Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HX49_LEIIN

TriTrypDb:

LINF_160021200

Length:

113

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HX49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.679
CLV_NRD_NRD_1	24	26	PF00675	0.472
CLV_NRD_NRD_1	61	63	PF00675	0.591
CLV_PCSK_KEX2_1	24	26	PF00082	0.472
CLV_PCSK_KEX2_1	61	63	PF00082	0.616
CLV_PCSK_KEX2_1	74	76	PF00082	0.319
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.460
CLV_PCSK_SKI1_1	27	31	PF00082	0.421
CLV_PCSK_SKI1_1	47	51	PF00082	0.431
DOC_MAPK_gen_1	53	60	PF00069	0.522
DOC_MAPK_gen_1	74	80	PF00069	0.423
DOC_MAPK_MEF2A_6	103	112	PF00069	0.683
DOC_PP4_MxPP_1	66	69	PF00568	0.516
DOC_WW_Pin1_4	104	109	PF00397	0.626
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_CaM_IQ_9	89	105	PF13499	0.669
LIG_FHA_1	3	9	PF00498	0.654
LIG_FHA_2	8	14	PF00498	0.614
LIG_LIR_Apic_2	64	68	PF02991	0.604
LIG_Pex14_2	81	85	PF04695	0.431
LIG_SH2_CRK	65	69	PF00017	0.587
LIG_SH2_GRB2like	36	39	PF00017	0.537
LIG_SH2_STAT5	36	39	PF00017	0.468
LIG_TRAF2_1	10	13	PF00917	0.569
LIG_UBA3_1	49	55	PF00899	0.463
MOD_CK1_1	2	8	PF00069	0.641
MOD_CK1_1	91	97	PF00069	0.605
MOD_CK2_1	45	51	PF00069	0.425
MOD_CK2_1	7	13	PF00069	0.558
MOD_GSK3_1	104	111	PF00069	0.629
MOD_NEK2_1	85	90	PF00069	0.503
MOD_NEK2_1	98	103	PF00069	0.557
MOD_NEK2_2	108	113	PF00069	0.621
MOD_PIKK_1	2	8	PF00454	0.690
MOD_PIKK_1	29	35	PF00454	0.548
MOD_PIKK_1	67	73	PF00454	0.479
MOD_PIKK_1	91	97	PF00454	0.609
MOD_Plk_4	45	51	PF00069	0.452
MOD_ProDKin_1	104	110	PF00069	0.630
TRG_ER_diArg_1	16	19	PF00400	0.627
TRG_ER_diArg_1	60	62	PF00400	0.597
TRG_NLS_MonoExtN_4	24	29	PF00514	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Y0	Leptomonas seymouri	88%	98%
A0A0S4IH66	Bodo saltans	60%	84%
A0A0S4IPB4	Bodo saltans	69%	84%
A0A1X0NYT5	Trypanosomatidae	75%	99%
A0A3S7WU56	Leishmania donovani	100%	100%
A0A422N416	Trypanosoma rangeli	75%	99%
A4H8T0	Leishmania braziliensis	91%	100%
C9ZVU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	99%
E9AQW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QEL4	Leishmania major	99%	100%