DNA polymerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA polymerase

Gene product:

DNA polymerase I alpha catalytic subunit - putative

Species:

Leishmania infantum

UniProt:

A4HX52_LEIIN

TriTrypDb:

LINF_160021500

Length:

1340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0000428	DNA-directed RNA polymerase complex	4	1
GO:0005658	alpha DNA polymerase:primase complex	4	1
GO:0030880	RNA polymerase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0042575	DNA polymerase complex	3	1
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HX52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX52

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006270	DNA replication initiation	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0022402	cell cycle process	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1902292	cell cycle DNA replication initiation	3	12
GO:1902315	nuclear cell cycle DNA replication initiation	4	12
GO:1902975	mitotic DNA replication initiation	4	12
GO:1903047	mitotic cell cycle process	3	12
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0006272	leading strand elongation	7	1
GO:0006273	lagging strand elongation	7	1
GO:0022616	DNA strand elongation	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003887	DNA-directed DNA polymerase activity	5	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0034061	DNA polymerase activity	4	12
GO:0036094	small molecule binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003682	chromatin binding	2	1
GO:0003688	DNA replication origin binding	7	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1
GO:0017076	purine nucleotide binding	4	1
GO:0019103	pyrimidine nucleotide binding	4	1
GO:0043565	sequence-specific DNA binding	5	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.754
CLV_C14_Caspase3-7	439	443	PF00656	0.371
CLV_C14_Caspase3-7	814	818	PF00656	0.380
CLV_NRD_NRD_1	1061	1063	PF00675	0.304
CLV_NRD_NRD_1	1162	1164	PF00675	0.375
CLV_NRD_NRD_1	1216	1218	PF00675	0.544
CLV_NRD_NRD_1	1285	1287	PF00675	0.478
CLV_NRD_NRD_1	1292	1294	PF00675	0.471
CLV_NRD_NRD_1	13	15	PF00675	0.744
CLV_NRD_NRD_1	159	161	PF00675	0.473
CLV_NRD_NRD_1	321	323	PF00675	0.327
CLV_NRD_NRD_1	382	384	PF00675	0.424
CLV_NRD_NRD_1	504	506	PF00675	0.389
CLV_NRD_NRD_1	543	545	PF00675	0.420
CLV_NRD_NRD_1	66	68	PF00675	0.695
CLV_NRD_NRD_1	727	729	PF00675	0.305
CLV_NRD_NRD_1	819	821	PF00675	0.304
CLV_NRD_NRD_1	980	982	PF00675	0.301
CLV_PCSK_KEX2_1	1285	1287	PF00082	0.492
CLV_PCSK_KEX2_1	1292	1294	PF00082	0.491
CLV_PCSK_KEX2_1	1324	1326	PF00082	0.432
CLV_PCSK_KEX2_1	159	161	PF00082	0.686
CLV_PCSK_KEX2_1	321	323	PF00082	0.320
CLV_PCSK_KEX2_1	382	384	PF00082	0.362
CLV_PCSK_KEX2_1	504	506	PF00082	0.345
CLV_PCSK_KEX2_1	543	545	PF00082	0.417
CLV_PCSK_KEX2_1	562	564	PF00082	0.147
CLV_PCSK_KEX2_1	669	671	PF00082	0.331
CLV_PCSK_KEX2_1	715	717	PF00082	0.337
CLV_PCSK_KEX2_1	727	729	PF00082	0.305
CLV_PCSK_KEX2_1	819	821	PF00082	0.304
CLV_PCSK_KEX2_1	823	825	PF00082	0.304
CLV_PCSK_KEX2_1	930	932	PF00082	0.424
CLV_PCSK_KEX2_1	98	100	PF00082	0.684
CLV_PCSK_KEX2_1	980	982	PF00082	0.308
CLV_PCSK_PC1ET2_1	1324	1326	PF00082	0.501
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.686
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.362
CLV_PCSK_PC1ET2_1	562	564	PF00082	0.361
CLV_PCSK_PC1ET2_1	669	671	PF00082	0.331
CLV_PCSK_PC1ET2_1	715	717	PF00082	0.337
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.320
CLV_PCSK_PC1ET2_1	823	825	PF00082	0.304
CLV_PCSK_PC1ET2_1	930	932	PF00082	0.424
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.684
CLV_PCSK_PC7_1	558	564	PF00082	0.320
CLV_PCSK_PC7_1	819	825	PF00082	0.304
CLV_PCSK_SKI1_1	1036	1040	PF00082	0.320
CLV_PCSK_SKI1_1	1183	1187	PF00082	0.494
CLV_PCSK_SKI1_1	1261	1265	PF00082	0.370
CLV_PCSK_SKI1_1	290	294	PF00082	0.366
CLV_PCSK_SKI1_1	321	325	PF00082	0.361
CLV_PCSK_SKI1_1	363	367	PF00082	0.373
CLV_PCSK_SKI1_1	383	387	PF00082	0.228
CLV_PCSK_SKI1_1	510	514	PF00082	0.320
CLV_PCSK_SKI1_1	61	65	PF00082	0.663
CLV_PCSK_SKI1_1	669	673	PF00082	0.348
CLV_PCSK_SKI1_1	681	685	PF00082	0.320
CLV_PCSK_SKI1_1	703	707	PF00082	0.304
CLV_PCSK_SKI1_1	728	732	PF00082	0.392
CLV_PCSK_SKI1_1	805	809	PF00082	0.304
CLV_PCSK_SKI1_1	810	814	PF00082	0.304
CLV_PCSK_SKI1_1	820	824	PF00082	0.304
CLV_PCSK_SKI1_1	843	847	PF00082	0.320
CLV_PCSK_SKI1_1	877	881	PF00082	0.304
CLV_PCSK_SKI1_1	944	948	PF00082	0.304
CLV_PCSK_SKI1_1	95	99	PF00082	0.638
CLV_PCSK_SKI1_1	971	975	PF00082	0.314
CLV_Separin_Metazoa	1064	1068	PF03568	0.424
DEG_APCC_DBOX_1	1061	1069	PF00400	0.424
DEG_APCC_DBOX_1	362	370	PF00400	0.373
DEG_APCC_DBOX_1	509	517	PF00400	0.309
DEG_APCC_DBOX_1	557	565	PF00400	0.424
DOC_CKS1_1	1184	1189	PF01111	0.500
DOC_CKS1_1	483	488	PF01111	0.412
DOC_CKS1_1	629	634	PF01111	0.549
DOC_CKS1_1	704	709	PF01111	0.304
DOC_CYCLIN_RxL_1	1258	1265	PF00134	0.366
DOC_CYCLIN_RxL_1	840	851	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	1184	1190	PF00134	0.464
DOC_MAPK_gen_1	1060	1068	PF00069	0.304
DOC_MAPK_gen_1	1203	1212	PF00069	0.551
DOC_MAPK_gen_1	1324	1331	PF00069	0.443
DOC_MAPK_gen_1	159	168	PF00069	0.427
DOC_MAPK_gen_1	382	393	PF00069	0.338
DOC_MAPK_gen_1	543	550	PF00069	0.424
DOC_MAPK_gen_1	687	696	PF00069	0.304
DOC_MAPK_gen_1	727	738	PF00069	0.305
DOC_MAPK_gen_1	819	828	PF00069	0.408
DOC_MAPK_gen_1	915	924	PF00069	0.377
DOC_MAPK_gen_1	927	937	PF00069	0.329
DOC_MAPK_gen_1	950	959	PF00069	0.304
DOC_MAPK_gen_1	98	108	PF00069	0.686
DOC_MAPK_MEF2A_6	1205	1214	PF00069	0.551
DOC_MAPK_MEF2A_6	1324	1333	PF00069	0.435
DOC_MAPK_MEF2A_6	639	648	PF00069	0.430
DOC_MAPK_MEF2A_6	915	924	PF00069	0.387
DOC_MAPK_MEF2A_6	930	939	PF00069	0.207
DOC_MAPK_RevD_3	937	953	PF00069	0.304
DOC_PP1_RVXF_1	319	326	PF00149	0.320
DOC_PP2B_LxvP_1	425	428	PF13499	0.424
DOC_PP2B_LxvP_1	51	54	PF13499	0.667
DOC_PP2B_LxvP_1	798	801	PF13499	0.392
DOC_PP4_FxxP_1	1264	1267	PF00568	0.384
DOC_PP4_FxxP_1	226	229	PF00568	0.586
DOC_PP4_FxxP_1	293	296	PF00568	0.320
DOC_PP4_FxxP_1	332	335	PF00568	0.304
DOC_PP4_FxxP_1	704	707	PF00568	0.304
DOC_USP7_MATH_1	1001	1005	PF00917	0.424
DOC_USP7_MATH_1	151	155	PF00917	0.681
DOC_USP7_MATH_1	232	236	PF00917	0.677
DOC_USP7_MATH_1	298	302	PF00917	0.373
DOC_USP7_MATH_1	371	375	PF00917	0.304
DOC_USP7_MATH_1	481	485	PF00917	0.419
DOC_USP7_MATH_1	625	629	PF00917	0.556
DOC_USP7_MATH_1	657	661	PF00917	0.456
DOC_USP7_MATH_1	879	883	PF00917	0.424
DOC_USP7_UBL2_3	1036	1040	PF12436	0.304
DOC_USP7_UBL2_3	157	161	PF12436	0.477
DOC_USP7_UBL2_3	382	386	PF12436	0.389
DOC_USP7_UBL2_3	60	64	PF12436	0.691
DOC_USP7_UBL2_3	727	731	PF12436	0.305
DOC_USP7_UBL2_3	74	78	PF12436	0.721
DOC_USP7_UBL2_3	823	827	PF12436	0.304
DOC_USP7_UBL2_3	911	915	PF12436	0.389
DOC_USP7_UBL2_3	967	971	PF12436	0.310
DOC_WW_Pin1_4	1183	1188	PF00397	0.510
DOC_WW_Pin1_4	203	208	PF00397	0.725
DOC_WW_Pin1_4	225	230	PF00397	0.639
DOC_WW_Pin1_4	411	416	PF00397	0.282
DOC_WW_Pin1_4	482	487	PF00397	0.322
DOC_WW_Pin1_4	628	633	PF00397	0.555
DOC_WW_Pin1_4	703	708	PF00397	0.304
DOC_WW_Pin1_4	73	78	PF00397	0.782
LIG_14-3-3_CanoR_1	1026	1030	PF00244	0.373
LIG_14-3-3_CanoR_1	1046	1051	PF00244	0.273
LIG_14-3-3_CanoR_1	1081	1089	PF00244	0.420
LIG_14-3-3_CanoR_1	1093	1100	PF00244	0.252
LIG_14-3-3_CanoR_1	1217	1221	PF00244	0.537
LIG_14-3-3_CanoR_1	1254	1260	PF00244	0.364
LIG_14-3-3_CanoR_1	1292	1298	PF00244	0.491
LIG_14-3-3_CanoR_1	275	279	PF00244	0.508
LIG_14-3-3_CanoR_1	402	410	PF00244	0.296
LIG_14-3-3_CanoR_1	479	484	PF00244	0.387
LIG_14-3-3_CanoR_1	603	608	PF00244	0.507
LIG_14-3-3_CanoR_1	670	678	PF00244	0.328
LIG_14-3-3_CanoR_1	931	936	PF00244	0.320
LIG_Actin_WH2_2	378	394	PF00022	0.424
LIG_Actin_WH2_2	688	705	PF00022	0.304
LIG_Actin_WH2_2	831	848	PF00022	0.304
LIG_Actin_WH2_2	880	897	PF00022	0.338
LIG_APCC_ABBA_1	118	123	PF00400	0.601
LIG_APCC_ABBA_1	455	460	PF00400	0.338
LIG_APCC_ABBAyCdc20_2	741	747	PF00400	0.304
LIG_BIR_II_1	1	5	PF00653	0.718
LIG_BRCT_BRCA1_1	1156	1160	PF00533	0.545
LIG_BRCT_BRCA1_1	619	623	PF00533	0.522
LIG_CaM_NSCaTE_8	679	686	PF13499	0.338
LIG_Clathr_ClatBox_1	175	179	PF01394	0.632
LIG_Clathr_ClatBox_1	825	829	PF01394	0.237
LIG_CtBP_PxDLS_1	975	981	PF00389	0.304
LIG_eIF4E_1	745	751	PF01652	0.304
LIG_EVH1_1	425	429	PF00568	0.424
LIG_FHA_1	1052	1058	PF00498	0.389
LIG_FHA_1	212	218	PF00498	0.452
LIG_FHA_1	237	243	PF00498	0.494
LIG_FHA_1	252	258	PF00498	0.385
LIG_FHA_1	274	280	PF00498	0.499
LIG_FHA_1	535	541	PF00498	0.316
LIG_FHA_1	625	631	PF00498	0.517
LIG_FHA_1	654	660	PF00498	0.394
LIG_FHA_1	666	672	PF00498	0.252
LIG_FHA_1	881	887	PF00498	0.318
LIG_FHA_1	899	905	PF00498	0.227
LIG_FHA_2	1148	1154	PF00498	0.595
LIG_FHA_2	1294	1300	PF00498	0.488
LIG_FHA_2	134	140	PF00498	0.598
LIG_FHA_2	22	28	PF00498	0.573
LIG_FHA_2	437	443	PF00498	0.371
LIG_FHA_2	696	702	PF00498	0.424
LIG_FHA_2	768	774	PF00498	0.320
LIG_FHA_2	956	962	PF00498	0.389
LIG_Integrin_isoDGR_2	273	275	PF01839	0.610
LIG_IRF3_LxIS_1	388	394	PF10401	0.451
LIG_LIR_Apic_2	291	296	PF02991	0.365
LIG_LIR_Apic_2	701	707	PF02991	0.389
LIG_LIR_Gen_1	1102	1113	PF02991	0.373
LIG_LIR_Gen_1	1327	1338	PF02991	0.477
LIG_LIR_Gen_1	342	350	PF02991	0.389
LIG_LIR_Gen_1	389	398	PF02991	0.328
LIG_LIR_Gen_1	551	561	PF02991	0.426
LIG_LIR_Gen_1	640	648	PF02991	0.424
LIG_LIR_Gen_1	692	699	PF02991	0.304
LIG_LIR_Gen_1	746	754	PF02991	0.304
LIG_LIR_Gen_1	859	868	PF02991	0.351
LIG_LIR_Nem_3	1102	1108	PF02991	0.327
LIG_LIR_Nem_3	1206	1211	PF02991	0.407
LIG_LIR_Nem_3	1232	1237	PF02991	0.489
LIG_LIR_Nem_3	1255	1260	PF02991	0.374
LIG_LIR_Nem_3	1320	1326	PF02991	0.424
LIG_LIR_Nem_3	1327	1333	PF02991	0.449
LIG_LIR_Nem_3	1334	1340	PF02991	0.493
LIG_LIR_Nem_3	240	246	PF02991	0.424
LIG_LIR_Nem_3	26	32	PF02991	0.565
LIG_LIR_Nem_3	327	332	PF02991	0.309
LIG_LIR_Nem_3	342	347	PF02991	0.320
LIG_LIR_Nem_3	389	393	PF02991	0.368
LIG_LIR_Nem_3	551	556	PF02991	0.418
LIG_LIR_Nem_3	595	600	PF02991	0.351
LIG_LIR_Nem_3	640	645	PF02991	0.405
LIG_LIR_Nem_3	692	696	PF02991	0.304
LIG_LIR_Nem_3	698	702	PF02991	0.304
LIG_LIR_Nem_3	746	751	PF02991	0.320
LIG_LIR_Nem_3	753	757	PF02991	0.329
LIG_LIR_Nem_3	851	856	PF02991	0.304
LIG_LIR_Nem_3	859	863	PF02991	0.304
LIG_LIR_Nem_3	940	946	PF02991	0.404
LIG_LIR_Nem_3	982	986	PF02991	0.295
LIG_LYPXL_S_1	1110	1114	PF13949	0.304
LIG_LYPXL_S_1	757	761	PF13949	0.304
LIG_LYPXL_yS_3	1111	1114	PF13949	0.304
LIG_LYPXL_yS_3	353	356	PF13949	0.451
LIG_LYPXL_yS_3	758	761	PF13949	0.304
LIG_MYND_1	888	892	PF01753	0.424
LIG_NRBOX	537	543	PF00104	0.389
LIG_Pex14_2	765	769	PF04695	0.424
LIG_SH2_CRK	1234	1238	PF00017	0.499
LIG_SH2_CRK	1260	1264	PF00017	0.478
LIG_SH2_CRK	289	293	PF00017	0.424
LIG_SH2_CRK	597	601	PF00017	0.361
LIG_SH2_CRK	602	606	PF00017	0.314
LIG_SH2_CRK	642	646	PF00017	0.436
LIG_SH2_CRK	853	857	PF00017	0.304
LIG_SH2_CRK	954	958	PF00017	0.304
LIG_SH2_NCK_1	1295	1299	PF00017	0.493
LIG_SH2_PTP2	1211	1214	PF00017	0.484
LIG_SH2_PTP2	748	751	PF00017	0.320
LIG_SH2_STAP1	330	334	PF00017	0.373
LIG_SH2_STAP1	642	646	PF00017	0.456
LIG_SH2_STAP1	745	749	PF00017	0.304
LIG_SH2_STAT5	1010	1013	PF00017	0.338
LIG_SH2_STAT5	1027	1030	PF00017	0.248
LIG_SH2_STAT5	1074	1077	PF00017	0.304
LIG_SH2_STAT5	1105	1108	PF00017	0.290
LIG_SH2_STAT5	1211	1214	PF00017	0.449
LIG_SH2_STAT5	1224	1227	PF00017	0.327
LIG_SH2_STAT5	1295	1298	PF00017	0.438
LIG_SH2_STAT5	278	281	PF00017	0.473
LIG_SH2_STAT5	469	472	PF00017	0.429
LIG_SH2_STAT5	494	497	PF00017	0.328
LIG_SH2_STAT5	693	696	PF00017	0.304
LIG_SH2_STAT5	710	713	PF00017	0.304
LIG_SH2_STAT5	748	751	PF00017	0.306
LIG_SH3_2	1270	1275	PF14604	0.594
LIG_SH3_2	229	234	PF14604	0.591
LIG_SH3_3	1184	1190	PF00018	0.392
LIG_SH3_3	1264	1270	PF00018	0.423
LIG_SH3_3	13	19	PF00018	0.733
LIG_SH3_3	1305	1311	PF00018	0.504
LIG_SH3_3	183	189	PF00018	0.757
LIG_SH3_3	226	232	PF00018	0.653
LIG_SH3_3	332	338	PF00018	0.336
LIG_SH3_3	409	415	PF00018	0.279
LIG_SH3_3	423	429	PF00018	0.304
LIG_SH3_3	51	57	PF00018	0.751
LIG_SH3_3	626	632	PF00018	0.555
LIG_SH3_3	734	740	PF00018	0.304
LIG_SH3_3	779	785	PF00018	0.327
LIG_SH3_4	74	81	PF00018	0.798
LIG_SUMO_SIM_anti_2	164	170	PF11976	0.470
LIG_SUMO_SIM_anti_2	537	542	PF11976	0.340
LIG_SUMO_SIM_anti_2	660	666	PF11976	0.465
LIG_SUMO_SIM_anti_2	746	753	PF11976	0.320
LIG_SUMO_SIM_anti_2	882	888	PF11976	0.323
LIG_SUMO_SIM_par_1	167	174	PF11976	0.577
LIG_SUMO_SIM_par_1	253	258	PF11976	0.559
LIG_SUMO_SIM_par_1	487	493	PF11976	0.389
LIG_SUMO_SIM_par_1	603	609	PF11976	0.405
LIG_SUMO_SIM_par_1	746	753	PF11976	0.304
LIG_TRAF2_1	1199	1202	PF00917	0.453
LIG_TRAF2_1	1304	1307	PF00917	0.534
LIG_TRAF2_1	300	303	PF00917	0.315
LIG_TYR_ITIM	600	605	PF00017	0.424
LIG_TYR_ITIM	691	696	PF00017	0.304
LIG_TYR_ITSM	1230	1237	PF00017	0.493
LIG_TYR_ITSM	1319	1326	PF00017	0.518
LIG_UBA3_1	264	272	PF00899	0.431
LIG_UBA3_1	375	382	PF00899	0.320
LIG_UBA3_1	825	830	PF00899	0.412
LIG_UBA3_1	837	843	PF00899	0.373
LIG_UBA3_1	946	953	PF00899	0.307
LIG_Vh1_VBS_1	634	652	PF01044	0.435
LIG_WRC_WIRS_1	696	701	PF05994	0.389
MOD_CDK_SPK_2	203	208	PF00069	0.730
MOD_CDK_SPK_2	411	416	PF00069	0.320
MOD_CDK_SPK_2	73	78	PF00069	0.719
MOD_CDK_SPxK_1	703	709	PF00069	0.304
MOD_CDK_SPxxK_3	73	80	PF00069	0.719
MOD_CK1_1	1155	1161	PF00069	0.504
MOD_CK1_1	277	283	PF00069	0.394
MOD_CK1_1	411	417	PF00069	0.419
MOD_CK1_1	482	488	PF00069	0.387
MOD_CK1_1	493	499	PF00069	0.338
MOD_CK1_1	549	555	PF00069	0.423
MOD_CK1_1	628	634	PF00069	0.509
MOD_CK1_1	993	999	PF00069	0.391
MOD_CK2_1	1293	1299	PF00069	0.524
MOD_CK2_1	133	139	PF00069	0.629
MOD_CK2_1	28	34	PF00069	0.597
MOD_CK2_1	297	303	PF00069	0.355
MOD_CK2_1	371	377	PF00069	0.316
MOD_CK2_1	773	779	PF00069	0.305
MOD_CK2_1	815	821	PF00069	0.302
MOD_Cter_Amidation	725	728	PF01082	0.389
MOD_GlcNHglycan	1	4	PF01048	0.670
MOD_GlcNHglycan	1245	1248	PF01048	0.474
MOD_GlcNHglycan	161	164	PF01048	0.552
MOD_GlcNHglycan	181	185	PF01048	0.744
MOD_GlcNHglycan	234	237	PF01048	0.518
MOD_GlcNHglycan	393	396	PF01048	0.435
MOD_GlcNHglycan	398	401	PF01048	0.412
MOD_GlcNHglycan	47	50	PF01048	0.721
MOD_GlcNHglycan	495	498	PF01048	0.334
MOD_GlcNHglycan	57	60	PF01048	0.647
MOD_GlcNHglycan	635	638	PF01048	0.482
MOD_GlcNHglycan	70	73	PF01048	0.626
MOD_GlcNHglycan	775	778	PF01048	0.377
MOD_GlcNHglycan	798	801	PF01048	0.426
MOD_GSK3_1	1032	1039	PF00069	0.312
MOD_GSK3_1	1155	1162	PF00069	0.524
MOD_GSK3_1	1212	1219	PF00069	0.431
MOD_GSK3_1	232	239	PF00069	0.632
MOD_GSK3_1	273	280	PF00069	0.558
MOD_GSK3_1	436	443	PF00069	0.445
MOD_GSK3_1	45	52	PF00069	0.725
MOD_GSK3_1	548	555	PF00069	0.451
MOD_GSK3_1	586	593	PF00069	0.360
MOD_GSK3_1	6	13	PF00069	0.743
MOD_GSK3_1	624	631	PF00069	0.546
MOD_GSK3_1	653	660	PF00069	0.405
MOD_GSK3_1	665	672	PF00069	0.264
MOD_GSK3_1	753	760	PF00069	0.374
MOD_GSK3_1	80	87	PF00069	0.653
MOD_GSK3_1	811	818	PF00069	0.352
MOD_N-GLC_1	164	169	PF02516	0.636
MOD_N-GLC_2	766	768	PF02516	0.293
MOD_NEK2_1	1032	1037	PF00069	0.314
MOD_NEK2_1	1154	1159	PF00069	0.633
MOD_NEK2_1	1229	1234	PF00069	0.415
MOD_NEK2_1	213	218	PF00069	0.606
MOD_NEK2_1	288	293	PF00069	0.397
MOD_NEK2_1	369	374	PF00069	0.338
MOD_NEK2_1	391	396	PF00069	0.435
MOD_NEK2_1	451	456	PF00069	0.424
MOD_NEK2_1	548	553	PF00069	0.451
MOD_NEK2_1	567	572	PF00069	0.137
MOD_NEK2_1	695	700	PF00069	0.366
MOD_NEK2_1	815	820	PF00069	0.284
MOD_NEK2_1	84	89	PF00069	0.623
MOD_NEK2_1	845	850	PF00069	0.304
MOD_NEK2_1	858	863	PF00069	0.304
MOD_NEK2_1	905	910	PF00069	0.304
MOD_NEK2_2	1318	1323	PF00069	0.403
MOD_NEK2_2	679	684	PF00069	0.320
MOD_OFUCOSY	1228	1233	PF10250	0.505
MOD_PIKK_1	1093	1099	PF00454	0.340
MOD_PIKK_1	1227	1233	PF00454	0.382
MOD_PIKK_1	1252	1258	PF00454	0.458
MOD_PIKK_1	21	27	PF00454	0.728
MOD_PIKK_1	298	304	PF00454	0.373
MOD_PIKK_1	339	345	PF00454	0.373
MOD_PIKK_1	436	442	PF00454	0.316
MOD_PKA_1	159	165	PF00069	0.582
MOD_PKA_1	669	675	PF00069	0.346
MOD_PKA_2	10	16	PF00069	0.778
MOD_PKA_2	1025	1031	PF00069	0.373
MOD_PKA_2	1080	1086	PF00069	0.409
MOD_PKA_2	1216	1222	PF00069	0.541
MOD_PKA_2	159	165	PF00069	0.582
MOD_PKA_2	274	280	PF00069	0.533
MOD_PKA_2	391	397	PF00069	0.389
MOD_PKA_2	401	407	PF00069	0.241
MOD_PKA_2	665	671	PF00069	0.360
MOD_PKA_2	773	779	PF00069	0.237
MOD_Plk_1	112	118	PF00069	0.641
MOD_Plk_1	131	137	PF00069	0.708
MOD_Plk_1	164	170	PF00069	0.652
MOD_Plk_1	339	345	PF00069	0.389
MOD_Plk_1	408	414	PF00069	0.424
MOD_Plk_1	463	469	PF00069	0.433
MOD_Plk_1	49	55	PF00069	0.734
MOD_Plk_1	546	552	PF00069	0.395
MOD_Plk_1	858	864	PF00069	0.320
MOD_Plk_2-3	1147	1153	PF00069	0.629
MOD_Plk_2-3	775	781	PF00069	0.424
MOD_Plk_4	1155	1161	PF00069	0.520
MOD_Plk_4	1318	1324	PF00069	0.408
MOD_Plk_4	1332	1338	PF00069	0.495
MOD_Plk_4	164	170	PF00069	0.657
MOD_Plk_4	258	264	PF00069	0.381
MOD_Plk_4	274	280	PF00069	0.402
MOD_Plk_4	371	377	PF00069	0.361
MOD_Plk_4	386	392	PF00069	0.232
MOD_Plk_4	625	631	PF00069	0.431
MOD_Plk_4	753	759	PF00069	0.304
MOD_Plk_4	811	817	PF00069	0.386
MOD_Plk_4	848	854	PF00069	0.304
MOD_Plk_4	900	906	PF00069	0.304
MOD_Plk_4	990	996	PF00069	0.419
MOD_ProDKin_1	1183	1189	PF00069	0.508
MOD_ProDKin_1	203	209	PF00069	0.722
MOD_ProDKin_1	225	231	PF00069	0.635
MOD_ProDKin_1	411	417	PF00069	0.282
MOD_ProDKin_1	482	488	PF00069	0.322
MOD_ProDKin_1	628	634	PF00069	0.550
MOD_ProDKin_1	703	709	PF00069	0.304
MOD_ProDKin_1	73	79	PF00069	0.781
MOD_SUMO_for_1	1141	1144	PF00179	0.639
MOD_SUMO_for_1	171	174	PF00179	0.611
MOD_SUMO_for_1	826	829	PF00179	0.304
MOD_SUMO_rev_2	421	426	PF00179	0.384
MOD_SUMO_rev_2	554	564	PF00179	0.361
MOD_SUMO_rev_2	817	825	PF00179	0.304
MOD_SUMO_rev_2	919	926	PF00179	0.370
MOD_SUMO_rev_2	961	968	PF00179	0.323
TRG_DiLeu_BaEn_1	821	826	PF01217	0.338
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.451
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.690
TRG_ENDOCYTIC_2	1105	1108	PF00928	0.328
TRG_ENDOCYTIC_2	1111	1114	PF00928	0.281
TRG_ENDOCYTIC_2	1211	1214	PF00928	0.398
TRG_ENDOCYTIC_2	1234	1237	PF00928	0.498
TRG_ENDOCYTIC_2	1260	1263	PF00928	0.481
TRG_ENDOCYTIC_2	1323	1326	PF00928	0.405
TRG_ENDOCYTIC_2	289	292	PF00928	0.424
TRG_ENDOCYTIC_2	329	332	PF00928	0.320
TRG_ENDOCYTIC_2	353	356	PF00928	0.338
TRG_ENDOCYTIC_2	458	461	PF00928	0.320
TRG_ENDOCYTIC_2	545	548	PF00928	0.338
TRG_ENDOCYTIC_2	597	600	PF00928	0.361
TRG_ENDOCYTIC_2	602	605	PF00928	0.314
TRG_ENDOCYTIC_2	642	645	PF00928	0.440
TRG_ENDOCYTIC_2	693	696	PF00928	0.304
TRG_ENDOCYTIC_2	748	751	PF00928	0.304
TRG_ENDOCYTIC_2	758	761	PF00928	0.304
TRG_ENDOCYTIC_2	853	856	PF00928	0.304
TRG_ENDOCYTIC_2	860	863	PF00928	0.304
TRG_ENDOCYTIC_2	932	935	PF00928	0.304
TRG_ENDOCYTIC_2	954	957	PF00928	0.304
TRG_ER_diArg_1	1292	1294	PF00400	0.550
TRG_ER_diArg_1	187	190	PF00400	0.785
TRG_ER_diArg_1	283	286	PF00400	0.424
TRG_ER_diArg_1	321	323	PF00400	0.320
TRG_ER_diArg_1	503	505	PF00400	0.389
TRG_ER_diArg_1	542	544	PF00400	0.420
TRG_ER_diArg_1	979	981	PF00400	0.302
TRG_NES_CRM1_1	1320	1334	PF08389	0.547
TRG_NES_CRM1_1	82	94	PF08389	0.734
TRG_NES_CRM1_1	913	923	PF08389	0.424
TRG_NLS_Bipartite_1	715	732	PF00514	0.343
TRG_NLS_MonoCore_2	949	954	PF00514	0.304
TRG_NLS_MonoExtC_3	381	386	PF00514	0.389
TRG_NLS_MonoExtC_3	63	68	PF00514	0.682
TRG_NLS_MonoExtC_3	726	731	PF00514	0.320
TRG_NLS_MonoExtC_3	97	103	PF00514	0.716
TRG_NLS_MonoExtN_4	382	387	PF00514	0.385
TRG_NLS_MonoExtN_4	61	68	PF00514	0.688
TRG_NLS_MonoExtN_4	727	732	PF00514	0.320
TRG_NLS_MonoExtN_4	95	102	PF00514	0.683
TRG_NLS_MonoExtN_4	950	955	PF00514	0.304
TRG_Pf-PMV_PEXEL_1	1163	1167	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	1261	1265	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	1286	1291	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	639	643	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	918	923	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	997	1002	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I597	Leptomonas seymouri	81%	100%
A0A0S4IUC6	Bodo saltans	45%	95%
A0A1X0P042	Trypanosomatidae	60%	99%
A0A3R7MDF7	Trypanosoma rangeli	57%	100%
A0A3S5H6Z2	Leishmania donovani	100%	100%
A0A3S7X6W2	Leishmania donovani	25%	100%
A4H8T3	Leishmania braziliensis	89%	100%
A4HLN0	Leishmania braziliensis	26%	100%
A4I965	Leishmania infantum	25%	100%
C9ZVT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AQW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B406	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
O00874	Leishmania donovani	100%	100%
O48653	Oryza sativa subsp. japonica	37%	87%
O89042	Rattus norvegicus	37%	92%
P09884	Homo sapiens	37%	92%
P13382	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	91%
P26019	Drosophila melanogaster	34%	90%
P27727	Trypanosoma brucei brucei	57%	100%
P28040	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	95%
P30315	Plasmodium falciparum (isolate K1 / Thailand)	25%	100%
P30316	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P33609	Mus musculus	37%	91%
Q27152	Oxytricha trifallax	34%	89%
Q4Q418	Leishmania major	25%	100%
Q4QEL1	Leishmania major	96%	100%
Q54SV8	Dictyostelium discoideum	32%	89%
Q94636	Sterkiella nova	35%	90%
Q9DE46	Xenopus laevis	38%	92%
Q9FHA3	Arabidopsis thaliana	37%	88%
V5B2M9	Trypanosoma cruzi	59%	100%