RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HX48_LEIIN

TriTrypDb:

LINF_160021100

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HX48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HX48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	416	420	PF00656	0.564
CLV_NRD_NRD_1	139	141	PF00675	0.425
CLV_NRD_NRD_1	147	149	PF00675	0.405
CLV_NRD_NRD_1	216	218	PF00675	0.560
CLV_NRD_NRD_1	267	269	PF00675	0.483
CLV_NRD_NRD_1	3	5	PF00675	0.555
CLV_NRD_NRD_1	475	477	PF00675	0.524
CLV_NRD_NRD_1	48	50	PF00675	0.443
CLV_NRD_NRD_1	556	558	PF00675	0.533
CLV_NRD_NRD_1	567	569	PF00675	0.524
CLV_PCSK_KEX2_1	11	13	PF00082	0.524
CLV_PCSK_KEX2_1	139	141	PF00082	0.516
CLV_PCSK_KEX2_1	147	149	PF00082	0.461
CLV_PCSK_KEX2_1	216	218	PF00082	0.557
CLV_PCSK_KEX2_1	267	269	PF00082	0.483
CLV_PCSK_KEX2_1	3	5	PF00082	0.513
CLV_PCSK_KEX2_1	31	33	PF00082	0.367
CLV_PCSK_KEX2_1	475	477	PF00082	0.524
CLV_PCSK_KEX2_1	48	50	PF00082	0.427
CLV_PCSK_KEX2_1	556	558	PF00082	0.533
CLV_PCSK_KEX2_1	567	569	PF00082	0.524
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.570
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.367
CLV_PCSK_SKI1_1	186	190	PF00082	0.507
CLV_PCSK_SKI1_1	267	271	PF00082	0.443
CLV_PCSK_SKI1_1	309	313	PF00082	0.405
CLV_PCSK_SKI1_1	461	465	PF00082	0.609
CLV_PCSK_SKI1_1	475	479	PF00082	0.473
CLV_PCSK_SKI1_1	545	549	PF00082	0.567
CLV_PCSK_SKI1_1	66	70	PF00082	0.496
CLV_PCSK_SKI1_1	74	78	PF00082	0.487
DEG_APCC_DBOX_1	326	334	PF00400	0.293
DEG_APCC_DBOX_1	474	482	PF00400	0.505
DEG_Nend_Nbox_1	1	3	PF02207	0.486
DOC_CKS1_1	346	351	PF01111	0.600
DOC_CYCLIN_RxL_1	61	72	PF00134	0.558
DOC_MAPK_gen_1	147	153	PF00069	0.514
DOC_MAPK_gen_1	3	9	PF00069	0.514
DOC_MAPK_gen_1	84	94	PF00069	0.539
DOC_MAPK_MEF2A_6	293	302	PF00069	0.518
DOC_MAPK_MEF2A_6	87	95	PF00069	0.531
DOC_PP2B_LxvP_1	343	346	PF13499	0.492
DOC_USP7_MATH_1	396	400	PF00917	0.597
DOC_WW_Pin1_4	10	15	PF00397	0.552
DOC_WW_Pin1_4	173	178	PF00397	0.443
DOC_WW_Pin1_4	193	198	PF00397	0.429
DOC_WW_Pin1_4	315	320	PF00397	0.418
DOC_WW_Pin1_4	345	350	PF00397	0.663
DOC_WW_Pin1_4	374	379	PF00397	0.721
LIG_14-3-3_CanoR_1	170	178	PF00244	0.543
LIG_14-3-3_CanoR_1	20	25	PF00244	0.454
LIG_14-3-3_CanoR_1	249	255	PF00244	0.449
LIG_14-3-3_CanoR_1	283	289	PF00244	0.398
LIG_14-3-3_CanoR_1	293	299	PF00244	0.441
LIG_14-3-3_CanoR_1	3	8	PF00244	0.614
LIG_14-3-3_CanoR_1	556	566	PF00244	0.573
LIG_Actin_WH2_2	236	251	PF00022	0.447
LIG_APCC_ABBA_1	326	331	PF00400	0.404
LIG_APCC_ABBA_1	434	439	PF00400	0.519
LIG_BRCT_BRCA1_1	313	317	PF00533	0.517
LIG_DLG_GKlike_1	20	27	PF00625	0.635
LIG_FHA_1	187	193	PF00498	0.568
LIG_FHA_1	204	210	PF00498	0.412
LIG_FHA_1	283	289	PF00498	0.467
LIG_FHA_1	346	352	PF00498	0.742
LIG_FHA_1	360	366	PF00498	0.622
LIG_FHA_1	462	468	PF00498	0.480
LIG_FHA_1	489	495	PF00498	0.466
LIG_FHA_1	524	530	PF00498	0.563
LIG_FHA_1	558	564	PF00498	0.571
LIG_FHA_1	75	81	PF00498	0.523
LIG_FHA_2	159	165	PF00498	0.453
LIG_FHA_2	174	180	PF00498	0.388
LIG_FHA_2	23	29	PF00498	0.519
LIG_FHA_2	316	322	PF00498	0.396
LIG_GBD_Chelix_1	298	306	PF00786	0.531
LIG_LIR_Gen_1	115	125	PF02991	0.498
LIG_LIR_Gen_1	205	214	PF02991	0.499
LIG_LIR_Gen_1	355	365	PF02991	0.523
LIG_LIR_Gen_1	422	431	PF02991	0.513
LIG_LIR_Nem_3	115	120	PF02991	0.489
LIG_LIR_Nem_3	143	149	PF02991	0.434
LIG_LIR_Nem_3	205	210	PF02991	0.487
LIG_LIR_Nem_3	355	361	PF02991	0.526
LIG_LIR_Nem_3	422	427	PF02991	0.541
LIG_LIR_Nem_3	72	76	PF02991	0.406
LIG_LYPXL_SIV_4	423	431	PF13949	0.568
LIG_NRBOX	493	499	PF00104	0.440
LIG_PCNA_PIPBox_1	430	439	PF02747	0.488
LIG_PCNA_yPIPBox_3	215	228	PF02747	0.463
LIG_Pex14_2	100	104	PF04695	0.402
LIG_SH2_CRK	146	150	PF00017	0.495
LIG_SH2_SRC	329	332	PF00017	0.474
LIG_SH2_SRC	437	440	PF00017	0.448
LIG_SH2_STAT5	16	19	PF00017	0.560
LIG_SH2_STAT5	329	332	PF00017	0.412
LIG_SH2_STAT5	34	37	PF00017	0.530
LIG_SH2_STAT5	424	427	PF00017	0.466
LIG_SH2_STAT5	437	440	PF00017	0.398
LIG_SH2_STAT5	75	78	PF00017	0.517
LIG_SH3_3	152	158	PF00018	0.539
LIG_SH3_3	218	224	PF00018	0.554
LIG_SH3_3	343	349	PF00018	0.638
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.440
LIG_SUMO_SIM_anti_2	240	246	PF11976	0.386
LIG_SUMO_SIM_anti_2	429	435	PF11976	0.529
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.473
LIG_SUMO_SIM_par_1	490	496	PF11976	0.470
LIG_TRAF2_1	161	164	PF00917	0.466
LIG_TRAF2_1	520	523	PF00917	0.412
LIG_UBA3_1	485	490	PF00899	0.562
MOD_CK1_1	10	16	PF00069	0.553
MOD_CK1_1	22	28	PF00069	0.487
MOD_CK1_1	337	343	PF00069	0.523
MOD_CK1_1	368	374	PF00069	0.734
MOD_CK1_1	379	385	PF00069	0.626
MOD_CK1_1	399	405	PF00069	0.489
MOD_CK1_1	426	432	PF00069	0.466
MOD_CK2_1	158	164	PF00069	0.399
MOD_CK2_1	173	179	PF00069	0.405
MOD_CK2_1	20	26	PF00069	0.531
MOD_CK2_1	315	321	PF00069	0.404
MOD_CK2_1	426	432	PF00069	0.515
MOD_CK2_1	490	496	PF00069	0.466
MOD_CK2_1	52	58	PF00069	0.573
MOD_GlcNHglycan	289	292	PF01048	0.466
MOD_GlcNHglycan	336	339	PF01048	0.440
MOD_GlcNHglycan	370	373	PF01048	0.719
MOD_GlcNHglycan	410	413	PF01048	0.425
MOD_GlcNHglycan	419	422	PF01048	0.456
MOD_GlcNHglycan	508	511	PF01048	0.558
MOD_GlcNHglycan	535	538	PF01048	0.525
MOD_GSK3_1	277	284	PF00069	0.371
MOD_GSK3_1	3	10	PF00069	0.657
MOD_GSK3_1	311	318	PF00069	0.461
MOD_GSK3_1	370	377	PF00069	0.717
MOD_GSK3_1	419	426	PF00069	0.541
MOD_LATS_1	554	560	PF00433	0.550
MOD_NEK2_1	180	185	PF00069	0.455
MOD_NEK2_1	2	7	PF00069	0.503
MOD_NEK2_1	27	32	PF00069	0.555
MOD_NEK2_1	287	292	PF00069	0.446
MOD_NEK2_1	365	370	PF00069	0.721
MOD_NEK2_1	417	422	PF00069	0.531
MOD_NEK2_1	480	485	PF00069	0.389
MOD_PIKK_1	186	192	PF00454	0.516
MOD_PIKK_1	426	432	PF00454	0.479
MOD_PKA_1	3	9	PF00069	0.514
MOD_PKA_1	556	562	PF00069	0.583
MOD_PKA_2	19	25	PF00069	0.480
MOD_PKA_2	2	8	PF00069	0.552
MOD_PKA_2	282	288	PF00069	0.392
MOD_PKA_2	292	298	PF00069	0.422
MOD_PKA_2	556	562	PF00069	0.560
MOD_PKB_1	543	551	PF00069	0.591
MOD_Plk_2-3	159	165	PF00069	0.533
MOD_Plk_4	180	186	PF00069	0.404
MOD_Plk_4	3	9	PF00069	0.591
MOD_Plk_4	354	360	PF00069	0.744
MOD_Plk_4	370	376	PF00069	0.666
MOD_ProDKin_1	10	16	PF00069	0.553
MOD_ProDKin_1	173	179	PF00069	0.448
MOD_ProDKin_1	193	199	PF00069	0.426
MOD_ProDKin_1	315	321	PF00069	0.410
MOD_ProDKin_1	345	351	PF00069	0.667
MOD_ProDKin_1	374	380	PF00069	0.722
TRG_DiLeu_BaEn_1	124	129	PF01217	0.512
TRG_DiLeu_BaEn_1	496	501	PF01217	0.429
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.470
TRG_ENDOCYTIC_2	146	149	PF00928	0.432
TRG_ENDOCYTIC_2	424	427	PF00928	0.507
TRG_ENDOCYTIC_2	73	76	PF00928	0.398
TRG_ER_diArg_1	138	140	PF00400	0.503
TRG_ER_diArg_1	146	148	PF00400	0.464
TRG_ER_diArg_1	2	4	PF00400	0.521
TRG_ER_diArg_1	216	219	PF00400	0.541
TRG_ER_diArg_1	267	269	PF00400	0.483
TRG_ER_diArg_1	387	390	PF00400	0.655
TRG_ER_diArg_1	48	50	PF00400	0.427
TRG_ER_diArg_1	556	558	PF00400	0.501
TRG_ER_diArg_1	566	568	PF00400	0.484
TRG_NES_CRM1_1	321	331	PF08389	0.381
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	389	394	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T4	Leptomonas seymouri	65%	98%
A0A1X0NYU8	Trypanosomatidae	41%	100%
A0A3Q8ICN8	Leishmania donovani	99%	100%
A0A422N437	Trypanosoma rangeli	40%	100%
A4H8S9	Leishmania braziliensis	82%	100%
C9ZVU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AQW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QEL5	Leishmania major	94%	99%
V5B2M3	Trypanosoma cruzi	39%	100%