Putative U1 small nuclear ribonucleoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U1 small nuclear ribonucleoprotein - putative

Species:

Leishmania infantum

UniProt:

A4HX57_LEIIN

TriTrypDb:

LINF_160022000

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	9
GO:1990904	ribonucleoprotein complex	2	9
GO:0005634	nucleus	5	1
GO:0005681	spliceosomal complex	3	1
GO:0005685	U1 snRNP	5	1
GO:0005689	U12-type spliceosomal complex	4	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HX57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX57

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045292	mRNA cis splicing, via spliceosome	9	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003729	mRNA binding	5	1
GO:0017069	snRNA binding	5	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0044877	protein-containing complex binding	2	1
GO:0070990	snRNP binding	4	1
GO:1990446	U1 snRNP binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.470
CLV_NRD_NRD_1	139	141	PF00675	0.642
CLV_NRD_NRD_1	21	23	PF00675	0.435
CLV_NRD_NRD_1	213	215	PF00675	0.464
CLV_NRD_NRD_1	269	271	PF00675	0.244
CLV_NRD_NRD_1	282	284	PF00675	0.290
CLV_NRD_NRD_1	289	291	PF00675	0.269
CLV_PCSK_FUR_1	290	294	PF00082	0.312
CLV_PCSK_KEX2_1	106	108	PF00082	0.433
CLV_PCSK_KEX2_1	121	123	PF00082	0.479
CLV_PCSK_KEX2_1	139	141	PF00082	0.626
CLV_PCSK_KEX2_1	21	23	PF00082	0.435
CLV_PCSK_KEX2_1	213	215	PF00082	0.494
CLV_PCSK_KEX2_1	269	271	PF00082	0.269
CLV_PCSK_KEX2_1	292	294	PF00082	0.312
CLV_PCSK_KEX2_1	315	317	PF00082	0.413
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.466
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.479
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.312
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.413
CLV_PCSK_PC7_1	102	108	PF00082	0.447
CLV_PCSK_PC7_1	17	23	PF00082	0.431
CLV_PCSK_SKI1_1	122	126	PF00082	0.496
CLV_PCSK_SKI1_1	171	175	PF00082	0.739
CLV_PCSK_SKI1_1	270	274	PF00082	0.312
CLV_PCSK_SKI1_1	292	296	PF00082	0.396
CLV_PCSK_SKI1_1	315	319	PF00082	0.399
CLV_PCSK_SKI1_1	7	11	PF00082	0.523
DEG_Nend_UBRbox_1	1	4	PF02207	0.432
DOC_CKS1_1	31	36	PF01111	0.419
DOC_CKS1_1	323	328	PF01111	0.491
DOC_CYCLIN_RxL_1	312	322	PF00134	0.405
DOC_MAPK_gen_1	267	276	PF00069	0.506
DOC_MAPK_gen_1	290	301	PF00069	0.463
DOC_MAPK_gen_1	39	48	PF00069	0.512
DOC_MAPK_MEF2A_6	41	50	PF00069	0.525
DOC_PP1_RVXF_1	282	289	PF00149	0.512
DOC_PP4_FxxP_1	323	326	PF00568	0.478
DOC_USP7_MATH_1	178	182	PF00917	0.591
DOC_USP7_MATH_1	319	323	PF00917	0.429
DOC_USP7_UBL2_3	291	295	PF12436	0.487
DOC_WW_Pin1_4	12	17	PF00397	0.530
DOC_WW_Pin1_4	179	184	PF00397	0.618
DOC_WW_Pin1_4	30	35	PF00397	0.443
DOC_WW_Pin1_4	322	327	PF00397	0.579
DOC_WW_Pin1_4	48	53	PF00397	0.427
DOC_WW_Pin1_4	64	69	PF00397	0.465
LIG_14-3-3_CanoR_1	214	222	PF00244	0.541
LIG_14-3-3_CanoR_1	245	254	PF00244	0.463
LIG_14-3-3_CanoR_1	69	77	PF00244	0.467
LIG_14-3-3_CanoR_1	7	16	PF00244	0.439
LIG_AP2alpha_1	247	251	PF02296	0.512
LIG_BRCT_BRCA1_1	247	251	PF00533	0.395
LIG_CSL_BTD_1	323	326	PF09270	0.478
LIG_EH_1	214	218	PF12763	0.507
LIG_FHA_1	13	19	PF00498	0.437
LIG_FHA_1	345	351	PF00498	0.749
LIG_FHA_1	72	78	PF00498	0.456
LIG_FHA_2	237	243	PF00498	0.446
LIG_FHA_2	333	339	PF00498	0.700
LIG_LIR_Apic_2	321	327	PF02991	0.519
LIG_LIR_Gen_1	149	159	PF02991	0.351
LIG_LIR_Gen_1	268	279	PF02991	0.512
LIG_LIR_Nem_3	149	154	PF02991	0.504
LIG_LIR_Nem_3	248	254	PF02991	0.446
LIG_LIR_Nem_3	268	274	PF02991	0.429
LIG_LIR_Nem_3	275	279	PF02991	0.445
LIG_Pex14_1	120	124	PF04695	0.474
LIG_Pex14_2	247	251	PF04695	0.445
LIG_REV1ctd_RIR_1	122	128	PF16727	0.496
LIG_SH2_CRK	297	301	PF00017	0.416
LIG_SH2_PTP2	88	91	PF00017	0.317
LIG_SH2_SRC	88	91	PF00017	0.317
LIG_SH2_STAP1	297	301	PF00017	0.416
LIG_SH2_STAT5	88	91	PF00017	0.468
LIG_SH2_STAT5	92	95	PF00017	0.434
LIG_SH3_1	356	362	PF00018	0.603
LIG_SH3_3	126	132	PF00018	0.484
LIG_SH3_3	172	178	PF00018	0.637
LIG_SH3_3	28	34	PF00018	0.412
LIG_SH3_3	356	362	PF00018	0.627
LIG_SH3_3	39	45	PF00018	0.428
LIG_SH3_3	46	52	PF00018	0.424
LIG_TRAF2_1	198	201	PF00917	0.504
LIG_TRAF2_1	239	242	PF00917	0.445
MOD_CDK_SPK_2	12	17	PF00069	0.440
MOD_CDK_SPK_2	64	69	PF00069	0.474
MOD_CDK_SPxK_1	30	36	PF00069	0.418
MOD_CK1_1	12	18	PF00069	0.440
MOD_CK1_1	181	187	PF00069	0.687
MOD_CK1_1	322	328	PF00069	0.534
MOD_CK1_1	333	339	PF00069	0.531
MOD_CK2_1	195	201	PF00069	0.556
MOD_CK2_1	236	242	PF00069	0.312
MOD_CK2_1	332	338	PF00069	0.760
MOD_CK2_1	357	363	PF00069	0.577
MOD_GlcNHglycan	187	190	PF01048	0.765
MOD_GlcNHglycan	332	335	PF01048	0.643
MOD_GSK3_1	142	149	PF00069	0.612
MOD_GSK3_1	179	186	PF00069	0.623
MOD_GSK3_1	189	196	PF00069	0.554
MOD_GSK3_1	26	33	PF00069	0.537
MOD_GSK3_1	318	325	PF00069	0.555
MOD_GSK3_1	330	337	PF00069	0.604
MOD_GSK3_1	67	74	PF00069	0.589
MOD_GSK3_1	8	15	PF00069	0.437
MOD_NEK2_1	185	190	PF00069	0.615
MOD_NEK2_1	318	323	PF00069	0.423
MOD_NEK2_2	120	125	PF00069	0.504
MOD_OFUCOSY	23	30	PF10250	0.412
MOD_PK_1	253	259	PF00069	0.286
MOD_PK_1	295	301	PF00069	0.421
MOD_PKA_2	57	63	PF00069	0.459
MOD_Plk_1	98	104	PF00069	0.526
MOD_Plk_4	295	301	PF00069	0.421
MOD_Plk_4	319	325	PF00069	0.524
MOD_ProDKin_1	12	18	PF00069	0.529
MOD_ProDKin_1	179	185	PF00069	0.621
MOD_ProDKin_1	30	36	PF00069	0.445
MOD_ProDKin_1	322	328	PF00069	0.586
MOD_ProDKin_1	48	54	PF00069	0.424
MOD_ProDKin_1	64	70	PF00069	0.466
MOD_SUMO_for_1	173	176	PF00179	0.514
MOD_SUMO_rev_2	166	175	PF00179	0.592
TRG_DiLeu_BaEn_4	98	104	PF01217	0.508
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.397
TRG_ENDOCYTIC_2	151	154	PF00928	0.503
TRG_ENDOCYTIC_2	271	274	PF00928	0.279
TRG_ENDOCYTIC_2	297	300	PF00928	0.425
TRG_ENDOCYTIC_2	88	91	PF00928	0.468
TRG_ER_diArg_1	105	108	PF00400	0.499
TRG_ER_diArg_1	20	22	PF00400	0.433
TRG_ER_diArg_1	269	271	PF00400	0.280
TRG_ER_diArg_1	39	42	PF00400	0.436
TRG_NLS_MonoCore_2	289	294	PF00514	0.372
TRG_NLS_MonoExtC_3	290	295	PF00514	0.372
TRG_NLS_MonoExtN_4	102	109	PF00514	0.593
TRG_NLS_MonoExtN_4	290	296	PF00514	0.372
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T1	Leptomonas seymouri	60%	100%
A0A0S4J1P9	Bodo saltans	29%	100%
A0A1X0NYS6	Trypanosomatidae	37%	100%
A0A3Q8IAQ7	Leishmania donovani	99%	100%
A4H8T7	Leishmania braziliensis	80%	100%
E9AQX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QEK6	Leishmania major	91%	100%