 74 76 PF00675 0.464
CLV_NRD_NRD_1 745 747 PF00675 0.680
CLV_NRD_NRD_1 769 771 PF00675 0.638
CLV_PCSK_KEX2_1 140 142 PF00082 0.512
CLV_PCSK_KEX2_1 151 153 PF00082 0.266
CLV_PCSK_KEX2_1 272 274 PF00082 0.468
CLV_PCSK_KEX2_1 319 321 PF00082 0.541
CLV_PCSK_KEX2_1 323 325 PF00082 0.325
CLV_PCSK_KEX2_1 537 539 PF00082 0.583
CLV_PCSK_KEX2_1 582 584 PF00082 0.541
CLV_PCSK_KEX2_1 590 592 PF00082 0.538
CLV_PCSK_KEX2_1 662 664 PF00082 0.514
CLV_PCSK_KEX2_1 690 692 PF00082 0.473
CLV_PCSK_KEX2_1 718 720 PF00082 0.601
CLV_PCSK_KEX2_1 723 725 PF00082 0.463
CLV_PCSK_KEX2_1 74 76 PF00082 0.491
CLV_PCSK_KEX2_1 747 749 PF00082 0.561
CLV_PCSK_KEX2_1 756 758 PF00082 0.465
CLV_PCSK_KEX2_1 769 771 PF00082 0.638
CLV_PCSK_PC1ET2_1 140 142 PF00082 0.471
CLV_PCSK_PC1ET2_1 272 274 PF00082 0.457
CLV_PCSK_PC1ET2_1 319 321 PF00082 0.541
CLV_PCSK_PC1ET2_1 323 325 PF00082 0.325
CLV_PCSK_PC1ET2_1 537 539 PF00082 0.687
CLV_PCSK_PC1ET2_1 582 584 PF00082 0.546
CLV_PCSK_PC1ET2_1 662 664 PF00082 0.526
CLV_PCSK_PC1ET2_1 690 692 PF00082 0.493
CLV_PCSK_PC1ET2_1 747 749 PF00082 0.561
CLV_PCSK_PC1ET2_1 756 758 PF00082 0.465
CLV_PCSK_PC7_1 719 725 PF00082 0.586
CLV_PCSK_PC7_1 743 749 PF00082 0.544
CLV_PCSK_SKI1_1 167 171 PF00082 0.433
CLV_PCSK_SKI1_1 178 182 PF00082 0.437
CLV_PCSK_SKI1_1 231 235 PF00082 0.489
CLV_PCSK_SKI1_1 3 7 PF00082 0.619
CLV_PCSK_SKI1_1 330 334 PF00082 0.339
CLV_PCSK_SKI1_1 409 413 PF00082 0.471
CLV_PCSK_SKI1_1 430 434 PF00082 0.379
CLV_PCSK_SKI1_1 623 627 PF00082 0.406
CLV_PCSK_SKI1_1 671 675 PF00082 0.583
CLV_PCSK_SKI1_1 728 732 PF00082 0.524
CLV_Separin_Metazoa 624 628 PF03568 0.530
CLV_Separin_Metazoa 71 75 PF03568 0.499
DEG_APCC_DBOX_1 329 337 PF00400 0.345
DEG_APCC_DBOX_1 433 441 PF00400 0.454
DEG_Nend_UBRbox_2 1 3 PF02207 0.673
DEG_SPOP_SBC_1 532 536 PF00917 0.663
DEG_SPOP_SBC_1 552 556 PF00917 0.491
DOC_CKS1_1 42 47 PF01111 0.479
DOC_MAPK_DCC_7 39 48 PF00069 0.496
DOC_MAPK_gen_1 109 117 PF00069 0.527
DOC_MAPK_gen_1 277 287 PF00069 0.482
DOC_MAPK_MEF2A_6 92 101 PF00069 0.418
DOC_MAPK_RevD_3 127 141 PF00069 0.471
DOC_PP1_RVXF_1 165 172 PF00149 0.490
DOC_PP2B_LxvP_1 686 689 PF13499 0.429
DOC_PP4_FxxP_1 187 190 PF00568 0.475
DOC_PP4_FxxP_1 362 365 PF00568 0.550
DOC_USP7_MATH_1 11 15 PF00917 0.522
DOC_USP7_MATH_1 236 240 PF00917 0.265
DOC_USP7_MATH_1 33 37 PF00917 0.424
DOC_USP7_MATH_1 4 8 PF00917 0.612
DOC_USP7_MATH_1 416 420 PF00917 0.575
DOC_USP7_MATH_1 514 518 PF00917 0.665
DOC_USP7_MATH_1 519 523 PF00917 0.685
DOC_USP7_MATH_1 532 536 PF00917 0.705
DOC_USP7_MATH_1 575 579 PF00917 0.556
DOC_USP7_UBL2_3 319 323 PF12436 0.535
DOC_USP7_UBL2_3 577 581 PF12436 0.550
DOC_USP7_UBL2_3 628 632 PF12436 0.460
DOC_WW_Pin1_4 361 366 PF00397 0.566
DOC_WW_Pin1_4 383 388 PF00397 0.517
DOC_WW_Pin1_4 41 46 PF00397 0.496
LIG_14-3-3_CanoR_1 10 16 PF00244 0.540
LIG_14-3-3_CanoR_1 178 184 PF00244 0.435
LIG_14-3-3_CanoR_1 202 209 PF00244 0.464
LIG_14-3-3_CanoR_1 485 490 PF00244 0.536
LIG_14-3-3_CanoR_1 524 531 PF00244 0.659
LIG_14-3-3_CanoR_1 551 560 PF00244 0.515
LIG_Actin_WH2_2 65 83 PF00022 0.506
LIG_AP2alpha_2 346 348 PF02296 0.607
LIG_BRCT_BRCA1_1 295 299 PF00533 0.441
LIG_FHA_1 236 242 PF00498 0.405
LIG_FHA_1 299 305 PF00498 0.529
LIG_FHA_1 368 374 PF00498 0.527
LIG_FHA_1 376 382 PF00498 0.460
LIG_FHA_1 484 490 PF00498 0.452
LIG_FHA_1 653 659 PF00498 0.409
LIG_FHA_2 118 124 PF00498 0.545
LIG_FHA_2 292 298 PF00498 0.446
LIG_FHA_2 458 464 PF00498 0.554
LIG_FHA_2 700 706 PF00498 0.621
LIG_IRF3_LxIS_1 190 197 PF10401 0.432
LIG_LIR_Apic_2 186 190 PF02991 0.435
LIG_LIR_Apic_2 359 365 PF02991 0.543
LIG_LIR_Gen_1 282 292 PF02991 0.462
LIG_LIR_Gen_1 398 407 PF02991 0.494
LIG_LIR_Gen_1 443 454 PF02991 0.544
LIG_LIR_Gen_1 501 510 PF02991 0.480
LIG_LIR_Gen_1 522 533 PF02991 0.686
LIG_LIR_Nem_3 282 287 PF02991 0.474
LIG_LIR_Nem_3 346 351 PF02991 0.656
LIG_LIR_Nem_3 398 404 PF02991 0.491
LIG_LIR_Nem_3 443 449 PF02991 0.542
LIG_LIR_Nem_3 501 506 PF02991 0.487
LIG_LIR_Nem_3 522 528 PF02991 0.686
LIG_NRBOX 247 253 PF00104 0.447
LIG_NRBOX 653 659 PF00104 0.443
LIG_PCNA_yPIPBox_3 167 181 PF02747 0.462
LIG_PCNA_yPIPBox_3 350 362 PF02747 0.599
LIG_PCNA_yPIPBox_3 91 102 PF02747 0.452
LIG_Pex14_2 741 745 PF04695 0.613
LIG_RPA_C_Fungi 548 560 PF08784 0.566
LIG_SH2_GRB2like 464 467 PF00017 0.479
LIG_SH2_GRB2like 502 505 PF00017 0.544
LIG_SH2_NCK_1 382 386 PF00017 0.388
LIG_SH2_PTP2 446 449 PF00017 0.479
LIG_SH2_SRC 446 449 PF00017 0.535
LIG_SH2_STAP1 679 683 PF00017 0.561
LIG_SH2_STAT3 558 561 PF00017 0.563
LIG_SH2_STAT3 694 697 PF00017 0.570
LIG_SH2_STAT5 310 313 PF00017 0.395
LIG_SH2_STAT5 382 385 PF00017 0.386
LIG_SH2_STAT5 446 449 PF00017 0.474
LIG_SH2_STAT5 464 467 PF00017 0.435
LIG_SH2_STAT5 502 505 PF00017 0.546
LIG_SH2_STAT5 605 608 PF00017 0.576
LIG_SH2_STAT5 713 716 PF00017 0.587
LIG_SUMO_SIM_anti_2 282 289 PF11976 0.467
LIG_SUMO_SIM_anti_2 49 56 PF11976 0.462
LIG_SUMO_SIM_par_1 192 198 PF11976 0.456
LIG_SUMO_SIM_par_1 469 477 PF11976 0.499
LIG_TRAF2_1 223 226 PF00917 0.529
LIG_UBA3_1 372 379 PF00899 0.494
MOD_CK1_1 13 19 PF00069 0.543
MOD_CK1_1 198 204 PF00069 0.450
MOD_CK1_1 239 245 PF00069 0.372
MOD_CK1_1 364 370 PF00069 0.538
MOD_CK1_1 402 408 PF00069 0.481
MOD_CK1_1 517 523 PF00069 0.711
MOD_CK1_1 526 532 PF00069 0.557
MOD_CK2_1 457 463 PF00069 0.562
MOD_CK2_1 564 570 PF00069 0.498
MOD_CK2_1 699 705 PF00069 0.618
MOD_GlcNHglycan 197 200 PF01048 0.359
MOD_GlcNHglycan 238 241 PF01048 0.417
MOD_GlcNHglycan 288 291 PF01048 0.421
MOD_GlcNHglycan 440 443 PF01048 0.496
MOD_GlcNHglycan 521 524 PF01048 0.657
MOD_GlcNHglycan 542 545 PF01048 0.542
MOD_GlcNHglycan 645 648 PF01048 0.556
MOD_GlcNHglycan 77 80 PF01048 0.480
MOD_GSK3_1 194 201 PF00069 0.410
MOD_GSK3_1 235 242 PF00069 0.461
MOD_GSK3_1 310 317 PF00069 0.407
MOD_GSK3_1 361 368 PF00069 0.580
MOD_GSK3_1 412 419 PF00069 0.479
MOD_GSK3_1 481 488 PF00069 0.460
MOD_GSK3_1 509 516 PF00069 0.651
MOD_GSK3_1 519 526 PF00069 0.733
MOD_N-GLC_1 117 122 PF02516 0.543
MOD_N-GLC_1 159 164 PF02516 0.423
MOD_N-GLC_1 173 178 PF02516 0.350
MOD_N-GLC_1 457 462 PF02516 0.564
MOD_NEK2_1 194 199 PF00069 0.409
MOD_NEK2_1 234 239 PF00069 0.460
MOD_NEK2_1 407 412 PF00069 0.470
MOD_NEK2_1 440 445 PF00069 0.490
MOD_NEK2_1 491 496 PF00069 0.525
MOD_NEK2_1 518 523 PF00069 0.660
MOD_NEK2_1 741 746 PF00069 0.629
MOD_NEK2_1 80 85 PF00069 0.461
MOD_NEK2_2 173 178 PF00069 0.448
MOD_NEK2_2 300 305 PF00069 0.398
MOD_PIKK_1 57 63 PF00454 0.355
MOD_PIKK_1 598 604 PF00454 0.582
MOD_PIKK_1 80 86 PF00454 0.450
MOD_PK_1 553 559 PF00069 0.536
MOD_PKA_1 167 173 PF00069 0.477
MOD_PKA_2 11 17 PF00069 0.506
MOD_PKA_2 491 497 PF00069 0.567
MOD_PKA_2 523 529 PF00069 0.685
MOD_PKA_2 552 558 PF00069 0.466
MOD_PKA_2 80 86 PF00069 0.468
MOD_PKB_1 551 559 PF00069 0.537
MOD_Plk_1 159 165 PF00069 0.424
MOD_Plk_1 173 179 PF00069 0.354
MOD_Plk_1 474 480 PF00069 0.540
MOD_Plk_1 526 532 PF00069 0.687
MOD_Plk_1 638 644 PF00069 0.546
MOD_Plk_1 652 658 PF00069 0.312
MOD_Plk_1 741 747 PF00069 0.543
MOD_Plk_1 86 92 PF00069 0.436
MOD_Plk_2-3 476 482 PF00069 0.549
MOD_Plk_4 167 173 PF00069 0.479
MOD_Plk_4 300 306 PF00069 0.405
MOD_Plk_4 368 374 PF00069 0.456
MOD_Plk_4 498 504 PF00069 0.559
MOD_Plk_4 553 559 PF00069 0.468
MOD_Plk_4 638 644 PF00069 0.486
MOD_Plk_4 93 99 PF00069 0.491
MOD_ProDKin_1 361 367 PF00069 0.559
MOD_ProDKin_1 383 389 PF00069 0.508
MOD_ProDKin_1 41 47 PF00069 0.487
MOD_SUMO_for_1 596 599 PF00179 0.557
MOD_SUMO_rev_2 20 30 PF00179 0.472
MOD_SUMO_rev_2 570 578 PF00179 0.588
MOD_SUMO_rev_2 667 673 PF00179 0.580
TRG_DiLeu_BaEn_1 49 54 PF01217 0.454
TRG_DiLeu_BaEn_1 65 70 PF01217 0.336
TRG_DiLeu_BaEn_1 653 658 PF01217 0.416
TRG_DiLeu_BaEn_1 759 764 PF01217 0.482
TRG_DiLeu_BaEn_2 229 235 PF01217 0.496
TRG_DiLeu_BaEn_4 766 772 PF01217 0.619
TRG_DiLeu_BaLyEn_6 149 154 PF01217 0.455
TRG_DiLeu_LyEn_5 653 658 PF01217 0.517
TRG_DiLeu_LyEn_5 759 764 PF01217 0.619
TRG_ENDOCYTIC_2 292 295 PF00928 0.378
TRG_ENDOCYTIC_2 446 449 PF00928 0.538
TRG_ENDOCYTIC_2 525 528 PF00928 0.685
TRG_ENDOCYTIC_2 633 636 PF00928 0.431
TRG_ER_diArg_1 150 152 PF00400 0.458
TRG_ER_diArg_1 73 75 PF00400 0.499
TRG_ER_diArg_1 745 748 PF00400 0.699
TRG_ER_diArg_1 768 770 PF00400 0.622
TRG_ER_diArg_1 99 102 PF00400 0.512
TRG_NES_CRM1_1 49 62 PF08389 0.467
TRG_NLS_MonoExtC_3 661 667 PF00514 0.558
TRG_NLS_MonoExtN_4 743 750 PF00514 0.549
TRG_Pf-PMV_PEXEL_1 607 612 PF00026 0.517
TRG_Pf-PMV_PEXEL_1 762 766 PF00026 0.625
TRG_Pf-PMV_PEXEL_1 769 774 PF00026 0.651

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IGW0 Leptomonas seymouri 76% 100%
A0A0S4IU09 Bodo saltans 23% 95%
A0A1X0NTC2 Trypanosomatidae 34% 100%
A0A3Q8IDU4 Leishmania donovani 100% 100%
A0A422NFC9 Trypanosoma rangeli 33% 100%
A4H8U7 Leishmania braziliensis 93% 100%
C9ZTS8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9ARC2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4QEJ8 Leishmania major 98% 100%
V5D8P7 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS