LeishMANIAdb
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Putative endoplasmic reticulum oxidoreductin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative endoplasmic reticulum oxidoreductin
Gene product:
endoplasmic reticulum oxidoreductin - putative
Species:
Leishmania infantum
UniProt:
A4HX51_LEIIN
TriTrypDb:
LINF_160021400
Length:
443

Annotations

Annotations by Jardim et al.

Oxidoreductase, endoplasmic reticulum oxidoreductin

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 8, no: 4
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 13
GO:0016020 membrane 2 13
GO:0031090 organelle membrane 3 13
GO:0110165 cellular anatomical entity 1 13

Expansion

Sequence features

A4HX51
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX51

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 13
GO:0009987 cellular process 1 13
GO:0034975 protein folding in endoplasmic reticulum 3 13
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0005488 binding 1 13
GO:0015035 protein-disulfide reductase activity 3 13
GO:0015036 disulfide oxidoreductase activity 4 13
GO:0016491 oxidoreductase activity 2 13
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 13
GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 4 13
GO:0016972 thiol oxidase activity 5 13
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0050660 flavin adenine dinucleotide binding 4 13
GO:0071949 FAD binding 5 13
GO:0097159 organic cyclic compound binding 2 13
GO:0140096 catalytic activity, acting on a protein 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13
GO:0003756 protein disulfide isomerase activity 3 1
GO:0016853 isomerase activity 2 1
GO:0016860 intramolecular oxidoreductase activity 3 1
GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 200 204 PF00656 0.233
CLV_PCSK_KEX2_1 263 265 PF00082 0.336
CLV_PCSK_PC1ET2_1 263 265 PF00082 0.425
CLV_PCSK_SKI1_1 144 148 PF00082 0.369
CLV_PCSK_SKI1_1 213 217 PF00082 0.403
CLV_PCSK_SKI1_1 290 294 PF00082 0.344
CLV_PCSK_SKI1_1 320 324 PF00082 0.345
CLV_PCSK_SKI1_1 45 49 PF00082 0.539
CLV_PCSK_SKI1_1 70 74 PF00082 0.481
CLV_PCSK_SKI1_1 86 90 PF00082 0.327
DEG_APCC_DBOX_1 212 220 PF00400 0.425
DEG_Nend_UBRbox_4 1 3 PF02207 0.554
DEG_ODPH_VHL_1 265 277 PF01847 0.369
DEG_SCF_FBW7_1 135 141 PF00400 0.447
DOC_CKS1_1 135 140 PF01111 0.425
DOC_CYCLIN_RxL_1 210 217 PF00134 0.431
DOC_CYCLIN_RxL_1 408 416 PF00134 0.367
DOC_CYCLIN_yClb5_NLxxxL_5 404 413 PF00134 0.345
DOC_MAPK_DCC_7 144 152 PF00069 0.369
DOC_MAPK_HePTP_8 8 20 PF00069 0.507
DOC_MAPK_MEF2A_6 11 20 PF00069 0.455
DOC_MAPK_MEF2A_6 3 10 PF00069 0.447
DOC_MAPK_MEF2A_6 30 39 PF00069 0.599
DOC_PP1_RVXF_1 409 416 PF00149 0.425
DOC_PP1_SILK_1 209 214 PF00149 0.447
DOC_USP7_MATH_1 138 142 PF00917 0.447
DOC_USP7_MATH_1 41 45 PF00917 0.614
DOC_USP7_MATH_1 439 443 PF00917 0.524
DOC_USP7_UBL2_3 375 379 PF12436 0.425
DOC_WW_Pin1_4 134 139 PF00397 0.402
DOC_WW_Pin1_4 236 241 PF00397 0.311
DOC_WW_Pin1_4 25 30 PF00397 0.471
DOC_WW_Pin1_4 327 332 PF00397 0.338
DOC_WW_Pin1_4 58 63 PF00397 0.548
DOC_WW_Pin1_4 79 84 PF00397 0.376
LIG_14-3-3_CanoR_1 395 399 PF00244 0.449
LIG_14-3-3_CanoR_1 78 82 PF00244 0.447
LIG_APCC_ABBA_1 265 270 PF00400 0.410
LIG_BRCT_BRCA1_1 288 292 PF00533 0.452
LIG_BRCT_BRCA1_1 329 333 PF00533 0.303
LIG_BRCT_BRCA1_1 81 85 PF00533 0.347
LIG_deltaCOP1_diTrp_1 153 158 PF00928 0.345
LIG_eIF4E_1 98 104 PF01652 0.327
LIG_FHA_1 109 115 PF00498 0.425
LIG_FHA_1 292 298 PF00498 0.402
LIG_FHA_1 376 382 PF00498 0.327
LIG_FHA_1 48 54 PF00498 0.528
LIG_FHA_1 67 73 PF00498 0.215
LIG_FHA_2 104 110 PF00498 0.350
LIG_FHA_2 203 209 PF00498 0.369
LIG_FHA_2 307 313 PF00498 0.327
LIG_FHA_2 330 336 PF00498 0.311
LIG_FHA_2 49 55 PF00498 0.537
LIG_LIR_Apic_2 178 183 PF02991 0.325
LIG_LIR_Apic_2 229 235 PF02991 0.425
LIG_LIR_Gen_1 166 174 PF02991 0.304
LIG_LIR_Nem_3 166 170 PF02991 0.304
LIG_LIR_Nem_3 82 88 PF02991 0.315
LIG_MLH1_MIPbox_1 81 85 PF16413 0.393
LIG_NRBOX 211 217 PF00104 0.393
LIG_Pex14_1 189 193 PF04695 0.298
LIG_SH2_CRK 180 184 PF00017 0.327
LIG_SH2_CRK 247 251 PF00017 0.441
LIG_SH2_NCK_1 247 251 PF00017 0.447
LIG_SH2_PTP2 167 170 PF00017 0.311
LIG_SH2_STAT5 167 170 PF00017 0.306
LIG_SH2_STAT5 276 279 PF00017 0.350
LIG_SH2_STAT5 57 60 PF00017 0.524
LIG_SH2_STAT5 84 87 PF00017 0.371
LIG_SH3_3 143 149 PF00018 0.447
LIG_SUMO_SIM_anti_2 15 21 PF11976 0.498
LIG_SUMO_SIM_anti_2 208 214 PF11976 0.425
LIG_SUMO_SIM_anti_2 401 408 PF11976 0.302
LIG_SUMO_SIM_anti_2 71 77 PF11976 0.395
LIG_SxIP_EBH_1 343 354 PF03271 0.447
LIG_TRAF2_1 205 208 PF00917 0.435
MOD_CDC14_SPxK_1 239 242 PF00782 0.333
MOD_CDK_SPK_2 25 30 PF00069 0.457
MOD_CDK_SPxK_1 236 242 PF00069 0.333
MOD_CDK_SPxxK_3 79 86 PF00069 0.376
MOD_CK1_1 291 297 PF00069 0.440
MOD_CK1_1 425 431 PF00069 0.544
MOD_CK2_1 103 109 PF00069 0.350
MOD_CK2_1 118 124 PF00069 0.165
MOD_CK2_1 169 175 PF00069 0.431
MOD_CK2_1 202 208 PF00069 0.406
MOD_CK2_1 329 335 PF00069 0.313
MOD_CK2_1 58 64 PF00069 0.476
MOD_CMANNOS 155 158 PF00535 0.345
MOD_GlcNHglycan 106 109 PF01048 0.227
MOD_GlcNHglycan 180 183 PF01048 0.327
MOD_GlcNHglycan 216 219 PF01048 0.298
MOD_GlcNHglycan 91 94 PF01048 0.418
MOD_GSK3_1 130 137 PF00069 0.330
MOD_GSK3_1 138 145 PF00069 0.415
MOD_GSK3_1 207 214 PF00069 0.360
MOD_GSK3_1 25 32 PF00069 0.599
MOD_GSK3_1 291 298 PF00069 0.373
MOD_GSK3_1 394 401 PF00069 0.449
MOD_GSK3_1 99 106 PF00069 0.353
MOD_N-GLC_1 250 255 PF02516 0.317
MOD_N-GLC_1 356 361 PF02516 0.298
MOD_N-GLC_1 48 53 PF02516 0.451
MOD_N-GLC_2 110 112 PF02516 0.345
MOD_NEK2_1 103 108 PF00069 0.393
MOD_NEK2_1 219 224 PF00069 0.298
MOD_NEK2_1 286 291 PF00069 0.327
MOD_NEK2_1 322 327 PF00069 0.317
MOD_NEK2_1 356 361 PF00069 0.425
MOD_NEK2_1 413 418 PF00069 0.339
MOD_NEK2_1 48 53 PF00069 0.512
MOD_NEK2_2 250 255 PF00069 0.425
MOD_NEK2_2 279 284 PF00069 0.455
MOD_OFUCOSY 105 112 PF10250 0.330
MOD_PK_1 422 428 PF00069 0.301
MOD_PKA_2 394 400 PF00069 0.437
MOD_PKA_2 77 83 PF00069 0.444
MOD_Plk_1 118 124 PF00069 0.444
MOD_Plk_1 207 213 PF00069 0.446
MOD_Plk_1 250 256 PF00069 0.318
MOD_Plk_1 295 301 PF00069 0.366
MOD_Plk_1 306 312 PF00069 0.302
MOD_Plk_1 356 362 PF00069 0.301
MOD_Plk_1 6 12 PF00069 0.532
MOD_Plk_2-3 118 124 PF00069 0.463
MOD_Plk_2-3 394 400 PF00069 0.447
MOD_Plk_4 12 18 PF00069 0.509
MOD_Plk_4 142 148 PF00069 0.455
MOD_Plk_4 207 213 PF00069 0.405
MOD_Plk_4 227 233 PF00069 0.423
MOD_Plk_4 295 301 PF00069 0.372
MOD_Plk_4 402 408 PF00069 0.345
MOD_Plk_4 68 74 PF00069 0.433
MOD_Plk_4 99 105 PF00069 0.415
MOD_ProDKin_1 134 140 PF00069 0.402
MOD_ProDKin_1 236 242 PF00069 0.311
MOD_ProDKin_1 25 31 PF00069 0.476
MOD_ProDKin_1 327 333 PF00069 0.338
MOD_ProDKin_1 58 64 PF00069 0.544
MOD_ProDKin_1 79 85 PF00069 0.376
TRG_DiLeu_BaEn_1 402 407 PF01217 0.298
TRG_DiLeu_BaLyEn_6 323 328 PF01217 0.393
TRG_ENDOCYTIC_2 167 170 PF00928 0.311
TRG_ENDOCYTIC_2 87 90 PF00928 0.338
TRG_ENDOCYTIC_2 98 101 PF00928 0.270
TRG_ER_diArg_1 42 45 PF00400 0.521
TRG_ER_diArg_1 438 441 PF00400 0.678
TRG_Pf-PMV_PEXEL_1 345 350 PF00026 0.367

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYQ4 Leptomonas seymouri 75% 100%
A0A0S4JAH9 Bodo saltans 34% 92%
A0A0S4JHX0 Bodo saltans 39% 89%
A0A1X0P0B6 Trypanosomatidae 51% 99%
A0A3S7WU69 Leishmania donovani 100% 100%
A0A422NE38 Trypanosoma rangeli 52% 97%
A4H8T2 Leishmania braziliensis 86% 100%
A5PJN2 Bos taurus 31% 95%
B1H1F9 Xenopus tropicalis 29% 93%
B6CVD7 Sus scrofa 32% 95%
C9ZVU0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9AQW6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O74401 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 95%
Q03103 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 79%
Q4QEL2 Leishmania major 95% 100%
Q6DD71 Xenopus laevis 29% 95%
Q75BB5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 28% 81%
Q7SEY9 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 25% 66%
Q7T3D1 Danio rerio 29% 91%
Q7X9I4 Arabidopsis thaliana 31% 94%
Q7YTU4 Caenorhabditis elegans 28% 93%
Q86YB8 Homo sapiens 29% 95%
Q8NIP5 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 27% 79%
Q8R180 Mus musculus 31% 95%
Q8R2E9 Mus musculus 29% 95%
Q8R4A1 Rattus norvegicus 31% 95%
Q96HE7 Homo sapiens 31% 95%
Q9C7S7 Arabidopsis thaliana 33% 94%
Q9V3A6 Drosophila melanogaster 27% 92%
Q9Y7P1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 78%
V5BI75 Trypanosoma cruzi 51% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS